Prohibited in breastfeeding

Forbidden children

Has limitations for older people

Has limitations when problems with liver

Has restrictions on kidney problems

Constant stressful situations, alarming states, chronic neurosis can lead to severe disorders of not only the nervous system, but also to violations of the functions of the whole organism. To combat stress, depression and neurosis, the use of benzodiazepine tranquilizers or antidepressants is justified.

Uncompaired pluses of these funds include speed speed. Despite the effectiveness, the use of such medical preparations may cause dependence. Doctors recommend contacting such therapy exclusively in emergency cases. Afobazol differs from other drugs of this group by the fact that it, according to the instructions for use, does not cause addiction, and by the fact that it can be used for long-term treatment.

Aphobazol is an optimal substitute for antidepressants and tranquilizers. The absence of side effects in use, the effect of addiction and cancellation syndrome belong to the distinguishing features of the drug.

The significant advantages of Afobazole is considered low level toxicity for the body and the possibility of applying complex therapy.

Also long use Afobazola is not accompanied by drowsiness, irritability, lethargy and deterioration of the human life. The medicine is widespread among doctors and patients, and you can buy it in a pharmacy without a recipe.

Dosage Group, MNN, Application Scope

Aphobazol refers to selective nonxoisodiazepine preparations with anxolytic properties, a 2-mercaptobenzimidazole derivative (not refers to benzodiazepine receptor agonists). MNN drug - Afobazol.

The drug is widely used in psychiatry and neurology, in general-quality practice in the manifestations of the symptoms of depression, psychopathological disorders and in cases of pathological anxiety, which can proceed in the form of attacks or is constantly.

In cases of anxiety attacks, the patient complains about panic attacks, vegetative dysfunctions of the body, the development of social phobia. For chronic form The most commonly observed constant depressive and stressful states, as well as a violation of adaptation. For the treatment of these cases, if long medicia treatment, Doctors use Afobazole.

Forms of issue and price for the drug, average in Russia

Medicine can be purchased in the form of beige or white tablets round flat form. They are produced in the amount of 10, 20, 25 pieces in plates and 30, 50, 60, 100 pieces in plastic jars. Most often sold in an amount of 60 pieces in the bank. Producer Country - Russia. The average prices of Afobazola are presented in the table.

Composition and pharmacology

In one tablet contains 5 mg or 10 mg of the Faboothizol of dihydrochloride. Additional substances include:

• potato starch - 48 mg;
• lactose monohydrate - 48.5 mg;
• medical media molecular polyvinylpyrrolidone - 7 mg;
• magnesium stearate - 1.5 mg.

Before starting therapy, it is important to understand how Aphobazol acts. The effect of the drug is directed to sigma-1-receptors of brain nerve cells, so that the GABA receptor is stabilized.

The medicine restores the structure of the GAMK-benzodiazepine receptor complex due to sigma-1-receptors, which leads to a normal binding process of the GABC with receptors. Also restores high sensitivity of receptor data to braking mediators. The medicine has a protective and reducing effect against nerve cells, and also retains their bioenergy supply.

The effect of Afobazola is represented by a combination of anxiolytic and weak stimulating action. Anxiolytic action is responsible for troubleshooting. Thanks to these effects, the medicine is able to significantly reduce the feeling of anxiety and the preceding feelings of concerns and concerns, irritability, tension.

Patients feel the getting rid of federation, fright, insomnia, unreasonable fears, depressive mood and constant feeling of stress, dysfunction of digestive, cardiovascular, respiratory and musculoskeletal system, sweating, malaise.

After taking the drug, people note the restoration of the concentration of attention and memory, the complete absence of incretion and the occurrence of anxiety thoughts, uncertainty and apathy. Patients disappears a tendency to bright emotional reactions to minor events.

The medicine is good and quickly absorbed in digestive system. Substances are transferred to blood and quickly apply throughout the body. The drug in the liver is metabolized due to the processes of hydroxylation and oxidative reactions.

From the body is excreted not only in the form of metabolites, but also in unchanged form with the feces, urine. The elimination occurs quickly, which is associated with the collapse on the products of metabolism in the liver immediately after entering the body. With long-term intake, the substance is not accumulated in the body.

When does it start to act?

The effectiveness of the drug can be seen after a weekly drug intake. The maximum action from treatment is observed a month after the start of application and is preserved a few more weeks after its end. Reception of Afobazola does not provoke the emergence of muscle weakness, drowsiness, reduction of the concentration of attention and memory. At the end of treatment, the occurrence of the dependence or syndrome of the cancellation of the drug is not recorded.

Indications and contraindications

Aphobazol is used as an anxiolytic agent in cases of alarming states. It is important to know exactly what the tool helps. It employs, the states that manifest themselves:

Also, testimony for use includes:

• attacks of anxiety and neurasthenia;
• bronchial asthma;
• lupus;
• hypertension;
• arrhythmia;
• dermatological diseases;
• oncological diseases;
• acute premenstrual syndrome;
• panic attacks;
• syndrome cancellation of long-term alcohol or smoking;
• insomnia.

Contraindicated to take medicine to persons with increased sensitivity to components, people with intolerance to lactase and galactose (as they are present in the composition), for children under 18 and during pregnancy, because it penetrates through the placenta and may adversely affect the development of the fetus.

Under GW, it is also not recommended to take medicine, however, in cases where treatment is necessary, breast-feeding Stop before the end of the admission of Afobazola (which is associated with the possibility of penetration of substances into breast milk).

It is also forbidden to take the drug to people with:

• brain diseases or its injuries;
• diseases and dysfunctions of peripheral and CNS;
• oppression of the functionality of the CNS.

The drug does not affect the ability to manage transport and perform work that require increased concentration of attention.

Instructions for use

According to the instructions for use, Afobazol is used inside after meals, drinking water. The dosage depends on the nature of the bottom pathology.

Dosage course duration for adults?

For adults, minimum one-time doses in tablets - 10 mg, and daily - 30 mg. The dose is recommended to distribute for 3 receptions during the day. Efficiency from the drug intake can be seen after a few weeks, and the maximum effect manifests itself in a month. In some cases, the doctor may increase the daily dose of up to 60 mg, and the treatment extend to several months.

In the case of admission of Afobasol, it is important when it is accepted - before eating or after, since the security of therapy depends on this. Optimal is the option of reception after half an hour after eating.

For ICC and panic attacks

For VD I. panic attacks It is very important to comply with the rules for taking medication. It must be remembered that the use of Afobazole for one-time binding attack is not effective. In order to see the result and eliminate the appearance of attacks, it is necessary to take the drug regularly. With severe forms of manifestation, panic drink 6 tablets 3 times a day. When light shape Violations doctors recommend taking 3 tablets 3 times a day.

Panic attack treatment can last from a few weeks to several months, which completely depends on the degree of manifestation of attacks. The result from the reception of the Afobazole is held for several weeks after the cancellation of the tablets. When returning panic attacks and manifestation of symptoms, the NDC can prescribe a re-treatment. In some cases, 6 Aphobazole tablets can cause side effectsBecause the dose is individually adjusted by a doctor for each patient.

Afobazol does not treat the causes of attacks, and only eliminates the manifestation and consequences of attacks.

In order to completely get rid of the attacks, it is necessary to undergo a course of treatment at the psychotherapist, as such attacks are the result of mental injuries received in childhood, hidden fears, strong stress and emotional shocks, depression or manifestations of FMR.

Especially dangerous cases when panic is caused by prolapse mitral valve, hypothyroidism, hypoglycemia or CNS disorder that only a doctor can diagnose. Therefore, treatment with this medicine is recommended under the supervision of a specialist.

When climax

Afobazol is popular in gynecology. This medicine is discharged by patients with bright symptoms of the coming climax, namely:

• sharp fluctuations in body temperature;
• feeling of weakness and ailments, reduced performance;
• increased emotionality;
• sweating;
• problems with sleep, insomnia;
• lack of sexual attraction.

In such cases, the drug is recommended to take three times a day on 1 tablet. The duration of treatment is set by the gynecologist. In cases where these symptoms are accompanied by a protracted depression and stressful states, doctors recommend afobazole in a sedative complex.

Possible side effects and overdose by Afobazol

The drug causes side effects rarely. The most common includes itching, rash, redness of the skin, which is provoked by increased sensitivity to the composition of the medication. Dyspepsic processes may also occur, which are manifested by nausea, vomiting, stomach pain, constipation, diarrhea or diarrhea. These symptoms disappear immediately after stopping the reception of the tablets.

Overdose by the drug is manifested when receiving a large amount of tablets. For such quantities, one is considered a unite reception of more than 6 tablets.

Develop an overdose by the drug possible due to the appearance of such symptoms:

• the appearance of harsh headaches resembling migraneous;
• drowsiness, weakness, malaise;
• difficult, inadvertent speech;
• inhibited reaction;
• loose or heavy breathing;
• a sharp increase in heartbeat and its sharp weakening;
• appearance of convulsion;
• apathetomy.

These symptoms provoked by the oppression of the CNS under the action of a large amount of active substance. If you find at least several symptoms of overdose, you must have the victim first medical care.

First of all, it is necessary to drink a person with plenty of water and put pressure on the root of the tongue, causing a vomit reflex. This will help to remove substances from the body that have not yet had time to worry in the digestive system. After that, a person give an adsorbent, such as activated coal in order to derive all toxins. In cases of overdose, doctors are advised to water the victims of strong coffee, as caffeine reduces the effect of Afobazole on the nervous system.

In the following hours, it is necessary to disappear a person with plenty of water, which will help withdraw the remaining substances in the body. After improving the state, it is necessary to take the victim to the doctor for inspection. In cases of strong intricensication of the body, under the overdose of the victims, treated in the hospital under the supervision of doctors to the complete restoration of the functions of the body.

Aphobazole compatibility with medicines and alcohol

Afobazole enhances the action that eliminates cramps, and, which helps to cope with frequent anxieties. Does not affect action.

With glycine

Glycine is food supplementwhich is represented by replaceable amino acid. It has a positive effect on the central nervous system, improves the concentration of attention, especially in the educational process, and also improves the cognitive properties of the body. No harmful effect on the body. Glycine is used as a nootropic medication that has sedative and soothing properties. It can be applied not only for treatment, but also for complex therapy and prophylaxis.

It is recommended to drink not only the patient, but also healthy people For prevention. Glycine is prescribed to improve the quality of sleep and the stability of the emotional state of the person. This is achieved due to the influence of glycine on the launch of the GABA, that is, the braking neuromediator. The drug is also widely used for treatment. different shapes ICC, since it has an antioxidant and alpha-adrenoblochetic property.

Aphobazol in turn is used with more serious manifestations of nervous disorders and IRS. These drugs can be used simultaneously, as they do not affect the efficiency and action of each other.

With alcoholic beverages

According to the manufacturer, alcohol does not affect the effect of the drug. Despite this, doctors do not recommend taking medicine and alcohol together. With a unite parallel reception of medication and alcohol, significant negative effects will not arise.

In such cases, the drug may simply not show its actions, which is due to the fact that alcohol has a sedative and relaxing effect due to the oppression of the work of the CNS. Afobazol gradually stimulates the work of the nervous system, thus helping the patient to cope with stress or disturbing states.

With long-term simultaneous reception, unwanted and unpredictable side effects may appear. Also, the medicine may lose its effectiveness due to the negative effect of alcohol on metabolism. In such cases, a person may begin to take tablets in large quantities, and a large amount of active substance and alcohol intoxication can cause death.

Doctors categorically prohibit medication treatment in cases of alcohol intoxication. The optimal period that should pass between alcohol intakes and the beginning of treatment is several days.

This period is individual for each person and depends on the amount of drinking alcohol. It should be remembered that in the case of the interaction of alcohol and the active substance, the patient's condition can significantly deteriorate, possibly a manifestation of unexpected consequences, primarily associated with the enhanced disease.

Acceptance of the drug for removing the symptoms of a hangover is meaningless, since by the time of the beginning of the action of Afobazol, the body itself will be eliminated from intoxicating alcohol. A positive effect has only in cases of treating the effects of long-term alcohol intake.

Features of therapy for stress and disturbing disorders

Afobazole helps to cope with the symptoms of stress and anxiety. Despite this, it does not affect the causes of these states. At the end of the reception of medication, the attacks can appear again. To eliminate the causes of stress and anxiety, it is necessary to contact narrow specialists.

To determine the effectiveness of the drug, studies were conducted on the basis of Moscow and St. Petersburg Research Psychoneurological Institutions. It has been proven that in its agency afobazol looks like diazepams. The medicine differs from diazepam high tolerance, the absence of a muscle relaxant action and inhibition of cognitive functions. This was the reason for further research.

Scientists considered the main goal to establish the effectiveness of the drug in cases of anxiety. For this, a naturalistic study was conducted, in which people from 18 to 65 years old with nervous disorders, depression and anxiety participated. Exceptions were cases of schizophrenia, epilepsy, frequent panic attacks, somatic diseases in the acute stage.

The examined preparations took the drug three times a day at 15-20 mg of a month and a half. For better definition of efficiency, various assessment techniques were used. Each patient had its own card with marks about the status that was checked every 7 days.

194 patients were investigated, men - 45, women-149. Since the disorders of the nervous system are more characteristic of women, there were most of them. People with disorders from several months to several years participated in the experiment. For treatment, patients previously used antidepressants or tranquilizers.

In the first week, studies the level of anxiety of patients decreased by 22%. At the 3rd week, the indicators rose to 50%. By the 6th week, the indicator reached 73%. The analysis of the results showed the presence of a permanent and harmonious decrease in the expression of anxiety. Starting from the first week, patients complained about well-being.

Earlier studies have been proven that side effects show themselves more in the first week.

These effects were presented with anxiety, drowsiness and sleep disorders. The most acute manifestation was the exacerbation somatic disease. In general, side effects manifested very rarely. The results showed that the effect of Afobazole does not depend on age or gender. It was also shown that the drug reaches its maximum action at the 3rd week after the start of treatment. At the end, it was found that the stimulating effect prevailed over sedatives.

The main minus of this study is its insufficient objectivity. This is due to the fact that not all patients could soberly assess the results of the drug. And the positive effect could occur solely due to the self-impact of people.

To avoid such situations, the method of double placebo is used when half of the patients are given a placebo tablet, and the other half is a real drug. Patients do not know what pills they are treated and do not know about important research details. It is this method that helps determine that the effect of the drug is based on its properties, and not on the self-imposition of patients. Data on such research methods for afobazole was not detected.

Studies confirmed high efficiency drug in the treatment of neurotic disorders. Also, the drug is characterized by good tolerance and ease of use.

Aphobazol is a drug from anxiolytic group (tranquilizers) of an unshaisal structure that has a moderate activating effect in combination with the relief of anxiety.

It has a very soft, compared to benzodiazepines, action, does not cause drug dependence and does not provoke the cancellation syndrome after the termination of therapy.

The use of Afobazole is shown for individuals with asthenic personality in the form of anxious imperidity, uncertainty, increased vulnerability and emotional lability, tendency to emotional-stressful reactions.

The result of therapy is noticeable for the 5-7th day of treatment. The maximum effect is achieved by the end of the 4th week and persists after the end of treatment up to 2 weeks.

Aphobazol is a 2-mercaptobenzimidazole derivative, a selective anxiolytic, not refer to the class of benzodiazepine receptor agonists. Prevents the development of membrane-dependent changes in the GAB-receptor.

After oral administration, the Afobasol is well and quickly absorbed from the gastrointestinal tract. CMAX plasma - (0.13 ± 0.073) μg / ml; Tmax - (0.85 ± 0.13) h.

Aphobazol is produced in tablet form. Tablets are flat, cylindrical shape, with favors, packed for 10 or 25 pieces into contour cellular packaging. Color them can vary from white to white with a cream tint.

Indications for use

What does Afobazol help? Prescribed the drug in the following cases:

• anxiety in adults:
• generalized alarming disorders;
• neurasthenia;
• in patients with different somatic (bronchial asthma, irritable bowel syndrome, SLE, IBS, arterial hypertension, arrhythmias), dermatological, oncological and other diseases;
• sleep disorders associated with anxiety;
• cardiopsychoneurosis;
• premenstrual voltage syndrome;
• alcohol abstineent syndrome;
• facilitate the abolition syndrome when smoking failure.

The effect of the drug is implemented mainly in the form of a combination of anxiolytic (eliminates the alarm) and the stimulating (activating) effects.

Instructions for use afobazole and dosage

Take inside, after eating.

Motherwise dose is 10 mg; daily dose - 30 mg, divided into 3 receptions during the day.

The duration of the course therapy is 2-4 weeks. If necessary, the daily dose of afobazole can be increased to 60 mg, and the duration of treatment is up to 3 months.

Contraindications

Increased sensitivity to components of Afobazole.

The drug contains lactose, so patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome cannot be prescribed by the drug.

special instructions

There are several special instructionsthat is important to take into account during the start of reception of the Afobazol tablets, they include:

• Enhancing the anxiolytic effect of diazepam and the anticonvulsant effect of carbamazepim.
• The drug does not affect the ability of a person to perform work, conjugate with increased attention and the need for a sufficient rate of psychomotor reactions.

Overdose

With significant overdose and intoxication, the sedative effect is possible and increased drowsiness without manifestation of miolaxation.

As emergency care Caffeine benzoate-sodium is used 20% solution in ampoules 1.0 ml 2-3 times a day subcutaneously.

Application during pregnancy

Apply afobazole during pregnancy is prohibited. If necessary, during the lactation, it is necessary to stop breastfeeding for the entire period of therapy with the drug, as it penetrates into breast milk.

Side effects

When appointing Afobazol, the development of side effects is possible:

• Allergic reactions.
• Rarely - headache, which usually passes independently and does not require the abolition of the drug.

According to the reviews of doctors, therapy Afobazol is moved well in the overwhelming majority of cases.

Afobazol, in contrast to other tranquilizers, is not able to enhance the narcotic action of alcohol, so the taking of alcohol during treatment does not cause negative consequences. Nevertheless, use alcoholic beverages It can significantly reduce the therapeutic effect of the drug or reduce the effect of its use to zero, as they have the opposite effect on the nervous system.

This article allows you to familiarize yourself with the instructions for the use of the drug. Afobazol.. Reviews of site visitors - consumers of this medicine, as well as the views of the doctors of specialists in the use of Afobazola in their practice. A big request to more actively add your reviews about the preparation: helped or did not help the medicine to get rid of the disease, which complications were observed and side effects, possibly not stated by the manufacturer in annotations. Analogs of Afobazole in the presence of available structural analogues. Use for the treatment of neurasthenia, disturbing disorders, abstineent syndrome in adults, children, as well as during pregnancy and breastfeeding. Indications, contraindications and side effects of drug intake.

Afobazol. - a derivative of 2-mercaptobenzimidazole, a selective anxiolytic, not related to the class of agonists of benzodiazepine receptors. Prevents the development of membrane-dependent changes in the GABA receptor.

The drug has an anxiolytic effect with an activating component that is not accompanied by hyuosted effects (sedative effect is detected in doses, 40-50 times larger than ED50 for anxiolytic action). The drug has no muscle relaxant properties, a negative impact on memory and attention. When applying the drug is not formed drug addiction and does not develop cancellation syndrome.

The effect of the drug is implemented mainly in the form of a combination of anxiolytic (antitrusive) and easily stimulating (activating) effects. Reducing or eliminating anxiety (concern, bad premonition, fears, irritability), tensions (bugs, fiscalness, feeling of anxiety, inability to relax, insomnia, fear), and, therefore, somatic (muscle, sensory, cardiovascular, respiratory, gastrointestinal Intestinal symptoms), vegetative (dry mouth, sweating, dizziness), cognitive (difficulties at a concentration of attention, weakened memory) violations are observed for 5-7 days of treatment by Afobazol. The maximum effect is achieved by the end of 4 weeks of treatment and is maintained in the post-hour period of 1-2 weeks.

The use of the drug in persons with predominantly asthenic personality features in the form of anxiety, uncertainty, increased vulnerability and emotional lability, inclinations towards emotional and stressful reactions is particularly shown. Afobazol non-toxic.

Indications

Anxiety in adults:

• generalized anxiety disorders, neurasthenia, adaptation disorders;
• in patients with different somatic (bronchial asthma, irritable bowel syndrome, SLE, IBS, arterial hypertension, arrhythmias), dermatological, oncological and other diseases;
• sleep disorders associated with anxiety;
• cardiopsychoneurosis;
• premenstrual voltage syndrome;
• alcohol abstineent syndrome;
• to facilitate the cancellation syndrome when smoking failure.

Forms of release

Tablets 5 mg and 10 mg.

Instructions for use and dosing mode

The drug is prescribed inside, after meals. One-time dose is 10 mg; Daily dose - 30 mg, divided into 3 receptions during the day.

The duration of the course use of the drug is 2-4 weeks.

If necessary, the daily dose of the drug can be increased to 60 mg, and the duration of treatment is up to 3 months.

Side effect

• allergic reactions
• increased individual sensitivity.

Contraindications

• pregnancy;
• lactation period (breastfeeding);
• age up to 18 years old (children drug contraindicated);
• increased sensitivity to the components of the drug.

Application in pregnancy and breastfeeding

The drug is contraindicated to use during pregnancy and during lactation (breastfeeding).

Medicinal interaction

With the simultaneous use of Afobazol, it does not affect the drug effect of ethanol (alcohol) and the hypnotic effect of thiopental.

With the simultaneous use of Afobazol potentials the anticonvulsant effect of carbamazepine.

With the simultaneous use of Afobazole causes an increase in the anxiolytic effect of diazepam.

Analogs of the drug Afobazol

Structural analogues of PO active substance:

• Afobazol c;
• Neurophasol.

In the absence of analogues of drugs on the active substance, you can follow the links below on the disease, which helps the appropriate drug, and see the analogues on therapeutic effects.