Persen is a combination drug plant origin. It has a mild sedative effect and eliminates spasm of smooth muscles. Active active substances of this drug reduce the activity of the central nervous system, as a result, the severity of reactions to external influences decreases, sleep and emotional state normalize.

Composition and forms of release

The drug contains several active components plant nature and a number of auxiliary. Persen includes dry extracts from the following plants:

• Valerian rhizomes.
• Peppermint.
• Melissa.

Auxiliary components of the drug are added to give the dosage form and maintain the activity of the therapeutic components.

This medicine is for oral use only. That is why it is available in the form of tablets and capsules.

The dosage of active ingredients in capsules and tablets is different, this affects the therapeutic effects.

Tablets

Persen tablets have round shape and a dark brown protective sheath. Packed in blisters of 10 pieces. Each package may contain from 2 to 8 blisters. The composition of 1 tablet includes an extract of dry rhizome of valerian in the amount of 50 mg, peppermint and lemon balm 25 mg each.

Capsules

This form of release has a dark brown color. Inside contains active substances in granular or compressed form.

Capsules are packaged in blisters of 10 pieces. In turn, blisters are packed into cardboard packs. Each capsule contains dry in the amount of 125 mg and 25 mg of lemon balm and mint extracts. Since the dosage of the drug in capsules is greater than in tablets, this form has a more pronounced therapeutic effect.

Persen night

This dosage form is available in capsules and is completely identical in composition and quantitative ratio to Persen forte.

Persen cardio

This type of capsule has a mild calming effect and has a beneficial effect on the heart and blood vessels. Its composition has significant differences from other forms of release. In addition to the usual components, Persen cardio contains a dry extract of passionflower 200 mg, an extract of flowers and leaves of hawthorn 160 mg.

Mechanism of pharmacological action

The therapeutic effects of Persen are due to its active ingredients.

Indications for admission

The drug Persen is used to relieve conditions accompanied by excitability of the nervous system.

Indications for prescribing tablets are the following states:

Persen capsules are prescribed mainly for the treatment of long-term insomnia. You can also use them in the complex treatment of severe neurosis and neurasthenia.

Indications for the use of Persen cardio are:

It is not advisable to use Persen to stop panic attacks, because in order to achieve therapeutic effect of Persena it will take several hours, while panic attack needs faster help. At the same time, the course complex treatment with the use of Persen will reduce nervous excitability and reduce the frequency of panic attacks.

Instructions for use

Persen is sold in pharmacies without a doctor's prescription. However, uncontrolled intake can cause unwanted side effects.

Instructions for use Persen in tablets prescribes taking the drug orally with a small amount of boiled water and regardless of food intake.

Adult patients and children over 12 years of age are prescribed 2-3 tablets or capsules 1-3 times a day. For insomnia, 2-3 tablets or 1-2 capsules are prescribed at night before bedtime.

The maximum allowable daily dosage is 12 tablets. The total duration of the course of treatment should not exceed 2 months. The drug does not cause a withdrawal syndrome upon discontinuation of use.

Children aged 3 to 12 years are prescribed 1 tablet of the drug 2-3 times a day.

The medicine should be stored in a dark, cool place. Do not use it if the expiration date on the package has expired. Otherwise, instead of benefit, the drug can cause significant harm to your body.

Contraindications

For Persen, contraindications for taking tablets and capsules are completely identical:

With caution, the drug is prescribed to patients who have gastroesophageal reflux disease.

special instructions

Each of the active active ingredients in itself has no contraindications during pregnancy. However, one should not forget about the increased risk of side effects in a pregnant woman. Like many medicines Persen can cause allergic reactions. A woman's body during pregnancy can react in a completely unexpected way to any drug, even the usual one.

In addition, the agent reduces arterial pressure which can lead to fetal hypoxia.

It is not recommended to take the medicine while breastfeeding, as this may adversely affect the condition of the child. Some active components are able to get into breast milk, and with it - into the baby's body.

Studies of the effect of the drug on the body of children have not been conducted. It is not recommended to prescribe this remedy to children under the age of three years, as there is a risk of depression of the nervous system and the occurrence allergic reactions. For children aged 3 to 12 years, the drug is prescribed in reduced doses and a short course. Do not prescribe to children under the age of 12 years capsules Persen night and Persen cardio. Starting from the age of 12, the drug can be prescribed to children in the same dosages as for adult patients.

It is not recommended to combine treatment with Persen with alcohol intake, as this can lead to the development of side effects and complications. Alcohol enhances the effect of the active components of the drug and can cause depression of the nervous system and other undesirable effects. Small doses of alcohol can provoke excitation of the central nervous system and thereby reduce therapeutic effect from medicinal product.

While taking Persen, it is not recommended to administer vehicles or engage in other work that requires increased attention and high speed of reactions. This recommendation is especially relevant when taking capsules that contain increased amount active components. Do not drive for 4 hours after taking the tablet or capsule.

Side effects and overdose

Instructions for use Persen and patient reviews note the following adverse events in the treatment of this drug:

Persen in all forms of release is well tolerated and does not cause addiction, drug addiction and withdrawal syndrome, even if treatment is stopped abruptly. Since the dosage of active substances is small, the effect of an overdose is extremely rare. However, with a single dose of 60 tablets or 25 capsules, a number of undesirable effects may occur. With a single use of 103 tablets possible severe side effects:

• Weakness, severe drowsiness, loss of consciousness.
• Dizziness.
• Nausea and vomiting.
• Cramping pains in the abdomen.
• Hand tremor.
• Sharp dilation of pupils.

All of the symptoms described can resolve on their own within 24 hours. Treatment of overdose symptoms consists in washing the stomach and intestines, giving enterosorbents and laxatives.

Persen contains a number of active components of plant origin: dry extracts lemon balm , valerian , peppermint . As additional substances, the tablets include: magnesium stearate, talc, corn starch, crospovidone, lactose, colloidal silicon dioxide, MCC.

The shell of the tablet consists of the following components: talc, hydroxypropylcellulose, sucrose, sodium carboxymethylcellulose, povidone, titanium dioxide, colloidal silicon dioxide, , calcium carbonate, wax E, dye brown 75.

Release form

Available in the form of coated tablets; biconvex tablets, round, dark brown. Foil blisters contain 10 tablets, 3, 4, 6, 8 blisters can be put into a cardboard pack.

pharmachologic effect

The abstract indicates that the tablets act as antispasmodic and soothing means. All components of this medicine in the complex have a mild effect on the body. sedative action.

Valerian extract provides a calming effect, lemon balm extract has an antispasmodic and calming effect. Peppermint extract provides a mild sedative as well as antispasmodic effect.

In general, Persen relieves feelings of anxiety and irritability, has a calming effect on people in a state of excitement and psycho-emotional stress. During facilitates the process of falling asleep, while not causing a condition in the daytime.

Pharmacokinetics and pharmacodynamics

The drug affects the body due to the total effect of its components, so kinetic observations were not carried out. drug is also impossible to identify.

Indications for use

The following indications for the use of this remedy are determined:

• that accompany states of arousal, anxiety, insomnia, and in which there is no need to prescribe potent drugs;
• the period after the abolition of potent drugs with a sedative effect;
• prevention of psychosomatic manifestations in people who are exposed to stress factors.

Contraindications

Such contraindications for taking Persen are determined:

• fructose intolerance, lack of sucrase and isomaltase;
• glucose-galactose malabsorption, lack of lactase, lactose intolerance;
• diseases of the biliary tract - , cholangitis, etc.;
• arterial hypotension ;
• high sensitivity to the components of Persen;
• the patient's age is up to 12 years.

Carefully appoint Persen to people who suffer from gastroesophageal reflux disease.

Side effects

In the process of taking the tablets, the following side effects may occur:

• allergic manifestations in the form of a rash on the skin, hyperemia, peripheral edema, bronchospasm;
• with prolonged use may develop .

Tablets Persen, instructions for use (Method and dosage)

Instructions for use Persen in tablets provides for the use of the drug orally. At the same time, its intake does not depend on the period of eating. You need to take the tablets with water.

Adults and children after 12 years of age receive 2-3 tablets, you need to take the drug 2-3 times a day. For more information about how to take the medicine, you should ask a specialist.

If the patient is suffering from insomnia , he is prescribed 2-3 tablets in the evening - 30-60 minutes before going to bed. Maximum dose drug - 12 tablets per day.

You can not continuously take the sedative Persen for more than 1.5 months.

After the patient stops treatment, he does not experience a withdrawal syndrome.

Overdose

In case of an overdose (if more than 60 tablets have been taken), the patient may develop nausea, weakness, mydriasis, pain during internal organs, hand shake. A day after taking large doses of the drug, the symptoms of an overdose disappear. No toxic effects are noted. If necessary, practice symptomatic therapy.

Interaction

Under the influence of Persen, the effect of hypotensive, hypnotic, painkillers is potentiated. Therefore, with simultaneous treatment with drugs that depress the central nervous system, the effect of such drugs is enhanced. In this case, dose adjustment may be necessary.

Terms of sale

Implemented without a prescription.

Storage conditions

Persen tablets should be stored at t no more than 25 ° C.

Best before date

special instructions

Before taking this medicine, you should understand how Persen tablets work, what they help with. If symptoms do not disappear during treatment, or they become more severe, you should consult a doctor and get his advice.

People with GERD may experience worsening symptoms during treatment.

While taking Persen, be sure to be careful when driving vehicles and when working with dangerous mechanisms.

You can not use the product for longer than 2 months without a break. With the development of side effects, you should consult a doctor.

Persen's analogs

There are currently no analogues of the drug for the active substance. There are variations of this drug - , Persen Cardio .

Analogues according to indications and therapeutic effect drugs are on the body , Valdispert , , , Doppelhertz Nervotonik , Melison , Neurobutal , etc. Taking any of these drugs should be discussed with your doctor beforehand.

Persen or Novopassit – what's better?

Novopassit - This is a drug, which also includes herbal ingredients. However, unlike Persen, Novopassit contains 8 components - 7 plant components and a substance guaifenazine . The prices of both drugs differ insignificantly. In terms of the severity of the action, the drugs are similar, but only a specialist should determine which of the drugs is advisable to use.

children

Persen is not prescribed for children under 12 years of age. If there is a need to treat younger patients, it is carried out only under the supervision of a specialist. The maximum dose per day is 1-2 tablets.

Persen and alcohol

It is better not to combine Persen tablets and alcohol. Alcohol can increase the sedative effect of Persen, as well as significantly exacerbate side effects.

Persen during pregnancy and lactation

The effect of this drug during pregnancy has not been studied, so its use is not practiced. If necessary, the doctor carefully weighs the risk-benefit ratio, and also carefully monitors the condition of the pregnant woman during treatment. Persen at breastfeeding also administered with caution.

Reviews about Persen

Many users write that Persen tablets are a very effective sedative for them. It is noted that it helps with insomnia, relieves anxiety and irritability. There are also reviews about Persen for children, but parents, in most cases, do not risk giving this drug to children under 12 without a doctor's prescription.

There are also reviews of women about taking Persen with pregnancy , in which we are talking about the fact that this remedy made it possible to quickly cope with a feeling of anxiety, strengthen the nervous system.

When discussing the Persen remedy, the doctors' reviews are also mostly positive. It is noted that the tool has vegetable origin and acts gently. But at the same time, doctors warn against uncontrolled intake of pills.

Price Persen, where to buy

How much the tablets cost depends on the packaging. The price of Persen tablets (40 pcs.) Is on average 300 - 350 rubles. The price of Persen in Ukraine (Kharkov, etc.) is 100 - 120 UAH. (cost of a pack of 40 pieces). You can buy the drug at any pharmacy.

• Internet pharmacies in Russia Russia
• Internet pharmacies in Ukraine Ukraine
• Internet pharmacies in Kazakhstan Kazakhstan

ZdravCity

Persen tab. p.o n60 Lek d.d.

Persen night caps. n40 Lek d.d.

Persen tab. p.o n20 Lek d.d.

Persen night caps. n10 Lek d.d.

Persen night caps. n20 Lek d.d.

Pharmacy Dialog

Persen night (caps. No. 10)

Persen (tab. p / ob. No. 20)

One coated tablet contains:
- 35 mg dry water-alcohol extract of valerian roots (Valeriana officinalis L.) (4-7:1); extractant: ethanol 70% (v/v);
- 17.5 mg dry extract of lemon balm leaves (Melissa officinalis L.) (3-6:1); extractant: ethanol 50% (v/v);
- 17.5 mg of dry extract of peppermint leaves (Mentha piperita L.) (3-6:1); extractant: ethanol 40% (v/v).
Excipients:
nucleus: lactose monohydrate, microcrystalline cellulose, corn starch, crospovidone, talc, colloidal anhydrous silica, magnesium stearate, liquid glucose, maltodextrin, peppermint flavor powder;
shell: hypromellose, carmellose sodium, povidone, sucrose, colloidal anhydrous silicon dioxide, calcium carbonate, brown iron oxide (E172), titanium dioxide (E171), glycerin, talc, montan glycol wax.

Description

Round, biconvex brown coated tablets.

Pharmacological group"type="checkbox">

Pharmacological group

Other sleeping pills and sedatives.
ATX code: N05CM.

Pharmacological properties"type="checkbox">

Pharmacological properties

The drug has a sedative and antispasmodic effect.
The rhizome extract with valerian roots has a calming effect.
Melissa leaf extract - soothing and antispasmodic effect.
Peppermint leaf extract - antispasmodic, moderate sedative effect.

Indications for use

AT complex therapy non-severe functional disorders central nervous system (neurasthenia and sleep disturbances).
The use of the medicinal product is based solely on the experience of traditional long-term use.

Contraindications

Hypersensitivity to the components of the drug, childhood up to 12 years, arterial hypotension, pregnancy, lactation.

Dosage and administration

Adults and children over 12 years old
With increased nervous excitability, irritability - 3 coated tablets, 3 times a day;
in case of sleep disorders, it is recommended to take 3 coated tablets half an hour - 1 hour before bedtime.
Tablets should be taken with a small amount of boiled water. room temperature(1/4 cup), regardless of the meal.
The effect of taking the drug Persen develops gradually. To achieve the optimal effect, it is recommended to take the drug for at least 14 days. The duration of the course of treatment is determined by the doctor, taking into account the disease, the tolerance of the drug and the effect achieved.
If symptoms persist after taking the drug for fourteen days or if the condition worsens, you should consult a doctor.
Use in children
Due to the lack of data on safety and efficacy, Persen is not recommended for children under 12 years of age.

Side effects"type="checkbox">

Side effects

Frequency adverse reactions listed below: very often (≥1/10), often (≥1/100 to<1/10), нечасто (≥1/1000 до <1/100), редко (≥1/10000 до <1/1000), очень редко (<1/10000), не известно (не может быть оценена на основании доступных данных).
Perhaps the development of allergic reactions, bronchospasm.
Gastrointestinal Disorders
Not known: Nausea, spasmodic abdominal pain. With prolonged use - constipation.
May increase the symptoms of gastroesophageal reflux (heartburn).
In case of adverse reactions, including those not listed in the instructions for use, you should consult a doctor.

Use during pregnancy and lactation

The safety of use during pregnancy and lactation has not been established. Due to the lack of sufficient data, it is not recommended to use during pregnancy and lactation.

Influence on the ability to drive a car and work with mechanisms

Taking Persen may impair the ability to drive and use machines. During treatment, it is not recommended to drive a car and work with mechanisms.

Overdose

A single intake of 20 g of valerian root extract with rhizomes (approximately 103 Persen tablets) can cause general weakness, spastic abdominal pain, chest tightness, dizziness, hand tremors and dilated pupils.
In case of symptoms of an overdose, you should consult a doctor. Treatment is symptomatic.

Interaction with other drugs

There is limited information on interactions between Persen and other medicinal products. Before taking other medicines, the patient should consult a doctor. Clinically significant interactions with substances that are metabolized by CYP 2D6, CYP 3A4 / 5, CYP 1A2 and CYP 2E1 have not been observed. Simultaneous administration of the drug Persen with synthetic sedatives (for example, benzodiazepines) is not recommended and is allowed only under medical supervision.

special instructions

Patients with gastroesophageal reflux (heartburn) should avoid taking medicinal products containing mint due to possible aggravation of heartburn.
Patients with gallstone disease, other diseases of the gallbladder and biliary tract should not take peppermint leaf preparations without medical supervision.
One tablet contains 99.5 mg lactose monohydrate, 66.988 mg sucrose and 14 mg liquid glucose. The content of sucrose and glucose must be taken into account when prescribing the drug to patients with diabetes mellitus.
Due to the lactose content, patients with galactose intolerance, lactase deficiency or glucose/galactose malabsorption syndrome should not take Persen.
Due to the sucrose content, patients with fructose intolerance, glucose/galactose malabsorption syndrome or sucrase-isomaltase deficiency should not take Persen.
Due to the glucose content, patients with glucose/galactose malabsorption syndrome should not take Persen.
If the symptoms persist while taking the drug or if the condition worsens, you should consult a doctor.

In this article, you can read the instructions for using the drug Persen. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Persen in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Persen's analogues in the presence of existing structural analogues. Use for the treatment of excitability, irritability and insomnia in adults, children, and during pregnancy and lactation. The composition of the drug.

Persen- a herbal sedative. It has a sedative and antispasmodic effect.

The extract of rhizomes with valerian roots causes a moderately pronounced sedative effect.

Melissa extract and peppermint extract have a sedative and antispasmodic effect.

Compound

Extract of valerian rhizomes with roots (dry) + extract of lemon balm leaves (dry) + extract of peppermint leaves (dry) + excipients.

Pharmacokinetics

The action of the drug is the result of the cumulative action of its components, so it is not possible to conduct kinetic observations; all together the components cannot be traced using markers or bioassays. For the same reason, it is impossible to detect drug metabolites.

Indications

• increased nervous excitability;
• insomnia;
• irritability.

Release form

Coated tablets.

Capsules Persen forte.

Instructions for use and dosage

Adults and adolescents over 12 years old are prescribed 2-3 tablets or 1-2 capsules. The drug is taken 2-3 times a day.

For insomnia - 2-3 tablets or 1-2 capsules 1 hour before bedtime.

For children aged 3 to 12 years, the drug is prescribed only under medical supervision and only in the form of tablets. The dose depends on the patient's body weight and averages 1 tablet 1-3 times a day.

Do not use Persen Forte continuously for more than 1.5-2 months.

Side effect

• allergic reactions;
• with prolonged use - constipation.

Contraindications

• arterial hypotension;
• children's age up to 3 years (for coated tablets);
• children's age up to 12 years (for capsules);
• hypersensitivity to the components of the drug.

Use during pregnancy and lactation

The use of the drug during pregnancy and lactation has not been studied. The appointment of the drug during pregnancy (especially in the 1st trimester) and during breastfeeding is possible only in cases where the intended benefit to the mother outweighs the potential risk to the fetus or infant.

special instructions

When the drug is discontinued, withdrawal syndrome does not occur.

Do not use the drug continuously for more than 1.5-2 months.

Influence on the ability to drive vehicles and control mechanisms

drug interaction

With the simultaneous use of Persen with other drugs that depress the central nervous system (including hypnotics, antihypertensive drugs of central action, analgesics), it is possible to increase the effect on the central nervous system (dose adjustment may be required).

Analogues of the drug Persen

Persen has no structural analogues for the active substance.

Analogues for the therapeutic effect (sedatives):

• Altalex;
• Bellaspon;
• Belloid;
• Bromocamphor;
• Valdispert;
• Valerian;
• Valerian Forte;
• Validol;
• Gelarium Hypericum;
• Glycine;
• Dexdor;
• Deprim;
• Doppelhertz Nervotonik;
• Dormiplant;
• Oregano herb;
• St. John's wort;
• Life 600;
• Life 900;
• Melison;
• Melissa officinalis herb;
• Negrustin;
• Neurobutal;
• Nervoflux;
• Nobrassite;
• Novopassit;
• Passiflora extract;
• Peony evasive tincture;
• Motherwort tincture;
• Sanason Lek;
• Pretty;
• Stressplant;
• Ethyl bromoisovalerianate.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Persen from the Slovenian pharmaceutical company Lek d.d. is a patented combined herbal remedy with a sedative effect. Natural sedatives are one of the main attributes of the recent popular trend towards the naturalization of the healing process. According to a WHO survey, "natural products" are preferred by about 80% of the world's population to medicines. And the patient's high confidence in the method of treatment used in relation to him can significantly increase the effectiveness of the latter. Persen contains three plant extracts: valerian, lemon balm and peppermint. Valerian extract has long earned fame as a sedative. Studies have shown that the action of valerian is aimed at stimulating GABAergic mediation. This is due to a decrease in the reflex reactivity of the CNS with a simultaneous increase in the processes of neuronal inhibition. Such qualities of valerian make it possible to use it as a sedative in case of excessive nervous excitement. Valerian has a positive effect on sleep, improving its quality. At the same time, it is absolutely non-toxic and does not cause jumps in blood pressure even in high doses. The list of adverse events that can be observed when taking valerian is limited to allergic reactions alone. The second "whale" on which the sedative effect of persen is based is lemon balm. Which, in itself having a sedative effect, potentiates that of valerian, which makes these two plants a truly "shocking" combination used in many sedative herbal preparations.

As scientists suggest, the effect of lemon balm on the central nervous system is mediated by its interaction with brain acetylcholinesterase and suppression of the activity of muscarinic and nicotinic receptors in the cerebral cortex. The last member of this natural-sedative triumvirate is peppermint, which has a wide range of uses: this object of the plant world is used as an antispasmodic, sedative, vasodilator and analgesic. There is information that peppermint in the form of essential oil eliminates nervous strain, increases vitality, and relieves stress. Persen is widely used in pediatric practice, because. dThis preparation is considered “pure”, free of synthetic products and ethyl alcohol. Its reception can be successfully combined with almost any psychotropic drug. The indisputable advantage of Persen is its good tolerance, which favorably distinguishes it from a number of other drugs used to correct sleep disorders and anxiety.

Persen is available in tablets and capsules (in the latter case, the drug contains more valerian and "forte" is added to its name). It is recommended to take this drug 2-3 tablets 2-3 times a day (with increased excitability) and 2-3 tablets 1 hour before going to bed with insomnia. For children, the doctor selects the optimal dose. Capsules are taken in a slightly smaller amount: 1-2 at a time.

Pharmacology

Herbal sedative. It has a sedative and antispasmodic effect.

The extract of rhizomes with valerian roots causes a moderately pronounced sedative effect.

Melissa extract and peppermint extract have a sedative and antispasmodic effect.

Pharmacokinetics

The action of the drug is the result of the cumulative action of its components, so it is not possible to conduct kinetic observations; all together the components cannot be traced using markers or bioassays. For the same reason, it is impossible to detect drug metabolites.

Release form

Tablets, film-coated dark brown, round, biconvex.

Excipients: talc, magnesium stearate, crospovidone, corn starch, colloidal silicon dioxide, microcrystalline cellulose, lactose.

Shell composition: hydroxypropylcellulose (Hypromellose, Pharmacoat), talc, sodium carboxymethylcellulose, povidone, sucrose, colloidal silicon dioxide, calcium carbonate, titanium dioxide, brown 75 dye, glycerol, wax E Hoechst (Capol 600).

10 pieces. - blisters (4) - packs of cardboard.

Dosage

It is taken orally with water, regardless of the meal.

Adults and children over 12 years of age with increased nervous excitability, irritability are prescribed 2-3 tablets. The drug is taken 2-3 times / day. For insomnia, 2-3 tablets are prescribed. 30 min-1 hour before bed.

The maximum daily dose is 12 tab.

When treatment is stopped, withdrawal syndrome does not occur.

Overdose

Symptoms: A single dose of 20 g of rhizomes with valerian roots (approximately 103 tab.) may cause a feeling of fatigue, stomach cramps, a feeling of tightness in the chest, dizziness, hand tremors, dilated pupils, which can pass on their own within 24 hours.

In case of overdose, the patient should consult a doctor.

Interaction

With the simultaneous use of the drug with other drugs that depress the central nervous system (including hypnotics, antihypertensive drugs of central action, analgesics), it is possible to increase the effect on the central nervous system (dose adjustment may be required).

Side effects

Perhaps: allergic reactions (hyperemia, skin rash, peripheral edema, allergic dermatitis), bronchospasm; with prolonged use - constipation.

Indications

• increased nervous excitability;
• insomnia;
• irritability.

Contraindications

• lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
• sucrase/isomaltase deficiency, fructose intolerance;
• arterial hypotension;
• cholangitis, cholelithiasis and other diseases of the biliary tract;
• pregnancy;
• breastfeeding period;
• children's age up to 12 years;
• hypersensitivity to the components of the drug.

With caution, the drug should be prescribed to patients with gastroesophageal reflux disease (GERD).

Application features

Use during pregnancy and lactation

Use in children

special instructions

Patients with GERD may experience worsening of symptoms.

If during the use of the drug the symptoms persist or worsen, you should consult your doctor.

Do not use the drug continuously for more than 1.5-2 months.

Influence on the ability to drive vehicles and control mechanisms

During the period of treatment with the drug, care should be taken when performing potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions (driving vehicles, working with moving mechanisms, the work of a dispatcher, operator).