Norfloxanits - that's antibacterial drug from a group of quinolone with bactericidal action. It suppresses the key to the synthesis of bacterial DNA and the proteins enzyme-DNA gyrase, which is the most destructive way affects the health of microorganisms - they are dying without any chance of salvation. The spectrum of Norfloxacin's action is impressive with its breadth. If we talk about internal infections, it is better not to come across the way in Nifloxacin, for example, gram-positive aerobam, like Staphylococcus Saprophyticus, Staphylococcus Aureus, Streptococcus Agalactiae, Staphylococcus Epidermidis, Enterococcus Faecalis. Among gram-negative aerobic microorganisms norfloxacin most emphatically opposed Citrobacter freundii, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Enterobacter cloacae, Serratia marcescens, Neisseria gonorrhoeae, Proteus mirabilis, Pseudomonas aeruginosa, Proteus vulgaris. A little less hostile, but with severe antipathy Norfloxacin refers to gram-negative bacteria strains Haemophilus influenzae., Yersinia Enterocolitica, Salmonella SPP., Shigella SPP.

With eye infections norfloxacin used to combat Gram Haemophilus influenzae, Proteus mirabilis, Acinetobacter calcoaceticus, Aeromonas hydrophila, Serratia marcescens, Pseudomonas aeruginosa and gram-positive Staphylococcus epidermidis, Staphylococcus aureus, Staphylococcus warneri, Streptococcus pneumoniae, and others. At the same time, norfloxacin powerless infections caused by bonden anaerobes and Treponema Pallidum.

Norfloxacin resistance is recently produced relatively rarely, in less than 1% of cases of treatment with this preparation. The tendency to generate resistance to the drug is more than the other degree microorganisms, Enterococcus SPP., Klebsiella Pneumoniae, Pseudomonas Aeruginosa, Acinetobacter SPP. But the so-called cross-stability between Norfloxacin and other antimicrobial means was not observed, so this drug You can also use in cases where other means no longer cope with the invasion of pathogens. Norfloxacin can successfully replace tetracycles, macrolides, penicillins, aminoglycosides, sulfanimidi, etc.

Under the trade name "Norfloxacin", the drug is produced only in Russia (there are still foreign nolitsin, the norms, norilequet and Lokson-400). Dosage form - tablets covered with film shell. With absence special instructions On the side of the attending physician, the drug takes 400 mg twice a day in 1 hour before meals or 2 hours after it. The standard duration of the therapeutic course is 7-10 days, but other options are also possible. An important nuance: During treatment with Norfloxacin, the patient must ensure sufficient fluid flow into its body. And another recommendation: because Norfloxacin increases the body's vulnerability to sunlight, direct sunlight should be avoided.

Pharmacology

Antimicrobial synthetic means of a wide range of fluoroquinolones. It has a bactericidal action. Suppressing DNA gyrase, violates the process of DNA superspiration.

Highly active with respect to most gram-negative bacteria: Escherichia Coli, Salmonella SPP., Shigella SPP., Proteus SPP., Morganella Morganii, Klebsiella SPP. (including Klebsiella Pneumoniae), Enterobacter SPP., Serratia SPP., Citrobacter SPP., Yersinia SPP., Providencia SPP., Haemophilus Influenzae, Pseudomonas Aeruginosa, Neisseria Gonorrhoeae, NEISSERIA MENINGITIDIS.

Activated for some gram-positive bacteria (including Staphylococcus aureus).

Norfloxacin is resistant anaerobic bacteria, small-sensitive Enterococcus SPP. and Acinetobacter SPP.

Resistant to β-lactamas.

Pharmacokinetics

When ingestion is absorbed about 30-40%, food intake reduces the absorption rate. Bonding with plasma proteins is 14%. Norfloxacin is well distributed in the tissues of the urogenital system. Penetrates through a placental barrier. About 30% is displayed with urine unchanged.

Form release

Tablets, covered with film shell of white or almost white, round, double-screw; Two layers are visible on the break - the kernel from white to light yellow and film sheath.

Auxiliary substances: monohydrate lactose - 85 mg, microcrystalline cellulose - 98 mg, sodium crossarmellosis - 37 mg, water - 10 mg, poveney K25 - 24 mg, magnesium stearate - 6 mg.

The composition of the film shell: hypimloose - 11 mg, macrogol-4000 - 3 mg, titanium of dioxide - 6 mg.

10 pieces. - Packaging cell contour (1) - packs cardboard.
10 pieces. - Packaging cell contour (2) - packs cardboard.
10 pieces. - Packaging cell contour (3) - packs cardboard.
10 pieces. - Packaging cell contour (4) - packs cardboard.
10 pieces. - Packaging cell contour (5) - packs cardboard.
10 pieces. - Packaging cell contour (10) - packs cardboard.
20 pcs. - Packaging cell contour (1) - packs cardboard.
20 pcs. - Packaging cell contour (2) - packs cardboard.
20 pcs. - Packaging cell contour (3) - packs cardboard.
20 pcs. - Packaging cell contour (4) - packs cardboard.
20 pcs. - Packaging cell contour (5) - packs cardboard.
20 pcs. - Packaging cell contour (10) - packs cardboard.
5 pieces. - Polymeric banks (1) - packs cardboard.
10 pieces. - Polymeric banks (1) - packs cardboard.
20 pcs. - Polymeric banks (1) - packs cardboard.
30 pcs. - Polymeric banks (1) - packs cardboard.
40 pcs. - Polymeric banks (1) - packs cardboard.
50 pcs. - Polymeric banks (1) - packs cardboard.
100 pieces. - Polymeric banks (1) - packs cardboard.

Dosage

Individual. Motherwise dose When taking inside is 400-800 mg, the multiplicity of application is 1-2 times / day. The duration of treatment is determined individually.

In ophthalmology and ENT practices are used locally.

Interaction

With the simultaneous use of norfloxacin with warfarin, the anticoagulant effect of the latter is enhanced.

With the simultaneous use of norfloxacin with cyclosporin, an increase in the concentration of the latter in the blood plasma is noted.

With simultaneous intake of norfloxacin and antacid agents or preparations containing iron, zinc, magnesium, calcium or sucralfat, the absorption of norfloxacin decreases due to the formation of complexions with metal ions (the interval between their reception should be at least 4 hours).

With simultaneous taking, Norfloxacin reduces theophylline clearance by 25%, therefore, while simultaneously use, the dose of theophylline should be reduced.

The simultaneous administration of Norfloxacin with drugs, having a potential ability to reduce blood pressure, can cause a sharp decline. In this regard, in such cases, as well as with the simultaneous introduction of barbiturates, anesthetics, the heart rate, blood pressure, ECG indicators should be monitored. Simultaneous use with drugs reduced epileptic threshold can lead to the development of epileptiform seizures.

Reduces the effect of nitrofuran.

Side effects

From side digestive system: nausea, heartburn, anorexia, diarrhea, abdominal pain.

From the CNS: headache, dizziness, feeling of fatigue, sleep disorders, irritability, feeling of anxiety.

Allergic reactions: skin rash, itching, swelling of quinque.

CO side of the urinary system: interstitial jade.

Indications

Infectious inflammatory diseases caused by norfloxacin microorganisms sensitive.

For reception inside: disease urinary tract, prostatic gland, Gastrointestinal tract, gonorrhea, prevention of recurrence of urinary tract infections, bacterial infections In patients with granulocytopenia, "traveler diarrhea".

For local applications: conjunctivitis, keratitis, keratoconjunctivitis, cornea ulcers, blufarite, blepharoconjunctivitis, acute inflammation of bulletium glands and dacryocystitis, prevention of eye infections after removing the foreign body from cornea or conjunctiva, after damage chemicals, before and after surgical interventions in the eyes; Outdoor otitis, acute average otitis, chronic average otitis, prevention of infectious complications in surgical interventions on the hearing body. Application in violations of the function, the liveride is used with caution in patients with pronounced liver function.

Application with violations of the kidney function

It should be used with caution in patients with pronounced disorders of the kidney function.

Application in children

Contraindicated in children and adolescence (up to 15 years).

special instructions

It should be used with caution in patients with epilepsy, a convulsive syndrome of other etiology, with pronounced disorders of the function of the kidneys and liver. During the treatment period, patients should receive a sufficient amount of fluid (under the control of diuresis).

Norfloxacin should be taken at least 2 hours before or 2 hours after receiving antacid or preparations containing iron, zinc, magnesium, calcium or sucralfat.

Eye drops Norfloxacin - antibacterial drug, which has a wide range of action. In ophthalmology it is used in inflammatory eye diseases. Norfloxacin is also prescribed to patients suffering from infectious diseases of the genitourinary system (cystitis, pyelonephritis, urethritis and prostatitis), diseases gastrointestinal tract (Salmonellosis). Norfloxacin drops use otolaryngologists with inflammatory processes in the outer and middle ear.

Composition, form of release

Norfloxacin - a drug, which refers to the group of fluoroquinolones. It is the main active substance of the same name. eye drops. Their composition includes such auxiliary ingredients: purified water; sodium chloride; Trilon B; decamexin; Buffer solution having pH 4.7.

Norfloxacin eye drops are transparent or slightly greenish liquid. They are produced in vials with a dispenser, the volume of which is 5 ml. In 1 ml of solution contains 3 mg of norfloxacin.

pharmachologic effect

Norfloxacin manifests bactericidal activity against many microorganisms. It blocks the replication of the DNA of bacteria, as a result of which their reproduction is oppressed. This antiseptic manifests bactericidal activity against such gram-positive and gram-negative microorganisms:

• enterococci;
• streptococci;
• staphylococci;
• enterobacteria;
• klebsiella;
• escherichia;
• proteins;
• pseudomonads;
• shigella;
• salmonella;
• jersinia.

It also acts on pseudomonads, cholera vibrion and ureaplasma.

Norfloxacin shows resistance to the action of β -Laktamaz - the enzymes of microorganisms capable of destroying its structure. The drug is inactive against the pale treponam (syphilis pathogen) and is able to conceive signs of the disease, which should be used in the treatment of syphilitic lesion of organs of vision.

When using such dosage form Norfloxacin, like eye and ear dropsThe antibacterial agent acts directly at the place of the defeat, which makes it possible to achieve the rapid and best treatment result. The drug begins to act 1 hour after instillation of eye drops, and the maximum concentration active substance It is observed in 2 days. It is absorbed into the blood and is well processed by the liver, and from the body is excreted by the kidneys.

Indications for use

Norfloxacin eye drops are prescribed in ophthalmological practice With such eye diseases:

• and keratoconjunctivitis;
• blufarite and blepharoponjunctivitis;
• lesions;
• inflammation of the Maberium glands in the acute period;
• after operations in the eyes;

They are also prescribed after the extraction of a foreign body from eyeball and ear, as well as in LOR-Practice with outdoor and middle otitis. The drug is also used after the extraction of the foreign body from the eye and ear, after surgical interventions.

Method of application and dose

Norfloxacin eye drops are prescribed to adults and children who have reached the fifteen-year-old age, 1-2 drops in a conjunctival bag every 15-30 minutes. Then, when decreasing inflammation symptoms, the frequency of instillations are reduced. After the signs of the disease disappeared, the procedures should be performed for another 2 days.

If a inflammatory process It is expressed moderately, it is enough to bury 1-2 drops of eye drops of Norfloxacin after 4-12 hours. In the case of acute or chronic trachomas, the course of treatment is from 1 to 2 months in 2 drops of the drug 2-4 times a day.

Contraindications

Norfloxacin eye drops are not prescribed to children under 15 years old. There are data on the penetration of the main active substance through the placenta and breast milkTherefore, the drug should not be used by a burden and nursing breasts. This can lead to a violation of the health of the fetus and a newborn baby. If there is a need to apply Norfloxacin's eye drops during lactation, during treatment with the drug should be abandoned to breastfeeding.

The drug is contraindicated in the presence of data as an anamnesis of norfloxacin intolerance. It is not prescribed in viral and fungal eye lesions.

Side effects

When using eye drops of Norfloxacin in some patients can be observed allergic reactions In the form of skin rashes, swelling swelling, increased sensitivity to sunlight, itching, burning, swelling and feelings of discomfort in the eye. After applying the drug, exudative erythema sometimes developed.

In some cases, with local use of eye drops, Norfloxacin in patients had such side effects:

• bitterness in the mouth;
• heartburn;
• nausea;
• stomach ache;
• sense of anxiety;
• dizziness.

Overdose

Cases of overdose of eye drops of Norfloxacin with them local application not registered. In case of accidental use of the drug, nausea may occur, vomiting, stool disorder, headache and dizziness. Since the antidote to Norfloxacin does not exist, if the drug suspected, it is necessary to rinse the stomach, to put the cleansing enema and give the patient to take sorbents.

Interaction with other means

With the local use of eye drops of Norfloxacin with other ophthalmological preparations, they do not interact with each other. Nevertheless, if there is a need to instillation of several drugs, the fifteen-minute interval between procedures should be observed.

Storage conditions and special instructions

Norfloxacin eye drops are recommended to be stored in a darkened place to which children should have access to room temperature air. After opening the bottle, its content should be used for 10 days. Norfloxacin eye drops are not designed to receive inside.

After instillation of the drug, it may sometimes be disturbed by the quality of view. In this regard, before its full recovery, it is necessary to drive with care vehicles and work with mechanisms requiring high concentration attention.

Eye drops of Norfloxacin are actively used for the treatment of ophthalmic infectious pathologies. This pharmaceutical preparation with a pronounced antimicrobial effect has a wide range of action. It is necessary to apply it to the appointment of a qualified physician-ophthalmologist, solely after the diagnostic survey and confirmation of the diagnosis. By self-medication, it is only possible to aggravate the course of illness and harm health.

Composition and mechanism of work

Instructions for use represents NorFloxacin, like eye and ear drops, which are located active Component - Norfloxacin and additional ingredients such as:

• purified water;
• decamexin;
• sodium salt of hydrochloric acid;
• buffer solution;
• trilon B.

Eye drops have a pronounced antibacterial activity in relation to many bacteria. Norfloxacin helps prevent various complications in the form of infection after transferred surgical intervention on spectator. Apply antimicrobial medication for therapy of fungal and viral diseases is impractical.

When is it appointed and who hurt?

In ophthalmology, Norfloxacin drops are prescribed with the following pathologies of the eyes:

The drug in this form will help to relieve inflammation that has developed in the mabomiye gland.

• Inflammation:
  • edges of the century, cornea eyes;
  • mabomic glands of acute character;
  • connective shell of the visual organ;
  • on the mucous meter of the organ of vision.
• Ulceration of the horny shell.
• States after an ophthalmic surgery.

In addition, medication is prescribed to patients who have learned foreign body From the eyeball. But despite high efficiency "Norfloxacin", it is not allowed to apply it. Pharmaceutical preparation It is categorically contraindicated to persons with personal intolerance to any component from the composition. You can not use for therapy of the eyes and women in the period of the baby tooling, as well as nursing mothers and children under 15.

Instructions for use

Before using eye drops, it is important to thoroughly examine the annotation attached to the medicine, in which the correctness of the administration of an ophthalmic solution based on Norfloxacin is described in detail. So, using Norfloxacin, you must follow the following rules:

Install the drug is necessary after pulling down the lower eyelid.

1. Pre-wash your hands with soap and dry them.
2. If there are purulent discharge or crusts - rinse your eyes.
3. Throw back your head back and delay the lower eyelid.
4. Enter 1-2 drops, repeating the procedure to 6 times a day.
5. After instillation of Norfloxacin, it does not get behind the wheel for half an hour, as well as do not start working that requires increased definition of vision.

The duration of therapeutic course is usually 1-2 months, but also as the multiplicity and dosage of the drops, it can be changed individually a profile doctor.

Overdose

In medical practice there are no information about overdose eye drops Norfloxacin applied locally. If the medicine accidentally swallows inside, then nausea arises, urge to vomiting, headache, diarrhea and vertigo. Specific antidote considered the pharmaceutia has no. In case of an overdose you need to rinse the gastrointestinal tract and take the sorbent.

• eyefatherhood;
• feeling of discomfort and an extraneous object in the eye;
• swelling, burning and redness of conjunctiva;
• increased painful sensitivity to light.

Applying droplets for Norfloxacin's eyes, some patients face allergy reactions that are manifested in the form of a dermatological rash, quinque swelling, itching the eye. Occasionally against the background of therapy with an ophthalmic drug, multiform erythema develops. And also with the local use of Norfloxacin, other negative effects were observed, such as:

• burning pain in the esophagus;
• bitterness in the oral cavity;
• racking, painful discomfort in the stomach;
• anxiety;
• dizziness.

Norfloxacin is a solution of droplets for eyes and ears with antibacterial effect. In ophthalmology is used to treat surface infections (bacterial conjunctivitis, blufarites, keratitis).

Composition and form of release

Norfloxacin - a solution of an eye drop of 0.3% transparent colorless, sometimes weakly greenish, contains:

• Active substance: Norfloxacin - 3 mg;
• Auxiliary components: decamexin, sodium chloride, Dinatari Edetat, buffer rr, water.

Packaging: White Plastic Bicon Drops software 5ml in a pack of cardboard.

Pharmacological properties

Norfloxacin - antimicrobial preparation Fluorochinolone group. Its action is based on the suppression of the activity of DNA hyracean of bacterium cells and replication of DNA bacteria. A wide range of antimicrobial action, which has the drug, applies to gram-positive and gram-negative microorganisms: Klebsiella SPP., Escherichia coli, Proteus SPP., Enterobacter SPP., Citrobacter SPP., Acinetobacter SPP., Serratia SPP., Providencia SPP., Pseudomonas Aeruginosa, Neisseria Gonorrhoeae., Haemophilus Influenzae., Neisseria Meningitidis., Salmonella and Schigella, Campylobacter. Enterococcus and Acinetobacter to the action of the drug are simple sensitive, anaerobic bacteria are not sensitive.

The beginning of the action of the drug is at first an hour after it is injected. It is excreted from the body to a greater degree of kidneys, half-life - 3 - 4 hours.

Indications for use

Drops Eye Norfloxacin are used to treat surface infections of the eye (bacterial conjunctivitis, keratitis, blufarites), during the sensitivity of the pathogen to this antibiotic.

Method of application and dose

With acute infectious eye processes, the drug is prescribed conjunctivatives 1-2 drops with an interval of 15 to 30 minutes, then the instillation frequency is reduced.

In the therapy of a moderately pronounced infectious process, the norfloxacin solution is prescribed from 2 to 6 times daily.

For the treatment of trachomas (acute and chronic), the drug is prescribed 2 drops 2 - 4 times daily, duration up to 2 months.

After the disappearance of the symptoms of the infectious process, the norfloxacin solution is recommended to continue to apply another 48 hours.

Contraindications

• Individual intolerance.
• Pregnancy, lactation.
• Age up to 15 years.

Drops Norfloxacin should be appointed with caution to patients with epilepsy, convulsive syndrome of any etiology, atherosclerosis of the brain vessels, pronounced disorders of the liver or kidney function.

Side effects

After instillations of the Norfloxacin solution, local allergic reactions are possible, accompanied by a feeling of burning, pain, hyperemia and edema conjunctiva, photophobia.

Overdose

Overdose cases are not described.

With random receipt of the solution inside, nausea may occur, vomiting, diarrhea, dizziness and headache. Sometimes - a feeling of anxiety.

Treatment of overdose is symptomatic (large amount of liquid and "acidification" of urine to prevent the occurrence of crystalluria).

Medicinal interactions

Interaction with other medicinal preparations Under the local application of a solution, Norfloxacin was not detected.

special instructions

The solution of norfloxacin drops is intended exclusively for local applications. The best healing effect of eye drops is achieved with systemic antimicrobial therapy (exception - easy cases).

To avoid the development of symptoms of photophobia, during treatment with the drug it is recommended to wear darkened glasses, avoid long stay on bright light.

The drug is able to call short-term change spectatic perceptionIt makes it serious difficult to driving vehicles and work with moving mechanisms.

Stored a solution of Norfloxacin away from the effects of sun rays at room temperature. Do not give children. Shelf life - 2 years. After opening the bottle, the suitability of the solution does not exceed 10 days.

Norfloxacin Drops Eye and Ear (Guttae Norfloxacinum)

international and chemical name:norfloxacin; (1-ethyl-6-fluoro-4-oxo-7- (piperazine-1-yl) -1, 4-dihydrokhinolin-3-carboxylic acid);

basic physico-chemical properties: transparent colorless or with a weak greenish tinge liquid;

Structure.1 ml of solution includes norfloxacin 3 mg (0.003 g);

auxiliary substances: sodium chloride, decamexin, Dinatari Edetat, buffer solution, purified water.

The form of the release of the drug. Eye drops and ear.

Pharmacotherapeutic group. Funds used in ophthalmology and degree. Antimicrobial means. Norfloxacin. PBX code S03A A09 **.

Pharmacological properties.

Pharmacodynamics. Norfloxacin - antimicrobial drug of the fluoroquinolone group; Suppresses the activity of the DNA gigrase of the bacterial cell and the replication of DNA bacteria. Norfloxacin has wide spectrum Antimicrobial action relating to the predominant majority of gramnegative microorganisms. MIK for Escherichia Coli, Klebsiella SPP., Enterobacter SPP., Proteus SPP., Citrobacter SPP., Is 2 mg / l or less. Less Sensitive Acinetobacter SPP., Providencia SPP., Serratia SPP. MPK for Pseudomonas Aeruginosa - less than 1 - 2 mg / l, for Haemophilus Influenzae, Neisseria Gonorrhoeae and Neisseria Meningitidis - less than 2 mg / l, for pathogenic strains of Salmonella and Schigella - less than 1 mg / ml, for Campylobacter - less than 4 mg / ml For staphylococci 1 - 4 mg / ml, for streptococci - 2 - 16 mg / l. Anaerobic bacteria are insensitive to the action of the drug, ENTEROCOCCUS and ACINETOBACTER.

Pharmacokinetics. There is no information about the distribution of Norfloxacin when applied in ophthalmology and dedication is absent, however, it is known that Norfloxacin is distributed in most liquids and tissues of the body, including eyes and ear. Proteins binds from 10% to 15% drug. Begins to act 1 hour after instilcing in the eye. The maximum concentration in serum, for a daily ophthalmic dose 2, 5 mg, is 10, 2 ng / ml.

Norfloxacin disintegrates on 6 active metabolites, the antibacterial activity of which is lower than the source substance. Norfloxacin is metabolized in the liver and kidneys. Approximately 30% of the active substance is displayed with urine unchanged. The half-life of the drug is 3 - 4 hours.

Indications for use. Surface infections of the eye (bacterial conjunctivitis, keratitis, blufarites), external and middle ear infections (external otitis, chronic purulent otitis).

Method of use and dose.Othmy. With sharp infectious diseases The eye is prescribed 1 - 2 drops every 15 to 30 minutes, then the income frequency is reduced.

With a moderately pronounced process, 1 to 2 drops 2 - 6 times a day are prescribed.

With acute and chronic trachus, 2 drops are prescribed 2 drops in each eye 2 - 4 times a day for 1 - 2 months.

After the disappearance of the symptoms of the disease, the use of the drug should be continued over the next 48 hours.

Ears. In case of diseases, the ear is prescribed in the ear of 5 drops 3 times a day.

Drops must have body temperature. Before applying, droplets should carry out the external auditory passage. The patient must lie on the side or tilt his head to facilitate instillation. After the introduction, the head should be stored in this position approximately 2 minutes. In an external hearing aisle, you can put a cotton tourundum.

When the symptoms of the disease pass, the use of the drug should be continued over the next 48 hours.

Side effect.Local reactions (sensation of burning or pain, hyperemia and edema conjunctiva, photophobia are possible.

Contraindications.Increased sensitivity to Norfloxacin and the rest of the fluoroquinolone row. Pregnancy and lactation. Children's and teenage age up to 15 years.

Overdose.There were no reports of the overdose of Norfloxacin in ophthalmology and reporting reports.

With random reception, droplets inside are nausea, vomiting, diarrhea, headache, dizziness, alarm feeling.

Treatment: if necessary, spend symptomatic therapy; It is necessary to ensure sufficient flow of fluid into the body, the formation of an acidic urine reaction to prevent crystaluria.

Features of use.Norfloxacin in the form of droplets is assigned only to local use. To achieve the best therapeutic effect Drops should be used in combining with systemic antimicrobial therapy (with the exception of light cases).

Caution is prescribed a drop of Norfloxacin with patients with epilepsy, convulsive syndromes Another etiology, with pronounced disorders of the liver / kidney function, during atherosclerosis, brain vessels.

The development of lights is possible; should wear light-protective glasses and avoid long action Bright light.

During 30 minutes after the injection of the drug in the eyes should be kept from driving vehicles and classes potentially unsafe activities that require increased attention.

Interaction with other drugs.Interaction with other drugs under the local application of norfloxacin is not described.

Terms and Storage Terms. Store in an unavailable for children protected from light at temperatures from 15 ° C to 25 ° C. Shelf life - 2 years. The shelf life of the solution after disclosure of the bottle is 10 days.