The atopic march and the atopic triad. The essence of the concept is atopy, a description of the atopic march, emollients for a disease, treatment of children, adults and pets What is an atopic march

14.07.2020 Insulin

Allergic diseases have recently become common, second only to viral infections... Moreover, atopic pathologies occupy a leading position in both adults and children.

Skin atopy is a hereditary predisposition to the possibility of allergic reactions... In order to correctly approach the treatment of the problem, it is important to know the causes, manifestations and methods of diagnosing the disease.

Atopy: what is it?

The term "atopy" refers to the presence of a genetic abnormality in the body immune system... That is, there is a certain ability to produce an excess amount of antibodies (immunoglobulin E) to the action of various allergens. When these antibodies combine with allergens, a pronounced reaction is activated.

Therefore, it turns out that the immune system, due to excessive protein production, cannot function normally and perform its protective function.

And it is she who creates the prerequisites against which the symptoms of atopic disease appear.

What are the forms of pathology?

The atopic group consists of allergic forms of rhinitis, dermatitis and bronchial asthma, as well as hay fever (that is, a reaction to pollen). The disease begins in infancy with the onset of atopic dermatitis, which can gradually be supplemented by rhinitis or asthma. They are classic forms of atopy that last all year round.

Atopic rhinitis

"Allergic rhinitis" or atopic rhinitis is inflammatory process occurring in the nasal mucosa and caused by external stimuli. The disease often appears in childhood when the child is just starting to face various allergens. It can take place both seasonally and all year round. It all depends on the provoking factor.

The main symptoms of the disease include:

nasal congestion, due to which you have to breathe through your mouth;
violation of the sense of smell;
sneezing that occurs after contact with an irritant or in the morning;
swelling;
itchy nose;
lacrimation;
mucous, watery discharge.

Year-round atopic rhinitis is often complicated by secondary infections because mucosal edema clogs the sinuses.

The disease has a hereditary predisposition and occurs in children with a family history of urticaria, allergic asthma and other types of atopy. Therefore, a thorough history taking is very important in the diagnosis.

Dermatitis

Represents chronic illness skin caused by allergic exposure. The degree of spread of the disease will depend on the etiology and correctly selected treatment.

The primary elements of dermatitis are various skin rashes (spots, blisters, blisters). Other manifestations include:

swelling of the affected areas;
itching, the strength of which depends on the degree of irritation of the nerve endings;
in the area that has undergone inflammation, the temperature rises;
there is a burning sensation.

Otherwise, the symptoms are variable, they depend on the form of the disease and provoking factors.

Chronic dermatitis rarely acts as an independent disease, proceeding together with bronchial asthma, rhinitis or hay fever. Most women suffer from pathology (65% of patients). The main cause of dermatitis is genetic predisposition, especially in the female line.

Bronchial asthma - atopic form

Is a chronic lesion respiratory tract... This disease develops against the background of a genetic tendency towards atopy. And the provoking factor is the external influence of various non-infectious allergens (household, food, plant or animal substances).

Atopic asthma is often diagnosed in childhood and has severe allergic reactions. Pathology is striking in most cases of boys. The first symptoms can appear from the second year of life. There is an asthmatic attack of suffocation, accompanied by sneezing, nasal congestion, dry cough.

With prolonged contact, seizures can last throughout the day. This poses a threat to the patient's life due to respiratory failure or impairment heart rate... Bacterial infections can also be complications.

Urticaria, hay fever, Quincke's edema

Other common allergic manifestations resulting from the immune system's reaction to contact with external stimuli include:

Quincke's edema is a lesion of the deep layers of the dermis of a localized and acutely developing nature. During an allergic reaction, mucous membranes are affected, the temperature rises or arterial pressure, there is a chill, abdominal pain, nausea. In the future, there may be disruptions in the work of various organs or systems. The most negative developmental option is anaphylactic shock, accompanied by a sharp decrease in pressure and impaired blood supply internal organs.
Hives is a condition in which a rash appears on the skin. The appearance of hives is preceded by contact with an allergen (to food or medications). The reaction begins with severe itching when the affected skin is scratched. Only after that a typical allergic rash appears, consisting of small blisters.
Pollinosis is a complex of atopic diseases provoked by plant pollen. Therefore, for character symptoms, seasonality and cyclicality. The main manifestations of hay fever include swelling or nasal congestion, itching, skin rashes, impaired sense of smell, dry cough, choking, and sneezing.

What is the difference between allergic and atopic dermatitis?

Distinguishing atopic dermatitis from other forms of allergy is difficult. Several symptoms can help in this matter:

The condition of the mucous membranes - during allergies, they become inflamed, and with atopy they turn red, but not inflamed.
Duration - redness caused by allergies will go away on its own in a few days. Only the itching of the affected areas can cause discomfort. Manifestations in atopic dermatitis do not go away without drug treatment... At the same time, indigestion occurs, weakness or dizziness is felt.
General well-being - the atopic form negatively affects nervous system, due to which there is a strong loss of strength, fatigue, decreased performance. These symptoms do not bother with common allergies.

There are differences between these concepts and in the mechanism of occurrence. Atopic dermatitis is of a genetic nature and is exacerbated by external influences. Whereas the allergic form is provoked by an allergen that enters the body along with food or air.

To treat allergies, it is enough to eliminate the provoking factor. Whereas with atopy, drug therapy is required, aimed at normalizing the functioning of the immune system.

Causes contributing to the appearance of pathology

Atopic allergy occurs due to a number of reasons, which include:

Allergic reactions can occur to any of these groups. The more factors influence the onset of pathology, the more severe the form of the disease will be.

"Atopic March": what is it?

There are three main allergic diseases: atopic dermatitis, runny nose (or conjunctivitis), and asthma. Each has a certain symptomatology. When they replace each other in stages, we are talking about an atopic march. Moreover, the trigger is skin allergy.

The characteristic features of the disease are:

the problem appears in early infancy;
atopic dermatitis further portends the appearance of conjunctivitis or rhinitis, after which asthmatic disease develops;
when analyzing blood plasma, elevated level immunoglobulin E.

All three types of diseases are part of the same process, therefore it is required complex treatment... With qualified and timely therapy started in childhood, the atopic march can be stopped.

Why does the skin suffer from pathology?

A disease such as atopy implies an increased sensitivity of the skin to allergens, which leads to a change in its protective properties. Therefore, even on minimal stimuli, hyperactivity of the skin is observed.

An exacerbation of the disease is facilitated by a violation of the epidermis, which most often occurs due to excessive dryness. Simultaneously appears severe itching... Violation of the integrity of the skin leads to the fact that irritating agents easily and quickly penetrate into the deep layers of the epidermis, causing an increase in the inflammatory response.

The reduced barrier function of the skin leads to the penetration of bacteria, fungi or viruses into the body, which only worsens the course of the disease. In addition, it is far from always possible to identify a provoking factor.

Symptoms of the disease in children and adults

Despite the decisive role of the hereditary factor in the onset of atopy, the symptoms of pathology can appear even in those children whose parents are completely healthy. Therefore, it is important to know the main atopic manifestations that are observed already in early childhood:

From the side of the skin - rashes appear on the skin, characteristic of dermatitis, urticaria or eczema.
In the oropharynx - the voice becomes hoarse, dry mouth is felt, Quincke's edema is possible.
Respiratory system - shortness of breath, persistent nasal congestion, bronchial cough is observed.
Neurological apparatus - with atopy, headaches, fainting or dizziness are possible.
Gastrointestinal tract - abdominal cramps, nausea, diarrhea, vomiting.
The cardiovascular system is characterized by the appearance of low blood pressure or arrhythmias.

It turns out that an atopic disease is characterized by both allergic symptoms and general disorders in the work of many internal organs. Since the external manifestations of pathology are immediately noticeable, it is important to immediately find the allergen and minimize contact with it.

Doctor Komarovsky: atopic manifestations in a child and infant

The well-known children's doctor Evgeny Komarov has repeatedly covered the causes of atopic manifestations in infants and the methods of their treatment. He believes that the symptoms of pathology occur in the first year of life. The insidiousness of the disease lies in its ability to mutate.

The main symptom of an allergic form of dermatitis is a skin rash: red or pink, rare or solid. She is accompanied by a strong itchy skin, which brings severe discomfort to the baby. The rash is concentrated most often on the face, arms or legs, in rare cases on the abdomen and chest.

Dr. Komarov notes that parents often consider atopic manifestations to be skin ailments. But this is not true, since the disease is based on a genetic factor.

Diagnosis of the disease

Identifying the problem begins with taking a family history. Methods for diagnosing atopy include the following activities:

Skin allergy testing - assesses the reaction of the skin to contact with different kinds allergens. For diagnostics, you can use a prick test, when the epithelium is damaged by a thin needle containing an allergen. Another type of examination is skin testing, when an applicator soaked in an allergen is applied to an intact skin area.
A blood test for immunological research, aimed at finding and determining the amount of a protein involved in allergic reactions (immunoglobulin E).

Any of these methods are used to make a diagnosis. If, as a result, the presence of a relationship between the increased production of immunoglobulin E by the body was not revealed, then the atopic nature of the disease is excluded.

Fadiatop for children: allergy or not, description of the allergen test procedure

One of the comprehensive studies designed for children under 5 years of age is Fadiatop. Its action is aimed at identifying the predisposition in a small child to allergic reactions to the main food or inhalation allergens. At the same time, during the study, the presence of atopy is revealed, after which the causative allergen can be looked for.

To perform the analysis, you will need to donate blood in the morning on an empty stomach, since the material for the study is serum. No special preparation is required before the test. It is enough that the last meal was at least 8 hours ago.

The Fadiatop test includes 11 different allergens that are most common in childhood. This diagnostic method allows you to identify the level of globulins not to one specific allergen, but to a whole group of provoking factors.

The quality and accuracy of the study is not affected age features, the state of health of the patient or his skin, as well as taking antihistamines.
Fadiatop is completely safe and perfect for children, since skin contact with the allergen is excluded (unlike skin tests).

Treatment for atopy in adults

Successful treatment of atopic diseases largely depends on the identification and elimination of the provoking allergen. For this, special attention should be paid to personal hygiene and thorough cleaning of the premises.

These measures will help reduce the risk of allergic symptoms, but will not cure the disease. Therefore, for atopy, two main therapeutic areas are used:

Maximum cessation of contact with the allergen and further control of the environment as a preventive measure.
Symptomatic treatment of allergic manifestations: taking medications, using local remedies, physiotherapy and diet therapy.

Medication is aimed at blocking and relieving symptoms and restoring the normal functioning of the immune system. For this, doctors prescribe antihistamines, homeopathic and immunomodulating drugs. If an adult patient experiences severe itching or sleep disturbances, medications that have a sedative effect are prescribed.

Dosage and selection medicines is individual, depends on the specificity of the disease and the state of the organism as a whole.

Disease therapy in children

For pediatric patients, the treatment of atopy focuses on the complete cessation of exposure to allergens. The basic principles of treatment of the disease in children consist of the following measures:

the appointment of antihistamines;
hypoallergenic diet;
anti-inflammatory ointments are used as local remedies;
sedatives are used to relieve itching;
with advanced forms, basic therapy is used, aimed at suppressing inflammation in the body;
when infections enter the body, antibacterial agents are prescribed;
are prescribed vitamin complexes aimed at strengthening the body as a whole.

Emollients: basic concept, what is their role in skin atopy?

In atopic dermatitis, the patient's skin is dry to the touch, with thickened rough areas of the epidermis. At the same time, reduced elasticity is observed. Therefore, such skin requires special care.

There are a variety of emollients, that is, moisturizers. These products do not contain classic medicinal substances... Fatty alcohols, fats, ethers, paraffin, wax, silicones - all these components are emollients. Their action is aimed at moisturizing the skin, as well as relieving inflammation.

Thanks to natural composition they help fight the following problems:

promote the rapid penetration of medicinal components through the layers of the dermis;
help fight infectious diseases skin, therefore, are actively used in the treatment of dermatitis;
moisturizing and increasing the elasticity of the dermis.

Since emollients are separate substances with different properties, they work together to give the best effect. But when choosing a drug, it is important to study the composition, since some auxiliary components can cause allergic reactions.

How often should the drug be applied to the skin?

With atopic dermatitis, the patient's skin becomes very dry. Therefore, the more often moisturizers are applied, the less it will be injured. Experts do not make any restrictions on the number of applications of emollients on the skin. They recommend using moisturizers as often as possible. The main thing is to monitor the reaction of the skin to the components that make up the drug.

Adult emollients

The pharmaceutical market offers a huge selection of emollients designed for any manifestation of atopy. Depending on the composition of the drug, the price will differ. A suitable emollient is selected by a specialist, since each of these funds has its own characteristics and principle of action on the dermis. Therefore, the selection takes into account the type of skin.

The list of drugs aimed at treating atopy in adults includes dozens of drugs from post-Soviet countries and foreign production. Among the huge selection of emollients, a good effect is noted in Trixer, Exomega, Topikrem, Exipial M, Lipikar. The use of these drugs is an indispensable component of the successful treatment of atopic dermatitis.

Children's drugs

With atopic dermatitis in children, emollients are one of the main remedies that help relieve unpleasant symptoms and moisturize dry skin. To choose the right remedy, you should contact your pediatrician. It will help you choose an effective, and most importantly, safe drug for baby's skin.

The most common emollients intended for young patients are Locobase, La Roche-Pose, Emolium, Mustella Stelatopia. They contain natural fats, paraffin, silicone, essential oils and wax, thanks to which you can relieve the symptoms of dermatitis and prevent relapse.

Emollients for newborns

Immediately after the birth of a child, parents are very careful about the choice of drugs. Therefore, for atopy in infants, experts recommend Topikrem, Physiogel, A-Derma milk or Dardia balm. These drugs treat dermatitis redness, nourish and restore the delicate skin of the baby. Milk A-Derma is perfect as prophylactic, especially in families with a burdened history.

Diet therapy for atopic dermatitis

The main direction in the prevention of atopic dermatitis is to eliminate potential allergens from the diet. These include:

citrus;
chocolate;
cow's milk;
nuts;
a fish;
sausages;
spices.

In the future, it is necessary to monitor the body's response to any new foods that are introduced into the diet. This is especially true for pregnant and lactating mothers with a history of atopic diseases.

Preventive measures of the disease in an adult and a child

The basis of preventive measures is the creation of such living conditions in which contact with the allergen is reduced to a minimum. Prevention measures include:

observance of personal hygiene;
exclusion from life of factors provoking pathology;
proper skin care using hypoallergenic products - includes cleansing, moisturizing and nourishing the skin;
adherence to a certain diet;
creating a certain home environment where provoking allergens will be excluded - for this, wet cleaning is regularly carried out.

Since atopy is a hereditary disease, it will not be possible to completely get rid of it. Therefore, it is important to control its course, adhere to the treatment prescribed by the doctor, and do not forget about preventive measures to prevent exacerbations.

Atopy in cats and dogs

Not only humans suffer from hereditary allergic diseases. This problem is widespread among our pets. Atopy in dogs or cats is a predetermined problem, as they are already born with genes responsible for the occurrence of allergic reactions to external stimuli. Animals with this problem are especially vulnerable in the first few months of life.

Causes of the disease

The main reason for the appearance of allergic reactions in animals is a hereditary predisposition. But the main provoking factor that triggers the development of the disease is contact with an allergen.

The disease can be triggered by pollen, some plant species, insects (for example, fleas, ants, ticks) or their waste products. Therefore, atopy in animals is most often a seasonal problem, which peaks in the spring and summer.

Signs and symptoms

Various allergens first enter the body of a dog or cat with a burdened heredity through the respiratory system, digestion, and skin. In response, the immune system triggers specific antibodies to fight off allergens. They are released in a huge volume, which leads to the appearance of inflammation, itching or swelling of skin areas. The condition is aggravated by fungal or bacterial infections.

Atopy in cats or dogs is similar to hay fever symptoms that occur in humans. The only addition is the fact that the animals also itch a lot. Unbearable itching is the main symptom that leads to severe scratching of the affected area. And this becomes an excellent environment for the penetration and reproduction of infections.

Other symptoms that a sick animal may experience include:

lacrimation, which can lead to conjunctivitis;
sneezing with clear nasal discharge;
a cough appears;
purulent wounds appear at the site of scratching.

Quite often, these symptoms are confused by the owners of cats or dogs with other diseases. And until the problem is recognized, it may take several months. This aggravates the condition of the animal, exacerbating its treatment.

Diagnostics

A thorough history and physical examination of the animal is required to make a diagnosis. After that, clinical analyzes of urine, feces and blood are carried out. Sowing is taken for fungal infections. Additionally, skin scraping and intradermal testing are performed. All these activities will help to exclude possible potential diseases of the animal.

Treatment of pathology in animals

The difficulty in treating a disease in animals lies in the variety of allergic or other external factors. This explains the differences in symptoms, as well as the unpredictability of the body's responses to treatment.

All therapeutic measures are aimed at relieving the symptoms of the disease. An integrated approach is required, including various interventions:

eliminate the allergen and minimize contact with it in the future;
antihistamines are used to relieve itching, for example, Suprastin;
in advanced cases, antifungal drugs are used;
topically treat the skin with creams (Nystoform, Travocort);
in parallel, appropriate treatment of the affected organs (eyes, ears) is carried out;
a constant hypoallergenic diet is prescribed for the animal.

Treatment of pathology for the animal is prescribed for life. Therefore, when selecting drugs, the veterinarian takes into account possible side effects.

How to control disease in your pet

Since atopy in pets is not curable, it must be carefully controlled. And although the pet owner is unlikely to be able to avoid all allergens, you can at least protect the animal from obvious provoking factors - dust, pollen, insects. To do this, special attention should be paid to the hygiene of the dog or cat, as well as the cleanliness of the room. At the onset of the allergy season, you need to prepare in advance - purchase medications and begin therapeutic measures when the first symptoms appear.

Atopy is a serious, and most importantly, lifelong problem for a person or animal. Therefore, to relieve symptoms and reduce the frequency of relapses, it is very important to choose the right treatment, adhere to the basic preventive methods and pay special attention to proper, hypoallergenic nutrition.

Hello dear readers! In today's article we are talking about what an atopic (allergic) march is.

When and how it appears, how it threatens the child, how it is treated.

What is the atopic march

Three allergic diseases, changing in stages, represent an atopic (allergic) march (one symptomatology is replaced by another).

The term "atopy" is almost a century old: it means an increased sensitivity to environmental factors.

Parents should be aware that not after any atopic dermatitis, the child will develop asthma after a while, but the risk is great.

Therefore, if manifestations of atopic dermatitis are noticed, the child should be immediately shown to a specialist.

The more pronounced the clinical picture of blood pressure, the more likely the next stage of the allergic march will occur.

An even greater risk of asthma is with rhinitis and conjunctivitis. Such an allergic disease is a mandatory reason for visiting an allergist with a child.

By the age of five, atopic dermatitis is most commonly diagnosed. Its progression may end in an atopic march.

Doctors state that the process can begin to form in the womb in order to manifest itself at an early age.

Allergic rhinitis subsequently affects two thirds of atopics, asthma affects about half of children with atopic dermatitis.

Skin allergy is the trigger for the allergic march. This is why proper treatment of AD can protect a child from developing asthma.

The atopic march in children can be slowed down or even canceled out by qualified therapy. It is important to start it in a timely manner and in no case self-medicate.

Characteristic features of the atopic march

With an atopic march, diseases progress from the earliest infancy. Atopic dermatitis is diagnosed in every fifth child born.

A third of atopic children from one to three suffer from allergic reactions to, in 40% of atopics develop a runny nose and conjunctivitis of an allergic nature after a year.

Of these babies, one in ten can get asthma by the age of five or six.

It is possible to highlight the features of the characteristic features of the disease:

Begins in infancy.
Blood pressure and intolerance to a number of foods can portend rhinitis with conjunctivitis, as well as asthmatic disease in the future.
The course of the developed asthma can be made easier. It is practically impossible to completely cure asthma that has already appeared.

A child with blood pressure and food intolerance is not necessarily asthmatic in the future.

However, such children must constantly be under the supervision of a specialist, undergo timely treatment... Preventive measures are also important.

Symptoms

The doctor diagnoses atopic march in a child if:

The skin is red, dry, excruciatingly itchy, and has a persistent rash.
Runny nose and conjunctivitis are year-round or seasonal. There is a lot of mucus in a stuffy itchy nose, sneezing is present, the child's eyes turn red and watery.
There are obvious symptoms of asthma: the child is breathing heavily, he has moments of suffocation, a prolonged cough,. In the case of a very serious course of the disease, shortness of breath occurs during exertion.
The concentration in blood plasma increases significantly. The number of antibodies to various stimuli is also significantly increased.

Complex therapy

To the parents' question: what is the atopic march? - the specialist will answer that blood pressure, rhinitis with conjunctivitis and asthma with an allergic march do not appear certain diseases, but by stages of one process.

If treatment for blood pressure is started without delay, the chances of stopping the march increase significantly.

Therapy may include:

Elimination of exposure to allergens and blood pressure triggers. The triggers of the disease are stimuli that are standard for atopics: mechanical, chemical, thermal, food.
Elimination of skin reactions (antihistamines are prescribed, due to the action of which the skin heals, allergic manifestations decrease; used local funds in the form of ointments, creams, gels; both internal and external medications can be non-hormonal or hormonal in the most severe cases).
Providing a hypoallergenic life for the child: diet, lack of contact with potential allergens (pollen, pet hair, personal hygiene products).
Cure chronic infections.
Hardening, increasing immunity.
Maintaining the period of remission of chronic diseases (gastritis, cholecystitis, pancreatitis, etc.)
Control over endocrine pathologies.

When treating AD, diet is very important in infancy. Any food is removed from the diet of an atopic child. high rate allergenicity (regardless of whether the product is a specific allergen for your child).

If the effect of an allergen known to the doctor cannot be ruled out, a specialist may prescribe ASIT therapy (allergen-specific immunotherapy).

At this method a small amount of an irritant or a group of irritants that are allergenic specifically to your child is regularly injected into the body. The body begins to slowly wean from allergens.

Treatment can last up to five years. You can start it after the child reaches the age of five. This can prevent the progression of the allergic march.

Autolymphocytotherapy

She is shown to children after five years. This method uses its own lymphocytes, which help restore immunity and reduce sensitivity to allergens.

Blood from a vein is used to obtain lymphocytes. One procedure requires no more than five milliliters of blood. Next, the vaccine, which is a mixture of lymphocytes and saline, is administered subcutaneously in the forearm.

The therapy regimen, doses, frequency of procedures are prescribed individually for each specific case. Doses are gradually increased. The course consists of six to eight sessions.

Normalization of the immune system, a decrease in sensitivity to stimuli do not occur immediately. The effect of therapy depends on the individual characteristics of the immune system.

It is important to remember

Atopic dermatitis, rhinitis and conjunctivitis of allergic origin, as well as asthma during atopic march, are not separate allergic diseases, but stages of one process.
The march begins with atopic dermatitis in early childhood, therefore, at the first signs of skin lesions, it is necessary to contact an allergist for timely correct treatment.
Skilled therapy can interrupt the atopic march and the child will not develop bronchial asthma.

See you in the next article!

Autolymphocytotherapy is the only treatment for the "atopic march" in children!

Children are treated with the "Autolymphocythotherapy" method after 5 years.

The method of "Autolymphocytotherapy", in addition to the treatment of "Atopic March", is widely used for: atopic dermatitis, urticaria, angioedema, bronchial asthma, allergic rhinitis, hay fever, food allergies, allergies to household allergens, to pets, allergies to cold and ultraviolet rays (photodermatitis).

ALT METHOD ELIMINATES INCREASED SENSITIVITY OF THE BODY TO SEVERAL ALLERGENS IMMEDIATELY, DIFFERENT FROM ASIT.

Grain pollen allergy

The essence of the ALT method is to use one's own immune cells - lymphocytes to restore normal immune function and reduce the body's sensitivity to various allergens.

Autolymphocythotherapy is carried out on an outpatient basis, in an allergological office as directed and under the supervision of an allergist-immunologist. Lymphocytes are secreted from a small amount venous blood patient in sterile laboratory conditions.

The isolated lymphocytes are injected subcutaneously into the lateral surface of the shoulder. Before each procedure, the patient is examined in order to individually prescribe the dose of the injected autovaccine. In addition to its own lymphocytes and physiological saline, the autovaccine does not contain any drugs. Treatment regimens, the number and frequency of injected immune cells depend on the severity of the disease.

Autolymphocytes are injected in gradually increasing doses with an interval between injections from 2 to 6 days. Treatment course: 6-8 procedures.

The normalization of the functions of the immune system and a decrease in the body's sensitivity to allergens occurs gradually. The extension of the hypoallergenic diet is carried out within 1-2 months. The abolition of supportive symptomatic therapy is also carried out gradually under the supervision of an allergist. The patient is provided with the opportunity of 3 free repeated consultations within 6 months of observation after the end of the course of treatment with the "Autolymphocythotherapy" method.

The effectiveness of treatment is determined by the individual characteristics of the immune system. This process, to a certain extent, depends on the patient's compliance with the recommendations of the allergist during the period of treatment and rehabilitation.

WITH possible contraindications you can find it on a separate page.

Ask a question to a specialist

The effectiveness of the treatment of individual symptoms of the "Atopic March" by the ALT method

SYMPTOMS	The frequency of the severity of clinical symptoms,%
SYMPTOMS		One year after the course of ALT treatment
Asthmatic status	45.5	4.5
Astmoid syndrome	70.5	11.4
	72.7	6.8
Conjunctivitis	59.1	2.3
Hay fever	59.1	29.5
Urticaria, Quincke's edema, atopic dermatitis	50.0	6.8
	18.2
Pharyngitis	13.6

A significant decrease in the level of total IgE was also established in 70% of cases, and a significant decrease in the level of specific IgE antibodies to household, pollen, food and fungal allergens, which is most pronounced in food and pollen allergies.

Benefits of treating atopic march with ALT

We treat the cause of the disease, not its symptoms

Minimum of contraindications

No hospitalization or interruption from work required

The course of treatment is only 3-4 weeks

1 procedure takes only 1-2 hours

It is possible to carry out treatment in the absence of persistent remissions

Autolymphocytotherapy can be combined with any symptomatic treatment

APPROVED BY THE FEDERAL HEALTH SUPERVISION SERVICE

How much does a child's treatment cost?

Cost of 1 procedure - 3700 rubles... The cost of a course of subcutaneous autolymphocytotherapy (6-8 procedures), respectively, is 22 200-29 600 rubles.

After a course of ALT within 6 months of observation by an allergist, 3 free consultations are held. If it is necessary to repeat the course of treatment for atopic march in a child, an individual system of discounts is provided.

Initial allergy screening is carried out in accordance with the standards of the Department of Health. Previous examinations and tests for IgE and allergens in other medical institutions are taken into account.

You can donate blood for allergens and IgE in medical centers where ALT is performed in 2020.

Allergologist-immunologist Loginina Nadezhda Yurievna will receive you in Moscow on a weekday

Fill out an application for an appointment

In children, atopic dermatitis is usually diagnosed within the first five years of life. With age, it progresses and can cause an atopic march.

The atopic march is called the sequence of development of atopic manifestations, when some signs disappear, and they are replaced by others.

In most cases, atopic dermatitis develops into bronchial asthma, and then into allergic rhinitis. These 3 interrelated diseases are called the "atopic triad".

Statistics show that half of people with atopic dermatitis are diagnosed with bronchial asthma over time (with a mild course of the disease, it occurs in 30% of patients, and in severe cases - in 70%), and two-thirds have allergic rhinitis.

Often, the formation of the "atopic march" occurs in the process of intrauterine development, and its manifestation is found in early childhood and does not disappear throughout life.

Symptoms of pathology

The "Atopic March" makes itself known:

redness and dryness of the skin, persistent rashes, constant itching;
perennial or seasonal rhinitis, which is expressed in the profuse formation of mucus, nasal congestion, itching, sneezing, possibly redness of the eyes and watery eyes;
asthmatic syndrome: heavy breathing and asthma attacks, prolonged cough and bronchospasm (with a severe course of the disease with physical activity shortness of breath appears).

A characteristic feature of the "atopic march" is high concentration in the blood serum of total immunoglobulin E (IgE). The rate can increase thousands of times. There is also an increased level of specific IgE antibodies to a variety of allergens.

Features of the treatment of atopic march

In the treatment of the "atopic march" asit therapy does not give results. Antiallergic drugs are also ineffective.

The only treatment for the disease is autolymphocythotherapy. But it can only be used when children reach the age of five.

Autolymphocytotherapy involves the use of one's own lymphocytes - cells of the immune system. They help restore normal immune function and reduce the body's sensitivity to allergens.

A session of therapy is carried out on an outpatient basis under the supervision of an allergist immunologist. Lymphocytes for the procedure are taken from the patient's venous blood under sterile conditions. For one session, 5 milliliters of blood is enough.

General patterns of age-related dynamics of allergic diseases

Allergic diseases, like everyone else chronic diseases, with age, change the clinical picture, severity. In addition, the spectrum of allergens and other factors provoking exacerbations is changing.

For each of the groups of diseases, there are peculiarities of age dynamics. There are also general patterns of age-related dynamics of allergic diseases.

Perhaps the most basic law of age dynamics is the impossibility of complete disappearance of allergic diseases with age.

There are no former allergy sufferers. This is partly due to the fact that the predisposition to atopy is caused, among other things, by hereditary causes, which, by definition, are irreparable.

Although the specific mechanisms of predisposition to atopy are not fully known, to date there are data on the genetic conditionality of various links of the allergic process, when combined, an allergic disease occurs against the background of the external environment (3).

Another important general trend in age dynamics is the tendency to expand the spectrum of sensitization, that is, the list of allergens that exacerbate allergic diseases. This is facilitated by the development between respiratory and food allergens.

For example, cross-allergic reaction between birch pollen and apple pollen allergens.

Also, an exacerbation of allergies can cause the presence of common antigenic determinants in different groups of inhalation and food allergens. vegetable origin(for example, profilins, the minor allergen bet v 6 birch pollen and a homologous protein in timothy pollen and a number of fruits).

However, the tendency to develop atopy in itself can cause the acquisition of sensitization to new allergens, regardless of the phenomenon of cross-allergy (1, 3).

In addition, it should be noted the inevitable progression of a number of allergic diseases, the addition of irreversible complications, an increased risk of severe allergic reactions and life-threatening conditions.

Below will be described the progression and increase in the severity of the course separately for each group of allergic diseases.

Allergic rhinitis

For year-round allergic rhinitis, as well as for all true allergic diseases, there is a risk of widening the spectrum of sensitization, the addition of sensitization to allergens against the background of existing house dust.

With a long course of persistent perennial allergic rhinitis in children, there is a violation of the development of the facial skull:

malocclusion,
arched sky
flattening of large molars (molars) (1).

Perhaps the most striking manifestation of the negative age-related dynamics of allergic rhinitis is accession.

According to statistics, this disease develops in 10 - 40% of patients with allergic rhinitis (1,7).

Hay fever

For pollen allergic rhinoconjunctivitis, as itself frequent manifestation the variability of the flow is characteristic depending on the year, the weather, prevailing in the season of pallination of causal plants, the content of pollen in the air.

With the prevalence of rainy cold weather in a certain year, the manifestations of hay fever may be less pronounced than in previous years or be absent altogether. This leads patients to mistakenly believe that self-healing from the disease has occurred.

However, in subsequent years with a predominance of sunny weather, symptoms recur with renewed vigor (3).

It should be remembered that a visit to a doctor for hay fever should not be postponed even with an apparent positive dynamics in the course of the disease, since pollen allergy is most characterized by an expansion of the spectrum of sensitization with an lengthening of the exacerbation season.

The reason for this is fast development cross-allergy to antigenic determinants common for different groups of wind-pollinated plants (1, 8).

As for year-round allergic rhinitis, pollinosis is characterized by the addition of pollen bronchial asthma (3).