1. Green color - Medicines are compatible
2. Red color - medications are not compatible
3. Yellow- You need to click on the yellow field and read the recommendation.

IMPORTANT! On compatibility is always checked existing substance in medicine, not the name of the drug.

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ATTENTION! Compatibility table is given exclusively for informational purposes and is not a guide to action, on all issues on the compatibility of drugs on therapy you should consult with your doctor. We are not responsible for questions about the compatibility of drugs on therapy. Thank you for understanding.

Inhibitor interaction direct action (HCV DAAS) and drugs used for cardiovascular diseases

Green: not detected clinically significant interaction
Yellow: You may need a dose adjustment and preparation time, additional control is required.
Red: Joint Reception of Preparations is prohibited

The table describes:
The interaction of drugs used in cardiovascular diseases: antiarrhythmic drugs (amiodaron, digoxin, freakinide, loyakalante), antitrombocytic drugs and anticoagulants (clopidogrel, Dabigatran, Warfarin), beta blockers (atenolol, bisoprolol, propranolol), calcium channel blockers (amlodipine, diltiazene, nifedipine), drugs for hypertension and Heart failure (Aliskairen, Kandesartan, Doxazozin, Enalapril)
and

Interaction of direct operation inhibitors (HCV DAAS) and immunosuppressants.
(Recommendations of the European Association for the Study of Liver Diseases)

The table describes:
Immunosuppressant interaction:Azatioprin, Cyclosporine, Etnercit, Everolimus, Mikophenolate Mofetil, Sirolimus, Tharolimus and anti-virus preparations of direct action against hepatitis C: SimePrevir, Daclatasvir, Sofosbuvir, Ladipasvir, combination of Wakeira Pak (ombitasvir + parityrevir + dasabuvir + ritonavir)
(Immunosuppressive drugs are used primarily when transplantation of organs and tissues, such as kidneys, heart, liver, light, bone marrow)

Interaction of direct operation inhibitors (HCV DAAS) and antiretroviral drugs (hepatitis C + HIV)
(Recommendations of the European Association for the Study of Liver Diseases)

The table describes:
The interaction of drugs for antiretroviral therapy HIV: Abacavir Abacavir, Didanosine Didanosine, Emtricitabine emtricitabine, Lamivudine Lamivudine, Stavudine stavudine, Tenofovir Tenofovir, Zidovudine zidovudine, Efavirenz efavirenz, Etravirine etravirine, Nevirapine nevirapine, Rilpivirine rilpivirine, Atazanavir Atazanavir, Atazanavir / ritonavir atazanavir / ritonavir, Darunavir / ritonavir darunavir / ritonavir, Darunavir / Cobicistat Darunavir / Kobitsistat, Fosamprenavir Fosamprenavir, Lopinavir Lopinavir, Saquinavir Savinavir, DoluteGravir Dolutegorvir, ElviteGravir / Cobicistat ElviTegravir / Kobicistat, Maraviroc Maravirock and anti-virus preparations of direct action against hepatitis C:SimePrevir, Daclatasvir, Sofosbuvir, Ladipasvir, combination of Wakeira Pak (ombitasvir + parityrevir + dasabuvir + Ritonavir).

Before taking any medications on therapy parallelly with Sofosubuvir Daclatasvir (LadaPasvir, Velpatasvir), it is necessary to see their compatibility. Some medications, such as some types of antibiotics, can reduce therapeutic therapeutic effect or can enhance side effects.

For example, drugs such as antibiotic levomecitin, riafampicin tuberculosis medicine, herbal infusions (St. John's wort, milk, etc.) will weaken the effect of Sofosbuvir, because their parallel use on therapy is not recommended.

On therapy is prohibited by the reception of any hepatoprotectors (terminal, Carsil, heptral, phosphoglyph.

Sorbents, such as activated carbon, polysorb and others, can be taken at least 3 hours before and after the reception of Sofosbuvir Daclatasvir.

Omeza, omeprosol must be taken at least 6 hours before or after intake of inhibitors.

Compatibility Database Instructions:

1. Green Color - Medicines Compatible
2. Red Color - Drugs are not compatible
3. Yellow color - you need to click on the yellow field and read the recommendation.

ATTENTION! Compatibility table is given exclusively for informational purposes and is not a guide to action, on all issues on the compatibility of drugs on therapy you should consult with your doctor. We are not responsible for questions about the compatibility of drugs on therapy.

Modern medicine is impossible without modern drugs. Unfortunately, some drugs have a dangerous couple - drugs that, when admission, cause side effects!

Antibiotics and oral contraceptives

Antibiotics - These are substances that are produced by alive organisms to destroy others. The first antibiotic was highlighted by Alexander Fleming in 1928, for which he received the Nobel Prize.
Since then, antibiotics have changed the life of humanity. Diseases that were previously a death sentence, learned to treat: pneumonia. , tuberculosis , meningitis and other infections. Precisely thanks to antibiotics there was a demographic explosion of the 20th century, when the population began to increase in geometric progression. Antibiotics are a real miracle of medicine.
Oral contraceptives. Regardless of the release form, the principle of operation of hormonal contraceptives is the same: change the hormonal background so that ovulation (exit of the egg from the ovary), and therefore the pregnancy becomes impossible. There is also another important action: they change the consistency of the mucus of the cervix, and it becomes impenetrable for spermatozoa. In addition to preventing unwanted pregnancy, hormonal contraceptives have a positive effect on the health of women as a whole: reduce the risk of breast cancers and ovaries, prevent the appearance of acne, make it easier for menstruation and so on.

The combination of these drugs can reduce the effectiveness of contraceptive pills, and you risk becoming pregnant. There are two reasons:
1. Microbes in the intestine improve the absorption of hormones. That is, the hormones remain longer in the body, and they are protected longer from unwanted pregnancy. Antibiotics destroy intestinal microbes, hormones are not absorbed, so a large number of hormones is simply lost with Calla.
2. Many antibiotics stimulate the work of liver enzymes, so they begin to destroy the hormones strongly. As a result, the concentration of contraceptives in the blood decreases, and together with it and the effectiveness of preventing pregnancy.

What to do
If you need to take antibiotics and contraceptives at the same time, then use condoms.

Loperamide and calcium

Loperamide (Imodium) is the most common cure for diarrhea. It is sold without a recipe under various brands. He reduces the motorcy and soothes the intestines, so you are less likely to go to the toilet. It should be emphasized that Loperamide cannot be used if diarrhea is associated with infection (that is, when fever is present, chills, poor well-being). In this case, the microbes will be lingering in the intestine, which is fraught with aggravation of infection.

Calcium It is part of two groups of non-receptible drugs:
1. Preparations for bones (in combination with vitamin D). He is accepted after menopause to reduce the risk of osteoporosis.
2. Antacids (preparations from heartburn) - calcium is part of some drugs that reduce the acidity of gastric juice.

Why is it dangerous to combine these drugs?
The main action of Loperamid is the braking of motorcycles. But calcium has a similar side effect! Therefore, the combination of these two drugs can lead to a very pronounced painful constor.

What to do
If you start taking Loperamide from diarrhea, take a break from calcium preparations, otherwise your diarrhea can change the constipation.

Verapamil and beta blockers

Cardiac aspirin and painkillers

Statins and Fluconazole.

Statins - Basic drugs to reduce cholesterol. They violate the production of cholesterol liver, so the liver is forced to recycle already existing cholesterol in the blood.
Fluconazole. (Flucostat, Diflucan) is one of the key antifungal drugs. First of all, it is effective against the candidiasis - thrush, which most often amazes the genital path and mucous meal.

Why is it dangerous to combine these drugs?
Statins are processed by liver enzymes. Fluconazole brakes the effect of these enzymes, which leads to excessive accumulation of statins in the body. In large quantities, statins can cause rhadomyolysis - muscle damage.

What to do
Since fluconazole is usually driving with short courses (from one to several days), it is advisable to cancel statins for this period.

APF inhibitors and spironolactone

ACE inhibitors (leasing, captopril, and other drugs with the end of "-pril") - The most important drugs to combat elevated arterial pressure.
APE is an enzyme that participates in the product of a substance called angiotensin II, which narrows blood vessels. ACE inhibitors block the products of this enzyme, as a result of which the vessels are expanding, and pressure decreases.
Spironolactone (Veroshpiron) - One of the most important drugs to combat heart failure. With heart failure, the heart works badly, it is difficult for him to pump large volumes of fluid. Spironolacton derives excess salt and fluid from the body, the amount of blood decreases, the load on the heart is reduced. In addition, this drug reduces the replacement of normal heart fabric on the scarsing, which will not work.

To check the interaction of medicines on the site or use the cloud service RLS ® to integrate with an automated medical information system (MIS).

Cloud Service "Interaction of Medicines"

RLS ® offers a new service for automated MIS. The service is designed to be embedded in the "Electronic Medical Card" module.

When prescribed by the doctor, the system automatically checks the interaction of drugs from the destination sheet, as well as with the appointments made by the doctors of other specialties.

The integration of the service in the automated MIS will allow:

• improve the quality of information support doctors;
• reduce the risks of erroneous appointments;
• increase the level of medical care.

Requires connection to the Internet, as well as the presence of radar ® drug nomenclature.

Certificate of state registration of the database "Interaction of Medicines V 1.0" No. 2014621047 of April 11, 2014

Services for MIS developers

RLS ® provides a modern way to obtain data on medical products using Web services located in the Microsoft Azure cloud system.
The service is designed to embed in MIS.

When integrating with the MIS service gets access to the following data:

• structured nomenclature information about medical products;
• extended descriptions of drugs, active substances, Bid, etc.;
• color images of drug packaging;
• barcodes (EAN codes), Roszdravnadzor codes;
• classifications for pharmaceutical groups, ICB-10, ATH, OKPD-2, etc.;
• tags accessories to different lists: ONLS (DLO), ZHHVLP, non-pressed vacation, narcotic drugs, potent drugs and others;
• monitoring prices for ZHHVLP with regard to regional allowances;
• checking the interaction of medicines.

• the creation of a single information space in the field of treatment of medical products;
• improvement of the system of monitoring the movement of medical products in the Regional Fragment of Echisz;
• maintenance of commodity accounting;
• centralized procurement of medical products;
• monitoring of rejected series of medicines and prices for ZHHVLP;
• building automatic reports;
• information and reference accompanying medical professionals;
• building decision support systems.

RLS-Patent LLC:

Kiberis is able to check the interaction and evaluate drug compatibility online directly in the instructions thanks to the latest artificial intelligence technologies. with an accuracy of more than 80%. Moreover, the medical online service takes into account all medication groups of selected drugs and all their components. And since the database contains 20,000 drugs with detailed instructions, not every pharmacologist will be able to compete with our artificial mind. You can check up to 15 drugs at the same time. List of popular interactions

Decoding colors of interactions and contraindications

You can click on such buttons to read more.
• No found - Kiberis did not find interactions between drugs, then they most likely do not interact.
• Dangerous! - pronounced negative interaction or contraindication that can be dangerous.
• Negative - negative interaction or by-effect, which can reduce efficiency.
• Positive - Interaction can sometimes be used as a positive (often needed a dose adjustment), or this is an indication of the drug.
• No - drugs do not interact, which is separately indicated in the instructions.
• It is unclear - the system could not pre-assess the danger.

The fact that the reception of any medicines should be kept strictly to the appointment of a doctor, it is known to everyone and everyone. But not many know that many drugs are absolutely incompatible with certain products. Meanwhile, it is necessary to own this information - this will help maintain the level of exposure to medicines on the body, will prevent the development of unwanted complications.

What can not combine drugs

This section contains information about which it is categorically impossible to combine the most common drugs.

Antibacterial drugs

Generally considered the most "capricious" drugs, most often when mentioning compatibility antibacterial drugs Meals and drinks are meant in view of the tetracycline row. They are categorically not recommended to combine with milk and dairy products - they are able to significantly reduce the effectiveness of the type of medication under consideration. It is worth refrangiving from acidic food and beverages - eliminate carbonated sweet-sour drinks, natural juices, fruits, dry wine, dishes using vinegar and lemon juice. Be sure to give up any alcoholic beverages.

Anticoagulants

Preparations that help can not be combined with Brussels and cauliflower, walnut nuts, zucchini, birds and animals, cranberry juice, any fatty food. The fact is that the listed products have a direct opposite effect on the composition of the blood, due to the high content of potassium in them. By-effect In violation of these recommendations, there will be suddenly developing bleeding.

Package preparations

Pyramidon, amidopin and other drugs with anesthetic effects doctors are not recommended to combine with smoked products. The action of these medicines will be generally reduced to no, there will be no relief from pain syndrome.

Antidepressants

In such drugs, the monoaminoxidase inhibitor is contained, so it is impossible to combine them with cheeses, sauerkraut, soy sauce, and bird, yogurt, dried fish, sour cream and raisins. All listed products are contained in large quantities - this substance in combination with the monoaminoxidase inhibitor has a negative effect on the level. arterial pressure, sharply increasing it.

If therapy is performed against iron deficiency anemia Or these drugs are used as prophylaxis, it is better to abandon the use, tea, any, all dairy products, flour and sweet products. These products will complicate the absorption of iron into the body and the necessary therapeutic effect The patient will not receive.

Many are driving it with milk, hoping that in this way the negative impact on the gastric mucosa will be reduced. But with a combination of milk with aspirin, the latter loses absolutely all its properties - there will be no effect on its reception.

Should not be eaten when taking aspirin acidic products and drinks - it will be stronger bad influence on the gastric mucosa, can lead to the development of gastritis and peptic disease stomach.

Diuretic drugs

It should never be combined with the diuretic drugs and means based on licorice root (for example, expectorant means) - this can lead to reinforced removal of liquid and potassium from the body, which will end with dehydration and muscle destruction.

But consider one feature of the presented medicinal preparations - Under their influence from the body, potassium is derived, its stocks must be replenished. Currently for this kuraga, beets, apples, onions, sorrel and green peas.

Statins

These are drugs that contribute to the elimination of harmful cholesterol from, and they should not be combined with citrus fruits. Substances contained in such products block the production of liver enzymes, which can lead to an increased concentration of statins in the body. And this is fraught with the destruction of muscles and disruption of the functionality of the liver.

Anthoreshotoids

All drugs from the specified group of medicines are very aggressive affect the gastric and intestine mucosa. That is why for the period of use of anthortsatoid drugs, it is necessary to strictly adhere to a diet that implies an exception from the diet of fried mushrooms and in general any dishes prepared by roasting, vegetables are raw, fruits, fish and meat broths.

Sulfanimida

These drugs that have anti-inflammatory and antimicrobial actions and are categorically impossible to combine with animals and bird offal, sugar and any sweets in general, any greens, fatty foods. Sulfanimiamids cause the suppression of the functionality of the kidneys - the process of urinary is disturbed, so it is necessary to drink a lot of clean water to drink a lot of clean water under consideration of the drug group in question (not coffee, not tea!). Fats and sugar violate the processes of digestion, which automatically reduces the effectiveness of sulfonamide.

APF inhibitors

These drugs are prescribed with elevated arterial pressure and as vessels. If these drugs are contained in the body in large quantities, it can lead to a sudden stop of the heart. At the time of the reception of the drugs under consideration, it is necessary to prevent HTTPS chocolate from the diet from the diet: // Site / Shokolad-Polza-i-Vred /, Kuraga, Potatoes, Bananas and Greens.

Bronchievous drugs

We are talking only about those manufactured on the basis of theophylline. If they were assigned to the attending physician, then from the menu you need to immediately exclude any food that is rich in carbohydrates.

Drugs lowering blood pressure

It is not recommended during the reception of this group of medicines to enter salted fish, sausage and ham. These products contribute to the decrease in the effects of drugs - reduce blood pressure is unlikely to succeed.

Warfarin

This medication doctors are prescribed for prevention. In no case cannot be used simultaneously with warfarin cranberry juice and it is generally desirable to abandon acidic drinks and products - such a combination increases the risk of gastric and intestinal bleeding at times.

Semi-synthetic penicillins

They relate to the group of antibacterial drugs, but specifically penicillins semi-synthetic can not be combined with orange juice, tomatoes and black coffee - these products and drinks significantly reduce the effectiveness of drugs under consideration.

Antifungal drugs

Everything is simple here - under the ban there are milk and all its derivatives, including cheeses and cottage cheese. It is these products that contribute to the growth of fungal colonies, and the effectiveness of the drugs under consideration comes on.

The effect of drugs on the action of drugs

What are usually sick pills, capsules and elixirs with syrups? Someone prefers juices, someone - tea, and someone and milk. But you need to understand that there are contraindications of simultaneous drinking drinks with some drugs.

This drink contains a lot of tannin - a substance that forms insoluble compounds with many drugs, and the result becomes the ineffectiveness of therapeutic measures. It is especially dangerous to drink tea antispasmodic drugs and heart glycosides.

Alcohol

First, it is strictly forbidden to be used simultaneously with the reception of antibacterial drugs (antibiotics). Secondly, if you use vasoconducting drops into the nose, the simultaneous use of alcohol can lead to a stroke. Thirdly, alcoholic beverages in the state of violate heartbeatif used on the background of receiving diuretics and heart glycosides.

In general, alcohol and any drugs are absolutely not compatible! Even a conventional paracetamol, safe and effective at different ages, under a glass of alcohol can lead to acute renal failure.

This drink acts on drugs in different ways. For example, coffee should not be used simultaneously with sedatives and antidepressants - anxiety may occur, a feeling of anxiety and fear, insomnia. Coffee is able to strengthen both the effect of psychoregulators, but in general it is worthwhile that if the coffee is used simultaneously with antibacterial drugs and contraceptive pillsYou can expect a large cluster of caffeine in the body, which ultimately leads to a violation of the activities of the central nervous system.

Grapefruit juice

This is generally a very harmful "thing" when conducting therapy of any level. In general, grapefruit (at least in a holistic form, even in the form of juice) is combined with single representatives of drugs. It is this product that is capable of increasing the toxicity of antibacterial drugs, provoke a sharp decrease in blood pressure on the background of taking antihypertensive drugs.

Note: Doctors insist on the fact that any drugs need to be littered with clean water.

Products that improve the effect of drugs

No need to think that when using certain medicines, the diet should be adjusted only towards the exception of some foods. Experts argue that there are those dishes, products that must be administered to the diet when conducting therapy by those or other drugs. It is worth remembering the following nuances:

1. The effect of taking antibacterial drugs (antibiotics) will be significantly increased, if we enter vegetables, fruits, nuts and fresh juices into the diet. But after the end of the course of treatment, antibiotics need to drink every evening a cup of kefir - this will help to quickly and fully restore the intestinal microflora.
2. If you are forced to take antitumor drugs, then there must be a liver of birds and animals, strawberries, fish, carrots, dill. By the way, it is in the case of passing therapy with such drugs can use dry red wine, but only after consulting with the attending physician and in small quantities.
3. Take the laxatives - combine them with, spinach, zucchini, wholegrain bread, fresh cucumbers and sweet plums. Of all the most useful, the spinach is spinach - with the laxative means it quickly and effectively improves, stabilizes the intestinal peristalsis.
4. Preparations of vitamins A, B, E and D can be safely complemented by oily foods - it will contribute to the rapid and full absorption of drugs.
5. Nicotinic acid will be more effective if during its use to introduce fish of skinny varieties, cottage cheese, eggs chicken and quail, meat into diet.