Viferon is a medical drug that has an immunostimulating and antiviral effect.

Release form and composition

Viferon is available in the form of rectal suppositories, gel and ointment. The active ingredient of the drug is recombinant human interferon alpha-2. Viferon suppositories can contain an active ingredient of 150,000, 500,000, 1,000,000 and 3,000,000 IU, the auxiliary substances in the composition are ascorbic acid, tocopherol acetate, solid fat or cocoa butter. Viferon ointment contains 40,000 IU of active substance (recombinant human interferon alpha-2), and the gel contains 36,000 IU. The auxiliary substances that make up the ointment are: tocopherol acetate, medical petroleum jelly, anhydrous lanolin and peach oil. The auxiliary components in the gel are represented by tocopherol acetate, benzoic and citric acid, sodium chloride, methionine, human serum albumin and glycerol.

Candles Viferon are yellowish and ovoid, packaged in 10 pieces in a blister strip packaging. Ointment for external use, viscous consistency, yellow-white, available in cans or tubes of 6 or 12 g. Gel for topical application, homogeneous and opaque, grayish, contained in tubes of 10 g.

pharmachologic effect

Viferon is a complex preparation, which includes human recombinant interferon alpha-2b, which has antiviral and antiproliferative activity. The presence of tocopherol acetate and ascorbic acid in the preparation promotes an increase in the antiviral activity of interferon alpha-2b and enhances its immunomodulatory effect on T- and B-lymphocytes. The antibacterial activity of the drug is due to the properties of interferon, to stimulate an increase in the phagocytic activity of macrophages and an increase in the cytotoxicity of lymphocytes to the affected cells. The course of the infectious process is always accompanied by damage and disruption of cell membranes, which reduce the effectiveness of interferon. Ascorbic acid and tocopherol acetate contained in Viferon, being powerful antioxidants, help to restore the permeability and elasticity of cell membranes, due to which the activity of alpha-interferon increases 10-15 times. When using Viferon, there are no side effects possible with parenteral use of interferon preparations, and also antibodies that can neutralize interferon do not appear. Numerous reviews of Viferon confirm that the use of the drug can significantly reduce the dosage and duration of treatment with antibiotics, cytostatics and hormones. When using Viferon suppositories, the concentration of interferon in the blood decreases 12 hours after administration.

Indications for use

According to the instructions of Viferon, the drug in the form of suppositories is used in children (including newborns) and adults with complex therapy various inflammatory and infectious diseases, such as acute viral respiratory infections, pneumonia, meningitis, sepsis, mycoplasmosis. Viferon, according to reviews and instructions, is also effective for intrauterine infections - herpes, chlamydia, cytomegaly, candidiasis. Viferon suppositories for children and adults are used in the complex therapy of hepatitis B, C and D, including chronic viral and complicated by liver cirrhosis. The drug is used by adults, in particular pregnant women, in the complex treatment of urogenital infections: cytomegalovirus infection, ureaplasmosis, trichomoniasis, gardnerellosis, bacterial vaginosis, recurrent vaginal candidiasis.

The gel is used in children for local treatment and prevention of acute respiratory infections and recurrences of laryngotracheobronchitis, and in adults - for chronic herpetic lesions of various localization. Viferon ointment is used in the treatment of viral (including those provoked by herpes) infections of the skin and mucous membranes: genital warts, vulgar warts, bowenoid papulosis.

Method of administration and dosage

According to Viferon's instructions, the drug is prescribed to newborns and premature babies with infectious diseases 1 suppository of Viferon 150,000 IU 2 times a day with an interval of 12 hours, the duration of treatment is 5 days. If necessary, it is possible to conduct repeated courses, but with a break of at least 5 days. Viferon suppositories for children under the age of 7 years - 1 suppository 150,000 IU every 12 hours, for children over 7 years old and adults, the drug is prescribed 1 suppository in 500,000 IU of interferon 2 times a day, for 5-10 days. In the treatment of chronic viral hepatitis, Viferon suppositories for children under 6 months are prescribed at 300,000-500,000 IU per day, from 6 months to 1 year - 500,000 IU per day. Children aged 1 to 7 years are prescribed candles at a dose of 3,000,000 IU per 1 m2 of body area per day, Viferon for children over 7 years of age - 5,000,000 IU per 1 m2 of body surface area per day, adults at 3,000,000 MN per day, the dose is divided for two doses at intervals of 12 hours. In the first 10 days, the drug is used every day, then 3 days a week every other day, for 6-12 months.

In the treatment of urogenital infections, including in pregnant women (from 14 weeks of gestation), 1 suppository of 500,000 IU is prescribed 2 times a day every 12 hours. The course of Viferon therapy lasts up to 10 days. In the future, pregnant women over the next 10 days are prescribed twice a week, 1 suppository 2 times a day, then after a 4-week break for 5 days, 150,000 IU 2 times a day, and in this dosage every 4 weeks before delivery.

Viferon ointment is applied to the affected skin 3-4 times a day, gently rubbing a thin layer, the course lasts 5-7 days.

Gel Viferon in the treatment of acute respiratory infections and laryngotracheobronchitis is used 3 times a day, applying to the surface of the tonsils for 20 days, prevention is carried out in spring and autumn. For herpes infections, the gel is used 4-7 times a day for one and a half weeks.

Contraindications

According to Viferon's instructions, the drug is contraindicated in case of hypersensitivity to the constituent components. It is not recommended to use Viferon suppositories during pregnancy up to 14 weeks.

Side effects

According to reviews about Viferon, the drug in rare cases can provoke the development of allergic reactions in the form of skin rash, urticaria, itching.

Storage conditions

The drug is stored away from light sources, in a dry place at a temperature of 2 ° to 8 ° C.

The immune system human body is not always able to effectively eliminate viral and infectious manifestations. Therefore, it is very important to timely select an effective drug for the treatment of viral diseases. Viferon candles for adults are effective remedy, which has a pronounced antimicrobial and antiviral effect.

Description of the medication

Before using any medication, you must familiarize yourself with its purpose, how to use the remedy correctly, and to whom it is contraindicated.

Viferon is a powerful drug whose main purpose is to activate immune system in the body, fighting viruses and infections. This is a combined pharmacological agent and it contains recombinant alpha interferon, as well as a complex of certain vitamins. Also included are auxiliary ingredients:

• polysorbate;
• tocopherol acetate;
• vitamin C;
• sodium ascorbate.

The main components can also include butter, cocoa and fat, which in total do not exceed 1 gram. The medication is produced in the form of suppositories, gel and ointment.

Description of suppositories:

• bullet-shaped candles, have a slightly pointed, oblong shape;
• the color is white, a slight yellowness is permissible;
• the blister pack contains 5 or 10 suppositories.

The remedy is dispensed without a doctor's prescription. There are several types of Viferon suppositories, with a dosage of 150,000, 500,000, 1,000,000 and 3,000,000 IU, in which not only the dosage of the main components differs, but also the auxiliary ones.

When buying a drug, you must definitely pay attention to the dosage, since the number of times of use per day and the possibility of using it for children and pregnant women depend on it.

Pharmacological properties

Many are interested in the question, why are Viferon suppositories prescribed and what are the main properties of the drug? It should be noted that this is a modern remedy, which contains main component- alpha interferon found in the human body. Suppositories with Viferon help to activate the protective functions of the human body, stimulate immunity and fight various kinds of viruses.

In addition to the main component, ascorbic acid is present in the composition of the drug, which also has an antiviral effect and protects the body from harmful free radicals that are the cause of most diseases.

Interesting fact:

Thanks to vitamin C, the activity of interferon increases, and tocopherol alpha helps to restore cells and relieve inflammatory processes.

Prescribing Viferon for adults eliminates the need for many antibiotics, while the use of other drugs that are usually prescribed for viruses and infections is significantly reduced. It should also be noted that the period of treatment is also significantly reduced. By choosing this therapy, the organs of the gastrointestinal tract and other systems are affected with less intensity. The risk of the onset and development of other diseases, characteristic after long-term therapy with various pills, is reduced.

It should be noted that the drug helps to reduce the production of its own interferon, and does not improve immunity. In this regard, it is not recommended to use the drug too often and for a long time in order to avoid dependence. The dosage of Viferon suppositories for adults depends on the doctor's prescription and the degree of damage to the body by the virus. In the instructions for the use of suppositories for adults Viferon there is more detailed information on the composition, as well as on the properties of the medication.

Video "Fight for immunity with Viferon"

Informational video with advice from a specialist who recommends using Viferon for immunostimulation.

Viferon for adults - indications

The main purpose of the product is to treat diseases of an infectious and viral nature. Diseases for which suppositories are used:

• pathologies caused by infections of the urogenital system;
• viral hepatitis;
• sepsis, various infectious diseases, enteroviruses;
• acute respiratory diseases in adults and children;
• cirrhosis of the liver;
• complication of influenza and ARVI;
• intrauterine infections;
• candidiasis;
• cytomegalovirus;
• chlamydial infections.

The drug is often prescribed to pregnant women and newborn children, since the drug has a fairly safe composition.

Contraindications

It has already been confirmed more than once that rectal suppositories Viferon is an absolutely safe pharmacological product, so they can be used by any category of patients.

However, there is also a certain contraindication here. This is an individual intolerance to any component.

Suppositories are allowed to be used even during pregnancy and breastfeeding... However, in the first trimester, it is still worth abandoning the use of the drug. This is due to the fact that the placenta has not yet fully formed, so all substances can penetrate the fetus. Starting from the second trimester, Viferon is completely safe.

You should not use the product if you have an allergy to the ingredients. If side effects and allergic reactions occur, you need to stop taking the drug and seek medical advice. Side effects are possible, most often they occur in the form of:

• itching;
• burning sensation;
• rashes.

Usually, after the suppository is canceled, such symptoms disappear after 2-3 days.

Mode of application

Depending on the form of Viferon, the method of using the device also depends. Suppositories are administered rectally, into the rectum, several factors affect the daily dose, such as:

• the age of the patient;
• the nature of the virus and the disease itself;
• features of the body (pregnancy, individual intolerances, etc.).

This pharmacological product is prescribed for the treatment of certain pathologies, while it can be used both as an independent agent and in complex treatment.

For newborns and children up to 6 months

For premature babies, as well as children under the age of six months, daily dose makes one suppository twice a day. It is necessary to choose a drug with a dosage of 150,000 IU. The duration of treatment depends on the stage and the disease itself, as well as on individual characteristics. Determined by a doctor after diagnosis.

For children aged 6 months to a year

Usually at this age, experts prescribe this drug for the treatment of viral hepatitis C, D, B. 1 suppository per anus, once a day. The dosage is 500 thousand IU. The course may vary.

Children under 12 years old

To eliminate the symptoms of flu, colds, you must use one suppository, twice a day. The dosage of one candle is 150 thousand IU.

Dosage for adults

The number of suppositories administered, as well as their dose, depends primarily on the disease, stage and individual characteristics.

Viral hepatitis chronic form is treated with suppositories with a dose of 3 million IU, one unit, twice a day. Typically, the treatment period is 10 days. After that, the attending physician should reduce the dosage, depending on whether the patient is recovering.

Viferon candles - instructions for use in gynecology:

• 500 thousand IU;
• the daily dose is 1 million IU, but at a time, in the evening.

The average course length is 5 days; after a five-day break, the course is usually repeated.

Most commonly used to treat:

• chlamydia;
• candidiasis;
• mycoplasmosis;
• vaginosis and so on.

For genital herpes, suppositories are prescribed, while their dosage is 1 million IU, twice a day. With viral colds suppositories of 500,000 IU are used, twice a day. The average duration of the course is a week. It is worth noting that suppositories melt quickly, so it is better to store them in the refrigerator and remove them from their individual packaging immediately before insertion.

Use during pregnancy and lactation

During lactation, Viferon is prescribed to eliminate bacterial as well as infectious pathologies. different types... The dosage is the same as for adults. Before 14 weeks, the use of suppositories is not recommended, due to insufficient research.

Overdose and adverse reactions

Another advantage of the drug is the fact that adverse reactions occur very rarely, since the agent has excellent tolerance.

If there are side effects, then they are expressed locally - allergies in the anus, itching, burning, rash and discomfort. In this case, the doctor must assess the degree of allergy and conclude whether to leave suppositories for therapy or refuse to use them.

There is no data on overdose, however, as a result of non-observance of the instructions, it is possible dangerous consequences... Therefore, doctors and manufacturers recommend strictly adhering to the instructions and dosage.

Interaction with other drugs

You should be careful when combining Viferon suppositories with other drugs, since their main component is able to enhance the effect of such pharmacological products:

• various kinds of antibiotics;
• antiviral drugs of various forms;
• antimicrobial agents;
• immunostimulants.

Doctors note that constipation and stool disorders negatively affect the main action of suppositories. Therefore, it is recommended to use laxatives or an enema.

Viferon candles for men

Recently, quite often, many urologists prescribe Viferon suppositories for men, as they are excellent at fighting infections. But it is known that it is infections that become the main root causes of various male diseases, starting with prostatitis.

That is why anti-infectious drugs must be included in complex treatment without fail. However, Viferon will not help get rid of male diseases on its own, therefore, it is necessary to prescribe additional drugs and procedures, such as prostate massage, warming up, and so on.

Viferon suppositories for prophylaxis in adults

To date, the effect of the use of suppositories for prevention has already been confirmed. viral diseases, as well as more serious pathologies. These include:

• chlamydia;
• cytomegalovirus;
• toxoplasmosis in children and adults;
• seasonal viral infections and diseases.

For the prevention of such infections and pathologies, it is necessary to use the drug according to the instructions, while using the smallest dosage. It is best to consult a doctor for help and advice to prevent addiction.

Analogs

Today, the pharmacology market is developing well, so many Viferon analogues can be seen in pharmacies. These drugs are similar in composition, properties and indications. Analogs include:

• Laferon;
• Alfarekin;
• Laferobion (no less effective and popular option);
• Interferon and so on.

The exact analogue of Viferon has not yet been invented, however, the above drugs are very similar in composition. Their main component is identical.

How to store candles?

Like most other medicines, candles must be kept away from sunlight and heat appliances - fireplaces, batteries. The maximum storage temperature is ten degrees. Therefore, the most suitable storage place is the refrigerator.

You need to save the pharmacological product in its original packaging, without removing the candles from the blister in advance. The shelf life is 24 months from the date of production; expired candles are not recommended to be used.

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If you have questions about the use of Viferon suppositories during pregnancy, see the article.
If you do not understand how to correctly inject Viferon rectal suppositories, see the article.
Viferon price: in Moscow, Ukraine, Belarus.
Read about the correct selection of the dosage of Viferon suppositories in questions and answers in the article

Information on how to properly store Viferon candles in the form of questions and answers can be found in the article

Trade name of the medicinal product

Viferon (VIFERON) ®

Manufacturer

Feron LLC, Russia

International non-proprietary name

Interferon human recombinant alpha-2

Dosage form

Rectal suppositories

Release form

Suppositories (150,000 IU, 500,000 IU, 1,000,000 IU, 3,000,000 IU) weighing from 0.95 g to 1.05 g, 10 pieces each in a blister strip packaging PVC / paper or weighing from 1.00 g to 1.10 g each 10 pieces in a blister strip PVC / PVC. 1 or 2 blister packs with instructions for use in a cardboard box

Description

The suppository has a bullet-like shape, yellowish-white color, homogeneous consistency. Inhomogeneity of color in the form of marbling and the presence of a funnel-shaped depression on the cut are allowed. The diameter of the suppository is not more than 10 mm.

Pharmacotherapeutic group

Immunomodulatory and antiviral agent.

Active substance

1 suppository VIFERON 150,000 IU contains the active substance - human recombinant interferon alpha-2 150,000 IU;
1 suppository VIFERON 500000 IU contains the active substance - human interferon recombinant alpha-2 500000 IU
1 suppository VIFERON 1,000,000 IU contains the active substance interferon human recombinant alpha-2 1,000,000 IU
1 suppository VIFERON 3,000,000 IU contains the active substance - human interferon recombinant alpha-2 3,000,000 IU

Excipients

Ascorbic acid 0.015 g, alpha-tocopherol acetate 0.055 g, base cocoa butter or solid fat

pharmachologic effect

Human recombinant interferon alpha-2 has pronounced antiviral, immunomodulatory and antiproliferative properties. Complex composition the drug causes a number of additional effects: in the presence of ascorbic acid and alpha-tocopherol acetate, the antiviral activity of human recombinant alpha-2 interferon increases, its immunomodulatory effect on T- and B-lymphocytes increases, the level of immunoglobulin E is normalized, and the functioning of the endogenous interferon system is restored. In addition, ascorbic acid and alpha-tocopherol acetate, being highly active antioxidants, have anti-inflammatory, membrane stabilizing and regenerating properties. It was found that when using VIFERON there are no side effects that occur with parenteral administration of interferon preparations, and antibodies are not formed that neutralize the antiviral activity of interferon.

Pharmacokinetics

After rectal administration, after 12 hours, a decrease in serum concentration is observed, which necessitates its repeated administration.

Indications for use

In the complex therapy of various infectious and inflammatory diseases in children, including newborns and premature babies:

• acute respiratory viral infections (influenza, ARVI, including those complicated bacterial infection),
• pneumonia (bacterial, viral, chlamydial),
• meningitis (bacterial, viral),
• sepsis,
• intrauterine infection (chlamydia, herpes, cytomegaly, enterovirus infection, candidiasis, including visceral, mycoplasmosis);

In complex therapy chronic viral hepatitis B, C, D in children and adults, including in combination with the use of plasmapheresis and hemosorption,
with chronic viral hepatitis of a pronounced degree of activity and complicated by cirrhosis of the liver;
in complex therapy in adults, including pregnant women, with urogenital infection(chlamydia, cytomegalovirus infection, ureaplasmosis, trichomoniasis, gardnerellosis, papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis),
primary or recurrent herpes infection of the skin and mucous membranes, localized form, mild and moderate course, including urogenital form;
in complex therapy, including those complicated by bacterial infection in adults.

Dosage regimen

Suppositories containing human recombinant alpha-2 interferon as an active substance in the indicated dosages (150,000 IU, 500,000 IU, 1,000,000 IU, 3,000,000 IU) are used rectally.
In the complex therapy of various infectious and inflammatory diseases in newborns, including premature: newborns, including premature babies with gestational age more than 34 weeks appoint VIFERON 150,000 IU * daily 1 suppository 2 times a day after 12 hours. The course of treatment is 5 days.
Premature newborns with gestational age less than 34 weeks appoint VIFERON 150,000 IU daily, 1 suppository 3 times a day after 8 hours. The course of treatment is 5 days.
The recommended number of courses for various infectious and inflammatory diseases in children, including newborns and premature babies:

• flu, ARVI, including those complicated by bacterial infection - 1-2 courses;
• pneumonia(bacterial, viral, chlamydial) - 1-2 courses,
• sepsis- 2-3 courses,
• meningitis- 1-2 courses,
• herpes infection- 2 courses,
• enterovirus infection- 1-2 courses,
• cytomegalovirus infection - 2-3 courses,
• mycoplasmosis, candidiasis, including visceral, - 2-3 courses.

The break between courses is 5 days. By clinical indications therapy can be continued.

In complex therapy chronic viral hepatitis B, C, D in children and adults: for children with chronic viral hepatitis, the drug is prescribed in the following age-specific dosages: up to 6 months 300,000-500,000 IU per day; from 6 to 12 months- 500,000 IU per day. Aged from 1 to 7 years- 3,000,000 IU per 1 m2 of body surface area per day. Aged over 7 years old- 5,000,000 IU per 1 m2 of body surface area per day. for each specific patient is produced by multiplying the recommended dosage for a given age by the body surface area calculated by nomogram to calculate body surface area in terms of height and weight according to Garford, Terry and Rourke, divided into 2 administrations, rounded to the dosage of the corresponding suppository. The drug is used 2 times a day after 12 hours for the first 10 days daily, then three times a week every other day for 6-12 months.
The duration of treatment is determined by clinical efficacy and laboratory parameters. Children with severe chronic viral hepatitis and cirrhosis of the liver before holding plasmapheresis and / or hemosorption shows the use of the drug for 14 days daily for 1 suppository 2 times a day after 12 hours(children under 7 years old VIFERON 150,000 IU, children over 7 years old - VIFERON 500,000 IU).
Adults with chronic viral hepatitis appoint VIFERON 3,000,000 IU 1 suppository 2 times a day after 12 hours for 10 days every day, then three times a week every other day for 6-12 months. The duration of treatment is determined by clinical efficacy and laboratory parameters.
In complex therapy in adults, including pregnant women, with urogenital infection(chlamydia, cytomegalovirus infection, ureaplasmosis, trichomoniasis, gardnerellosis, papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis), with primary or recurrent herpes infection skin and mucous membranes (localized form, mild and moderate course, including the urogenital form).
Adults, with the above infections, in addition to herpes, are prescribed Viferon 500,000 IU on 1 suppository 2 times a day after 12 hours. The course is 5-10 days. According to clinical indications, therapy can be continued with breaks between courses for 5 days.
At herpes infection appoint VIFERON 1,000,000 IU 1 suppository 2 times a day after 12 hours. The course of treatment is 10 days or more in case of recurrent infection. It is recommended to start treatment immediately when the first signs of lesions of the skin and mucous membranes appear (itching, burning, redness). When treating recurrent herpes, it is advisable to start treatment in the prodromal period or at the very beginning of the manifestation of signs of relapse.
Have pregnant women with urogenital infection, including herpetic, in the II trimester of pregnancy (starting from week 14) - Viferon 500,000 IU 1 suppository every 12 hours (2 times a day) for 10 days, then 1 suppository every 12 hours (2 times a day) twice a week - 10 days. Then, after 4 weeks, preventive courses of the drug Viferon are carried out 150,000 IU 1 suppository every 12 hours - for 5 days, the prophylactic course is repeated every 4 weeks. If necessary, it is possible to conduct a treatment course before childbirth.

Separate article in complex therapy flu and other acute respiratory viral diseases, including those complicated by bacterial infection in adults. Apply VIFERON 500,000 IU 1 suppository 2 times a day every 12 hours every day. The course of treatment is 5-10 days.

Contraindications

Hypersensitivity to any component of the drug

Pregnancy and lactation

The drug is approved for use from the 14th week of pregnancy. Has no restrictions for use during lactation.

Side effect

In rare cases, the development of allergic reactions (skin rashes, itching) is possible. These phenomena are reversible and disappear 72 hours after stopping the drug.

special instructions

It can be used in combination therapy with antibacterial drugs, GCS, immunosuppressive drugs, interferon inducers.

Overdose

No data provided

Drug interactions

VIFERON, rectal suppositories, compatible and goes well with all drugs used in the treatment of the above diseases (antibiotics, chemotherapy drugs, glucocorticosteroids)

Shelf life

2 years. Do not use the drug after the expiration date

Storage conditions

In a dark place at a temperature of 2 to 8 ° C. Transportation and storage in accordance with SP 3.3.2.1248-03 at a temperature of 2 to 8 ° C. Keep out of the reach of children

Terms of dispensing from pharmacies

Without a doctor's prescription

approximate price

Russia: 150,000 IU $ 5.3-7, 500,000 IU $ 7.9-9.5, 1,000,000 IU $ 10.9-13.8, 3,000,000 IU $ 18.7-21.1
Belarus: 150,000 IU $ 10-14.3, 500,000 IU $ 13.9-19.4

Content

The drug Viferon is an immunomodulatory agent with an antiviral effect, whose active ingredient is human recombinant interferon alpha-2b. The medication has the function of increasing immunity, produced by the Russian company Feron. Check out its instructions for use.

Composition and form of release

Viferon (Viferon) is presented in three forms of release: suppositories, ointment and gel. Their composition:

Description	Yellow-white homogeneous ointment with lanolin scent	Opaque white-gray homogeneous gel	White-yellow bullet suppositories with a diameter of 10 mm
Interferon concentration, IU			150,000, 500,000, 1,000,000 or 3,000,000 for 1 piece.
Additional components	Water, Tocopherol Acetate, Peach Oil, Anhydrous Lanolin, Medical Vaseline	Water, alpha-tocopherol acetate, ethanol, benzoic acid, carmellose sodium, sodium tetraborate decahydrate, glycerol (glycerin), methionine, serum human albumin solution, sodium chloride, citric acid monohydrate	Confectionery fat, alpha-tocopherol acetate, cocoa butter, ascorbic acid, polysorbate, disodium edetate dihydrate, sodium ascorbate
Package	Tubes of 6 or 12 g, jars of 12 g, in a pack with instructions for use	12 g tubes	Packs of 10

Pharmacodynamics and pharmacokinetics

Recombinant human interferon exhibits antiviral, immunomodulatory and antiproliferative effects, suppressing the replication of RNA and DNA of viruses that cause diseases. The drug enhances the phagocytic activity of macrophages, exhibits an antibacterial effect, does not affect hemosorption.

Interferon increases its activity in the presence of antioxidants (vitamin E, benzoic and citric acid), which increases the body's own immune response to infectious agents. Viferon exhibits a pronounced local immunomodulatory effect, increases locally formed antibodies, which prevent pathogenic microorganisms from fixing and multiplying on the mucous membranes. This gives the drug a preventive effect.

The rapidly absorbing base of all forms of release of the product gives them a prolonged action. Antioxidants in the composition show regenerating, anti-inflammatory and membrane-stabilizing effects, preserve the biological activity of interferon. Water-soluble protein alpha interferon is effective against influenza, hepatitis, herpes, mixed infections. It restores the functions of endogenous immunity, increases the production of antibodies.

The antiproliferative effect of Viferon is manifested in the form of growth suppression malignant tumors replicating the genome of viruses. The use of the drug locally or rectally leads to rapid absorption by the mucous membrane and skin, its penetration into the lymphatic system. 12 hours after use, the level of interferons decreases. The remainder of the dose is excreted by the kidneys, is metabolized in the liver and excreted to a lesser extent in the bile. The substance is not cumulated.

Indications for use

The drug has many indications for use. According to the instructions, these are:

• influenza, frequent and prolonged acute respiratory viral infections (ARVI), including complications with the addition of a bacterial infection;
• prevention of colds;
• recurrence of stenosing laryngotracheobronchitis;
• acute form or exacerbation of the course of chronic recurrent herpes infection of the skin, mucous membranes, urogenital tract;
• herpetic cervicitis;
• intrauterine fetal infection (herpes, chlamydia, enteroviruses, cytomegalovirus, candidiasis, visceral mycoplasmosis);
• bacterial, chlamydial or viral pneumonia;
• bacterial, viral meningitis, sepsis;
• chronic viral hepatitis B, C or D;
• bacterial vaginosis, chlamydia, mycoplasmosis, cytomegalovirus infection, trichomoniasis, ureaplasmosis;
• gardnerellosis, recurrent vaginal candidiasis, papillomavirus infection.

Method of administration and dosage

Instructions for the use of Viferon differ in the type of release of the drug. Ointment and gel are intended for application to the skin or mucous membranes - externally. Suppositories are inserted rectally into the anus, and can be used intravaginally for some diseases. The dosage of the drug and the course of treatment depend on the type of disease and its severity.

Candles Viferon

According to the instructions, Viferon suppositories for adults are used rectally. Dosage and frequency of use:

Disease	Dosage of suppositories, IU per piece.	Dosage, pcs.	Frequency rate of admission, times / day	Treatment course, days	Note
			2 q 12 h		Repetitions of treatment courses: sepsis - 2-3, meningitis - 1-2, herpes - 2, candidiasis - 2-3, CMV infection (cytomegalovirus) and enterovirus - 2-3
Chronic viral hepatitis					Then three times a week every other day for a course of 6-12 months
Urogenital diseases
					Treatment begins when the initial signs of damage are detected (burning, itching, redness)

Gel and ointment

If the skin is affected by the herpes virus, the ointment or gel is applied to the foci of inflammation 3-4 times a day for a course of 5-7 days. Therapy begins immediately upon detection of the initial signs - itching, burning, redness. This helps to cope with the disease faster and prevent relapse. According to the instructions, for the treatment of influenza, the funds are applied in a thin layer on the mucous membrane - for children 1-2 years old a pea 0.5 cm three times a day, 2-12 years old - 0.5 cm 4 times a day, 12-18 years old - 1 cm 4 once a day for 5 days.

With prolonged and frequent colds, including those complicated by a bacterial infection, a drop of gel 0.5 cm is rubbed into the mucous membrane of the palatine tonsils 3-5 times a day using cotton swab... For the prevention of ARVI, repeat the procedure 2 times a day for a course of 2-4 weeks. To eliminate the symptoms of laryngotracheobronchitis, a strip of gel is applied to the palatine tonsils 5 times a day for a course of 5-7 days, then three times a day for a course of 3 weeks. For the prevention of the disease, 0.5 cm of the agent is applied twice a day for a course of 3-4 weeks twice a year.

With herpetic cervicitis, 1 ml of gel is moistened with a cotton swab and the cervix, cleared of mucus, is treated twice a day for a weekly course. On the nasal mucosa, the agent is used after ensuring the patency of the nasal passages, on the tonsils - half an hour after eating. If the gel is applied to the skin or mucous membranes, a thin film forms after half an hour. You can rub the drug on it again, or peel it off or wash it off with water.

special instructions

As stated in the instructions, it has not been established that the use of the agent negatively affects the ability to drive a car or control mechanisms. Special instructions:

1. Injections, syrup or Viferon tablets are not available. This is due to the fact that if the interferon protein enters the digestive tract, it will undergo enzymatic processing and lose its effect. Injection administration of the drug is capable of showing dangerous side effects... Due to the release form of Viferon in the form of suppositories, gel and ointment, experts have achieved the safety of the product.
2. Suppositories are available in 4 dosages marked 1,2, 3 and 4.1 - for the treatment of children under 7 years old and the prevention of viral diseases in pregnant women, 2 - for children over 7 years old and the treatment of pregnant women, 3 - for the treatment of adults and viral childhood hepatitis , 4 - for adults only.
3. Local forms of drug release do not cause cancer.

During pregnancy

Viferon suppositories during pregnancy are prescribed from the 14th week of gestation (second trimester), 1 suppository of 500 thousand IU twice at knocks every 12 hours for a course of 10 days. Then women can use 1 candle twice a day every 4 days for 10 days. A month before the intended delivery, Viferon is prescribed, according to the instructions, for 1 suppository 150 thousand IU twice a day for a course of 5 days. From 38 weeks of gestation, the drug is 500 thousand IU, 1 pc. it is introduced twice a day every 12 hours for a course of 10 days.

Viferon for children

According to the instructions, Viferon for newborns can be used even in children born at 34 weeks of gestation. For such children and up to the age of 7 years, 150,000 IU are prescribed for 1 piece. twice a day with a course of 5 days. The break between courses lasts 5 days. In premature babies, 1 suppository of 150,000 IU is prescribed three times a day every 8 hours for a course of 5 days. Children under six months of age are recommended to 300-500 thousand IU per day, 6-12 months - 500 thousand IU. A child 1-7 years old is supposed to be 3 million IU per square meter of body surface area per day, over 7 years old - 5 million IU.

Drug interactions

Viferon perfectly combines and combines with most drugs used in the complex therapy of diseases. It can be combined with chemotherapy drugs, antibiotics, glucocorticosteroids, anti-inflammatory drugs, albumin drugs, plasmapheresis drugs. The prohibited combination with other drugs is not mentioned in the instructions for use.

Side effects

Most patients using Viferon say that it is well tolerated. As stated in the instructions, side effects such as skin rash, allergies, itching can rarely occur. The phenomena are reversible, stop on their own 3 days after stopping the drug. When processing the mucous membrane, sneezing, rhinorrhea, burning sensation may occur. The phenomena are weak and disappear on their own. Overdose with Viferon has not been identified.

Contraindications

All forms of release medicinal product contraindicated in case of individual intolerance to the constituent parts of the drug. There is one more contraindication for the ointment - it cannot be used in children under one year old, with cirrhosis of the liver. For such cases, the use of gel or suppositories is allowed.

Terms of sale and storage

All forms of release funds are dispensed without a prescription. They are stored at 2-8 degrees. Candles can be stored for two years, gel - 1 year, after opening - 2 months, ointment - 1 year, after opening the tube - a month, after opening the can - 14 days.

Analogs

You can replace the agent with drugs based on interferons different types... The analogs of Viferon include:

• Infagel is an antiviral gel based on interferon alpha-2a.
• Vitaferon - immunomodulating rectal suppositories with the same composition.
• Genferon - antiproliferative suppositories.
• Laferon is an immunostimulating nasal solution and lyophilisate powder.
• Laferobion - antitumor suppositories, nasal powder and lyophilisate for solution preparation.
• Anaferon - sublingual tablets containing affinity purified antibodies to human interferon gamma.
• Kipferon - antibacterial candles based on immunoglobulin and interferon.
• Grippferon - immunomodulating spray and drops.

Viferon's price

The cost of funds is influenced by the trade markup of the networks, the form of release, the amount of interferon in the dose. You can buy drugs through the Internet or pharmacies. In Moscow, prices will be.

Domestic drug Viferon is a complex of recombinant human interferon alpha-2b and an antioxidant complex (includes: alpha-tocopherol acetate and ascorbic acid). Claimed as an immunomodulatory drug with antiviral action.

Produced by Feron (Moscow).

The main active ingredient of the drug is interferon, the antiviral properties of which were discovered back in 1957, but at that time interferon required multiple and large doses to be administered to the body and in this regard had a large number of complications and side effects. According to pharmaceutical manufacturers modern drugs on the basis of interfreron, including Viferon, these side and even harmful and inconvenient effects are eliminated.

Forms of issue

At the moment, Viferon has three forms of release: rectal suppositories or suppositories, ointment and gel.

Rectal suppositories or suppositories... Bullet-shaped, yellowish-white in color. Contain different amounts active substance interferon alpha-2b: 150,000 IU, 500,000 IU, 1,000,000 IU, 3,000,000 IU. Because of this, you can find various types of this drug: Viferon 1, 2, 3 or 4. All these names come from different amounts of the active substance in suppositories and, accordingly, a different dosage regimen for different age groups (adults or children). Other differences between different kinds There is no Viferon in the candles, the rest of the composition is standard and includes, as additional substances, alpha-tocopherol acetate and ascorbic acid, and base preparations (cocoa butter and confectionery fat).

Ointment... Yellowish white in color. Contains the active ingredient interferon alpha-2b and tocopherol acetate.

Gel also contains interferon alpha-2b and alpha-tocopherol acetate as the main active ingredient. It is an opaque gel-like mass of white color.

Thus, Viferon different forms release contains approximately the same set of chemicals, all the difference lies in the form of release and different routes of administration into the body.

pharmachologic effect

Interferon alpha-2b as the main active ingredient of the drug Viferon has immunomodulatory, antiviral and antiproliferative properties, this is what we need in application of this drug for the treatment of influenza. The rest of the effects are too tricky to describe them simple language so let's leave them to medical professionals.

It should also be noted that, unlike parenteral administration of interferon into the body, these forms of Viferon release do not have a systemic negative effect on the body and reduce side effects. And such routes of administration of the drug into the body are due to the fact that interferon in gastrointestinal tract is destroyed, since it has a protein structure, in order to avoid this, the direct delivery of the active substance into the bloodstream is used.

Since under conditions of a destroyed cell membrane, the effect of the use of interferon decreases many times (interferon for work must contact the receptors of the cell, which are located on its membrane, and viruses, including influenza, destroy cell membranes in the course of their vital activity), then to stabilize cell membranes and additional substances are introduced into the preparation: alpha-tocopherol acetate and ascorbic acid, which are strong antioxidants.

It is stated that the use of Viferon helps to reduce doses antibacterial drugs and hormones in the treatment of a variety of infections.

It should also be noted that 12 hours after the rectal administration of Viferon into the body, the level of interferon in the blood drops and it is necessary re-introduction drug.

Indications for use

The drug Viferon is used in the complex therapy of the following infections:

1) acute respiratory viral infections (including influenza), complicated or uncomplicated by bacterial infection in adults and children (including newborns and premature babies)

2) sexually transmitted diseases (chlamydia, herpes, human papillomavirus (HPV), ureaplasmosis, mycoplasmosis), including in pregnant women with urogenital infection

3) meningitis, sepsis, intrauterine infection in children

4) chronic viral hepatitis B, C and D

Contraindications

Of the contraindications for Viferon declared by the manufacturer, only hypersensitivity to the ingredients of the drug is noted.

What is characteristic of other drugs based on recombinant human interferon alpha-2b (foreign Intron or our Altevir) have a fairly significant range of contraindications for admission, although they are the same interferon drugs as Viferon. This and cardiovascular diseases, renal and hepatic failure, epilepsy, diseases thyroid gland decompensated diabetes... Yes, these contraindications can be attributed to the fact that these substances are injected parenterally, that is, into the blood, but in the place of people with similar problems, I would be careful when taking Viferon or would recommend any other for the treatment of influenza. You need to be especially careful during pregnancy.

Side effects

Standard side effects can be observed as with any chemicals: skin rash or itching. The truth is rare. Allergic reactions are reversible and disappear after 72 hours.

Overdose

Data on an overdose of the drug Viferon was not found.

Evidence-based medicine

All the known ones were taken out in a separate article because of the volume of the material under study.

The use of the drug Viferon during pregnancy and lactation

Admission is allowed starting from the 14th week of pregnancy. There are no restrictions on use during lactation.

Method of administration and dosage

It should be noted that a large number of different forms and dosages of the drug implies an appointment with a doctor for an appointment. optimal scheme dosages depending on the severity of the infection and the age of the patient. Moreover, the drug is available on prescription.

V general view Viferon is applied 1 suppository 2 times a day, based on the period of excretion from the body of 12 hours. In children and newborns, it can be used 3 times a day, but with a reduced dosage.

For complex treatment acute respiratory viral infections, including influenza in children, are used at a dosage of 150,000 IU, 1 suppository 2 times a day. Treatment period is 5 days.

For the complex treatment of acute respiratory viral infections, including influenza in adults, a dosage of 500,000 IU is used, 1 suppository 2 times a day. The course of treatment is 5-10 days.

The ointment is used to treat viral (including herpetic) lesions of the skin and mucous membranes of various localization. It is applied with a thin layer on the lesion focus 3-4 times in knocks and lightly rubbed. The duration of the course of treatment is 5-7 days.

Viferon in the form of a gel is used to treat the entire spectrum of diseases for which this drug is indicated and can be considered as an alternative to the administration of suppositories (you must agree that this method of administration has certain inconveniences). The gel can be applied to the mucous membrane of the nose or tonsils. In addition, due to it, the range of application of this drug in gynecological practice is expanded, for the treatment of herpetic cervicitis by the method of application to the cervix.

The drug is well tolerated, including when taken with other drugs.