Latin name:Ampicid
ATX code:J01CR01
Active substance: ampicillin, sulbactamum
Manufacturer: Mustafa, Turkey
Pharmacy dispensing condition: On prescription

Ampisid is an antibacterial drug of the penicillin group. Contains two active ingredients. The first - sulbactamum is designed to inhibit the performance of beta-lactam elements, which disrupts the construction of pathogenic cell membranes. Second, ampicillin enters the nucleus of the pathogen, destroying it at the stage of division. The complex combination of both substances helps to prevent the resistance of susceptible viruses.

Indications

Ampisid is prescribed for the treatment of infectious pathologies caused by bacteria that exhibit instability to the action of an antibiotic. The therapy is carried out for patients of all age groups with the following diseases:

• Inflammations of the respiratory tract and laryngotorinological organs: sinusitis, chronic and acute pneumonia, bronchitis, otitis media, tonsillitis, tonsillitis
• Abdominal processes: peritoneal infections, biliary tract diseases, peritonitis
• Pathologies of the urethral and genital systems: pyelonephritis, cystitis, inflammation of the vagina and vulva, prostatitis, gonorrhea
• Lesions of the epidermis: dermatitis, boils, contagious skin diseases, erysipelas
• Joint and bone infections
• Meningitis
• Scarlet fever
• Endocarditis
• Dysentery and salmonellosis
• Septic postoperative complications.

Medicinal properties

Ampisid is resistant to acidic environments. The activity of the components is explained by their interaction and the ability to carry out specific effects on bacteria. Ampicillin provides antimicrobial activity, but is destroyed when attacked by beta-lactamase elements. Sulbactam does not have antiviral functions, but protects the work of the first substance, makes it possible to show its properties. The drug is effective against most strains:

• Streptococcus
• Staphylococcus
• Hemophilic infection
• Influenza stick
• Escherichia intestinal
• Gonococcus
• Moraxella
• Proteus
• Citrobacter
• Clostridia
• Meningococcus
• Bacteroids
• Peptococcus
• Acinetobacter
• Morganella.

The drug does not suppress the activity of all strains of Pseudomonas aeruginosa, staphylococci that produce penicillinase, enterobacteria and clibsiella.

Ampisid is well absorbed by the gastric and intestinal mucosa, is freely distributed throughout all tissues and cells, but is not able to penetrate the encephalobarrier. When taken orally, hydrolysis of sultamicillin is carried out, which determines the content of ampicillin and sulbactamum in the blood in equal proportions.

Bioavailability is 80%, twice the value of each substance separately. The half-life for ampicillin is one and a half hours, for sulbactam - 60 minutes. In elderly patients and patients with kidney pathologies, the time increases. The concentration decreases slowly, the period takes up to 6-7 hours. 50% ampicillin, 70% sulbactamum is excreted through urine, the rest through peristalsis. When using injections, the content reaches a maximum, the level of penetration through the spinocerebral fluid increases. About 30% of the antibiotic is combined with plasma protein elements.

Ampisid tablets

Tablets 375 mg No. 10 - 700-850 rubles.

• Sodium carboxymethylcellulose as a disintegrant for solid drug categories... Low viscosity and unstable in acidic environments
• Stearic acid magnesium salt to create a homogeneous mass and prevent lumps. Promotes calcium absorption
• Hypromellose - coating lubricant and moisturizer
• Titanium dioxide - food coloring, bleach
• Macrogol is an osmotic laxative component.

Tablets 375 mg oblong, cream color, covered with a thin film, have a dividing line on both sides. No taste or smell. Packaged in 10 pieces in dark brown glass bottles, closed with a polypropylene cap. The box is light, with a red stripe, contains 1 can and instructions.

Method of administration and dosage

If necessary, prolongation after injections is prescribed oral administration 2 hours before meals. Adults and children weighing more than 40 kg need to take 375-750 mg per day, that is, one or two tablets. Gonorrhea is treated with a single dose of 6 pieces.

Powder for suspension Ampisid

Powder for suspension 260 mg / 5 ml-40 ml - 280-300 rubles.

The suspension powder also contains guarana sweetener and flavorings.

Infusion powder - fine crystalline, white with a yellow tint. Packaged in glass vials with a narrowed neck, butylene rubber stopper and Teflon crimp cap. The package includes an ampoule of lidocaine or distilled water.

Method of administration and dosage

The suspension is recommended for children. The powder is diluted with cool water to the mark on the bottle. Shake the bottle until a homogeneous composition is obtained. Use a measuring spoon for the exact amount. The patient is given 750 mg of the antibiotic to drink per day, divided by 2 times.

Solution for infusion Ampisid

Powder for infusion 1500 mg + water - 220-250 rubles. 1500mg + lidocaine - 350-380 rubles.

The composition for the preparation of an infusion solution includes 375, 750 or 1500 mg of the active substance (ampicillin 250/500/1000 mg, sulbactamum 125/250/500 mg).

Powder for the preparation of a suspension of 250 mg of white or pale yellow color in a darkened bottle. When cooked, the liquid becomes lighter, has a viscous structure, with a pleasant taste and lemon scent. The cardboard box is bright red and contains a jar of medicine, a measuring spoon and instructions.

Method of administration and dosage

The antibiotic is prescribed in combination with a solvent intramuscularly. To prepare lidocaine (0.5%), pour it into a bottle with powder, shake it slightly, wait for the foam to settle. It is necessary to visually assess the liquid so that there are no lumps. Enter within 180 seconds. Before use, a test is made for allergic manifestations.

Adults

The dosage ranges from 1500 mg (1000 mg ampicillin, 500 mg sulbactamum) to 12000 mg (8000 mg ampicillin, 4000 mg sulbactamum). The amount depends on the severity of the pathology. The daily intake is divided by 6-8 times. For less complex forms of infection, the antibiotic is used after 12 hours.

Children

For newborns and premature infants in the first week of life, the dosage is calculated at 75 mg / kg per day, which corresponds to 50 mg / kg ampicillin, 25 mg / kg sulbactamum. Injections are made after 12 hours.

Children under one year old determine the amount based on body weight 150 mg / kg per day (100 mg / kg ampicillin, 50 mg / kg sulbactamum), spreading over time.

During surgical interventions, 2000-3000 mg are prescribed with the introduction of anesthesia so that the components are evenly distributed over the cells. It can be reused after 6 hours, after a day the application is stopped.

For the treatment of gonococcal infection, the antibiotic is used once at a dose of 1500 mg. To prolong the content of Ampisid in plasma, probenicid is additionally given orally.

In patients with renal insufficiency, the dosage and regimen are adjusted in accordance with the elimination time. It is required to control the clearance.

In hemodialysis, the antibiotic is administered immediately after the procedure; the period until the next use should not be less than 48 hours. The duration of therapy depends on the condition and age of the patient, traditionally taking from 7 days to two weeks.

Application for pregnant women

Ampisid during pregnancy is prescribed after an accurate assessment of the potential hazard to the fetus and in the absence of alternative options for treating the mother. Lactation should be discarded.

Contraindications

Combination with other medicines

Ampisid is not compatible with a number of drugs, therefore, it is unacceptable to use the following drugs at the same time:

• Aminoglycosides
• Tetracycline group
• Amphotericin
• Allopurinol may cause allergic reactions
• Nestoroid anti-inflammatory drugs increase the period of elimination of components
• Anticoagulants increase prothrombin gaps
• The action of estrogens is weakened by hormone therapy
• Antacids, laxatives impair the absorption of the antibiotic.

Adverse reactions

In some cases, during treatment, negative effects from different systems may appear:

• Stomach and intestines: nausea, vomiting, indigestion
• Urinary Organs: Nephritis
• Allergic reactions: burning, rash, anaphylactic shock, convulsions, erythema
• Hematopoiesis: anemia, increased platelet counts
• Locally: pain and phlebitis at the injection site.

Overdose

If the amount of antibiotic is exceeded, side effects appear. The treatment is traditional, according to the symptomatic picture. For severe patients, hemodialysis, measures to restore respiratory functions, and artificial ventilation are performed.

Storage rules

The antibiotic can be used for 3 years. The prepared suspension is left in the refrigerator, but not more than for 14 days. Solution for injection is stored for 24 hours. The medication is kept in a darkened place, remote from children, at a temperature of 25 0 C.

Analogs

Libaccil

Abolmed, Russia
Cost: since. for in. 750 mg No. 1 - 150-200 rubles, 3000 mg No. 1 - 300-350 rubles.

A penicillin antibiotic with two active components - ampicillin and sulbactamum. The first one destroys the membrane membranes of pathogens at the time of cell division, the second one protects the components from the negative effects of betalactamases. In connection with these properties, the drug is active against ampicillin-resistant strains. It is intended for the treatment of infectious pathologies caused by gram-positive and negative pathogens, anaerobic pathogens.

It is produced in the form of a light porous powder, which is used parenterally after preparation. The blue-trimmed cardboard box contains 1 bottle and instructions. The dissolving compound is sold separately. In this capacity, injection water or lidocaine 5% is used. When diluting, it is necessary to achieve a homogeneous liquid state.

Advantages:

• Pronounced antibacterial activity due to the two-component composition
• It is prescribed for children from the first minutes of life.

Disadvantages:

• Incompatible with aminoglycosides
• Penicillinase-producing strains are resistant.

Unazine

Haupt Pharma Latina, Italy
Cost: since. for in. 375 mg No. 1 - 450-500 rubles, 750 mg No. 1 - 600-650 rubles.

The drug is a combination of a betalactam inhibitor and a bactericidal agent: ampicillin and sulbactamum. Ampicillin inhibits the synthesis of pathogenic cells during the polyiferation period. Sulbactam enhances its action and protects against destruction by resistant strains. The medication is intended for the destruction of staphylococci, gonococci, bacteroids, streptococci, moraxella. Microorganisms that produce penicillin substances show resistance.

The medicine is produced only in the form of a powder for the preparation of a solution, which is administered parenterally. It is a free-flowing porous mass of light shade, tasteless and odorless, packaged in glass bottles. Banks containing 375 mg of the drug have a yellow Teflon lid, 750 mg - blue. The first bottle and instructions are included in the cardboard boxes. The dissolving compound is sold separately.

Advantages:

• No need to use other antibiotics
• High bioavailability.

Disadvantages:

• Not available in tablet or suspension form
• Not stable in glucose solutions.

Description up to date on 19.09.2014

• Latin name: Ampisid
• ATX code: J01CR04
• Active substance: Ampicillin + Sulbactam (Ampicillin + Sulbactam)
• Manufacturer: Mustafa Nevzat Ilach Sanai A.Sh. Turkey

Pills include 375 mg sultamicillin , as well as sodium carboxymethyl starch, microcrystalline cellulose, magnesium stearate.

Powder for oral suspension contains 250 mg / 5 ml sultamicillin , sucrose, acetic anhydride, xanthan gum, hyprolose, sodium dihydrogen phosphate, sodium carmellose, guarana flavor.

Powder for i / m injection consists of sultamicillin in different mass parts and the applied solvent ( lidocaine ).

Powder for i / v and i / m injections consists of sultamicillin in different mass parts and the supplied solvent (water for injection).

Medicine Ampisides is available in several pharmacological forms:

• in the shape of film-coated tablets - 375 mg No. 10 per package;
• in the shape of powder for further preparation of oral (for oral administration) suspension - 250 mg / 5 ml. The package contains 1 bottle of 70 ml or 40 ml;
• in the shape of powder for further preparation of an injection solution for intramuscular administration - 250 mg / 500 mg / 1000 mg + 125 mg / 250 mg / 500 mg, respectively. The package contains 1 bottle of powder + solvent;
• in the shape of powder for further preparation of an injection solution for intravenous and intramuscular administration 250 mg / 500 mg / 1000 mg + 125 mg / 250 mg / 500 mg, respectively. The package contains 1 bottle of powder + solvent.

Pharmacodynamics and pharmacokinetics

Ampisid is a bactericidal acid-fast antibiotic with a fairly wide spectrum of action. The mechanism of action is to block replication peptidoglycan bacterial cell wall.

One of the active ingredients of the drug is presented ampicillin - semi-synthetic penicillin antibiotic destructible beta-lactamases.

Another component drug – sulbactam , which in itself does not exhibit antibacterial activity, nevertheless plays an important role in the mechanism of action. Suppressing beta-lactamase , contributes to the effective action of ampicillin on resistant strains that produce beta-lactamase.

Sultamicillin active against most gram-negative and gram-positive microorganisms.

Ineffective against all strains pseudomonas aeruginosa, penicillinase-producing strains of staphylococci , most strains of enterobacteria and Klebsiella.

The effect of sultamicillin on microorganisms that produce beta-lactamase does not exceed the effectiveness of ampicillin.

When taken orally, hydrolysis of sultamicillin occurs, providing a concentration of sulbactam and ampicillin in the blood in a molar ratio of 1: 1.

Cmax of ampicillin is 2 times the concentration observed with oral administration of an equal dose of the drug Ampicillin.

Bioavailability is 80% of the equivalent iv dose of ampicillin and sulbactam.

T1 / 2 for sulbactam and ampicillin - 75 minutes and 1 hour, respectively (increases in elderly patients and in patients suffering from severe renal failure ).

50% of sulbactam and 75% of ampicillin are excreted in the urine unchanged.

When injected, it penetrates into most body fluids and tissues (CSF permeability increases sharply during inflammation).

Sufficiently high concentrations of active substances are achieved in the blood.

T1 / 2 for both active substances is 1 hour.

Sulbactam practically does not undergo metabolism.

Basically, 70-80% of the drug is excreted unchanged by the kidneys, the rest 20-30% with bile, as well as mother's milk.

Indications for use

Bacterial infectious diseases caused by susceptible to sultamicillin pathogens of various localization:

• infectious diseases of the ENT organs (including tonsillitis, otitis media );
• infectious diseases of the respiratory system (including chronic bronchitis, pneumonia, pleural empyema, lung abscess );
• infectious diseases of the genital organs and urinary tract (including endometritis, pyelitis, cystitis, pyelonephritis, urethritis, prostatitis );
• infectious diseases of soft tissues and skin (including impetigo, erysipelas, reinfected dermatitis );
• infectious diseases of the biliary tract (including cholangitis, cholecystitis );
• infectious diseases of the joints and bones;
• infectious diseases of the gastrointestinal tract (including dysentery, salmonella, salmonellosis );
• frompeptic endocarditis, gonococcal infection, meningitis, sepsis, scarlet fever, peritonitis.

Also, the antibiotic Ampisid is used to prevent possible complications in the postoperative period and during surgical interventions on the organs of the small pelvis and abdominal cavity.

Contraindications

• period breastfeeding ;
• infectious mononucleosis;
• hypersensitivity.

With extreme caution prescribed during pregnancy, as well as hepatic and / or renal failure.

Side effects

• decreased appetite;
• feeling of nausea;
• diarrhea;
• vomiting;
• increased activity of "hepatic" transaminases;
• sometimes - pseudomembranous enterocolitis.

Hematopoiesis and hemostasis system:

• thrombocytopenia;
• leukopenia;
• anemia.

• general malaise;
• headache;
• increased sleepiness.

• during long-term therapy it is possible superinfection, which is caused by microorganisms resistant to sultamicillin (candidiasis).

• increased urea content;
• azotemia;
• hypercreatininemia.

• when administered intramuscularly - pain at the injection site;
• when administered intravenously - phlebitis.

Instructions for use of Ampisid (Way and dosage)

For the drug Ampisid, the instructions for use provide for several methods of delivering the drug into the body: intravenously, orally (inside) and intramuscularly.

The method of administration of the drug and the required daily doses are determined by the attending physician, depending on the severity of the pathology, its course, localization and individual characteristics of the patient's body. Before starting therapy, be sure to carry out intradermal test in order to determine the body's characteristic sensitivity to this antibiotic for each patient, for further prevention of allergic reactions.

In accordance with the half-life of the drug, the administration of the daily dose of Ampisid is divided by 3-4 times. According to another treatment regimen, the drug is administered 2 times a day. The course of therapy, in general, does not exceed 14 days. It should be noted that after the disappearance of the symptoms of the disease and normalization general condition, it is advisable to continue taking the drug Ampisid for another 2 days.

For prevention postoperative infectionsth appoint 1500 mg-3000 mg Ampisid, just before the surgical procedure.

Overdose

The symptoms that are observed with an accidental overdose of Ampisid are fundamentally different from the possible side effects of the drug. It must be remembered that beta-lactam antibiotics in high doses can cause serious damage central nervous system functions including to convulsions.

Recommend symptomatic treatment with gastric lavage and prescribe hemodialysis which is effective for both breeding ampicillin and for sulbactam .

Interaction

The drug Ampisid is pharmacologically incompatible with aminoglycosides, protein hydrolysates and blood preparations.

With internal reception glucosamine, antacids, laxatives, aminoglycosides as well as food intake can reduce and / or slow down absorption sultamicillin while reception ascorbic acid raises it.

Bacteriostatic drugs ( chloramphenicol, macrolides, lincosamides, sulfonamides, tetracyclines ) have an antagonistic (lower efficiency) effect.

Bactericidal antibiotics (including cephalosporins, aminoglycosides, Cycloserine, Rifampicin, Vancomycin ) cause a synergistic (increase efficiency) effect.

Diuretics, NSAIDs, Phenylbutazone, Allopurinol and other drugs that reduce tubular secretion , increasing the content of ampicillin in plasma.

Reception Allopurinol increases the likelihood of a rash on the skin.

Sultamicillin inhibits intestinal microflora, lowers prothrombin index and replication vitamin K thus increasing the efficiency indirect anticoagulants.

Ampisid reduces the effect of oral contraceptives , ethinyl estradiol , as well as drugs, the metabolism of which in the body forms PABA.

Terms of sale

Storage conditions

List B. In a dry, dark place at temperatures below 25 ° C.

Shelf life

For oral forms - 24 months.

For injection forms - 36 months.

special instructions

When conducting a course of therapy using Ampisid, it is necessary to constantly monitor the function of the kidneys and liver, as well as the function of the hematopoietic organs.

In patients with a history of hypersensitivity to antibiotics of the penicillin series , possible manifestation of cross-allergic reactions with antibiotics of the cephalosporin series.

When treating patients with sepsis, there is a risk of developing jarisch-Herxheimer reactions (bacteriolysis reactions).

Due to the growth of insensitive to sultamicillin microflora formation is possible superinfection, what is the indication for revising antibacterial treatment .

If, when treating a patient suffering from gonorrhea, there is a suspicion of syphilitic lesions , it is necessary to appoint a study in a dark field, before using Ampisid, and then carry out serological tests every 30 days for at least 4 months.

Analogs of Ampisid

Analogues of the drug are presented by drugs from one pharmacological group and have a similar mechanism of action. The pharmaceutical industry produces quite a few analogues of the drug Ampisid, the most famous of which are:

It is used to treat pediatric patients in recommended doses.

With alcohol

You should not drink alcoholic beverages while taking Ampisid therapy.

Ampisid during pregnancy and lactation

When pregnancy it is used with extreme caution, after consultation with the attending physician and a comprehensive assessment of the risk to the fetus.

Better to give up breastfeeding during treatment with Ampisid.

Reviews about Ampisis

Reviews about Ampisid speak of the unconditional effectiveness of the drug in treatment infectious diseases caused by microorganisms sensitive to it. Describe the various side effects of the drug, which are transient and often mild. With the correct selection of the treatment regimen and in the absence of contraindications, Ampisid shows good results.

Ampisis price where to buy

In Russian pharmacies the price Ampisida tablets 375 mg No. 10 ranges from 250 to 350 rubles.

Price oral suspensions 40 ml on average is 230 rubles.

The cost injectable forms of the drug depends on the dosage and the number of vials.

Ampisid - instructions for use + analogues and reviews + recipe

Ampisid is a combined bactericidal antibiotic wide range actions. It contains two active substances: ampicillin and sulbactam. Ampicillin belongs to the third generation semi-synthetic penicillins. It inhibits the formation of the bacterial cell membrane, which leads to its death.

Sulbactam inhibits the specific bacterial enzyme beta-lactamase, thereby enhancing the antibacterial effect of the drug. The oral form of ampicillin with sulbactam is called sultamicillin.

Ampisid instructions for use

The combination of two active substances at once allows the widespread use of Ampisid in the empirical therapy of common infectious diseases, when treatment is prescribed based on the existing symptoms, without additional laboratory diagnostics... Widely applied in pediatric practice.

Composition and form of release

Active ingredients: ampicillin, sulbactam.

Available in the form of tablets, powder for the preparation of oral suspension, powder for the preparation of an injection solution.

Ampisid tablets 375 mg. White or yellowish-white film-coated tablets in capsule form.

Composition: sultamicillin tosylate (in terms of sultamicillin) 375 mg, auxiliary components.

Ampisid tablets 375 mg

Suspension Ampisid 250 mg / 5 ml. Powder for the preparation of oral suspension with the "Guarana" aroma: white or almost white powder, the finished suspension is homogeneous in texture, white or almost white.

Ampisid in suspension for children

Composition: 5 ml of the finished suspension contains 250 mg of sultamicillin; auxiliary components.

Ampisid for injection... Powder for preparation of injection solution, there are three dosages.

Ampisid in ampoules of 1.5 g (injections)

• Ampisid 375 mg. Ingredients: ampicillin sodium 250 mg, sodium sulbactam 125 mg.
• Ampisid 750 mg. Ingredients: ampicillin sodium 500 mg, sodium sulbactam 250 mg.
• Ampisid 1500 mg. Ingredients: ampicillin sodium 1000 mg, sodium sulbactam 500 mg.

Solvent: lidocaine hydrochloride, water for injection.

Ampisides recipe in Latin

D.t.s. No. 10

S. 1 tab. 2 r / d

Ampisid acts against gram-positive, gram-negative, anaerobic bacteria, including species resistant to traditional penicillins.

Used in the treatment of:

• gynecological infections;
• skin and joint infections (abscesses, boils, diabetic foot);
• diseases of the upper and lower respiratory tract;
• intra-abdominal infections, including trauma, peritonitis, ulcer perforation, acute appendicitis, cholangitis, liver abscess, acute pancreatitis and other infections;
• urinary tract infections, pyelonephritis;
• bacterial septicemia (sepsis);
• intestinal infections (bacterial esophagitis, complex therapy of H. pylori);
• gonococcal infection.

For preventive purposes:

• in abdominal surgery, after surgical interventions in the pelvic area in order to prevent infectious complications.

Contraindications

The use of Ampisid is contraindicated if you are allergic to any components of the drug or to any other antibiotic of the penicillin series. Use with caution if you are allergic to cephalosporin antibiotics (cross hypersensitivity is possible).

Do not use in patients with infectious mononucleosis and lymphatic leukemia due to the risk of developing skin complications similar to measles.

The injectable form should not be diluted with lidocaine in patients with local anesthetic hypersensitivity or heart block. If it is necessary to use Ampisid for this group of patients, another form of administration is selected or the solvent is replaced.

Interaction with other drugs

Shows synergy with aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin and other bactericidal antibacterial drugs.

Enhances the effect of anticoagulants. Enhances the toxic effect of methotrexate (requires medical supervision).

The simultaneous intake of ascorbic acid enhances the absorption of the drug. It is recommended to maintain an interval of 2 hours between taking Ampiside and antacids, oral forms of aminoglycosides, glucosamine and laxatives.

Simultaneous administration of probenecid, diuretics, allopurinol, phenylbutazone, NSAIDs, lengthen the half-life of Ampisid, increasing its toxic effect.

Reduces the protective effect of oral and hormonal contraceptives.

Uncomplicated gonorrhea: 2250 mg single dose (6 tablets), combined with 1000 mg probenecid.

For children under 30 kg, the dose is calculated according to weight: 12.5-25 mg / kg every 12 hours. To prepare a suspension of this, boiled chilled water is added to the vial to a special mark, shaken thoroughly until completely dissolved.

The finished suspension is stored in the refrigerator for no more than 14 days; it must be shaken again before each use. The date of preparation of the suspension is marked on the label. For accurate dosing, a measuring spoon is used, included in the set.

The required amount of solvent (0.5% lidocaine hydrochloride) is injected into the vial with the powder and wait 2-3 minutes until the foam completely dissolves and disappears. The diluted drug is not stored.

Ampisid injections are placed deep into the muscle, slowly, for at least 3 minutes.

Depending on the type of infection and the severity of the disease, the daily dose ranges from 1.5 g to 12 g, divided into 2-4 doses. The maximum daily dose is not more than 12 g.

For newborns in the first week of life, the daily dosage is 37.5 mg / kg 2 r / d. Children under 1 year old 75 mg / kg 2 r / d. Children over one year old 150 mg / kg, divided into 3-4 injections.

For prophylactic purposes in surgery, 1.5-3 g of Ampisid are used at the time of entering into anesthesia, then it can be repeated every 6-8 hours during the first days after surgery.

For patients with impaired renal function, the interval between doses is increased, according to the values \u200b\u200bof creatinine clearance.

No dose adjustment is required for patients with impaired hepatic function.

No dose adjustment is required for patients over 65 years of age.

The average course of treatment is 5 to 14 days, but it can be extended to treat chronic infections.

Side effects

The most common side effects associated with the work of the digestive tract. These are upset stools, heaviness in the stomach, bloating, lack of appetite, nausea and vomiting. To prevent diarrhea, it is recommended to stop eating fatty and spicy foods during treatment.

More rare side effects include:
Digestive organs: enterocolitis, gastritis, pseudomembranous colitis.

Nervous system: drowsiness, fatigue, headache, dizziness, convulsions.

Immune system: Allergic reactions including edema, anaphylaxis.

Laboratory indicators: reversible anemia, leukopenia, eosinophilia, thrombocytopenia, neutropenia, increased liver enzymes, bilirubinemia.

Urinary tract: interstitial nephritis, retention or absence of urine, blood in the urine.

Skin and mucous membranes: itching, rashes, skin reactions, inflammation of the oral mucosa.

Hepatobiliary system: jaundice, hepatitis, cholangiohepatitis.

Other: pain in muscles and joints, epistaxis, pain at the injection site.

Application during pregnancy and lactation

In animal studies, no teratogenic and embryotoxic effects on the fetus have been observed. The drug is used to treat pregnant women, but at the moment it is still not enough clinical researchto clearly classify its safety.

Ampisid is used to treat infections in pregnant women only when the expected benefit exceeds possible harm from the drug. Treatment should take place after additional laboratory tests, it can only be prescribed by a doctor.

Clinical studies on the safety of administration during lactation have not been conducted. In a small amount, the drug penetrates into breast milk, therefore it is necessary to stop breastfeeding during therapy with Ampisid.

Alcohol compatibility

Failure to comply with this recommendation will lead to increased side effects from the digestive system: pseudomembranous colitis develops, associated with excessive growth of Clostridia. As a result, the patient will also have to be treated for acute diarrhea, which is accompanied by pain, bloating, nausea, vomiting and fever.

In addition, the simultaneous use of alcohol with antibiotics puts a strong load on the liver and kidneys, increases the effect of alcohol on the nervous system: migraines, dizziness, drowsiness, fatigue and convulsions may appear.

Even at the end of the course, you should wait 72 hours before you can re-consume alcoholic beverages.

Analogs of Ampisid

You can replace the drug with other combined antibiotics that contain ampicillin and sulbactam (sultamicillin).

Analog Ampisid:

It is important to understand that drugs that contain only ampicillin (without sulbactam) are not analogues: their spectrum of action is much lower, and the result of treatment may not come. When buying similar medicines, you need to pay attention to the composition and dosage of the active ingredients.

Reviews about the drug Ampisid

A fast and effective drug, which is most often prescribed for the treatment of cystitis and various respiratory infections: tonsillitis, sinusitis, bronchitis and others. Ampisid is often prescribed to children: the smallest in the form of injections, older - a suspension. They note the pleasant taste and smell of the suspension, the children drink it themselves and with pleasure.

Many are also concerned about the safety of treatment during pregnancy, but there is not a single negative review. Of the disadvantages of the drug, it is noted that many people quickly develop diarrhea as a side effect. To prevent stool disorder, it is recommended to immediately buy probiotics to support a healthy microflora in the digestive tract and adhere to a healthy diet.

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"Ampisid": analogues, instructions for use, price

Antibiotics have long been used to combat serious pathologies. In most cases, it is impossible to cope with serious infectious diseases without them. One of these drugs is "Ampisid". Analogs of this medication can act due to the same basic substance. However, before using them, a doctor's consultation is necessary.

general characteristics

So, "Ampisid" (you will read reviews about it later) is a bactericidal combined agent that kills gram-positive and gram-negative bacteria.

Since most of the known pathogenic microorganisms have already developed immunity to ampicillin, sulbactam is introduced into its composition to increase the effectiveness of the antibiotic. This component increases the bactericidal properties of ampicillin.

Form of release and cost of the drug

"Ampisid" (analogs of the drug can also not be used at your own discretion) can be produced in this form:

• White or yellowish powder for suspension dilution. The prepared liquid is taken orally. This product contains 250 mg active substance 5 ml. The powder is placed in a dark glass bottle with a capacity of 40 or 70 ml. Most often, the package contains a measuring spoon.
• Substance for the preparation of a solution that will be administered intravenously or intramuscularly.
• Tablets, coated with a special coating, which reduces the negative effect of the drug on the esophagus. They are white or yellow in color and also in capsule form.

As for the cost of the medicine, it varies from 190 to 370 rubles. It all depends on the form of release and the concentration of the substance. You can store the product for 2 years. In this case, the drug should be contained in a closed bedside table, where there is no access to light and children, at a temperature of no more than +25 degrees

Pharmacological action and drug interaction

"Ampisid" (suspension) creates difficulties for cell division of pathogenic microorganisms. The active substance is absorbed quite well in the digestive tract. The highest concentration of the substance in the blood is reached within an hour or two. The half-life of a drug may be slower in infants and the elderly. The antibiotic is evenly distributed in the tissues. Most of it is removed from the body in the urine.

During treatment with this drug, the doctor must constantly monitor the activity of the hematopoietic organs and liver. Drugs such as Phenylbutazone, diuretics can increase the concentration of ampicillin. "Ampisid" is able to reduce the effectiveness of oral contraceptives. Ascorbic acid increases the absorption of the drug, and food and laxatives decrease.

It should be noted that the medication is incompatible with blood preparations.

"Ampisid" (the price of other drugs in the same group may be lower) can be used regardless of the patient's age, even for the treatment of newborns. Especially often it is prescribed to children. There are such indications for taking the drug:

1. Infectious pathologies of the ENT organs (sinusitis, otitis media, epilootitis) and the respiratory tract.
2. Inflammation of the lungs caused by bacteria.
3. Infectious damage to the kidneys and urinary tract: cystitis, urethritis.
4. Cholecystitis.
5. Inflammatory diseases of the skin and soft tissues.
6. Gonococcal pathologies.
7. Infectious lesions internal organs, bones and joints.
8. Sepsis, peritonin, meningitis.
9. Prevention of the development of infectious complications after surgical interventions.

Contraindications to use

As well as "Ampisid" itself, its analogs can not always be accepted either. There are such contraindications to the use of the drug:

• Patient's hypersensitivity to certain components of the drug.
• Breastfeeding period of the baby.
• Lymphomycosis.
• Infectious mononucleosis.
• Positive allergic test.

The substance should be used very carefully for pregnant women and people with renal failure.

What side reactions are possible?

The presented medicine can provoke the development of some undesirable consequences. It:

• Nausea and vomiting, diarrhea.
• Allergic skin reactions, rash, itching, anaphylactic shock.
• Leukopenia, thrombocytopenia, anemia.
• Candidiasis.
• Possible pain during the injection.

Administration methods and dosage features

There are several ways of using the drug: oral, intravenous and intramuscular. The dosage of the medicine depends on the severity of the pathology, the patient's age and the type of disease. Most often used "Ampisid" for children. The instruction provides for the features of taking the medicine for both small and adult patients:

• If the drug is prescribed intravenously, then the course of treatment should not be more than 7 days. The antibiotic can be administered by jet or through a dropper. If intravenous administration is not needed, then intramuscular injection therapy can be continued.
• The dose of the drug depends on the severity of the disease: with mild - 1.5-3 g / day twice a day, with an average - 3-6 g per day three times a day, with severe - up to 12 g / day in 4 doses.
• For the prevention of postoperative complications during anesthesia, a single dose of an antibiotic in the amount of 1.3-3 g is prescribed before the intervention, then during the day the patient should be given the same rate every 6-8 hours.
• If a child's weight does not exceed 35 kg, then the daily rate does not exceed 50 mg / kg. Divide this dose by 2-3 times. If the medicine is prescribed for a newborn baby, then this dose should be given every 12 hours.

The course of therapy usually lasts about 5 days - 2 weeks. After the symptoms of the pathology disappear, and the body temperature is normalized, the drug should be taken for at least two more days.

It should be borne in mind that you cannot prepare a suspension in advance. It is best to do this immediately before use. To do this, add 2-4 ml of water for injection to the powder bottle. You can use and boiled water... If the drug needs to be injected intramuscularly, then 0.5% lidocaine solution can be used to dilute it.

Analogues, reviews and special instructions

So, "Ampisid" (an analogue of this drug may not be suitable for the patient) is a fairly effective remedy for combating infectious pathologies. However, for some patients, this drug may seem quite expensive. Therefore, on the advice of a doctor, you can use the following analogs:

If the drug is prescribed to a pregnant woman, then it must be taken strictly according to the scheme that the doctor will approve. In principle, the medicine does not affect driving, however, being sick, this is still not worth doing.

As for the reviews, they are mostly positive. But parents often talk about diarrhea as a side effect. At a fairly high cost, the antibiotic after opening is stored for a very short time (about 10 days). In addition, some patients may experience an allergic reaction and addiction. The positive quality of the drug can be considered nice smell and a sweet taste that kids love. "Ampisid", the reviews about which you have already read, cannot be given to the baby without permission, since the consequences can be unpredictable.

Ampisid: instruction for use

ATX code: J01CR01.

Release form: film-coated tablets.

Dosage form: white oblong tablets with a scored.

Clinical and pharmacological group: A broad-spectrum antibacterial drug of the penicillin group with a beta-lactamase inhibitor.

Pharmacotherapeutic group: ampicillin and sulbactam double ester, a derivative of 6-aminopenicillic acid.

Actively active substance: sultamicillin tosylate dihydrate.

Excipients: microcrystalline cellulose, sodium starch glycolate, polyethylene glycol, hydroxypropyl methylcellulose, titanium dioxide, magnesium stearate.

Pharmacodynamics

The drug has a bactericidal effect on gram-positive and gram-negative aerobic and anaerobic bacteria, inhibiting the biosynthesis of peptoglycans of the bacterial cell membrane. Ampicillin double ester easily disintegrates under the influence of beta-lactamases, and sulbactam irreversibly inhibits a group of bacterial enzymes aimed at combating antibiotics of the penicillin series.

It is active against the family of staphylococci, streptococci, coli bacteria, klebsiella, morganella, peptococcus, clostridia, peptostreptococcus. Bacteroids.

Pharmacokinetics

After oral administration, Ampisid in the digestive tract breaks down into ampicillin and sulbactam (1: 1). Meal time does not significantly affect the bioavailability of the drug.

The maximum concentration in plasma reaches after 1-2 hours. The binding of the active substance to plasma proteins is 28% (ampicillin) and 38% (sulbactam). The drug is distributed throughout all tissues and body fluids. It quickly sinks into lung tissue, middle ear fluid, bronchial secretions, urine and bile. In high concentrations it accumulates in the liver. The concentration in bile is 2 times higher than the concentration in plasma.

The half-life is 45 minutes and 60 minutes, respectively. In patients with impaired kidney, people of advanced age and newborns, T1 / 2 is longer. About 55-75% of Ampisida is excreted by the kidneys, a small part by the intestines, along with feces. With inflammation of the pia mater, the drug is able to penetrate the blood-brain barrier, it is removed during hemodialysis. Penetrates into the placenta and is excreted in breast milk.

Indications for use

• Upper and lower respiratory tract infections;
• Gynecological diseases of bacterial etiology;
• Skin and soft tissue infections;
• Intra-abdominal infections;
• Inflammation of bone tissue and articular joints;
• Urinary tract infections;
• Gonorrhea;
• Postoperative prophylaxis after cesarean section and abortion;
• Bacterial septicemia.

Drug dosage

In children under 5 years old with a body weight of less than 30 kg, the daily dose of the drug is 50 mg per 1 kg of body weight, divided into 2 doses.

The average duration of treatment is 5-14 days. After the disappearance of clinical signs of the disease, the drug should be used for another 2-3 days.

Side effects

From the skin : itching, urticaria, erythema multiforme.

From the digestive tract : nausea, diarrhea, glossitis, enterocolitis, pseudomembranous colitis (quite rare).

From the hematopoietic system : decreased hemoglobin level, lymphocytosis, thrombocytopenia, eosinophilia, agranulocytosis, thrombocytosis (from ≥0.1% to

Contraindications

• Individual intolerance to the components of the drug;
• Hypersensitivity to penicillin and other beta-lactam antibiotics;
• Severe gastrointestinal disorders;
• Acute lymphoblastosis leukemia;
• Age up to 3 years;
• Infectious mononucleosis;
• Bronchial asthma;
• Hay fever;
• Viral infections;
• Allergic diathesis.

special instructions

Treatment with drugs of the penicillin group sometimes leads to the development of rather serious conditions, up to anaphylactic shock and death. Therefore, if even minor allergic reactions occur, the drug should be noted and the patient should be prescribed appropriate treatment.

In patients with septic complications, the formation of a bacteriolysis reaction is possible.

During treatment, the function of the liver, kidneys and hematopoietic system should be constantly monitored. Also, in this situation, excessive growth of microorganisms insensitive to Ampisidum (including fungal microflora) may be observed.

Overdose

In case of an overdose of an antibiotic, dizziness, increased fatigue, headaches, drowsiness, general malaise, sleep disturbances, emotional lability, depression, and increased anxiety are observed. At very high concentrations of the drug in cerebrospinal fluid the normal functioning of the central nervous system is disrupted, up to the development of seizures.

Terms of sale

Ampisid tablets are prescription drugs.

Storage conditions

Store in a dark place, protected from light and moisture, out of reach of children, at a temperature not exceeding 25 C.

Shelf life

The drug is suitable for use within 2 years from the date of release. It is prohibited to use the product after the expiration date indicated on the package.

• Sulacillin tablets
• Sultasin tablets
• Sulbacin tablets
• Unazine tablets

Prices for Ampisid tablets

Ampisid: instructions for use and reviews

Latin name: Ampisid

ATX code: J01CR04

Active ingredient: ampicillin (ampicillin) + sulbactam (sulbactam)

Manufacturer: Mustafa Nevzat Ilach Sanai A.Sh. (Mustafa Nevzat Ilac Sanayii, A.S.) (Turkey)

Description and photo update: 07/13/2018

Ampisid is a broad-spectrum antibiotic of the penicillin group in combination with a beta-lactamase inhibitor.

Release form and composition

Dosage forms of Ampisid:

• film-coated tablets: in the form of capsules, white with a yellow tinge or white, scored on both sides; at the break - a homogeneous almost white or white mass (10 pcs. in orange glass bottles together with a cylindrical container with silica gel, 1 bottle in a cardboard box; for hospitals - 200 bottles in a cardboard box);
• powder for suspension for oral administration: almost white or white; ready-made suspension - homogeneous, almost white or white (in yellow glass bottles with a volume of 40 or 70 ml, sealed with an aluminum cap, in a cardboard box 1 bottle complete with a measuring spoon; for hospitals - in a cardboard box 100 bottles);
• powder for the preparation of a solution for intravenous (i / v) and intramuscular (i / m) administration (powder for preparing a solution for i / m administration): almost white or white powder [by (250 mg + 125 mg), (500 mg + 250 mg) or (1000 mg + 500 mg) in colorless glass vials complete with a solvent ampoule of 1 / 1.8 / 3.5 ml, respectively; in a cardboard box 1 set; for hospitals - 100 bottles in a cardboard box];
• powder for preparation of solution for injections: white [at (1000 mg + 500 mg) or (500 mg + 250 mg) in vials complete with a solvent ampoule of 1.8 or 3.5 ml, respectively; in a cardboard box 1 set].

1 tablet contains:

• active substance: sultamicillin tosylate, in terms of sultamicillin - 375 mg;
• additional components: magnesium stearate, sodium carboxymethyl starch, microcrystalline cellulose;
• film shell: titanium dioxide, hypromellose, macrogol 400.

5 ml of a suspension made from powder contains:

• active ingredient sultamicillin - 250 mg;
• additional components: xanthan gum, acetic acid anhydride, sucrose, sodium dihydrogen phosphate, sodium carmellose, hyprolose, guarana flavor.

1 vial of powder for preparation of solution for parenteral administration contains the following active substances: ampicillin (in the form sodium salt) - 250/500/1000 mg and sulbactam (in the form of sodium salt) - 125/250/500 mg, respectively.

Solvent (colorless transparent liquid): complete with powder for preparation of solution for intramuscular and intravenous administration - water for injection; complete with powder for preparation of solution for injections and for intramuscular administration - lidocaine hydrochloride solution 0.5%.

Pharmacological properties

Pharmacodynamics

Ampisid is a combined antibacterial agent.

Ampicillin (the antibacterial component of the drug) belongs to the group of semisynthetic penicillins and exhibits a bactericidal effect against sensitive microorganisms during the phase of active reproduction, by suppressing the biosynthesis of mucopeptide of the bacterial cell wall.

Sulbactam does not show clinically significant antibacterial activity (with the exception of Acinetobacter and Neisseriaceae) and is an irreversible inhibitor of a large number of beta-lactamases produced by microorganisms resistant to beta-lactam antibiotics. Sulbactam is also characterized by a connection with some penicillin-binding proteins. For this reason, individual strains are more susceptible to a combination of active ingredients than to a single beta-lactam antibiotic.

A significant number of gram-positive and gram-negative microorganisms are sensitive to Ampisid, including: Staphylococcus epidermidis and Staphylococcus aureus (including penicillin-resistant and some methicillin-resistant strains); Streptococcus faecalis and Streptococcus pneumoniae and other streptococci, Haemophilus parainfluenzae and Haemophilus influenzae (strains producing and not producing beta-lactamases), Klebsiella spp., Escherichia coli, Branhamella catarrhalis, Proteus spp. (indole positive and indole negative), Enterobacter spp. and Citrobacter spp., Morganella morganii, Neisseria gonorrhoeae and Neisseria meningitidis; anaerobes, including Peptococcus spp., Bacteroides fragilis, Peptostreptococcus spp. and species close to it.

Pharmacokinetics

When taken orally, Ampisid is well absorbed and does not undergo destruction in the acidic environment of the stomach. The drug is distributed in most fluids and tissues of the body, poorly passes through the blood-brain barrier, but against the background of inflammation of the meninges, the passage is much improved. After intravenous and intramuscular injections, high concentrations of sulbactam and ampicillin are observed in the blood, for both active ingredients the half-life is approximately one hour.

The drug is excreted mostly by the kidneys (70-80%), while a very high content of unchanged antibiotic is found in the urine, and the drug is also excreted in the bile and penetrates into breast milk. Since sulbactam almost does not undergo biotransformation, it is excreted mainly unchanged, only 25% is excreted in the form of a metabolite.

With repeated injections, Ampisid does not accumulate, which allows it to be used for a long time in high doses.

Indications for use

• infections of the genitourinary system: pyelonephritis, endometritis, cystitis, urethritis; additionally for parenteral administration - prostatitis, pyelitis;
• infections of the upper and lower respiratory tract, and ENT organs: tonsillitis, sinusitis, epiglottitis, otitis media, bacterial pneumonia; additionally for parenteral administration - chronic bronchitis, lung abscess, pleural empyema;
• biliary tract infections: cholangitis, cholecystitis;
• infections of the skin and soft tissues: impetigo, erysipelas, secondarily infected dermatitis;
• infections of bones and joints;
• gonococcal infections.

In the form of injection solutions, Ampisid is also indicated for the following diseases: scarlet fever, dysentery, salmonella, salmonellosis, peritonitis, sepsis, meningitis, septic endocarditis.

In order to prevent complications, the antibiotic Ampisid is used in the postoperative period during surgical interventions on the organs of the abdominal cavity and small pelvis.

Contraindications

• lymphocytic leukemia;
• infectious mononucleosis (since the disease is of viral origin);
• severe violations of the liver and / or kidneys;
• age up to 3 years (with the appointment of tablets);
• hypersensitivity to any of the constituents of Ampisid and beta-lactam antibiotics.

Instructions for the use of Ampisid: method and dosage

Tablets and powder for oral suspension

The tablets and the prepared suspension are taken orally.

For children weighing more than 30 kg and adults, Ampisid is prescribed in a daily dose of 375-750 mg. Children with a body weight of less than 30 kg are recommended to take 25-50 mg of sultamicillin per day (taking into account the severity of the infection) per 1 kg of body weight. Daily dose should be divided into two steps. The course can vary from 5 to 14 days.

In the treatment of uncomplicated gonorrhea, Ampisid is prescribed once in a dose of 2250 mg (6 tablets), preferably in combination with probenecid in a dose of 1000 mg.

It is advisable for children to take the drug in the form of a suspension.

To prepare a suspension, immediately before the first dose, the powder should be diluted with boiled water at room temperature, gradually adding it to the mark on the bottle. In this case, the contents of the bottle must be constantly shaken. The suspension is recommended to be taken 5 minutes after the powder is dissolved in water to ensure its complete dissolution. The vial with the drug should be shaken before each dose. For accurate dosage the product must be used with the measuring spoon supplied with the preparation, which must be thoroughly rinsed with water after each use.

Powder for preparation of solution for parenteral administration

Ampisid solution prepared from a powder is injected intravenously (jet / drip) or intramuscularly.

The course of treatment is usually 5-14 days, but in severe cases it can be increased, or additional administration of ampicillin is possible. Treatment should be continued for another 48 hours after the normalization of body temperature and removal of symptoms of the disease.

To prevent the development of surgical infections, Ampisid is administered at 1500–3000 mg during induction of anesthesia, then within 24 hours after the operation, repeated injections of the antibiotic are allowed every 6–8 hours at the same dose.

In uncomplicated gonorrhea, Ampisid is administered as a single dose of 1500 mg. In order to increase the duration of the presence of active components in plasma, 1000 mg of probenecid should be taken orally simultaneously.

For children, in the treatment of most infections, the drug is prescribed per day at 150 mg / kg (ampicillin 100 mg / kg + sulbactam 50 mg / kg), the dose is divided into 3-4 injections. For newborns (especially premature babies), Ampisid is usually prescribed at a dose of 75 mg / kg per day, divided into 2 administrations with an interval of 12 hours.

Intravenous jet solution must be injected slowly over 3-5 minutes, the recommended single dose should be dissolved in 10-20 ml of isotonic sodium chloride solution.

For intramuscular administration, the powder is diluted in 2-4 ml of isotonic sodium chloride solution or 0.5% lidocaine solution.

Side effects

• digestive system: decreased appetite, nausea, diarrhea, vomiting, pseudomembranous enterocolitis, liver functional disorders (increased activity of hepatic transaminases, cholestatic jaundice);
• nervous system: malaise, drowsiness, headache; extremely rare - convulsions;
• allergic reactions: skin hyperemia, urticaria, conjunctivitis, rhinitis, arthralgia, fever, angioedema; rarely - itching, rash, eosinophilia, serum sickness, bronchospasm, anaphylactic shock; extremely rare - Stevens-Johnson syndrome, toxic epidermal necrolysis, polymorphic erythema;
• hematopoietic system: lymphopenia, neutropenia, leukopenia, anemia, hemolytic anemia, eosinophilia, thrombocytopenia (these disorders are transient, after the abolition of Ampisid, the blood picture returns to normal);
• laboratory parameters: increased urea levels, azotemia, hypercreatininemia, hyperbilirubinemia;
• local reactions: pain at the injection site, especially with intramuscular injection, rarely - hyperemia or phlebitis at the injection site;
• others: extremely rarely - interstitial nephritis; with prolonged therapy - superinfection caused by antibiotic-resistant microorganisms (candidiasis).

Overdose

Data on the toxic effects of ampicillin and sulbactam are limited. Violations resulting from an overdose of Ampisid differ significantly from its adverse reactions. High level beta-lactam antibiotics in the cerebrospinal fluid can provoke the development of undesirable effects from the central nervous system, including convulsions.

Both active components of the drug are removed from the body using hemodialysis, as a result of which, with an overdose of Ampisid, in order to accelerate its elimination (especially in patients with functional impairment kidney) carry out hemodialysis. Also, gastric lavage is prescribed in case of an overdose of oral forms of the drug and further symptomatic treatment.

special instructions

During the period of therapy with penicillins, very severe, and in some cases fatal, allergic (anaphylactic) reactions were recorded. If an allergic reaction occurs during the course, it is necessary to urgently stop using Ampisid and carry out appropriate treatment. With the development of this side effect, oxygen, adrenaline, glucocorticosteroid (GCS) hormones IV can be prescribed, and measures are taken to ensure airway patency (including intubation).

When patients with sepsis receive the drug, a bacteriolysis reaction may occur (Yarish-Herxheimer reaction).

During the use of Ampisid, as well as with any other antibiotic therapy, timely detection of signs of possible overgrowth of microorganisms resistant to the drug, including fungi, is of great importance. With the development of superinfection, the use of the drug should be discontinued and / or adequate concomitant therapy should be prescribed.

Against the background of long-term treatment, it is recommended to periodically monitor the indicators of the function of internal organs, including the liver, kidneys, and the hematopoietic system. This control is extremely important for newborns (primarily premature babies) and young children.

It was noted that with the appointment of ampicillin to pregnant women, a transient decrease in plasma levels in the blood of total bound estriol, estriol glucuronide, as well as bound estrone and estradiol was observed.

With Ampisid therapy, non-enzymatic methods for determining the level of glucose in urine using Felling's, Benedict's or KliniTest's reagents can show a false positive result.

Patients on a low sodium diet should remember that 1500 mg of Ampisid for parenteral administration contains approximately 115 mg (5 mmol) of sodium.

Application during pregnancy and lactation

There are no data indicating the effectiveness and safety of using an antibacterial agent during pregnancy and breastfeeding. If it is necessary to use Ampisid during pregnancy, it is required to scrupulously assess the expected benefits of treatment for the mother and the possible threat to the health of the fetus.

If the antibiotic Ampisid is prescribed to be taken during lactation, you must stop breastfeeding.

Childhood use

Children under 3 years old are contraindicated to take Ampisid in tablet form.

With impaired renal function

In the presence of renal failure with creatinine clearance below 30 ml / min, it is recommended to increase the intervals between the injections of Ampisid in accordance with the usual practice of using ampicillin.

For patients with severe functional impairment of the kidneys, the appointment of Ampisid is contraindicated.

For violations of liver function

In the presence of severe liver dysfunctions, antibacterial therapy is contraindicated.

Drug interactions

• allopurinol: the threat of skin reactions is aggravated;
• anticoagulants: the effect of these drugs is enhanced, since penicillins are capable of disrupting platelet aggregation and altering hemocoagulation parameters;
• laxatives, glucosamine, antacids, aminoglycosides (when taken orally), food: slow down and reduce the absorption of Ampisid;
• medicines showing bacteriostatic effect ( sulfa drugs, tetracyclines, erythromycin, chloramphenicol): their antagonistic effect is noted;
• ascorbic acid: absorption of the drug is enhanced;
• bactericidal antibiotics (including cephalosporins, aminoglycosides, rifampicin, vancomycin, cycloserine): a synergistic effect is noted;
• non-steroidal anti-inflammatory drugs, phenylbutazone, allopurinol, diuretics, probenecid and other substances that reduce tubular secretion: the plasma concentration of ampicillin and sulbactam increases, which leads to their longer storage in the blood, an increase in the half-life and an increased risk of toxicity;
• oral contraceptives containing estrogen (including ethinyl estradiol): the effectiveness of these drugs decreases, the threat of breakthrough bleeding increases (it is recommended to use additional methods of contraception);
• methotrexate: clearance decreases and the risk of toxicity of this drug is aggravated (due to the influence of penicillins); this combination requires careful monitoring;
• drugs, during the metabolism of which para-aminobenzoic acid is formed: their effect is weakened;
• aminoglycosides (with intramuscular injection): there was a significant mutual inactivation when mixing ampicillin and aminoglycosides (in in vitro studies); with the joint appointment of Ampisid and these funds, it is required to inject them into different parts of the body with a period between injections of at least 60 minutes;
• blood products or protein hydrolysates: Ampisid should not be mixed with these drugs, since they are pharmaceutically incompatible.

Analogs of Ampisid are: Sultasin, Libakcil, Sulbacin, Ampicillin + Sulbactam, Unazin, Amoxicillin + Sulbactam, etc.

Terms and conditions of storage

Keep out of the reach of children. Store in a place protected from light and moisture, at a temperature not exceeding 25 ° C. The finished suspension is stored for no more than 14 days at a temperature of 2–8 ° C.

Shelf life is 2 years.

Bacterial infections of various localization caused by sensitive pathogens:

- respiratory tract infections (including pneumonia, lung abscess, chronic bronchitis, pleural empyema);

- infections of the ENT organs (including sinusitis, tonsillitis, otitis media);

- infections of the urinary tract and genitals (pyelonephritis, pyelitis, cystitis, urethritis, prostatitis, endometritis);

- infections of the biliary tract (cholecystitis, cholangitis);

- infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatitis);

- Gastrointestinal infections (dysentery, salmonellosis, salmonella carriers);

- infections of bones and joints;

- septic endocarditis;

- meningitis;

- sepsis;

- peritonitis;

- scarlet fever;

- gonococcal infection;

- prevention of postoperative complications during operations on the abdominal and pelvic organs.

Contraindications to the use of Ampisid

Hypersensitivity to penicillins.

- hypersensitivity;

- Infectious mononucleosis;

- lactation period.

With caution: hepatic and / or renal failure, pregnancy.

Ampisid Use during pregnancy and children

Film-coated tablets
Powder for oral suspension

The safety of using sultamicillin during pregnancy and lactation has not been established.

Powder for preparation of solution for intravenous and intramuscular administration

With caution during pregnancy. Contraindicated during lactation.

Dosage of Ampisid

Film-coated tablets
Powder for oral suspension
For adults and children weighing more than 30 kg, the daily dose is 375-750 mg / day, for children weighing less than 30 kg - 25-50 mg / kg (depending on the severity of the infection). Frequency rate of admission - 2 times / day. The course of treatment is 5-14 days. In the treatment of uncomplicated gonorrhea, sultamicillin can be administered as a single dose of 2.25 g (in combination with probenecid).

Powder for preparation of solution for intravenous and intramuscular administration
In / m, in / in (drip at a speed of 60-80 drops / min, jet - slowly, for 3-5 minutes).

IV is administered for 5-7 days, then, if it is necessary to continue treatment, they switch to i / m use.

With a mild course of infection - 1.5-3 g / day. in 2 introductions; with a moderate course - 3-6 g / day. 3-4 injections; in severe cases - 12 g / day. 3-4 injections.

With uncomplicated gonorrhea - 1.5 g, once.

For the prevention of surgical infections - 1.5-3 g, during anesthesia; then within 24 hours after surgery - in the same dose every 6-8 hours.

For children - in a daily dose of 150 mg / kg (100 mg / kg ampicillin and 50 mg / kg sulbactam); frequency rate - 3-4 times / day.

For newborns under 1 week of age and premature babies - every 12 hours.

The course of treatment is 5-14 days (if necessary, it can be extended). After the temperature has returned to normal and other pathological symptoms disappear, treatment is continued for another 48 hours.

With chronic renal failure (CC less than 30 ml / min), it is necessary to increase the intervals between injections.

The solution for parenteral administration is prepared ex tempore. To the contents of the bottle add 2 or 4 ml of water d / i, 0.5% procaine solution or 0.9% sodium chloride solution. For intramuscular administration, dilution with 0.5% lidocaine solution is permissible. For intravenous administration, a single dose is dissolved in 0.9% sodium chloride solution or 5% dextrose solution in a volume of 10 to 200 ml.

• Instructions for the use of Ampisid
• The composition of the drug Ampisid
• Indications of the drug Ampisid
• Storage conditions of the drug Ampisid
• Shelf life of the drug Ampisid

ATX code: Antimicrobials for systemic use (J)\u003e Antimicrobials for systemic use (J01)\u003e Beta-lactam antibiotics - penicillins (J01C)\u003e Combinations of penicillins (including with beta-lactamase inhibitors) (J01CR)\u003e Ampicillin in combination with beta-lactamase inhibitors (J01CR01)

Release form, composition and packaging

powder for prigot. solution for injection 1 g + 500 mg: vial 1 PC. in set with solvent
Reg. No.: RK-LS-5-No. 008734 dated 02.06.2004 - Canceled

white.

Solvent: solution of lidocaine hydrochloride 0.5% - 3.5 ml.

powder for prigot. solution for injection 500 mg + 250 mg: vial 1 PC. in set with solvent
Reg. No.: RK-LS-5-No. 008733 dated 02.06.2004 - Canceled

Powder for solution for injection white.

Solvent: solution of lidocaine hydrochloride 0.5% - 1.8 ml.

Bottles (1) complete with solvent (amp. 1 pc.) - cardboard packs.

Description medicinal product AMPISID for injection based on the officially approved instructions for use of the drug and made in 2006. Updated date: 18.04.2006

pharmachologic effect

Combined antibacterial drug.

Ampicillin is an antibiotic from the group of semi-synthetic penicillins, which has a bactericidal effect on sensitive microorganisms during the phase of active reproduction by inhibiting the biosynthesis of the cell wall mucopeptide.

Sulbactam does not have clinically significant antibacterial activity (with the exception of Neisseriaceae and Acinetobacter), it is an irreversible inhibitor of most of the main β-lactamases that are produced by microorganisms resistant to beta-lactam antibiotics. Sulbactam also binds to some penicillin-binding proteins, so some strains are more sensitive to the combination than to a single beta-lactam antibiotic.

Ampisides active against a wide range of gram-positive and gram-negative bacteria, including Staphylococcus aureus and Staphylococcus epidermidis (including penicillin-resistant and some methicillin-resistant strains), Streptococcus pneumoniae, Streptococcus faecalis, other strains of streptococci, Haemophilus influenzae, lactamophilus-producing strains, non-lactamocytogenous parainhalosis-producing strains fragilis, Escherichia coli, Klebsiella spp., Proteus spp. (indole positive and indole negative), Enterobacter spp., Morganella morganii, Citrobacter spp., Enterobacter spp., Neisseria meningitidis and Neisseria gonorrhoeae.

Dosage regimen

The drug is administered intramuscularly, intravenously (jet or drip).

The dose of the drug varies from 1.5 g / day to 12 g / day. The daily dose is administered in several doses every 6 or 8 hours. severe infections the drug can be used every 12 hours.

Treatment is usually continued for another 48 hours after the normalization of body temperature and the disappearance of others pathological signs... The duration of the course of therapy is 5-14 days, but in more severe cases it can be increased or ampicillin is additionally prescribed.

For prevention of surgical infections 1.5-3 g of Ampisid should be administered during induction of anesthesia, allowing sufficient time to achieve effective serum and tissue concentrations during surgery. The dose can be re-administered every 6-8 hours; in most surgical procedures, the use of the antibiotic is usually stopped 24 hours after the operation, unless the administration of Ampisid is indicated for therapeutic purposes.

For treating uncomplicated gonorrhea Ampisid can be administered parenterally as a single dose of 1.5 g.

In order to increase the duration of the content of sulbactam and ampicillin in plasma, probenecid should be simultaneously prescribed at a dose of 1 g orally.

In children in the treatment of most infections, the dose of Ampisid is 150 mg / kg / day (which corresponds to 50 mg / kg / day of sulbactam and 100 mg / kg / day of ampicillin). In children, infants and newborns, the drug is usually administered every 6-8 hours in accordance with the usual practice of using ampicillin.

Have newborn in the first week of life (especially for premature babies), the drug is usually prescribed at a dose of 75 mg / kg / day with an interval of 12 hours.

In patients with renal failure (CC less than 30 ml / min) excretion of sulbactam and ampicillin is disturbed to the same extent, therefore the ratio of their plasma concentrations does not change. For such patients, Ampisid is prescribed at increased intervals between injections in accordance with the usual practice of using ampicillin.

Rules for the preparation and administration of solutions

For intramuscular administration, the contents of the vial are dissolved in 2-4 ml of 0.5% lidocaine solution or isotonic sodium chloride solution.

For intravenous administration, a single dose of the drug is dissolved in 100-200 ml of isotonic sodium chloride solution or 5% -10% glucose solution. Injected drip at a rate of 60-80 drops / min.

For intravenous jet injection, a single dose of the drug is dissolved in 10-20 ml of isotonic sodium chloride solution and injected slowly over 3-5 minutes.

Side effects

From the side of the central nervous system: the occurrence of seizures has been reported extremely rarely.

From the digestive system: nausea, vomiting, diarrhea, pseudomembranous colitis, liver dysfunction, jaundice, transient increase in ALT and ACT activity, hyperbilirubinemia.

From the hematopoietic system: anemia, hemolytic anemia, thrombocytopenia, eosinophilia and leukopenia (these changes are transient and the blood picture normalizes after drug withdrawal).

Others: cases of interstitial nephritis have been reported very rarely.

Allergic reactions: anaphylactic shock, rash, itching and other skin reactions;

very rarely - Stevens-Johnson syndrome, epidermal necrolysis and erythema multiforme.

Local reactions: pain at the injection site, especially with intramuscular injection. In a small number of patients, after intravenous administration, phlebitis or hyperemia at the injection site may develop.

Application for impaired renal function

Patients with renal insufficiency (CC less than 30 ml / min) Ampisid is prescribed with increased intervals between injections in accordance with the usual practice of using ampicillin.

Severe renal dysfunction is a contraindication to prescribing the drug.

special instructions

Ampisid should not be prescribed for the treatment of infectious mononucleosis, since infectious mononucleosis is a viral infection.

During treatment with Ampisid, serious allergic (anaphylactic) reactions may occur. If an allergic reaction develops, it is necessary to discontinue the drug and prescribe the appropriate treatment:

• the introduction of adrenaline, if necessary, prescribe oxygen, intravenous administration of GCS and take measures aimed at improving airway patency, including, if necessary, intubation.

When using Ampisid, constant monitoring is important to detect signs of overgrowth of insensitive microorganisms, including fungi. If superinfection occurs, the drug should be discontinued and / or adequate therapy should be prescribed.

Avoid the simultaneous use of Ampisid with drugs with bacteriostatic action (chloramphenicol, erythromycin, sulfa drugs and tetracyclines).

When treating patients on a low sodium diet, it should be borne in mind that 1.5 g of Ampisid contains approximately 115 mg (5 mmol) of sodium.

Non-enzymatic methods for the determination of glucose in urine using Benidict, Fehling or Clinitest reagents can give a false positive result while using Ampisid.

Control of laboratory parameters

With prolonged therapy with Ampisid, periodic monitoring of the function of the liver, kidneys and the hematopoietic system is recommended. It is especially important to control laboratory parameters for newborns (especially premature babies) and infants.

Overdose

Information on the toxic effects of ampicillin and sulbactam in humans is limited.

Symptomsarising from an overdose of the drug are significantly different from its side effects. It should be borne in mind that a high concentration of ampicillin in the cerebrospinal fluid can cause dysfunction of the central nervous system, including convulsions.

Treatment. Both ampicillin and sulbactam are removed from the body by hemodialysis, therefore, in case of overdose, hemodialysis is indicated in order to accelerate elimination.

Drug interactions

When using Ampisid while taking allopurinol, the risk of developing skin reactions is significantly increased.

Ampisid, when used simultaneously, can enhance the effect of anticoagulants.

Cases of a decrease in the effectiveness of contraceptive drugs in women receiving ampicillin have been reported, which led to an unplanned pregnancy. Although such an association seems unlikely, patients receiving Ampisid should use alternative or additional methods of contraception.

Ampisid, when administered together, can reduce the clearance of methotrexate, which leads to an increase in its toxicity.

Simultaneous administration of probenecid with Ampisid leads to a decrease in the tubular secretion of sulbactam and ampicillin, which is reflected in an increase in serum levels of ampicillin and sulbactam and their longer retention in the blood, a prolonged half-life and an increased risk of toxicity.

Pharmaceutical interactions

Mixing ampicillin and aminoglycosides in vitro led to their significant mutual inactivation; in cases where these antibiotics are prescribed together, they should be administered in different areas and with a time difference between injections of at least 1 hour.

Sulbactam is compatible with most intravenous solutions, but ampicillin and, therefore, Ampisid are less stable in solutions containing dextrose or other carbohydrates; it should not be mixed with blood products or protein hydrolysates.

Instructions for medical use

drug

AMPISID

Tradename

International non-proprietary name

Dosage form

Powder for preparation of solution for intravenous and intramuscular injections 3 g

Structure

One bottle contains

active substances:

Ampicillin sodium 2126.0 mg

(equivalent to ampicillin) (2000.0 mg)

Sulbactam sodium 1094.0 mg

(equivalent to sulbactam) 1000.0 mg

solvent:

water for injection 7 ml

Description

White or almost white powder with a characteristic odor.

Pharmacotherapeutic group

Beta-lactam antibacterial drugs. Penicillins. Penicillins in combination with beta-lactamase inhibitors. Ampicillin in combination with beta-lactamase inhibitors.

ATX code J01CR01

Pharmacological properties

Pharmacokinetics

The maximum plasma concentration is reached immediately after intravenous or intramuscular administration. After intramuscular injection of 1000 mg of ampicillin and 500 mg of sulbactam, the maximum concentration of ampicillin in plasma ranged from 8 to 37 μg / ml and the maximum plasma concentration of sulbactam was 6 to 24 μg / ml. Ampicillin binds about 28% reversibly to whey proteins, and sulbactam about 38%. The average elimination half-life is approximately 1 hour. Approximately 75 to 85% of ampicillin and sulbactam are excreted unchanged in the urine within the first 8 hours after ingestion by individuals with normal renal function. In patients with impaired renal function, the elimination of ampicillin and sulbactam suffers equally, therefore, the ratio with each other will remain constant, regardless of renal function. After parenteral administration, it is well distributed in tissues and body fluids. Both ampicillin and sulbactam penetrate the cerebrospinal fluid in the presence of meningeal inflammation.

Pharmacodynamics

Ampisid is a combined preparation consisting of sodium ampicillin and sodium sulbactam.

Ampicillin - an antibiotic from the group of semi-synthetic penicillins, which has a bactericidal effect on sensitive microorganisms during the phase of active reproduction by inhibiting the biosynthesis of the cell wall mucopeptide.

Sulbactamdoes not possess clinically significant antibacterial activity (with the exception of Neisseriaceae and Acinetobacter), it is an irreversible inhibitor of most of the main beta-lactamases, which are produced by microorganisms resistant to beta-lactam antibiotics. Sulbactam also binds to some penicillin-binding proteins, so some strains are more sensitive to the combination than to a single beta-lactam antibiotic. Ampisid is active against a wide range of gram-positive and gram-negative bacteria, including Staphylococcus aureus and Staphylococcus epidermidis (including penicillin-resistant and some methicillin-resistant strains); Streptococcus pneumoniae, Streptococcus faecalis and other streptococci, Haemophilus influenzae and Haemophilus parainfluenzae (strains producing and not producing beta-lactamases), Branhamella catarrhalis, Escherichia coli, Klebsiella spp., Protein (indole positive indole negative), Morganella morganii, Citrobacter spp. And Enterobacter spp., Neisseria meningitidis and Neisseria gonorrhoeae; anaerobes, including Bacteroides fragilis, Peptococcus spp., Peptostreptococcus spp. and species close to it.

Indications for use

Upper and lower respiratory tract infections, including sinusitis, otitis media, and epiglottitis

Bacterial pneumonia

Infections urinary tract and pyelonephritis

Intra-abdominal infections, including peritonitis, cholecystitis, endometritis, and pelvic phlegmon

Bacterial septicemia

Infections of the skin, soft tissues, bones and joints

Gonococcal infections

Prevention of postoperative sepsis

Method of administration and dosage

Ampisid can be administered intravenously or intramuscularly.

The recommended dosage for adults varies from 1.5 g (1 g ampicillin / 0.5 g sulbactam) to 12 g (8 g ampicillin / 4 g sulbactam). The maximum daily dose of sulbactam is 4 g. The daily dose is administered at 6-8 hour intervals, depending on the severity of the infection. For mild infections, the drug is given every 12 hours.

When administered intravenously, the dose is administered slowly over 10-15 minutes. Also, the drug can be administered in 50-100 ml of an appropriate solvent as an intravenous infusion over 15-30 minutes.

When injected intramuscularly, Ampisid should be injected deep into the muscle; when pain occurs, a 0.5% sterile solution of lidocaine hydrochloride for injection can be used to dissolve the powder.

Treatment usually continues for 48 hours after body temperature has returned to normal. The course of treatment is 5-14 days; with severe infections, this period can be extended with joint application ampicillin. For the prevention of infections in surgery, the drug is administered during induction of anesthesia at a dose of: 1.5-3.0 g intramuscularly or intravenously; administration of the drug is repeated after 6-8 hours.

Children: in the treatment of most infections in newborns and children, the dose of Ampisid is 150 mg / kg / day (which corresponds to 50 mg / kg / day of sulbactam and 100 mg / kg / day of ampicillin).

In children, infants and newborns, the drug is usually administered every 6-8 hours in accordance with the usual practice of using ampicillin. In newborns in the first week of life (especially premature infants), the drug is recommended to be prescribed at a dose of 75 mg / kg per day in divided doses with an interval of 12 hours.

Geriatrics (elderly and senile patients): there is no need to determine the dose for elderly patients.

Patients with impaired liver function:for patients with mild to moderate hepatic impairment, there is no need to determine the dose, except in cases where patients suffer from severe renal impairment.

Patients with impaired renal function: for patients with impaired renal function, the criterion for the release of ampicillin and sulbactam acts in the same way, since the ratio of blood volume to plasma volume remains the same. In this case, the following dose table can be applied:

If aminoglycosides are used together, they are prepared separately and injected into a different area. For patients on a salt-free diet, the administration of ampicillin / sulbactam is carried out with extreme caution.

The use of lidocaine as a solvent in pediatric practice is not recommended.

The use of lidocaine as a solvent for intravenous administration of Ampisid solution is strictly prohibited!

Side effects

• Local reactions: pain at the injection site and thrombophlebitis with intravenous administration.

• Gastrointestinal tract: stomatitis, glossitis, gastritis, diarrhea, enterocolitis, pseudomembranous colitis.
• Leather and soft tissue: skin rash, pruritus, urticaria, erythema multiforme, and very rarely scaly dermatitis and some hypersensitivity reactions, Stevens-Johnson syndrome, epidermal necrolysis.
• Hematopoietic system: a decrease in the level of hemoglobin, hematocrit, erythrocytes, leukocytes, lymphocytes, platelets or an increase in the level of lymphocytes, monocytes, platelets and eosinophils, as well as the occurrence of agranulocytosis. Most of these phenomena are reversible and normalize upon discontinuation of the drug.

• From the liver: increased AST, ALT, LDH, alkaline phosphatase, hyperbilirubinemia, anemia, thrombocytopenia and leukopenia
• Hematological: changes in the level of hemoglobin, hematocrit, erythrocytes, leukocytes, lymphocytes and monocytes.
• Renal: increased blood urea nitrogen and creatinine levels
• Urine: the appearance of erythrocytes, hyaline casts, a decrease in the level of serum albumin and protein.

Very rarely

Anaphylactic reactions

Nausea, vomiting, candidiasis, bloating, flatulence, glossitis

Fatigue, headache, chest pain

Retention of urination, dysuria, edema, puffiness, erythema

Chills and constriction in throat, chest pain, nose bleedblood-streaked feces

Convulsions, interstitial nephritis

Contraindications

Hypersensitivity to ampicillin, sulbactam and other beta-lactam antibiotics

Hypersensitivity to lidocaine

• infectious mononucleosis
• severe impairment of liver and kidney function

Lymphocytic leukemia

Pregnancy and lactation

Drug interactions

Allopurinol:in patients with gout receiving allopurinol, while using ampicillin, the risk of developing skin reactions will significantly increase.

Antibiotics from the aminoglycoside group: mixing ampicillin and aminoglycosides in vitro led to their significant mutual inactivation; in cases where these antibiotics are prescribed together, they should be administered in different areas and with a time difference between injections of at least 1 hour.

Anticoagulants: penicillins can change platelet aggregation and hemocoagulation parameters (enhance the effect of anticoagulants).

Drugs with bacteriostatic action (chloramphenicol, erythromycin, sulfa drugs and tetracyclines): simultaneous use should be avoided.

Oral contraceptives containing estrogen:reported cases of a decrease in the effectiveness of contraceptive drugs in women receiving ampicillin, which led to an unplanned pregnancy. Therefore, patients receiving ampicillin should use alternative or additional methods of contraception.

Methotrexate: the joint appointment of penicillins led to a decrease in the clearance of methotrexate and to an increase in its toxicity. Such patients should be closely monitored.

Probenecid: Simultaneous administration of probenecid leads to a decrease in the tubular secretion of sulbactam and ampicillin, which is reflected in an increase in serum levels of ampicillin and sulbactam and their longer retention in the blood, a lengthening half-life and an increased risk of toxicity.

Sulbactam is compatible with most intravenous solutions, but ampicillin and therefore sulbactam / ampicillin are less stable in solutions containing dextrose or other carbohydrates; it should not be mixed with blood products or protein hydrolysates.

special instructions

Serious hypersensitivity reactions may occur during the course of treatment with Ampisid for injection. Anaphylactic-type reactions are often observed in individuals diagnosed with sensitivity to various allergens, including penicillins and cephalosporins. Before starting therapy, the patient is subject to a thorough examination. In the event of an allergic reaction during treatment, the drug is stopped immediately, after which the treatment continues with antihistamines, corticosteroids and pressor amines. If serious anaphylactic reactions occur, urgent treatment with epinephrine, oxygen and corticosteroids may be required.

During prolonged therapy with the drug, it is recommended to periodically monitor the indicators of the function of internal organs, including the kidneys, liver and hematopoietic system. This is especially important for newborns (especially premature babies) and young children.

It should be borne in mind that, as is the case with any antibiotics, the number of resistant microorganisms may increase, which will lead to superinfection during treatment with Ampisid for injection. If superinfection is detected, the drug is stopped immediately, after which the necessary therapy is prescribed.

Since infectious mononucleosis is a viral infection, Ampisid should not be prescribed to treat it.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

The effect of the drug on the ability to drive and control cars has not been established.

Overdose

Symptoms:information on the toxic effects of ampicillin and sulbactam in humans is limited. Signs that occur during drug overdose differ significantly from its side effects. It should be borne in mind that high concentrations of beta-lactam antibiotics in the cerebrospinal fluid can cause dysfunction of the central nervous system, including seizures.

Treatment: ampicillin and sulbactam are removed from the blood using hemodialysis, therefore, in case of their overdose in patients with impaired renal function, in order to accelerate the elimination of drugs from the body, hemodialysis is recommended.

Release form and packaging

The drug is placed in a type III colorless glass bottle, sealed with a bromobutyl rubber stopper, crimped with an aluminum flip off cap.

7 ml of solvent is placed in a type I colorless glass ampoule.