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This article allows you to familiarize yourself with the instructions for use. medicinal preparation Amosic. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists in the use of antibiotic amosine in their practice. A big request to more actively add your reviews about the preparation: helped or did not help the medicine to get rid of the disease, which complications were observed and side effects, possibly not stated by the manufacturer in annotations. Amone analogues in the presence of available structural analogs. Use for the treatment of angina, pneumonia, hymorite and other infectious diseases in adults, children, as well as during pregnancy and breastfeeding. The composition and interaction of the drug with alcohol.

Amosic - Antibiotic wide spectrum Actions of a group of semi-synthetic penicillins. Acts bactericidal. Inhibits transpapeptide, disrupts peptideoglycan synthesis (the support polymer of the cell wall) during the division and growth period, causes lysis bacteria. Acid-resistant.

Active in relation to aerobic gram-positive bacteria: Staphylococcus SPP. (Staphylococcus) (with the exception of penicillinase strains), Streptococcus SPP. (streptococcus); Aerobic gram-negative bacteria: Neisseria Gonorrhoeae, Neisseria Meningitidis, Bacillus Anthracis, Listeria Monocytogenes (Listeria), Helicobacter pylori. (Helicobacter), Klebsiella SPP. (Klebseyella).

Microorganisms producing penicillinase, resistant to the action of amoxicillin.

The action is developing 15-30 minutes after administration and lasts 8 hours.

Structure

Amoxicillin (in the form of trihydrate) + excipients.

Pharmacokinetics

After receiving inside Amosin quickly and almost completely (93%) absorbed from the gastrointestinal tract. Meal does not affect the absorption of the drug, does not destroy in the acidic area of \u200b\u200bthe stomach. In high concentrations, plasma, sputum, bronchial secrete (in the purulent bronchial secrete, the distribution of weak), pleural and peritoneal fluid, urine, the contents of the skin blisters, the tissues of the lung, mucous membrane of the intestine, the female genital organs, prostate gland, medium ear liquids, bones, adipose tissue, bile bubble (with normal liver function), fetal tissues. With an increase in the dose of 2 times the concentration also increases by 2 times. The concentration in bile exceeds the plasma concentration of 2-4 times. In amniotic fluid and umbilical vessels, amoxicillin concentration - 25-30% of the plasma level in a pregnant woman. Poor penetrates through the hematostephalic barrier (GEB), when inflammation brain shells (meningitis) concentration in spinal fluid - about 20%. Binding with plasma proteins - 17%. In small quantities stands out with breast milk. Amoxicillin is partially metabolized with the formation of inactive metabolites. Amoxicillin is excreted by 50-70% with urine unchanged by canalic excretion (80%) and glomerular filtration (20%), with bile - 10-20%.

Indications

Infectious-inflammatory diseases caused by microorganisms sensitive to the drug:

• respiratory infections (including bronchitis, pneumonia);
• eNT infections (including sinusitis, pharyngitis, tonsillitis, acute average otitis);
• infections of the urogenital system (including pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea);
• gynecological infections (including endometritis, cervicitis);
• infections of the gastrointestinal organs (including peritonitis, enterocolitis, abdominal typhoid, cholangitis, cholecystitis);
• infections of the skin and soft tissues (including face, impetigo, secondally infected dermatoses);
• leptospirosis;
• listeriosis;
• lyme disease (borreliosis);
• dysentery;
• salmonellosis, salmoneselosis;
• meningitis;
• endocarditis (prevention);
• sepsis.

Forms of release

250 mg capsules.

Tablets 250 mg and 500 mg.

Powder for preparing a suspension for intake of 125 mg, 250 mg and 500 mg.

Instructions for use and dosage

The drug is taken inward, before or after meals. The dosing mode is established individually, taking into account the severity of the course of the disease, the sensitivity of the pathogen to the drug, the age of the patient.

Adults and children over 10 years old (with a mass of body more than 40 kg) are assigned 500 mg 3 times a day, with severe course Diseases - 0.75-1 g 3 times a day.

Children aged from 5 to 10 years are prescribed 250 mg 3 times a day, aged 2 to 5 years - 125 mg 3 times a day, under the age of 2 years - 20 mg / kg per day in 3 reception. Course treatment - 5-12 days.

Children at the age of 5 years old the drug is prescribed in the form of a suspension (the ideal children's form of the drug).

For the treatment of acute uncomplicated gonorrhea, the drug is prescribed in a dose of 3 g once; In the treatment of women, it is recommended to repeat the specified dose.

With sharp infectious diseases The gastrointestinal tract (parathy, abdominal title) and the biliary tract, with gynecological infectious diseases, adults are prescribed 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

When leptospirosis, adults are prescribed at 500-750 mg 4 times a day for 6-12 days.

At silmosenelease adults - 1.5-2 g 3 times a day for 2-4 weeks.

For the prevention of endocarditis at small surgical interventions, adults are prescribed at a dose of 3-4 g per 1 hour before the procedure. If necessary, prescribe a re-dose after 8-9 hours. Children dose are doubled.

Rules for the preparation of suspension from a monocot package

The pure glass poured a boiled and cooled water in the amount specified in the table, then the contents of one package are poured and stirred to obtain a homogeneous suspension.

• Dose in package 125 mg - the required amount of water 2.5 ml;
• dose in package 250 mg - the required amount of water is 5 ml;
• dose in package of 500 mg is the required amount of water 10 ml.

After receiving the cup, rinse with water, dry and store in a dry, clean place.

Side effect

• hives;
• skin hyperemia;
• erythema;
• angioedema edema;
• rhinitis;
• conjunctivitis;
• fever;
• pain in the joints;
• eosinophilia;
• exfoliative dermatitis;
• multiform exudative erythema;
• stevens-Johnson syndrome;
• reactions similar to serum disease;
• anaphylactic shock;
• dysbacteriosis;
• a change in taste;
• vomiting, nausea;
• diarrhea;
• stomatitis;
• glossitis;
• pseudomambranous enterocolitis;
• excitation;
• anxiety;
• insomnia;
• confusion of consciousness;
• change behavior;
• depression;
• peripheral neuropathy;
• headache;
• dizziness;
• convulsive reactions;
• interstitial nephritis;
• leukopenia, neutropenia, thrombocytopenic purpura, anemia;
• labored breathing;
• tachycardia;
• candidiasis of the vagina;
• superinfection (especially in patients with chronic diseases or reduced organism resistance).

Contraindications

• allergic diathesis;
• bronchial asthma, pollinosis;
• infectious mononucleosis;
• lympholoicosis;
• liver failure;
• the diseases of the gastrointestinal tract (especially colitis associated with the use of antibiotics);
• lactation period (breastfeeding);
• increased sensitivity to the components of the drug;
• increased sensitivity to other penicillins, cephalosporins, carbapenes;
• children's age up to 3 years (for tablets and capsules).

Application in pregnancy and breastfeeding

Application in children

Contraindicated children under the age of 3 years (for the form of release in the form of tablets and capsules). Children at the age of 5 years old are prescribed in the form of a suspension.

special instructions

When conducting a course of treatment with amoSin, it is necessary to monitor the state of the function of the blood formation organs, liver and kidney.

It is possible to develop superinfection due to the growth of microflora insensitive to amoxicillin, which requires an appropriate change in antibacterial therapy.

In the treatment of patients with bacteremia, the reaction of bacteriolization is rarely developed (Yarish-Gersheimer's reaction).

In patients having increased sensitivity to penicillins, crosst allergic reactions with cephalosporin antibiotics.

For treatment easy Diarrhea Against the background of the use of amosine, it should be avoided the prescription of anti-diagram preparations that reduce intestinal peristalsis; Can be used kaolin- or attapulgite-containing anti-diagracial agents. With severe diarrhea it is necessary to spend differential diagnosis and assign appropriate therapy.

Treatment should be continued 48-72 hours after disappearance clinical signs Diseases.

With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, if possible, use additional methods of contraception.

Medicinal interaction

Antacids, glucosamine, laxatives, food, antibiotics of aminoglycoside groups, while simultaneous use, slow down and reduce amosine absorption; Ascorbic acid - increases its absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) exhibit synergism with amoxicillin; Bacteriostatic preparations (macrolides, chloramphenicol, lincoosamines, tetracyclines, sulfonamides) - antagonism.

Amoxicillin with simultaneous use increases efficiency indirect anticoagulantov (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); Reduces the effectiveness of estrogen-containing oral contraceptives, ethinyl estradiol (the risk of intermented bleeding), as well as drugs, in the process of metabolism of which para-aminobenzoic acid is formed.

The joint use of the drug amosyn with alcohol is prohibited (the hepatotoxic effect of ethanol is enhanced).

Diuretics, Allopurinol, Oxyphenbutazone, phenylbutazone, nonsteroidal anti-inflammatory agents (NSAIDs) and drugs that block the tubular secretion, while simultaneously use with amosine, reducing the channel secretion, increase the concentration of amoxicillin.

With the simultaneous use of amosine with allopurinol, the risk of skin rash is increased.

Amoxicillin, while simultaneously use, reduces the clearance and increases the toxicity of methotrexate.

Amoxicillin with simultaneous use enhances the absorption of digoxin.

Analogs of the Medicinal Amosin

Structural analogues for the acting substance:

• Amoxisar;
• Amoxicillin;
• Amoxicillin trihydrate;
• Gonoform;
• Grunamox;
• Danemoks;
• OSPAMOKS;
• Flexin Soluteab;
• Hikcotil;
• Ecobol.

In the absence of analogues of drugs on the active substance, you can follow the links below on the disease, from which the appropriate drug helps and see the existing analogues on therapeutic effects.

Amosin is a semi-synthetic preparation from the penicillin group of antibacterial spectral action.

Its exposure is manifested in the oppression of the enzyme of transpapeptidase, in violation of the stability of the cell walls, the braking of the processes of the development of pathogenic microorganisms and dividing them at the cellular level, which the final account causes lysis of the pathogenic microflora.

On this page you will find all the information about Amosyn: Complete instructions for use in this medicinal medium, average prices in pharmacies, full and incomplete analogues of the drug, as well as the reviews of people who have already used amosyn. Want to leave your opinion? Please write in the comments.

Clinical and Pharmacological Group

Antibiotic group of penicillins of a wide range of action that is destroyed by penicillinase.

Conditions of vacation from pharmacies

Recommended by a doctor's prescription.

Prices

How much is Amosin? The average price in pharmacies is at the level of 30 rubles.

Release form and composition

Amosin is produced in several dosage forms.

Amosin gelatin capsules of white color, size number 0. Content capsules - white granules. Packed in contour cells of 10 pieces.

Amosic tablets - white or almost white, flat cylindrical shape, with separation risk and chamfer. Packed in contour cells of 10 pieces.

Amosin powder for the preparation of a suspension for intake - has a white with a yellowish color color and a specific smell. The prepared suspension is obtained by white with a yellowish color shade and a specific smell. Packaged in single-bar packets of 1.5; 3 and 6 g

Pharmacological effect

The active component of therapeutic agent is actively affected by gram-negative bacteria - Neisseria Meningitidis and Listeria Monocytogenes and Bacillus Anthracis, Klebsiella SPP., Neisseria Gonorrhoeae and Helicobacter Pylori; on gram-positive staphylococcal and streptococcal bacteria. Pathogenic microflora producing peculinated anti-impact active component Amosine.

Effect of reception therapeutic drug It manifests itself at 15-30 minutes and is preserved 8 hours. The medicine is easily and for a short time is absorbed by the tract walls, and the presence of food does not affect the rate of absorption. The maximum content of amoxicillin is achieved in the blood plasma in the first 1-2 hours. Bloodstock is conveying the acting component of the drug to the mucous membranes, bone and connective tissue, intraocular wet and liquid. The dismissal time through the kidney is on average from two to three hours and can increase in patients with impaired renal function.

Indications for use

AMOSIN antibiotic is prescribed with bacterial infections:

• Urogenital infections (cystitis, pyelonephritis, urethritis, pelitis, gonorrhea);
• Infectious diseases of the digestive tract (dysentery, abdominal type, salmonellosis, cholecystitis);
• Borreliosis;
• Meningitis;
• Acute infectious diseases of the upper respiratory tract;
• Acute infectious diseases of the lower respiratory tract (bronchitis, pneumonia);
• ENT infections (acute average otitis, sinusitis, angina);
• Sepsis;
• Skin and soft tissue diseases (secondally infected dermatosis, impetigo, corrosive inflammation);
• Prevention of endocarditis and surgical infection.

Contraindications

Contraindications to the use of amosine are:

• Liver failure;
• Bronchial asthma and pollinosis;
• Allergic diathesis;
• Lympholoicosis;
• Infectious mononucleosis;
• Diseases of the gastrointestinal tract;
• Increased sensitivity to amoxicillin and other penicillins, as well as carbapenes and cephalosporins;
• Breastfeeding period;
• Children's age up to 3 years (for dosage form in the form of capsules and tablets).

Amosic caution is prescribed to pregnant women and patients with renal failure and bleeding in history.

Application during pregnancy and lactation

The use of the drug during pregnancy is possible only in cases where the intended benefit of therapy for the mother exceeds the potential risk to the fetus.

Application during lactation is contraindicated. If necessary, use during lactation should be stopped breastfeeding.

AMOSIN INSTRUCTIONS

In the application instructions, it is indicated that amosyn is taken inward, before or after meals. The dosing mode is established individually, taking into account the severity of the course of the disease, the sensitivity of the pathogen to the drug, the age of the patient.

• Adults and children over 10 years old (with a mass of body\u003e 40 kg) are prescribed 500 mg 3 times / day, with a serious course of the disease - at 0.75-1 g 3 times / day.
• Children aged from 5 to 10 years are prescribed 250 mg 3 times / day, aged 2 to 5 years old - 125 mg 3 times / day, under the age of 2 years - 20 mg / kg / day in 3 reception. Course treatment - 5-12 days.
• Children at the age of 5 years old are prescribed in the form of a suspension.

For treatment of acute uncomplicated gonorrhea The drug is prescribed at a dose of 3 g once; In the treatment of women, it is recommended to repeat the specified dose.

For acute infectious diseases gasts (Parathines, abdominal typhoids) and biliary tract, with gynecological infectious diseases Adults are prescribed 1.5-2 g 3 times / day or 1-1.5 g 4 times / day.

For leptospirosis Adults are prescribed at 500-750 mg 4 times / day for 6-12 days.

For salmonellace Adults - 1.5-2 g 3 times / day for 2-4 weeks.

For endocarditis Prevention with Small Surgical Interventions Adults are prescribed at a dose of 3-4 g per 1 hour before the procedure. If necessary, prescribe a re-dose after 8-9 hours. Children dose are doubled.

In patients with impaired kidney function (CC from 15 to 40 ml / min), the interval between the techniques increases to 12 hours, in the terminal stage of chronic renal failure (QC

When the child is very sick, only a competent doctor can help. If you are lucky, the child is separated by several doses antiviral drugs. If the doctor arises at least the slightest concerns about possible complications, most likely, he will appoint an antibiotic.

Recently, according to the Ministry of Health, seasonal "sores" mutate and leak harder, especially in children aged 2-3 years. It is at this time that the kids begin to attend kindergarten, actively know the world, contact with peers. And there - grateful soil for mutual exchange of bacteria. As a result, mom has to go to hospital with enviable regularity.

What diseases lie most often a little man? Plot pediatricians know exactly this question. The most common among children in winter and in the offseason bronchitis, angina, pharyngitis, different forms of otites, tonsillitis. If the child rolled on an ice hill or rink, another trouble can happen - the supercooling often causes inflammation of the urogenital system. The conclusion of the doctor then sounds differently - cystitis, pyelonephritis. Often, the kids suffer from intestinal diseases (they usually "bring" from the kindergarten). There is an exit. In all of these cases, it effectively helps modern antibiotic widespread "Amosin".

What it is?

Let's try to tell about it simple language. If your child is reluctant to take this drug now, read it, and then tell him the fairy tale about the courageous defender of all the sick guys amosine. Believe me, to persuade the kid to take another dose no longer have to. He himself will gladly drink medicine.

So, "amosin 250" is a modern antibiotic of a wide range of action. It has loved ones related relations with semi-synthetic penicillins. It works like a riot police - quickly and decisively. Active substance - amoxicillin. His goal is malicious microbes of various origin. The drug enters the body, after 15-20 minutes penetrates into a malicious bacterium cell and reduces the speed of all chemical processes that flow in it. Destroys the structure, membrane, enzymes.

The "angry" cell also wants to live, it begins to actively resist and as a result spends the last forces. Amosin is adamant. Its action continues up to 8 hours.Some "enemy" cells are trying to influence it with acid. But the valiant antibiotic is stable to it. Therefore, it wins 100% of cases. From the body is excreted pretty quickly, with the formation of inactive metabolites. This means that decay products are not toxic.

In addition to otitis, bronchitis and masses of others cold illnessThe remedy successfully copes with such "serious" rivals as sinusitis, salmonellosis and meningitis. Running with skin infections. Most often, the drug is recommended for angina, since this disease causes bacteria of various species.

Instructions for use

Amosic 250 is different: powder, granules. There is a solution for intramuscular and intravenous application. But the children most often are prescribed in tablets. Todders aged 2-3 years are usually recommended to take an antibiotic in the form of a suspension. It is easy to drink, she is pleased with the taste and smell due to vanillina added by the manufacturer in the main composition. In the form of the Syrope "Amosin" is not available.

The preparation in the form of a suspension is the optimal choice for a child 2-3 years

The dosage is determined by the doctor. It depends on the age of the child. Amosin 250 can be given even a newborn from the first days of life.

Suspension for children to parents will have to be prepared independently. For this, the powder is simply added to the cooled boiled water. "AMOSIN 125" (the drug with an active active substance in the amount of 125 mg) should be diluted in 2.5 ml. water. For a means of 250 mg, it will take 5 ml of water, respectively. For 500 mg - 10 ml. liquids.

Dosage and reception schedule is usually like that.

• Baby from birth to 2 years:three times a day. Total day dosage 20 mg of suspension per kilogram of patient weight.
• Reached up to 5 years inclusive can take 125 mg. Suspension three times a day.
• Guys from 5 to 10 years:three times a day 250 mg.
• Schoolchildren older than 10 years 500 mg "Amosine" also three times a day.

Tablets and drug capsules do not give children up to 2 years!

Sometimes "Amosin" is prescribed children for the prevention of endocarditis or surgical infection. In this case, doctors recommend starting from half an adult dose.

Amosine 250 dosage only chooses a doctor after inspecting a child's contraindication

Be sure to inform the doctor appointing your child "Amosin" if the baby has at least one of these diseases:

• allergic diathesis;
• flowering allergies (pollinosis);
• bronchial asthma;
• liver failure;
• kidney disease;
• frequently repetitive bleeding.

All these diagnoses are strict contraindications to the reception of this antibiotic.

The drug cannot be taken also to children who have ever acted with colitis or suffer allergies on antibiotics.

Amosin 250 acts and destroys various types of bacteria side effects

Do not forget that, like any powerful antibiotic, the tool may cause side effects.The instructions for use describes such symptoms:

• disorders of the gastrointestinal tract;
• nausea;
• allergic runny nose;
• the appearance of rash and itching;
• shortness of breath, sleep disorder, depression of central nervous system, child's consideration.

If your son or daughter has at least something from the listed, be sure to report this to Dr. - it will adjust the dosage and will give the necessary recommendations.

Overdose

If it happened that the child accepted the dose of the drug exceeding the prescribed by the doctor, watch him carefully. "Copy help" should be caused by the appearance of such symptoms as nausea, severe vomiting, abdominal pain, dizziness. Only "Emergencies" experts will be able to help in this situation, because the powerful antibiotic acts quickly, and there is simply no antidote to him. Doctors promptly wet the stomach with brine and remove intoxication of the body. In this case, self-treatment in this case is extremely dangerous.

Amosin is more than available. The average cost in Russian pharmacies is about 70 rubles (sachets for the preparation of suspension), 27-40 rubles (pills). A little more than 60 rubles is a drug in capsules. Prices in different regions of the country and pharmaceutical networks may differ, the truth is slightly.

A amosine pills and capsules do not give children under 2 years of shelf life and storage conditions

The drug should be stored in a place protected from moisture and direct sunlight, at a temperature not higher than + 25 ° C and not lower than + 15 ° C, not more than 2 years from the date of manufacture. The drug is released strictly by recipe.

AMOSIN 250 - antibiotic domestic production. Manufacturer - Pharmaceutical Company Synthesis AKO OJSC (Kurgan region).

The situation with the analogs is quite interesting. Usually the original drug is more expensive than analogues. But here it's the opposite. Preparations with similar action are as follows:

Flexin SOLUTAB. Produced in Holland. Packing tablets (20 pieces) costs more than 300 rubles.

Augmentin. Antibiotic bacterial action Right from England. Packing tablets (20 pieces) costs more than 250 rubles. By the way, somewhere "Augmenten" love to prescribe pediatricians to their patients. Parents not to overpay, it makes sense to clarify the doctor if it is possible to replace it with our original Amosin, which is almost 5 times cheaper.

Amoxiclav.. Another drug is similar. Produced in Slovenia. It is more expensive than other analogues. For packaging of 14 tablets will have to give 250 rubles.

Reviews

At the Internet of the Internet, Amosin also know and most often approve.Since the doctors have recently began to appoint it more often, parents already have a certain experience of using an antibiotic for the treatment of children. The main part of those who published their impressions of the medication, emphasize that the main advantage of the drug is in the speed of its action. In the first day, after the start of reception, the child decreases the temperature, and in 5-6 days the kid is healthy. Mom it can not but rejoice, since they have to sit less on the hospital. Almost everyone notes that this is a worthy alternative to expensive imported medicines.

Part of the parents note that their kids in the course of treatment "amosine" a tummy hurts and digestion is disturbed. In this case, it is saved to restore intestinal microflora, such as "Bifidumbacterin", "Laratylae", etc. They will also appoint them.

Only a minor part of moms and dads complain of sleep disorders in a child against the background of taking an antibiotic. And few units - collided with side phenomena of the drug.

Some parents all ways avoid taking antibiotics, even if they strongly recommended a doctor. But when appointing a doctor, they should not be afraid.

Help the baby quickly overcome the disease - the main task of caring parents. And when the child is again healthy, life in the house enters the usual bed, with its small joys and daily children's discoveries. Let the kids smile!

You can learn more about antibiotics from the transfer of Dr. Komarovsky.

Instructions for the use of amosine in tablets, description of the action of the drug, indications for the use of amosine tablets, interaction with other drugs, the use of amosine (tablets) during pregnancy. Instructions:

Amosin in powder

Composition amosine in tablets

One tablet contains

Bir Tabletikanyң ұұRamanda

Azerosine active substance

amoxicillin trihydrate (in terms of amoxicillin) 250 mg, 500 mg

amoxicillin trihydrates (ferkand amoxicilling) 250 mg, 500 mg

Auxiliary substances in amosine

starch Potato, Magnesium Stearat, Talc, Pisidon, Calcium Stearat

cardboard Starch, Magnesium Stearati, Talc, Pisidon, Calcium Stearats

Indications for the use of amosine tablets

• bronchitis, pneumonia

• sinusitis, pharyngitis, tonsillitis, acute middle otitis

• pyelonephritis, Pelitis, Custitis, Urethritis, Gonorrhea, Endometritis, Cervicitis

• cholecitis, cholecystitis, dysentery, salmonellosis, salinelose

• ryg, Impochigo, Secondary infected dermatoses

• leptospirosis

• liseriosis

• lyme disease (borreliosis)

• endocarditis (prevention)

• bronchitis, pneumonia

• sinusitis, pharyngitis, tonsillitis, taped ortāi otitte

• pyelonephritis, Pelitis, Cystitis, Ureretrite, Pos, Endometritis, Cervicitte

• cholant, cholecystitis, Dieseneria, Salmonellosis, Salmonellez Tatsymaldausylқt

• tіlma, impetigo, Ekinsіli jұұұtylғan dermatozard

• leptospyrosda

• listeriosda

• Lime Aurynda (Burrelioz)

• endocardite (Aldyn Allu)

Contraindications AmoSin in tablets

• hypersensitivity to the drug (including to other penicillins, cephalosporins, carbapenes)

• children's age up to 6 years (for this dosage form)

• period lactation

• preparatқa (Sons ІШІnde Basқa Penicillonderge, Cephalosporinderg, Carbapenemderg) Asa Joғara Semmaldaққ

• 6 Jasқa Diіngі Balalarғa (OSS DәRіlіk Tүr үшіn)

• lactation Keszңі.

Side effects amosine tablets

• dysbacteriosis, change in taste, stomatitis, glossite, vomiting, nausea, diarrhea, moderate increase in the activity of "liver" transaminase

• pseudommbranous enterocolit

• excitation, anxiety, insomnia, ataxia, confusion of consciousness, change behavior, depression, peripheral neuropathy, headache, dizziness, epileptic reactions

• leukopenia, neutropenia, thrombocytopenic purpura, anemia

• urticaria, skin hyperemia, erythematous rashes, angioedema edema, rhinitis, conjunctivitis; Rarely - fever, arthralga, eosinophilia, exfoliative dermatitis, multiform exudative erythema (incl. Stevens-Johnson syndrome), reactions similar to serum disease, very rarely - anaphylactic shock

• others: Vaginal candidation, difficulty breathing, tachycardia, interstitial nephritis, superinfection (especially in patients with chronic diseases or reduced organism resistance)

• dysbacteriosis, DME SEUDIңң өZHERAI, Stomatitis, Glossitis, Zhүr Ain, ұұsu, diarrhea, "Bauyr" Transaminazalary Belsendіlіgnің ortasha joғaarylaua

• strank Zhғғshaly Enterocolit

• зу, үрелену, ұyosyzdyқ, Ataxia, Sananaң Shatasuy, Minez-ұұLқ өZhRUI, Depression, Shetkergі Neuropathy, Bass Ayru, Bass Ainalu, Epilesylayla Reaction

• leukopenia, neutropenia, thrombocytopenia in purple, anemia

• esgging, Teri Hyperemias, erythematozda bөrttener, angioederate іsіnu, rhinitis, conjunctivitis; Sirek: Kyzba, Arthralgia, Eosinophilia, Exfoliativeti dermatitis, Multiformals Exudattyқ Erythema (Sonsidias Ішіnde Stevens-Johnson Syndromes), Sarysu ұұu Auruyna ұұsas Reaction, ө Sirek - Anaphylactical Shock

• basқalera: Kynaptiқ Candidationism, Tynystiң Taryluy, Tachycardia, Interstician Nephritis, Aschane Jұұұpa (әSіres, Costlings of Aurulars Bar Nemethn the body TөzіmdіlіGі TөMentegen Emdelosled)

Special instructions for use

With caution: allergic diseases (including history), diseases of the gastrointestinal tract in history (especially colitis associated with the use of antibiotics), renal failure, severe disorders of the liver function, infectious mononucleosis, lympholoicosis.

In case treatment, it is necessary to monitor the condition of the function of the blood formation organs, liver and kidneys.

It is possible to develop superinfection due to the growth of microflora insensitive to it, which requires an appropriate change in antibacterial therapy.

When prescribing patients with sepsis, the reaction of bacteriolization is possible (Yarish-Gersheimer's reaction) (rarely).

In patients having increased sensitivity to penicillins, cross-allergic reactions with other beta-lactam antibiotics are possible.

In the treatment of light diarrhea, against the backdrop of course treatment, antidiaryaric drugs that reduce the intestinal peristalsis should be avoided; Can be used kaolin- or attapulgite-containing anti-diagracial agents. With severe diarrhea, it is necessary to consult a doctor.

Treatment necessarily continues 48-72 hours after the disappearance of clinical signs of the disease. With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, if possible, use other or additional methods of contraception.

Pregnancy and lactation period

The use of the drug during pregnancy is possible in the case when the intended benefit for the mother exceeds the potential risk to the fetus. If it is necessary to prescribe the drug during the lactation, it is necessary to stop breastfeeding.

Features of the influence of the medicinal product on the ability to control the vehicle or potentially hazardous mechanisms

There were no reports about the effect of amoxicillin on car control or work with mechanisms. However, some patients may occur headache and dizziness. In their occurrence, the patient must comply with special precautions when driving a car and working with mechanisms.

Saktyқpen: Allergy to Aurwar (Syons Ішіnde Syrertқydaғy), Syrtartқydaғi Askazan-issek Zholi Aurulary (әSіres, Antibiotikter Koldanumen Baylanista Colitis), Bүyr Zhetkіlіksіdіgі, Bauhr FunctionSyni Auyr BұZyluy, Jäұpals Mononuclease, Lympholoicosis.

Kurstyk Emdeeud анan Tuza Aғzalarynaң, Bauyre Zhona Bүyr, FunctionSyniң Zhaғdayyn Baқylap ion қат.

DәRIGE SEVIMAL EMES of Microfloranң өSusіnen Asian Jұұұpanaң Lamuy Mүmkіn, Boltariyaғa қRaesi EMDI TIISІrtshe өZhertudі Talap Uti.

Sepsisispan Naukastarғa Taғayandalғanda Bacterioliz Recovery (Yarish Hersheimer Reactions) Lamuy Mүmkіn (Sirecha).

Penicillonge Joғara Semmaldaғi Bar Emdelushelda Basқa Beta-Lacmda Antibioticterman Ayқaspal Allergyuyuyu Reaction Bolua Mүmkіn.

Kurs United Emmey Ayasanda Sameңl diarins of Emedegende Ogener Peristalticusyn Tөrekdetetin Diaraiusғa қRasa PreparatTarkan Aulak Bola Kerk; ұramynda Kaolin Nememet Attapulgit Bar Diaraiusғa қResa DәReldi Paidalanuғa Bolada.

Auyre Diareyada Dәrіgerge алала қжet.

Emada Aurudaң Clinical Belg'lerі Basylғannan Keyin Mіndettі TүRDA TAғғ 48-72 SAAP of stainsads.

ҰRamenda Estrogen Bar ІШгуга Arnalғan Contraceptive meters Amoxicillin Bіr Mesgіld Koldanlғanda Mүmkіnche Basқa Nemez қoshasha contraception әДіsterіn Paidalan Kerek.

Zhүktіlіk Zhәna Lactation Keszңі

Zhүktіlіk Kesynde Preparattes Ana үшіn Bolznatyn Paidasi ұрақққ Tөnetіn Zor Katerden Artты Bolatyn Zhaғdide ғana Koldanuғa Bolada.

DәRіlіk Tattiң Kөlіk ұұraln Nemesto қauіptіlіgі zor mechanism holder kaқaru қab_letіна әser ETU YEREKSELІKTERI

Amoxicillinnің Avtokөlіk Basқaruғa Nemez Mechanisternator Zhamya ІSteuga әser ETUI Zhanіnde Khabarlamalar Boloғan. Degenemen de, Keibіr Emdelushelda Bass Ayuru Zhona Bas Ainal Boluy Mүmkіn. Ollar Bіlіgende Emdeluschi Autochalіk Basırғanda Zhona Mechanistendent Zhammy ІStegende Yershech Saktan Sharalaryn қадағalauy Tiis.

Dosage and method of application

Inside, accepted independently of meals. A tablet can be swallowed entirely, divided into parts or dear, picking a glass of water.

Adults and children over 10 years old (with a mass of the body more than 40 kg) are prescribed 500 mg 3 times a day; In case of severe infection - 750-1000 mg 3 times a day.

Children aged 6-10 years prescribe 250 mg 3 times a day; In case of severe infection - 60 mg / kg / day 3 times a day. Course of treatment 5-12 days.

With acute uncomplicated gonor Assign 3000 mg once; In the treatment of women, it is recommended to repeat the specified dose in a day.

With acute infectious diseases of the gastrointestinal tract (Parathines, abdominal typhoids) and biliary tract, with gynecological infectious diseases adults - 1500-2000 mg 3 times a day or 1000-1500 mg 4 times a day.

Under leptospirosis Adults - 500-750 mg 4 times a day for 6-12 days.

At silmosenelease Adults - 1500-2000 mg 3 times a day for 2-4 weeks.

For the prevention of endocarditis at small surgical interventions Adults - 3000-4000 mg per 1 hour before the procedure. If necessary, prescribe a re-dose after 8-9 hours. Children re-dose reduce 2 times.

In patients with impaired kidney functionwith QC 15-40 ml / min The interval between the techniques increases to 12 hours; At QC below, 10 ml / min dose is reduced by 15-50%; with anouria - maximum dose 2000 mg / day.

Ішка, АС ісуга байланансизЗ қабландададададада. Tabletacans Bіr Stқhan Sumen ІШІP, Bүtіndea Zhұteuғa, Ekiga Bөluga Nememe Shaynauғa Bolada.

Sheektherg Zhane 10 Zhistan лакен (Dene Salmaғa 40 kg-den kөp) Balalarғa Tәulіngіn 3 retro 500 mg Taғyanda; Jұұұpanaң Auyre Aғymenand - Tәulіgіn 3 retro 750-1000 mg.

6-10 Zhastana Balalarғa Tәulіngіn 3 Ret 250 mg-den Taғayanda; Jұұұpanaң Auyre Aғymenanda - Tәulіgіn 3 retro 60 mg / kg / tәulіk. Emmey courses 5-12 kүn.

He graduated from Asynbaғan Pop Czinde Bіr Ret 3000 mg Taғayanda; әelderdі Emedegend Kөrsetіlgen dose Kүnara қaita қAbyldau ұSyana.

Askazan-issek zholynyңң (Parathyl, ІШ Сүзегі) Zhәnu Zhaldarynaj Zhodeli Zhұұpalya Aurularynda, Gynec StologyLejpals Aurulard Hynectertherg - Tәulіgіn 3 Ret 1500-2000 mg Nemez Tәulіgіn 4 retro 1000-1500 mg.

Leptospyrosa of hesektherg - 6-12 Kүn bats Tәulіngіn 4 retro 500-750 mg.

Salmonelle Tatimaldausyluyuzhetterg - 2-4 APTA Boy Tәulіgіn 3 retro 1500-2000 mg.

Shaғyn Sirurgiayyyлы Aralsulard Endocargitchtің Aldene Alu үShіn Sheektherg - Yemshar Jasaluyan 1 Salad Barryn 3000-4000 mg. Bax, 8-9 Saouttan Sңтаtalau Doszasa Taғyanda Fores. Balalarda Katalau Dosaszyn 2 Esse Azaytada.

Bүyr the functions of BұZylғan Emploral KK 15-40 ml / min Kesynde Abyldaular Arakanda Aralқta 12 Sadқa Dain ұZartada; KK 10 ml / min TөMEM Bolғanda dose 15-50% of the azaytada; Anuriada - Eң Joғara Dossas 2000 mg / Tәulik.

Interaction with medicine

Antacids, glucosamine, laxative drugs, food, aminoglycosides slow down and reduce absorption; Ascorbic acid increases absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) have a synergistic effect; Bacteriostatic drugs (macrolides, chloramphenicol, lincoosamides, tetracyclines, sulfonamides) - antagonistic.

Increases the efficiency of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives; drugs, in the process of metabolism of which a para-aminobenzoic acid is formed, ethinyl estradiol - the risk of developing bleeding "breakthrough".

Amoxicillin reduces clearance and increases the toxicity of methotrexate; Enhances the absorption of digoxin.

Diuretics, Allopurinol, Oxyphenbutayon, phenylbutazone, non-steroidal anti-inflammatory preparations, and other drugs that block the tubular secretion increase the concentration of amoxicillin in the blood.

Allopurinol increases the risk of skin rash.

Antacider, glucosamine, ІШ Zhrgіzgіsh DәRіlіk Tatar, Tamaқ, Aminoglikosydter SІңірілін Баяутадададада жәна ТөENDEDII; Ascorbin Kyshқyli S_іrіlіn Arttyrada.

Bactericidti antibioticter (Sounds Ішіnde aminoglycosideter, cephalosporinder, vancomycin, rifampicin) synergidth; Bacteriostualsқ DәRіlіk Tatar (Macrolidter, Chloramphenicol, Lincosamidter, Tetracyclander, Sulfonilamidter) Antagonist әster KөRSeti.

T_KELEEL EMES anticoagulantar Tiimdiligіn Arttyrada (Ішер microfloraphs BәseңDeman, to Vitaminі Synthesine Zhon Prodromin Index_n TөMenBedi); ұұRamend estrogen Bar ІШугара Arnalғan contraceptiverdің; Metabolism үDerіsіnde Paraolanobenza қyshқyli Tүzіletnіn DәRіlіk Trechvadyң, Ethinyl Estradioldiң Tiimdilіng Azaytada - "ұұyylғan" анAN етапіі.

Amoxicillin methotrexattyң clearance Azayyp, Wyttylғyn Arttyrada; Digoxinnің sіңyn Kүsyted.

DiureticTer, Allopurinol, Oxyphenbutaon, Phenylbutan, Abinғa қAsya steroids Yezaz Preparattar Zhong өzecselіk Secretion Bagaten Basқa Yes Dәrіlіk Tattim қandaғa Amoxicillin Concentrations of Joғaääääladays.

Allopurinol Teri Bөrtpesіnің Dama апін Arttyrada.

Overdose amoene in tablets

Symptoms : nausea, vomiting, diarrhea, violation of the water and electrolyte balance (as a result of vomiting and diarrhea).

Treatment: washing the stomach, activated carbon, salt laxatives, drugs for maintaining water and electrolyte balance; hemodialysis.

Simptomdara : Zhүrek Ain, ұұsu, diarrhea, su-electrolyte Teңgerіmіңң Bұziluy (ұұSu Zhane Diarrhea Saldarynan).

EMI: Aschazandda Schau, Belneddіlgen Kөmіr, Tұzdi ІШЖЖРГізгіштер Su-electrolyte Teңgerіmіn Saktap Tұruғa Arnalғan Dәrіlіk Tatar; hemodialysis.

Pharmacological properties

Pharmacokinetics

Absorption is fast, high (93%), food intake does not affect absorption, does not destroy in the acidic area of \u200b\u200bthe stomach. When taking inside at a dose of 125 and 250 mg, the maximum concentration is 1.5-3 and 3.5-5 μg / ml, respectively. The time to achieve maximum concentration after oral administration is 1-2 hours.

It has a large amount of distribution: in high concentrations are found in plasma, sputum, bronchial secrecy (in the purulent bronchial secrete, the distribution of weak), pleural and peritoneal fluid, urine, the contents of the skin blisters, the tissue of the lung, intestinal mucosa, female genital organs, prostate gland, Middle Ear liquids (with inflammation), bones, adipose tissue, bustling bubble (with normal liver function), fetal tissues. With an increase in the dose of 2 times the concentration also increases by 2 times.

The concentration in bile exceeds the plasma concentration of 2-4 times. In amniotic fluid and umbilical vessels, amoxicillin concentration - 25-30% of the level in the plasma of a pregnant woman. It penetrates poorly through the hematorecephalic barrier, but with inflammation of the brain shells, the concentration in the cerebrospinal fluid is about 20% of the plasma level. Communication with plasma proteins - 17%. Partially metabolized with the formation of inactive metabolites. The half-life period is 1-1.5 hours. Is excreted by 50-70% by the kidneys unchanged (by the tubular secretion - 80% and glomerular filtration - 20%), liver - 10-20%. In small quantities stands out with breast milk. In disruption of the kidney function (Creatinine clearance (CC) less than or equal to 15 ml / min), the half-life increases to 8.5 hours.

Amoxicilline is removed during hemodialysis.

Сііірілі - Жылдам, joғara (93%), AU SІшуІІІІLUNE SKAPALYN TIGІSBEYDI, ACAZAN KYSHқYLDA Ortasanda Odaramide. 125 mg Zhәna 250 mg Dozada Іshka Abyldғanda Eң Joғara Concentrations, Tisіntsh, 1.5-3 μg / ml Zhәna 3.5-5 μg / ml. ІША ARқYLY ABILDAғANNANN KEYIN Eң Joғara ConcentrationSyna Zhetu Waқtya - 1-2 Sauat.

Taralu kөlemі үlken: zhoғary kontsentratsiyalarda plazmadan, қaқyryқtan, bronchus sekretіnen (іrіңdі bronchus sekretіnde taraluy әlsіz) plevralyқ zhane peritonealdі sұyyқtyқtan, nesepten, terі kүldіreuіkterіnің іshіndegіsіnen, өkpe tіnderіnen, іshektің shyryshty қabyғynan, әyeldің zhynys aғzalarynan, қuyқ Asta bezіnen, ortaңғy құlaқ sұyyқtyғynan ( Ol Kyabynғanda), Sүeekten, May Tіnіnen, өT. өAbinan (Kalikta Bauyr FunctionSinda), ұryқ T_NDERINEN Tabylad. Rezana 2 Egg Arttyrғanda concentrations Yes 2 ECE ұLғyad.

ӨTtegі plasma concentrations concentrations of 2-4 ECE Assyper Keti. Amnioticalyқ Sұyuyқtujtsu Zhon Kіndіk Tamyrlandnda Amoxicillin Concentrations - Zhusktі әyel Plasmatsndaғa deңgadің 25-30%. GEMATEENETSEFALDAK BөGET ARқYLA NABARS өDEDII, MI қABYAKATARYң ңABYNUYNDA Zhalyn Sұyқyқydaғy concentrations - Plasmadғa Deңgenen 20% Zhuyқ. Plasma Aқuyzdaryman Baylanix - 17%. Belsendi Yezes Metabolitter TZumen Ishіnar metabolized. Roasted seed keseңі - 1-1.5 Sauat.

Өzgerisіz Kүyde Bүyropen 50-70% (өzecelіk secretion Zholman - 80% of the guise of Shumaқtyқ SZіlisterster ARқYL - 20%), Bauyrman 10-20% shyғa yard. Azdaan Mөlsherda Ana CuTimen Bөlіnedi. Bүyri Function Syluyuynd (Creatine Cleales (QC) 15 ml / Minutan Az Nemema Oғan Teң) Zhasylai Shyғyl Kezңі 8.5 Sauatқa Denin ұ Zarada. Amoxicillin hemodialysis Kesynde Shuyғyada.

Pharmacodynamics

Amosin® is a bactericidal antibiotic of a wide range of action from a group of semi-synthetic penicillins. The synthesis of peptidoglycan (supporting polymer of the cell wall) dislocation and growth, causes lysis bacteria.

Active in relation to: aerobic gram-positive microorganisms: Staphylococcus SPP. (With the exception of penicillinase strains), Streptococcus SPP. and aerobic gram-negative microorganisms: Neisseria Gonorrhoeae, Neisseria Meningitidis, Escherichia Coli, Shigella SPP., Salmonella SPP., Klebsiella SPP. Penicillinase strains, resistant to amoxicillin action.

Amosin® - Zhasylai Synthetic Penicilloner Tobobya әser ETU Auқyim Keң bactericidtі antibiotic. Bөlіnu Zhәna Zu Kesңіnde Peptidoglycan (Zhassusha қabirғaSynaң Tіrek Polymer) Synthesian Bұzadi, Bakteriylar Lisisin Tudeyrada. Airbets Sprumen Microorganisser: Staphylococcus SPP. (Penicillinase өndіretіn stamesdards Kazpaғanda), Streptococcus SPP. Luck Airbits Gramitters Microorganisser: Neisseria Gonorrhoeae, Neisseria Meningitidis, Escherichia Coli, Shigella SPP., Salmonella SPP., Klebsiella SPP. Katysts Belsendi. Penicillinase өndіretіn stammer amoxicillin әserіne Tөzіmdі.

Packaging and release form

Tablets 250 mg, 500 mg. 10 tablets in the contour cellular packaging from the film of polyvinyl chloride and foil aluminum printed lacquered. 1 Contour cell packaging with instructions for medical application In state and Russian languages \u200b\u200bare placed in a pack of cardboard.

250 mg, 500 mg Tabletclar. 10 Tabletakan Polyvinyl Chloridtі лбрірден Жена Баспала Латtalғan aluminum folgadan jasalғan pіshіndі ұyashyқti aptamada. 1 Пішінді ұyashyқti аптамаданданда для колданару жөніндегі mememkettіk zhәn ore t_ldderindegі nұsқaulқpen bіrge Cardon Pәshkeg Salad.

This article allows you to familiarize yourself with the instructions for the use of the drug. Amosic. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists in the use of antibiotic amosine in their practice. A big request to more actively add your reviews about the preparation: helped or did not help the medicine to get rid of the disease, which complications were observed and side effects, possibly not stated by the manufacturer in annotations. Amone analogues in the presence of available structural analogues. Use for the treatment of angina, pneumonia, hymorite and other infectious diseases in adults, children, as well as during pregnancy and breastfeeding. The composition and interaction of the drug with alcohol.

Amosic - antibiotic wide range of a group of semi-synthetic penicillins. Acts bactericidal. Inhibits transpapeptide, disrupts peptideoglycan synthesis (the support polymer of the cell wall) during the division and growth period, causes lysis bacteria. Acid-resistant.

Active in relation to aerobic gram-positive bacteria: Staphylococcus SPP. (Staphylococcus) (with the exception of penicillinase strains), Streptococcus SPP. (streptococcus); Aerobic gram-negative bacteria: Neisseria Gonorrhoeae, Neisseria Meningitidis, Bacillus Anthracis, Listeria Monocytogenes (Listeria), Helicobacter Pylori (Helicobacter), Klebsiella SPP. (Klebseyella).

Microorganisms producing penicillinase, resistant to the action of amoxicillin.

The action is developing 15-30 minutes after administration and lasts 8 hours.

Structure

Amoxicillin (in the form of trihydrate) + excipients.

Pharmacokinetics

After receiving inside Amosin quickly and almost completely (93%) absorbed from the gastrointestinal tract. Meal does not affect the absorption of the drug, does not destroy in the acidic area of \u200b\u200bthe stomach. In high concentrations, plasma, wet, bronchial secrete (in the purulent bronchial secrete, the distribution of weak), pleural and peritoneal fluid, urine, the contents of the skin blisters, the tissue of the lung, mucous membrane of the intestine, the female genital organs, the prostate gland, the liquid of the middle ear, bone , adipose tissue, bustling bubble (with normal liver function), fetal tissues. With an increase in the dose of 2 times the concentration also increases by 2 times. The concentration in bile exceeds the plasma concentration of 2-4 times. In amniotic fluid and umbilical vessels, amoxicillin concentration - 25-30% of the plasma level in a pregnant woman. Poor penetrates through the hematostephalic barrier (BEB), with inflammation of brain shells (meningitis), a concentration in the spinal fluid is about 20%. Binding with plasma proteins - 17%. In small quantities stands out with breast milk. Amoxicillin is partially metabolized with the formation of inactive metabolites. Amoxicillin is excreted by 50-70% with urine unchanged by canalic excretion (80%) and glomerular filtration (20%), with bile - 10-20%.

Indications

Infectious-inflammatory diseases caused by microorganisms sensitive to the drug:

• respiratory infections (including bronchitis, pneumonia);
• eNT infections (including sinusitis, pharyngitis, tonsillitis, acute average otitis);
• infections of the urogenital system (including pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea);
• gynecological infections (including endometritis, cervicitis);
• infections of the gastrointestinal organs (including peritonitis, enterocolitis, abdominal typhoid, cholangitis, cholecystitis);
• infections of the skin and soft tissues (including face, impetigo, secondally infected dermatoses);
• leptospirosis;
• listeriosis;
• lyme disease (borreliosis);
• dysentery;
• salmonellosis, salmoneselosis;
• meningitis;
• endocarditis (prevention);
• sepsis.

Forms of release

250 mg capsules.

Tablets 250 mg and 500 mg.

Powder for preparing a suspension for intake of 125 mg, 250 mg and 500 mg.

Instructions for use and dosage

The drug is taken inward, before or after meals. The dosing mode is established individually, taking into account the severity of the course of the disease, the sensitivity of the pathogen to the drug, the age of the patient.

Adults and children over 10 years old (with a mass of body more than 40 kg) are appointed 500 mg 3 times a day, with a serious course of the disease - at 0.75-1 g 3 times a day.

Children aged from 5 to 10 years are prescribed 250 mg 3 times a day, aged 2 to 5 years - 125 mg 3 times a day, under the age of 2 years - 20 mg / kg per day in 3 reception. Course treatment - 5-12 days.

Children at the age of 5 years old the drug is prescribed in the form of a suspension (the ideal children's form of the drug).

For the treatment of acute uncomplicated gonorrhea, the drug is prescribed in a dose of 3 g once; In the treatment of women, it is recommended to repeat the specified dose.

With acute infectious diseases of the gastrointestinal tract (paratyphids, typhoids) and biliary tract, with gynecological infectious diseases, adults are prescribed 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

When leptospirosis, adults are prescribed at 500-750 mg 4 times a day for 6-12 days.

At silmosenelease adults - 1.5-2 g 3 times a day for 2-4 weeks.

For the prevention of endocarditis at small surgical interventions, adults are prescribed at a dose of 3-4 g per 1 hour before the procedure. If necessary, prescribe a re-dose after 8-9 hours. Children dose are doubled.

Rules for the preparation of suspension from a monocot package

The pure glass poured a boiled and cooled water in the amount specified in the table, then the contents of one package are poured and stirred to obtain a homogeneous suspension.

• Dose in package 125 mg - the required amount of water 2.5 ml;
• dose in package 250 mg - the required amount of water is 5 ml;
• dose in package of 500 mg is the required amount of water 10 ml.

After receiving the cup, rinse with water, dry and store in a dry, clean place.

Side effect

• hives;
• skin hyperemia;
• erythema;
• angioedema edema;
• rhinitis;
• conjunctivitis;
• fever;
• pain in the joints;
• eosinophilia;
• exfoliative dermatitis;
• multiform exudative erythema;
• stevens-Johnson syndrome;
• reactions similar to serum disease;
• anaphylactic shock;
• dysbacteriosis;
• a change in taste;
• vomiting, nausea;
• diarrhea;
• stomatitis;
• glossitis;
• pseudomambranous enterocolitis;
• excitation;
• anxiety;
• insomnia;
• confusion of consciousness;
• change behavior;
• depression;
• peripheral neuropathy;
• headache;
• dizziness;
• convulsive reactions;
• interstitial nephritis;
• leukopenia, neutropenia, thrombocytopenic purpura, anemia;
• labored breathing;
• tachycardia;
• candidiasis of the vagina;
• superinfection (especially in patients with chronic diseases or reduced organism resistance).

Contraindications

• allergic diathesis;
• bronchial asthma, pollinosis;
• infectious mononucleosis;
• lympholoicosis;
• liver failure;
• the diseases of the gastrointestinal tract (especially colitis associated with the use of antibiotics);
• lactation period (breastfeeding);
• increased sensitivity to the components of the drug;
• increased sensitivity to other penicillins, cephalosporins, carbapenes;
• children's age up to 3 years (for tablets and capsules).

Application in pregnancy and breastfeeding

The use of the drug during pregnancy is possible only in cases where the intended benefit of therapy for the mother exceeds the potential risk to the fetus.

Application during lactation is contraindicated. If necessary, use during lactation should be stopped breastfeeding.

Application in children

Contraindicated children under the age of 3 years (for the form of release in the form of tablets and capsules). Children at the age of 5 years old are prescribed in the form of a suspension.

special instructions

When conducting a course of treatment with amoSin, it is necessary to monitor the state of the function of the blood formation organs, liver and kidney.

It is possible to develop superinfection due to the growth of microflora insensitive to amoxicillin, which requires an appropriate change in antibacterial therapy.

In the treatment of patients with bacteremia, the reaction of bacteriolization is rarely developed (Yarish-Gersheimer's reaction).

In patients having increased sensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.

In the treatment of light diarrhea, against the background of the use of amosine, the appointment of antiodeary drugs, which reduce the intestinal peristalsis should be avoided; Can be used kaolin- or attapulgite-containing anti-diagracial agents. With severe diarrhea, it is necessary to carry out differential diagnostics and assign appropriate therapy.

Treatment should be continued 48-72 hours after the disappearance of clinical signs of the disease.

With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, if possible, use additional methods of contraception.

Medicinal interaction

Antacids, glucosamine, laxatives, food, antibiotics of aminoglycoside groups, while simultaneous use, slow down and reduce amosine absorption; Ascorbic acid - increases its absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) exhibit synergism with amoxicillin; Bacteriostatic preparations (macrolides, chloramphenicol, lincoosamines, tetracyclines, sulfonamides) - antagonism.

Amoxicillin, while simultaneously use, increases the efficiency of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); Reduces the effectiveness of estrogen-containing oral contraceptives, ethinyl estradiol (the risk of intermented bleeding), as well as drugs, in the process of metabolism of which para-aminobenzoic acid is formed.

The joint use of the drug amosyn with alcohol is prohibited (the hepatotoxic effect of ethanol is enhanced).

Diuretics, Allopurinol, Oxyphenbutazone, phenylbutazone, nonsteroidal anti-inflammatory agents (NSAIDs) and drugs that block the tubular secretion, while simultaneously use with amosine, reducing the channel secretion, increase the concentration of amoxicillin.

With the simultaneous use of amosine with allopurinol, the risk of skin rash is increased.

Amoxicillin, while simultaneously use, reduces the clearance and increases the toxicity of methotrexate.

Amoxicillin with simultaneous use enhances the absorption of digoxin.

Analogs of the Medicinal Amosin

Structural analogues for the acting substance:

• Amoxisar;
• Amoxicillin;
• Amoxicillin trihydrate;
• Gonoform;
• Grunamox;
• Danemoks;
• OSPAMOKS;
• Flexin Soluteab;
• Hikcotil;
• Ecobol.

In the absence of analogues of drugs on the active substance, you can follow the links below on the disease, which helps the appropriate drug, and see the analogues on therapeutic effects.

For the treatment of a wide range of bacterial infections, modern pharmacology annually offers new and new antibiotic drugs. Maximum efficient as for adults and for children in this case is the reception of amosine antibiotic. The drug can be purchased in pharmacies in any of the forms (tablets, capsules, suspension). However, in the material below, we consider the action and use of amosic tablets in a 500 mg dosage and find out whether it is possible to give a medicine to a child up to 2 years.

Composition and description

Amosin refer to the group penicillin antibioticswhich can actively affect both gram-positive bacteria and gram-negative. The peculiarity of the effective impact on the patient's body amoene is that the components of the drug oppress the synthesis of peptidoglycan. He is the basis of the membrane of the cell of the pathogenic bacterium. As a result, this leads to the destruction of the cell membranes of pathogenic flora, and the disease retreats under the onslaught of the drug.

Therapeutic concentration of the drug is delayed in the patient's body for 8 hours, after which it is necessary to repeat the reception of amosine. The maximum concentration in the blood and plasma of the person the drug reaches 1-2 hours after oral administration. At the same time, food eaten does not affect the absorption rate of the drug components.

Important: active substance Amosine is resistant to aggressive (acidic) human stomach.

The composition of one pill amosine 500 mg looks like this:

• Amoxicillin 500 mg (active substance);
• Talc and Calcium Stearate;
• Starch potato and magnesium stearate;
• Colidon 90f (Pisidone).

Drug packaging contains 10 dragies.

Instructions for use of the drug

If the reader is interested in amosine medicine from what, the instruction on the use of the drug for children and adults reports that amosine can be appointed with such bacterial infections:

• Pathology of respiratory tract in the form of pneumonia and bronchitis, as well as sinusitis, otitis and pharyngitis (tonsillitis);
• Inflammatory bacterial infectious processes of the urogenital system in the form of pyelonephritis, urethritis, as well as gonorrhea, endometritis, cystitis and cervicitis;
• Intestinal bacterial infections, such as typhoid (abdominal), dysentery, peritonitis, enterocolitis, salmonellosis;
• Inflammatory and purulent processes in the gastrointestinal bodies in the form of cholangitis, cholecystitis;
• As well as meningitis and endocarditis;
• Sepsis;
• Inflammatory and purulent infections of soft tissues and skin (face, secondary dermatosis, Lyme disease, etc.).

Tip: You can replace the preparation in the form of tablets to replace the suspension to children up to 2 years. It will be more convenient for mom and baby.

Dosing the drug Amosin 500 mg looks like:

Important: Simultaneously with the antibiotic, it is recommended to take probiotic preparations that improve and restoring intestinal microflora. Patients with chronic kidney failure dose of the drug are reduced by 20-50% with an interval between receptions 24 hours.

Contraindications

Despite the fact that the amosin antibiotic has a fairly wide range of action, there is a number of contraindications to its use. These are:

• Asthma bronchial;
• Tendency to allergic reactions;
• Increased sensitivity or individual intolerance to one / several components of the drug;
• Pollnosis;
• Liver failure;
• Colitis and other intestinal pathology;
• Mononucleosis infectious;
• Breastfeeding period.

With high caution, amosine is prescribed with such states:

• Any bleeding in history;
• Pregnancy.

Important: When prescribing a medicinal product, a pregnant doctor must evaluate the potential benefit to the health of the mother and a potential threat to the development of fetal pathologies. When receiving amosine during lactation, it is better to translate baby to artificial feeding, since the components of the drug are present in a small amount in breast milk.

Side effects

When using amosine in the patient, in rare cases such may occur adverse reactions:

• Genital system - nephritis interstitial;
• The digestive system is an anal itching, diarrhea, colitis hemorrhagic or pseudomambranous;
• Blood-formation system - thrombocytopenia or agranulocytosis in very rare cases;
• Skin reactions - rash, itching, erythema;
• Anaphylactic shock (single extremely rare cases).

Amosine Analogs

If the patient has the need to replace Amosin with one of the counterparts, then you can purchase such medicines in the pharmacy:

• Amoxicillin;
• Flexin Soluteab;
• OSPAMOKS DT;
• Gramoks;
• OSPAMOKS (tablets or powder for cooking a white suspension);
• Hikcotil.

At the same time, each patient should understand that the antibiotic is a complex drug disturbing immune system. Therefore, it is not necessary to joke with drugs of this group, especially if you are going to give the drug to kids. An independent reception of antibiotic drugs may result in extremely serious and / or unwanted consequences. And therefore to get effective therapy It is better to seek help from a specialist.

Amosin is an antibacterial drug of a wide range of action. Produced in the form of capsules, tablets and powder for the preparation of suspension.

Pharmacological action amosine

In accordance with the instructions for amosine, the active active component of the drug is amoxicillin.

The auxiliary substances that are part of the capsules are gelatin, acetic acid, propyl hydroxybenzoate, methyl hydroxybenzoate, titanium dioxide.

Auxiliary substances as part of amosin powder: sucrose, vanillin, food flavoring, sodium α -Glutamata monohydrate, sodium hydrophosphate, Dinatari Edetat, dextrose, poverant.

The auxiliary components belonging to the tablets are povenesses, magnesium stearate, magnesium hydrosilicate, calcium stearate, starch potato.

Amosin is an antibiotic belonging to a group of semi-synthetic penicillins. It has a bactericidal effect and good acid resistance. The mechanism of action of the drug is due to the braking of transpeptidase and the violation of the synthesis of peptideoglycan (supportal polymer of cell walls) during the period of growth and division, due to which the lysis of bacteria is ensured. Amoxicillin is destroyed under the influence of beta lactamas.

In applying Amosin is active against aerobic Gram positive (Streptococcus spp., Staphylococcus spp., Except for strains producing penicillinase) and Gram-negative (Klebsiella spp., Neisseria gonorrhoeae, Helicobacter pylori, Listeria monocytogenes, Bacillus anthracis, Neisseria meningitidis) bacteria. Microorganisms that produce penicillinase are resistant with respect to the action of amoxicillin.

The effect of AMOSIN antibiotic is marked after 15-30 minutes after the reception and persists for 8 hours.

After use, amosin is completely and quickly absorbed from the gastrointestinal tract. Meal does not affect drug absorption. Amoxicillin's maximum blood concentration reaches after 1-2 hours. The drug penetrates into bone tissues, mucous membranes, intraocular wet and liquid. Derived by kidney. The period of complete removal of amoene from the body is 2-3 hours and increases in premature and children of perinatal age, as well as in people with impaired kidney functions.

Indications for the use of amosine

Indications to amosine are infectious inflammatory diseases caused by amoxicillos of microorganisms:

• Breath organs: pneumonia, bronchitis;
• GOOD SYSTEM: Gonorrhea, urethritis, cystitis, pyelitis, pyelonephritis;
• LOR organs: acute middle otitis, tonsillitis, pharyngitis, sinusitis;
• Female sexual system: cervicitis, endometritis;
• Gastrointestinal tract organs: cholecystitis, cholangitis, abdominal typhoid, enterocolitis, peritonitis;
• Skin and soft tissues: secondary infected dermatoses, impetigo, face.

Amosine is also prescribed during sepsis, endocarditis, meningitis, salmonellosis, dysentery, limemium disease, leaferiosis, leptospirosis.

Methods for using amosine and dosage

In the presence of these readings, Amosin is taken inward to or after meals. The dosage of the drug is prescribed and is adjusted by the attending physician for each patient and depends on its age, condition and severity of the disease.

Adults and children over 10 years, whose weight exceeds 40 kg, as a rule, recommend 500 mg of AMOSIN antibiotic 3 times a day, with a severe course of the disease - 750-1000 mg.

The one-time dose of amosine, according to the instructions, for children aged 5-10 years is 250 mg, 2-5 years - 125 mg, up to 2 years - 6.5 mg / kg. Multiplicity of reception - 3 times a day. Therapy duration - 5-12 days. Children under 5 years old prescribe medication in the form of a suspension.

With acute uncomplicated gonor, amosyn is taken in a one-time dose of 3000 mg.

For the treatment of acute infectious diseases of the gastrointestinal tract, the biliary tract and organs of the female sexual system, as well as for salmonelles, adults are recommended 1500-2000 mg 3 times a day or 1000-1500 mg amosine 4 times a day.

Adults for leptospirosis therapy are prescribed by 500-750 mg of the drug 4 times a day. The course of treatment is 6-12 days.

In order to prevent endocarditis with small surgical interventions, adults take 3000-4000 mg amosine in 1 hour before the operation. If necessary, repeated medication is possible after 8-9 hours. Children dosage decreases twice.

For the preparation of suspension 1, amosin powder package is dissolved in a certain amount of boiled chilled water: 125 mg of the preparation - 2.5 ml of water, 250 mg - 5 ml, 500 mg - 10 ml.

Side effects Amosina

With the use of amosine, side reactions from the body are possible. These include: thrombocytopenic purpura, anemia, neutropenia, depression, peripheral neuropathy, dizziness, insomnia, ataxia, anxiety, arthralgia, a minor increase in the activity of liver enzymes, glossitis, stomatitis, violations of taste sensations.

A amosin antibiotic can provoke the development of diarrhea, nausea, dysbacteriosis, exfoliative dermatitis, eosinophilia, conjunctivitis, fever, urticaria, rhinitis, leather hyperemia.

Contraindications for the use of amosine

Are not testimony to amosine:

• Increased sensitivity to the components of the drug;
• Liver failure;
• Lympholoicosis;
• Infectious mononucleosis;
• Polleoz, bronchial asthma;
• Diseases of the gastrointestinal tract in history;
• Allergic diathesis;
• Lactation period;
• Children's age up to 3 years (for capsules and tablets);
• Pregnancy.

According to the instructions, amosyn with caution prescribe people with renal failure and cystic cycling.

Overdose

When applying amosine in quantities exceeding the recommended, nausea, diarrhea, vomiting, water-electrolyte balance disorders are noted.

Additional Information

After the disappearance of the main symptoms of the disease, Amosin antibiotic therapy must be continued for another 2-3 days.

The medicine reduces the effectiveness of oral contraceptives.

When treating this drug, regular control of kidney functions, liver and blood formation organs should be carried out.

The Instructions for AmoSin states that it is necessary to store the remedy in a dry, dark and inaccessible to children.

From the pharmacy is discharged by a doctor's prescription.

Shelf life - 24 months.

Approved

Order of the Chairman of the Committee

Control medical I.

Pharmaceutical activity

Ministry of Health

Republic of Kazakhstan

From "____" ___________ 20 __ years

№__________________________

Instructionmedical application

drug

Amosin®

Tradename

International non-proprietary title

Amoxicillin

Dosage form

Powder for the preparation of suspension for intake, 125 mg, 250 mg and

Structure

One single-window package contains

active substance- amoxicillin trihydrate (in terms of amoxicillin) - 0.125 g, 0.250 g or 0.500 g,

excipients: Povidone, dextrose, dinatari Edatat, sodium hydro phosphate, sodium α-glutamin 1-water, food flavoring, vanillin, sucrose.

Description

White powder with a yellowish color shade, with a specific smell. The finished suspension is a white suspension with a yellowish colors, with a specific smell.

Pharmacotherapeutic group

Beta-lactam antibacterial drugs, penicillins.

PBX code J01CA04.

Pharmacological properties

Pharmacokinetics

When ingestion, amoxicillin is absorbed quickly with bioavailability of 93%. In a dose of 125 mg and 250 mg, the maximum concentration in blood plasma is 1.5-3 μg / ml and 3.5-5 μg / ml, respectively. The time of achieving the maximum concentration in the blood plasma after oral administration is 1-2 hours. It has a large amount of distribution - high concentrations are found in blood plasma, sputum, bronchial secrecy (in the purulent bronchial secrete, the distribution of weak), pleural and peritoneal liquid, urine, skin content blisters, fabric of the lung, mucous membrane of the intestines, female genital organs, prostate gland, medium ear liquid, bone, adipose tissue, bustling bubble (with normal liver function), fetal tissues. With an increase in the dose of 2 times the concentration also increases by 2 times. The concentration in bile exceeds the concentration in the blood plasma is 2-4 times. In amniotic fluid and vessels of umbilical bodies, amoxicillin concentration is 25-30% of the level in the blood plasma level. Poor penetrates through the hematorencephalic barrier, with inflammation of the brain shells (meningitis) concentration in the spinal fluid - about 20%. Communication with blood plasma proteins - 17%.

Partially metabolized with the formation of inactive metabolites. The half-life period is 1-1.5 hours. Excreted by 50-70% by kidneys unchanged by canalis excretion (80%) and glomerular filtration (20%), liver - 10-20%. In small quantities stands out with breast milk. The half-life period in premature, newborns and children up to 6 months - 3-4 hours. With a violation of the kidney function (creatinine clearance is less or equal to 15 ml / min), the half-life increases to 8.5 hours. Amoxicillin is removed during hemodialysis. The effect of the drug is developing in 15-30 minutes after the reception and lasts 8 hours.

Pharmacodynamics.

Amosin bactericidal antibiotic of a wide range of action from a group of semi-synthetic penicillins. The synthesis of peptidoglycan (supporting polymer of the cell wall) dislocation and growth, causes lysis bacteria. Active in relation to aerobic gram-positive microorganisms: Staphylococcus SPP. (With the exception of penicillinase strains), Streptococcus SPP. and aerobic gram-negative microorganisms: Neisseria Gonorrhoeae, Neisseria Meningitidis, Escherichia Coli, Shigella SPP., Salmonella SPP., Klebsiella SPP. Penicillinase strains, resistant to amoxicillin action.

Indications for use

Bronchitis, pneumonia

Sinusitis, pharyngitis, tonsillitis, acute middle otitis

Pyelonephritis, Pelitis, Custitis, Urethritis, Gonorrhea, Endometritis, Cervicitis

Dieseneria, Salmonellus, Salmonell Necklace, Halgitis, Cholecystitis

Ryg, Impochigo, Secondary infected dermatoses

Leptospirosis, Lamiosis, Lyme Disease (Borreliosis), Endocarditis (Prevention)

Method of application and dose

Inside, before or after meals.

Adults and children over 10 years old(with a mass of the body more than 40 kg) are prescribed 0.5 g 3 times a day; In case of severe infection - 0.75 -1 g 3 times a day.
Children aged 5-10 yearsprescribe 0.25 g 3 times a day; 2-5 years - 0.125 g 3 times a day;
under 2 years old - 20 mg / kg 3 times a day. With acute infectious diseases of the gastrointestinal tract (paratifies, abdominal typhoids) and biliary tract, with gynecological infectious diseases, adults are 1.5-2 g 3 times a day or 1-1.5 g 4 times a day. Course treatment - 5-12 days.

With acute uncomplicated gonor, 3G is prescribed once; In the treatment of women, it is recommended to repeat the specified dose.

With leptospirosis, adults - 0.5-0.75 g 4 times within 6-12 days.

At silmosenelease adults - 1.5-2 g 3 times a day for 2-4 weeks.

For the prevention of endocarditis at small surgical interventions of adults - 3-4 g per 1 hour before the procedure. If necessary, prescribe a re-dose after 8-9 hours. Children dose are doubled.

In patients with impaired kidney function during creatinine clearance of 15-40ml / min interval between receptions increase to 12 hours; When creatinine clearance, 10 ml / min dose is reduced by 15-50%; With anuria - the maximum dose of 2 g / day.

Preparation of suspension.

Single Package

The pure cup pours boiled and cooled water (see table), then the contents of one package are poured and stirred to obtain a homogeneous suspension.

Dose in package, mallow amount of water, ml

125 2.5 (1 teaspoon)

2505 (2 teaspoons)

50010 (4 teaspoons)

Apply strictly by appointment of a doctor.

Side effects

Urticaria, hyperemia of the skin, erythema, angioedema edema, rhinitis, conjunctivitis

Dysbacteriosis, change in taste, vomiting, nausea, diarrhea, stomatitis, glossite, violation of liver function, moderate increase in the activity of "liver" transaminase, pseudomambranous enterocolit

Candidiasis vagina

Fever, joint pain, eosinophilia, exfoliative dermatitis, polyform exudative erythema, Stevens-Johnson syndrome, reactions similar to serum disease

Excitation, anxiety, insomnia, ataxia, confusion of consciousness, change behavior, depression, peripheral neuropathy, headache, dizziness, convulsive reactions

Leukopenia, neutropenia, thrombocytopenic purpura, anemia

Difficult breathing, tachycardia, interstitial jade

Superinfection (especially in patients with chronic diseases or reduced organism resistance)

In single cases: anaphylactic shock

Contraindications

Hypersensitivity to the components of the drug (including to other penicillins, cephalosporins, carbapenes)

Allergic diathesis

Bronchial asthma

Pollnosis, infectious mononucleosis, lympholoicosis

Liver failure

Diseases of the gastrointestinal tract in history (especially colitis associated with the use of antibiotics)

Period lactation

Medicinal interactions

Antacids, glucosamine, laxatives, amino-glycosides - slow down and reduce amosine absorption; Ascorbic acid increases amosine absorption.

Amosin® is not destroyed in an acidic stomach environment, eating does not affect its absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) - has a synergide effect; Bacteriostatic preparations (macrolides, chloramphenicol, lincoosamides, tetracycles, sulfonamides) - antagonistic.

Increases the efficiency of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); Reduces the effectiveness of estrogen-containing oral contraceptives, drugs, in the process of metabolism of which para-aminobenzoic acid is formed, ethinyl estradiol - the risk of "breakthrough" bleeding.

Amoxicillin reduces clearance and increases the toxicity of methotrexate; Enhances the absorption of digoxin.

Diuretics, allopurinol, oxyphenbutayone, phenylbutazone, non-steroidal anti-inflammatory drugs; Preparations that block the tubular secretion increase the concentration of amoxicillin in the blood.

Allopurinol increases the risk of skin rash.

special instructions

It is possible to develop superinfection due to the growth of microflora insensitive to it, which requires an appropriate change in antibacterial therapy.

When prescribing patients with sepsis, the reaction of bacteriolization is possible (Yarish-Gersheimer's reaction) (rarely).

In patients having increased sensitivity to penicillins, cross-allergic reactions with other beta-lactam antibiotics are possible.