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Timur A worthwhile vaccine this Grippol +

Thanks to Grippol +, I forgot what it means to have the flu and to get sick somehow became less, a couple of times a year with acute respiratory infections, bronchitis once was, the tooth was treated, nothing more. I learned about the drug for prevention from a friend, we were on the train, talked about life, about sores, I told her what severe flu transferred. He tells me that ... Thanks to Grippol +, I forgot what it means to have the flu and to get sick somehow became less, a couple of times a year with acute respiratory infections, bronchitis once was, the tooth was treated, nothing more. I learned about the drug for prophylaxis from a friend, we were on the train, talked about life, about sores, I told her what a severe flu I had. He tells me that the grandson is a pharmacist in the pharmacy, that the Grippol + vaccine has been actively purchased for a year. It is produced by a domestic company, the composition is sparing, there is no live virus inside at all. I also decided to try it once praised. There is no reason not to trust doctors. Now I don't have the flu and I recommend it to my friends

The vaccine has shown itself with better side

Brother last year I did Grippol + in the clinic, and the vaccine showed an excellent result, he was not sick. This year and I decided to go the beaten track. In early September, as soon as the vaccination began, we are both in the forefront of the vaccination. The procedure itself is absolutely painless, I personally have not experienced any negative emotions, only satisfaction ... Last year my brother did Grippol + at the clinic, and the vaccine showed an excellent result, he was not sick. This year and I decided to go the beaten track. In early September, as soon as the vaccination began, we are both in the forefront of the vaccination. The procedure itself is absolutely painless, I personally have not experienced any negative emotions, only satisfaction from the fact that now it is under the protection of deadly dangerous disease... The drug, as I read and know, begins to work, namely, forms immunity to influenza a couple of weeks after vaccination, so this period is better to avoid crowds of people.

Аlya "Convenient" vaccine

Grippol + did the second time. The syringe dose is convenient. I must say right away that I did not feel anything. The injection does not cause pain at all. And in the team, no one had adverse reactions after vaccination. Those who were vaccinated did not get the flu. There was definitely not a single case of influenza infection in my department. Ever since ... Grippol + did the second time. The syringe dose is convenient. I must say right away that I did not feel anything. The injection does not cause pain at all. And in the team, no one had any adverse reactions after vaccination. Those who were vaccinated did not get the flu. There was definitely not a single case of influenza infection in my department. Since then, I have chosen only the domestic vaccine, I will not tolerate any foreignism. Protection against 3 strains is guaranteed, and the load due to the lower amount of antigen is lower. Vaccination really helps me, so I will do it again, prevention is protection from a disease that is deadly with its complications.

Sofia Statistics don't lie

My personal statistics showed that after the Grippol + vaccination, there were never any flu infections, and the main thing for me is that the children did not have the flu, I’m fine, but it’s a pity for them when the temperature is wild. This vaccine is very easily tolerated in my children, there were absolutely no local reactions. I read the negative and ... My personal statistics showed that after the Grippol + vaccination, there were never any flu infections, and the main thing for me is that the children did not have the flu, I’m fine, but it’s a pity for them when the temperature is wild. This vaccine is very easily tolerated in my children, there were absolutely no local reactions. I read the negative and bewildered. To each, of course, his own, and every year I vaccinate my children with Grippol +. I myself go to the hospital for vaccinations. But if they were offered somewhere at work, I would have done without thinking, the time savings are capital. And money, of course.

Evgeniya We are not afraid of infection

When I sent the child to kindergarten for the first time, the first year she had been ill many times, every 2 weeks at home, we go for 1 week and then we get sick. In September I did the Grippol + vaccine, and never regretted it. We don't get the flu after this vaccine. This moment is very memorable to me. After that, I vaccinate annually -... When I sent the child to kindergarten for the first time, the first year she had been ill many times, every 2 weeks at home, we go for 1 week and then we get sick. In September I did the Grippol + vaccine, and never regretted it. We don't get the flu after this vaccine. This moment is very memorable to me. After that, I vaccinate every year - we don't have the flu consistently. I made my daughter half a year old last year, and myself and my husband. We are not sick and happy immensely. Now we have done the same and we are not worried, we can go to the cinema, and to the theaters, we are not afraid of the infection. I recommend to parents of children, take care of children, prevention is salvation from a dangerous disease.

For children and adults!

For children and adults

I did Grippol + for children and myself with my husband. I AM medical education I have, I work in a hospital and therefore I managed it on my own. Everything is as it should be. I measured the temperature, the preparation withstood up to room temperature, pricked, rubbed with alcohol, and watched the state of health. My daughter had a slight redness, but I think she rubbed it herself, because in the morning ... I did Grippol + for children and myself with my husband. I have a medical education, I work in a hospital, and therefore I managed it on my own. Everything is as it should be. I measured the temperature, kept the drug up to room temperature, pricked it, rubbed it with alcohol, and watched my health. My daughter had a slight redness, but I think she rubbed it herself, because in the morning the pen was clean. Immunity sets in after about 10 days, so we took care of it a little. For a year they were not afraid of the flu. I think Grippol + is safe and effective. Children and adults can do.

Annushka Mom, thank you very much!

She was not going to get vaccinated against the flu. But my mother is very persistent. All summer, every single day, I repeated how important it is to get a flu shot. Just for the sake of this, I went in early September and took root for free Grippol +, at the hospital by registration, under the policy. I did not choose the drug, the doctors still have some kind of trust ... She was not going to get vaccinated against the flu. But my mother is very persistent. All summer, every single day, I repeated how important it is to get a flu shot. Just for the sake of this, I went in early September and took root for free Grippol +, at the hospital by registration, under the policy. I did not choose the drug, the doctors still have some kind of confidence. Later I read about this drug, it turned out that the vaccine was cleared of harmful additives and even without preservatives. I didn't have the flu, thanks to my mom.

Milena For the whole family

Grippol + is done by the whole family. That year, the vacation fell in the fall, and in order not to spoil it, and to protect the body from the terrible flu, they decided to get vaccinated. The children are brave, no one cried, they even amused everyone, I’m funny, they are clever like adults. The nurse got caring, courteous. And I measured the temperature once again, and ... Grippol + is done by the whole family. That year, the vacation fell in the fall, and in order not to spoil it, and to protect the body from the terrible flu, they decided to get vaccinated. The children are brave, no one cried, they even amused everyone, I’m funny, they are clever like adults. The nurse got caring, courteous. And I measured the temperature once again, and joked with the children. I'll tell you my feelings. There was no pain during the injection and administration of the drug, everything was so fast that I did not have time to recover. In the future, we all had no side effects. We rested well and did not get sick, we liked it, we will graft on again.

Container Excellent portability and reliable protection

The enterprise carries out mass vaccinations for all employees annually. I have never had the flu, quite often before. There are nozzles, but the vaccine and the symptoms of ARVI relieves. The advantages of Grippol + are that they give us the vaccine for free, additional protection against influenza infection appears, the drug is absolutely safe. In addition, a domestic manufacturer annually updates the composition of the vaccine .... The enterprise carries out mass vaccinations for all employees annually. I have never had the flu, quite often before. There are nozzles, but the vaccine and the symptoms of ARVI relieves. The advantages of Grippol + are that they give us the vaccine for free, additional protection against influenza infection appears, the drug is absolutely safe. In addition, the domestic manufacturer annually updates the composition of the vaccine. There are no shortcomings, the only thing that last year after the vaccination was a slight malaise, it passed after a couple of hours. So I am completely satisfied with the drug, and I recommend it to everyone, the main thing is to discuss it with your doctor first.

Aleksa The best of the best)

She was previously vaccinated with Influvac. Nice, but getting it is a quest. But, here in the clinic they offered me our Grippol +. I read a lot of controversial opinions on this drug, against the flu. Each coin has two sides, and so does this vaccine. It helps, but only for the flu. Not from ARVI, pharyngitis, ARI - it will not save ... She was previously vaccinated with Influvac. Nice, but getting it is a quest. But, here in the clinic they offered me our Grippol +. I read a lot of controversial opinions on this drug, against the flu. Each coin has two sides, and so does this vaccine. It helps, but only for the flu. Not from ARVI, pharyngitis, ARI - it will not save. All this has nothing to do with this vaccine. Many people doubt why the vaccine should be done if I get sick anyway. Yes, you can hardly protect yourself from colds, you can not get away from snot and cough. But the main disease, which can lead to fatal complications, will be avoided. So away doubt, go and create a barrier against the flu.

Michael And grandfather frost needs to be vaccinated)

I work in a drama theater, but on New Year's holidays I always earn extra money as Grandpa Frost. How many people are around, and the kids are on New Year! And many of them sneeze, cough, blow their nose, that is, they have the flu. Well, who wants to get the flu. And there is no time to get sick either, especially for me, when it’s time to earn income. So Grippol took root ... I work in a drama theater, but on New Year's holidays I always earn extra money as Grandpa Frost. How many people are around, and children for the New Year! And many of them sneeze, cough, blow their nose, that is, they have the flu. Well, who wants to get the flu. And there is no time to get sick either, especially for me, when it’s time to earn income. So Grippol Quadrivalent took root. So that 100%, from 4 virus stamps to be protected. There were no side reactions, and somehow I feel more confident. And, well, Snegurochka, too, dragged on for vaccination. I resisted, did not believe. But now, when she realized that she was not sick, she says that this fall she will take root for the company.

Kirill I was grafted, and glad

Good old flu) I remember they gave me this vaccine in the clinic. Who would not say that the drug worked normally. People did not get sick. Now they don't seem to let him out. There is only flu plus and the new flu quadrivalent formula. Here I was the last to take root in October. Since then, I have not been sick. Thanks to our ... Good old flu) I remember they gave me this vaccine in the clinic. Who would not say that the drug worked normally. People did not get sick. Now they don't seem to let him out. There is only flu plus and the new flu quadrivalent formula. Here I was the last to take root in October. Since then, I have not been sick. Thanks to our therapist for talking about the benefits of this vaccine. I didn’t even know how cool it was: there were no preservatives or antibiotics and protection against 4 types of viruses. And other domestic manufacturers are preparing drugs that protect against 3 types of influenza virus. There are probably foreign ones, which are also from 4x, but we do not have them in our country, so in this regard, the quadrivalent is unique

Reviews: 14

Since 2006, the Grippol Plus vaccine has been included in the routine immunization schedule. In 2009, it was allowed to be used on children, and since 2014 it has been used for vaccine prevention of pregnant women.

Let's find out what kind of vaccine it is, how it is used, is it tolerated, does it have side effects, can there be an allergy after application? How does Grippol Plus interact with other drugs, and does it have analogues? Below we describe the instructions for the use of "Grippol Plus" in accessible language.

Vaccine characteristics

"Grippol" differs in that it contains the immunoadjuvant polyoxidonium, which has the property of binding to influenza viral antigens.

Grippol Plus is an improved inactivated influenza vaccine called Grippol. What are the differences between Grippol and Grippol Plus? The vaccine "Grippol Plus" does not contain a preservative, so it can even be used by pregnant women and children.

The manufacturer of Grippol Plus is the Russian NPO Petrovax Pharm. This pharmaceutical company holds exclusive rights to the vaccine. Registration number of the drug - LSZ-006981/08.

Grippol Plus is an inactivated influenza trivalent polymer-subunit vaccine. It contains antigens of influenza A and B viruses. The vaccine strain was grown on chicken embryos. The drug also contains an immunoadjuvant - azoximer bromide. Usually "Grippol plus" from swine flu contains one antigen of the influenza B virus and 2 antigens - strain A. The composition of the antigens of the drug changes annually depending on the current strain of the virus, according to WHO.

Composition of "Grippol plus" in 1 dose:

• viral strain type A (H1N1), 5 μg;
• virus strain A (H3N2), 5 μg;
• viral strain type B, 5 μg;
• polyoxidonium 500 mcg;
• buffer solution 0.5 ml.

The immunogenic efficiency of Grippol Plus is 75–95%. That is, immunity is developed in so many vaccinated people. Influenza virus antibodies are produced after 1–2 weeks and persist for 12 months. Polyoxidonium, which is part of the preparation, enhances the immunogenicity (the ability to develop immunity) of the vaccine and the stability of antigens.

Release form and storage rules

The vaccine preparation is produced in dosage form- suspension, applied intramuscularly and subcutaneously. It is produced in disposable syringes with an atraumatic needle. The drug is also produced in ampoules and sealed vials. Packages are completed with 1, 5 or 10 syringes, ampoules or vials.

Storage conditions "Grippol plus" are as follows.

1. The drug is transported at a temperature of 2–8 ° C in a closed container. Transportation at a temperature of 25 ° C is possible for no longer than 6 hours.
2. Storage temperature 2-8 ° C.
3. The vaccine must not be stored in the freezer. In case of violation temperature regime the drug should not be used.
4. The shelf life of the drug is 1 year.

After the expiration date, the drug is not used. Do not use a drug with cracks in the vial or ampoule, as well as with a discolored vaccine.

How the Grippol Plus vaccine is used

Flu shots are given in September or October. At what age can the vaccine be used? - according to the instructions for the use of "Grippol plus", infants begin to vaccinate with this drug starting from 6 months.

The age dosage regimen is as follows.

1. Children from 6 months to 3 years old are vaccinated twice. The second inoculation is given 3-4 weeks after the first injection at a dose of 0.25 ml intramuscularly into the anterolateral part of the thigh.
2. "Grippol plus" is administered to a child from 3 years of age and adults as a single injection into the muscle or subcutaneously 0.5 ml into the upper outer part of the brachial muscle.
3. Patients suffering from immunodeficiency diseases are given 2 vaccinations with a break of 3-4 weeks.

On the day of vaccination, the drug is kept at room temperature and shaken before administration. The ampoule and bottle are opened, observing the rules of sterility. When vaccinating young children, half the dose is squeezed out of the syringe, after which the remaining 0.25 ml of the vaccine is injected. The injection site is wiped with a cotton swab with alcohol. After opening the bottle, the drug is not stored.

Indications for use

Vaccination is indicated for adults and children for specific prophylaxis of seasonal and swine flu. Mandatory vaccinations according to the National Calendar make the contingent at an increased risk of infection and complications:

Elderly people are given vaccinations without age restrictions. This category of people is at risk of complicating the disease in case of influenza infection.

Vaccination of pregnant women

According to available research data, "Grippol Plus" does not have a harmful effect on the fetus and embryo. The vaccine is safe during pregnancy because it contains no preservatives.

Since 2014, this drug has been used to vaccinate pregnant women. However, on a case-by-case basis, the decision to vaccinate during pregnancy is discussed with the doctor based on the risk of contracting the flu and the potential for a reaction after vaccination.

The safer period for vaccination of a pregnant woman is the II and III trimester of gestation. The Grippol Plus vaccine can also be vaccinated during breastfeeding.

Contraindications

Delayed contraindications for the use of "Grippol Plus" are possible in the case of acute respiratory infections with fever. In this case, the vaccination is done 1 month after the infection. Aggravation chronic illness- this is also a reason to postpone the vaccination until remission.

Permanent contraindications for Grippol Plus:

• allergy after the previous vaccination "Grippol plus";
• individual intolerance to the vaccine or its components;
• chicken protein allergy.

In the case of a mild intestinal disorder, the vaccination is postponed until the temperature returns to normal. Diseases nervous system and mental disorders are not a contraindication for vaccination.

Side effects

Grippol Plus is a highly purified product. The vaccine is well tolerated by children and adults. Most often, even local reactions do not occur after vaccination with the Grippol Plus vaccine.

According to the instructions for use of "Grippol Plus", the following side effects are allowed:

Some people are interested in the question of drinking alcohol after the Grippol Plus vaccination. The vaccine temporarily weakens the immune system as it forces the body to produce antibodies against the flu. Alcoholic drinks also reduce immunity. This unproductive "fellowship" suppresses the immune system and increases the risk of an allergic reaction. In addition, the presence of polyoxidonium in the composition of the vaccine preparation is a contraindication for alcohol consumption.

What to do before and after vaccination

For 3-4 days before vaccination, do not take new meals, as well as food allergens. Do not introduce new complementary foods to an infant. Avoid vitamin D, which is responsible for calcium production in the body, 4–5 days before vaccination. An imbalance in calcium increases the risk of an allergic reaction after vaccination. If you are prone to allergies, do not take "Suprastin" before and after vaccination - this drug dries out the mucous membrane respiratory tract, which promotes infection by viruses and bacteria. Instead of Suprastin, take Fenistil or Claritin.

On the day of vaccination, do not rush to leave the clinic immediately after vaccination. Sit near the vaccination room for another half hour. In case of complications, you will be quickly assisted.

Dangerous symptoms in case of immediate allergy:

If these signs appear, see your doctor immediately.

When you come home, do not wet the vaccination site. You can swim the next day, but you cannot rub the injection site. Eat light and low-calorie foods for 2-3 days after vaccination, and avoid foods containing allergens. These measures will reduce the risk of allergy after vaccination in susceptible individuals.

Interaction of "Grippol plus" with other drugs

Vaccination "Grippol Plus" can be combined with other inactivated and live vaccines, except for BCG and rabies. In this case, vaccinations are done in different parts of the body and with separate syringes.

The Grippol Plus vaccine can also be used during the treatment of a chronic illness with basic drugs.

Immunization of people with HIV infection and immunodeficiency states is not effective enough.

Analogs

Similar "Grippol Plus" vaccines are inactivated drugs against influenza of foreign and Russian production:

In all of the listed inactivated vaccines, the virus strains change annually according to the WHO recommendations.

In conclusion, we recall that "Grippol Plus" has been the official vaccine of the national vaccination calendar since 2006. It is a highly purified inactivated vaccine that is effective against influenza and is well tolerated. The drug does not contain preservatives and mercury. The Grippol Plus vaccine is harmless to children and pregnant women.

You can rate the article:

The child was given fluarix and neo flu a few years ago and there was no reaction. And the reaction to influenza plus was in contrast to a large number of children at school who did not have a reaction. The temperature was knocked down. Several fruitless hours trying to bring down the temperature and within an hour the temperature dropped from 39.2 to 36.3: happiness returned to the house. To find out what was the trick of this vaccine, but we will not do it again. Nafig-nafig.

09/07/19 got the Grippol Plus vaccine. Child 2.7, i.e. 32 months The annotation indicates that from 6 to 35 months. this drug injected twice, half a dose, and my child was injected with the entire vaccine at once. 09/08 a runny nose, sore throat appeared. I also took root and I feel unwell, there was a sore throat and headache... The question is, is it not dangerous for the child to exceed the dose? Maybe, who knows, write ...

After 8-9 days after this vaccination for a couple of days, the temperature rose to 37.2, the snot, as if from a bucket, the head was wildly splitting (as at 39). In general, the same flu, only in the easy form... I did it in a mobile station near the metro.

After vaccination, it swelled slightly.

We have been vaccinating for several years - everything is fine！

I have had mild side effects from many of the vaccines. Most often, swelling at the injection site or mild fever. And after Grippol plus this was not. And it's a sin to complain about the effect. A year has passed since the vaccination, and I still did not get sick. Although earlier, as it began to get colder on the street, I was one of the first to leave for sick leave with the flu).

And I was vaccinated with Grippol +. I endured it without any problems. No itching, swelling, or fever. So it's more of an individual response. Maybe intolerance to the composition or protein, but the vaccine is no longer to blame. There are no complaints about the effect either. I'm sick less now. And this year already Grippol Quadrivalent tested it on myself. From the description, it protects against four types of influenza, not three like other vaccines.

Get an annual influenza vaccination preventive measures highly desirable. Doctors say that the epidemiology of influenza is becoming more alarming from year to year. At risk are the elderly, as well as children with frequent respiratory diseases... This also includes people suffering from anomalies. of cardio-vascular system... An inexpensive domestic vaccine Grippol. In the attached instructions you can find all the information about the use of the vaccine, its composition, as well as indications for use and contraindications.

Vaccination Grippol is characterized by the fact that it includes the immunoadjuvant polyoxidonium, which is able to bind to viral influenza antigens.

The Grippol plus vaccine is a modified trivalent polymer-subunit inactivated preparation of the Grippol vaccine. The difference between these two medicines is that there are no preservatives in Grippol plus, which makes it possible to use it for pregnant women and children.

The manufacturer of Grippol plus is NPO Petrovax Pharm. It contains influenza A and B antigens, and the strain was created on chicken embryos. In addition, the drug contains an immunoadjuvant. The composition of the Grippol plus vaccine changes every year, and is determined by the current virus strain provided by WHO.

One injection of Grippol plus vaccine contains:

• strain type A (H1N1), 0.005 mg;
• strain type A (H3N2), 0.005 mg;
• strain type B, 0.005 mg;
• polyoxidonium, 0.5 mg;
• buffer solution, 0.5 ml.

Cell stimulation efficiency immune system vaccine "Grippol plus" reaches 75-95%. This means that this ratio of vaccinated people develops immunity from influenza. The appearance of antibodies occurs after 7-14 days and lasts about 1 year. The polyoxidonium contained in the drug increases the immunogenicity of the vaccine.

Instructions for use of the drug "Grippol" contains the following data:

1. Packaging. The vaccine is available in 0.5 ml ampoules.
2. Vaccination periods. The vaccination campaign begins in early autumn, that is, a month before the epidemiologically dangerous period, or at the very beginning.
3. Dosage. The Grippol plus vaccine is indicated for use in 0.5 ml in one injection both for children from three years old and for adults.
4. Small children in the age group from six months to three years are also allowed to be vaccinated against influenza. The dose for them is divided in two, that is, two injections of 0.25 ml are given with an interval of 28-30 days. If the child has previously been vaccinated against influenza, it is allowed to inject the entire dose of 0.5 ml at once.
5. Localization of the injection. The Grippol vaccine is injected into the brachial muscle or deeply subcutaneously. Small children are injected in the thigh.



Store the vaccine only at the correct temperature. The injections are given in strict accordance with the rules of antiseptics. If the ampoule is opened, it cannot be stored. The unused drug is disposed of together with consumables - syringes, needles, ampoules.

Indications for use

The flu vaccine Grippol is used to prevent seasonal and swine flu infections. It is approved for use for both children and adults.

• infants from six months of age and preschoolers;
• school students;
• applicants of vocational schools, technical schools and universities;
• military personnel of compulsory and contract service;
• employees of the Ministry of Internal Affairs;
• category of the population of retirement age (after 60);
• doctors, teachers, employees of transport and utilities;
• categories of the population that are susceptible to chronic diseases of the respiratory, cardiovascular, neuroendocrine systems;
• employees of trading companies and catering establishments.

There are no age restrictions for influenza vaccinations, since it is in old age that this disease can provoke severe complications.

There are certain contraindications in which Grippol plus vaccination is delayed. These include colds, which are accompanied by a rise in temperature. In this case, the flu shot is given only 30 days after full recovery. If the patient has an exacerbation of any chronic disease, immunization is also tolerated.



Grippol flu vaccination also has a number of permanent contraindications:

• pronounced allergic reaction on a previous flu shot;
• the presence of individual intolerance to the drug or its components;
• severe allergy to eggs and chicken meat.

If the patient develops an intestinal upset, the flu shot can be given when the body temperature returns to normal values... But disorders of a mental or nervous nature are not considered contraindications for vaccination.

Since the Grippol vaccine is an inactivated drug, that is, it does not contain live whole-cell viruses, it is generally well tolerated by patients. Complications after it are rare.

The reaction to the vaccine can be manifested by the following conditions:

1. Redness of the injection site and slight induration.
2. The rise in body temperature to 37-38 ℃, which lasts for about 1-2 days.
3. Fatigue, rhinitis, headache and feeling unwell.

There are a few precautions you should take before getting a flu shot. Do not introduce new foods and foods into the diet that can provoke allergies. This applies to both adults and children. It is not recommended to give vitamin D supplements to children for 4-5 days before vaccination, so as not to cause calcium imbalance. Otherwise, the risk of allergic reactions increases.



Allergic children who take Suprastin, before and after the Grippol injection, should replace the antihistamine. Suprastin dries the mucous membrane, opening access to pathogenic bacteria. It is better to temporarily switch to the reception of Claritin or Fenistil.

After the Grippol plus vaccine is introduced, it is worth staying in the medical facility for a short while. This is to make sure there are no allergies or any complications that may require urgent medical attention.


Seasonal incidence of influenza and ARVI is relevant for every person, regardless of gender, age and place of residence.

The danger of influenza lies in the complications that arise against the background of the multiplication of the virus in the body.

As a specific prophylaxis of this disease, a flu vaccine, influenza, was developed, which forms a stable anti-influenza immunity.

Grippol vaccine

In order to understand the full need for preventive measures, it is necessary to familiarize yourself with the most common complications of seasonal viral diseases. Potential complications of influenza include:

• Pathological changes in the mucous membrane of the nasopharynx (sinusitis, sinusitis, frontal sinusitis);
• Inflammatory diseases of the upper and lower respiratory tract. Against the background of influenza and SARS, it often occurs acute bronchitis, pneumonia and pleurisy;
• Infectious and inflammatory heart disease. Often, viral diseases cause complications such as myocarditis, endocarditis and pericarditis. The progression of these complications leads to irreversible processes in the heart;
• Purulent-inflammatory lesion of the middle ear (otitis media). This type of complication most often occurs in children of preschool and primary school age;
• Kidney disease. Viral damage to the body is fraught with diseases such as glomerulonephritis and pyelonephritis;
• Inflammatory lesions of large joints (arthritis);
• Digestive disorders (nausea, vomiting, stool disorder).

Types of prophylactic vaccines

Influenza vaccines are conventionally classified into inactivated, attenuated, and live drugs. The inactivated type is designed for injection, and the live type is designed for spraying onto the mucous membrane of the nasal passages.

An inactivated type of prophylactic agent is widely used to vaccinate adults and children. This type of drugs is conventionally divided into the following types:

• Split... The preparation contains proteins of the destroyed influenza virus. The hallmark of split vaccines is high degree cleaning, which guarantees a mild effect on the body.
• Whole viral... The preparations contain killed influenza viruses that have not been destroyed.
• Subunit funds... Vaccines of this type carry the surface antigen of the virus, which is necessary for the formation of persistent anti-influenza immunity.

Indications for vaccination

The following categories of the population are subject to compulsory vaccination against the influenza virus:

• Medical staff;
• Elderly persons (over 60 years old);
• Children over six months;
• People who often suffer from respiratory viral diseases (more often 7 times a year);
• Persons with chronic diseases of the cardiovascular and respiratory system;
• Pupils of preschool and school institutions;
• Service workers, trade, military personnel.

Grippol vaccine

This prophylactic agent belongs to the group of subunit influenza vaccines. High efficiency the drug is due to its composition. The conductor of the substance in the body is polyoxidonium, which has a detoxifying and antioxidant effect. A substance like polyoxidonium against influenza is used very often. Against the background of drug treatment, there is an improvement in the general condition of patients with a viral infection.

Since the influenza virus can take on different variations, the antigenic structure of the influenza vaccine varies according to the epidemiological situation.



Original packaging (photo)

Instructions for use

The manufacturer produces this product in the form of a solution for intramuscular injection. The volume of each ampoule is 0.5 ml. Official instruction flu shots, it recommends adhering to the following rules:

• Prophylactic vaccination against the influenza virus must be carried out in the autumn period, 1 month before the expected epidemic of a viral infection;
• It is recommended to vaccinate children no earlier than six months. Such babies are injected with 0.25 ml of solution, twice. The interval between vaccinations is 30 days;
• For adults and children over 3 years of age, the recommended dosage of influenza plus influenza vaccine is 0.5 ml once;
• For adults, the drug is injected into the upper third of the shoulder (intramuscularly), and for children, in the area of ​​the quadriceps muscle of the thigh.

Contraindications

Despite the fact that the drug has a mild effect on the body, its use is not always permissible. The main contraindications for the use of influenza vaccine influenza include:

• Exacerbation of chronic diseases of organs and systems;
• Increased body temperature;
• Allergic intolerance to egg white;
• Any diseases in the stage of decompensation;
• Individual intolerance to previously administered prophylactic vaccines;
• The presence of diseases of an infectious and inflammatory nature.

In all other cases, the Grippol vaccine is a reliable protector human body from causative agents of influenza and ARVI.

Side effects

Against the background of the introduction of this drug, adverse reactions very rarely occur. The likely consequences of vaccination include:

• General malaise, weakness;
• Headache;
• Difficulty nasal breathing;
• Neurological disorders;
• Parasthesia;
• Myalgia;
• Local redness and induration at the injection site;
• Increase in body temperature to 37.5-38 degrees. The high temperature lasts no more than 2 days.

Adverse reactions are not dangerous to human health, and do not require the intervention of medical specialists. Their duration is 1-2 days.

If there is one or more contraindications, it is necessary to notify the medical specialist who vaccinates about this.

Vaccination during pregnancy and breastfeeding

Preventive influenza vaccine " flu plus belmed»Does not have a negative effect on the developing fetus.

This allows the use of this drug to protect pregnant and lactating women from influenza and ARVI pathogens.

The decision to vaccinate a pregnant woman is made by a healthcare professional. The optimal vaccination period is 2 and 3 trimesters.

special instructions

In order to prevent a preventive measure from entailing a number of negative consequences, it is recommended to follow simple rules. The official flu vaccine instruction, influenza, recommends the following:

• It is strictly forbidden to administer the drug intravenously;
• Vaccination should be carried out in the manipulation rooms, which have medicines at their disposal to stop the anaphylactic reaction;
• Before manipulation, it is necessary to consult a doctor who will assess the body temperature and general state organism;
• For vaccination, the drug should be used in a sealed package and corresponding to the shelf life;
• After manipulation, it is not recommended to use alcoholic drinks within 7 days;
• If a person is taking any medications, then it is recommended that he inform the attending physician about this before the introduction of the vaccination;
• After vaccination, it is necessary to avoid hypothermia, excessive emotional and physical stress during the first 7 days;
• After vaccinating children, it is recommended to limit the presence of the baby in crowded places for 5-7 days.

The effectiveness of the remedy does not depend on which influenza virus influenza was introduced.



Vaccination with Grippol

Drug interactions

This prophylactic agent does not interact with most drugs... An exception is immunosuppressive drugs, the effect of which is weakened by contact with the vaccine. The simultaneous administration of influenza vaccination with BCG vaccines and BCG-m.

After the administration of the drug, a decrease in attention and concentration is not observed, therefore, routine vaccination does not affect the ability to drive a car.

Preventive vaccination with Grippol is included in the calendar compulsory vaccinations since 2006. This procedure annually helps to reduce the percentage of seasonal incidence of respiratory viral infections.

For more information on which influenza strains are effective against, see medical institutions polyclinic type.

Active ingredients

Azoximer bromide (azoximer bromide)
- hemagglutinin of viral strains (inactivated influenza vaccine)
- vaccine for the prevention of influenza trivalent inactivated polymer-subunit (inactivated influenza vaccine)

Release form, composition and packaging

Suspension for intramuscular and subcutaneous administration in the form of a colorless or yellowish slightly opalescent liquid.

* strains of influenza virus antigens - in accordance with WHO recommendations for the current epidemic season.

Excipients: phosphate-buffered saline solution - up to 0.5 ml.
Contains no preservative.

0.5 ml - disposable syringes (1) - contoured cell packs (1) - cardboard packs.
0.5 ml - disposable syringes (5) - contoured cell packs (1) - cardboard packs.
0.5 ml - disposable syringes (5) - contoured cell packs (2) - cardboard packs.
0.5 ml - disposable syringes (10) - contoured cell packs (1) - cardboard packs.
0.5 ml - ampoules (5) - contoured cell packs (1) - cardboard packs.
0.5 ml - ampoules (5) - contoured cell packs (2) - cardboard packs.
0.5 ml - ampoules (5) - cardboard packs.
0.5 ml - ampoules (10) - cardboard packs.
0.5 ml - bottles (5) - contoured cell packs (1) - cardboard packs.
0.5 ml - bottles (5) - contoured cell packs (2) - cardboard packs.
0.5 ml - bottles (5) - cardboard packs.
0.5 ml - bottles (10) - cardboard packs.

The antigenic composition of the vaccine changes every year in accordance with the epidemic situation and WHO recommendations.

pharmachologic effect

Grippol plus is a trivalent inactivated polymer-subunit influenza vaccine. It is a protective antigens (hemagglutinin and neuraminidase), isolated from purified influenza A and B viruses grown in chicken embryos, associated with a water-soluble high-molecular immunoadjuvant N-oxidized derivative of poly-1,4-ethylenepiperazine (azoxymer bromide). The antigenic composition of the vaccine changes every year in accordance with the epidemic situation and WHO recommendations.

The vaccine induces the formation high level specific immunity against influenza. The protective effect after vaccination usually occurs after 8-12 days and lasts up to 12 months, incl. in the elderly. Protective titers of antibodies to influenza viruses after vaccination of persons of different ages are determined in 75-95% of vaccinated persons.

The inclusion in the vaccine preparation of the immunomodulator azoxymer bromide, which has a wide range immunopharmacological action, provides an increase in the immunogenicity and stability of antigens, allows you to increase immunological memory, significantly reduce the vaccination dose of antigens, increase the body's resistance to other infections by correcting the immune status.

Indications

Specific prophylaxis of influenza in children from 6 months of age, adolescents and adults with no age limit.

Contingents to be vaccinated. The vaccine is especially indicated:

1. Persons with a high risk of complications in the case of influenza:

Over 60 years old; children preschool age, schoolchildren;

Adults and children, often with acute respiratory infections, suffering from chronic somatic diseases, including: diseases and malformations of the central nervous, cardiovascular and broncho-pulmonary systems, chronic kidney diseases, diabetes mellitus, metabolic diseases, autoimmune diseases, allergic diseases(except for allergy to chicken proteins); chronic anemia, congenital or acquired immunodeficiency, HIV-infected;

2. Persons by profession who have a high risk of contracting influenza or of other persons being infected by it:

To health workers, workers educational institutions, spheres social service, transport, trade, police, military, etc.

Contraindications

• Allergic reactions to chicken protein and vaccine components.
• Allergic reactions to previously administered influenza vaccines.
• Acute febrile conditions or exacerbation of a chronic disease (vaccination is carried out after recovery or during remission).
• Mild ARVI, acute intestinal diseases (vaccination is carried out after the temperature has returned to normal).

Application during and during breastfeeding.

Preclinical studies have shown that the inactivated polymer-subunit influenza vaccine does not have embryotoxic and teratogenic effects. The decision to vaccinate pregnant women should be made by the doctor individually, taking into account the risk of contracting influenza and possible complications influenza infection. The safest vaccinations are in the second and third trimesters.

Breastfeeding is not a contraindication for vaccination.

Influence on the ability to drive a car or control machines and mechanisms.

Influenza® plus does not affect the ability to drive a car or control machines and mechanisms.

Release form.

Suspension for intramuscular and subcutaneous administration.

0.5 ml (1 dose) in disposable syringes or in ampoules or vials, hermetically sealed with rubber stoppers and crimped with aluminum caps.

1, 5 or 10 syringes in a blister strip made of polyvinyl chloride film, polymer-coated aluminum foil, or laminated polymer-coated paper. 1 (containing 1 or 5 or 10 syringes) or 2 (containing 5 syringes) contour packs in a cardboard box together with instructions for use.

5 ampoules or vials in a blister strip made of polyvinyl chloride film. 1 or 2 blisters in a cardboard box together with instructions for use.

Or 5 or 10 ampoules or vials without a blister pack are placed in a cardboard box along with instructions for use.

Dosage

Vaccination is carried out annually in the autumn-winter period. Vaccination is possible at the beginning of an epidemic rise in the incidence of influenza.


For children over 3 years old, adolescents and adults, the vaccine is administered intramuscularly or deeply subcutaneously into the upper third outer surface shoulder (deltoid muscle), children younger age- into the anterolateral surface of the thigh intramuscularly.


Children from 6 to 35 months inclusive - 0.25 ml twice with an interval of 3-4 weeks.


Children older than 36 months and adults are injected with the vaccine once in a dose of 0.5 ml.


Previously not sick with influenza and unvaccinated children may receive two doses of the vaccine with an interval of 3-4 weeks.


Patients with immunodeficiency and receiving immunosuppressive therapy may receive the vaccine twice, 0.5 ml each, with an interval of 3-4 weeks.


Before use, the vaccine should be kept to room temperature and shaken well. Remove the protective cap from the needle and remove air from the syringe while holding it in upright position needle up and slowly pushing the plunger.


To immunize children who are shown the introduction of 0.25 ml (1/2 dose) of the vaccine, it is necessary to remove half of the contents of the syringe by pressing the plunger to the special risk marked on the syringe body, or to the red mark applied to the edge of the label, and inject the remaining 0.25 ml.


The opening of ampoules and vials and the vaccination procedure is carried out in strict observance of the rules of asepsis and antiseptics: before opening the ampoule knife, the neck of the ampoule or the bottle cap is wiped with cotton wool moistened with 70, the ampoule is opened or the rubber stopper of the bottle is pierced with a needle, the vaccine is drawn into a syringe from a disposable use and removed syringe excess air. Rub the skin at the injection site with alcohol. The drug in an opened ampoule or vial cannot be stored.

Side effects

The vaccine is a highly purified product that is well tolerated by children and adults.

The frequency of adverse reactions is defined as follows: often (> 1/100,<1/10), нечасто (>1/1000, <1/100), редко (>1/10 000, <1/1000), очень редко (<1/10 000).

Local reactions: often - soreness, hyperemia, induration and edema at the injection site.

General reactions: often - malaise, weakness, low-grade fever; infrequently - mild runny nose, headache and fever above subfebrile (these reactions usually go away on their own within 1-2 days); rarely - allergic reactions, incl. immediate type.

From the nervous system: very rarely -, paresthesia, neurological disorders.

From the musculoskeletal system: very rarely - myalgia.

The patient should be informed about the need to inform the doctor about any expressed or not specified in the instructions for adverse reactions.

Overdose

Overdose cases of the Grippol plus vaccine have not been reported.

Drug interactions

Grippol® plus vaccine can be used simultaneously with inactivated and live vaccines of the National vaccination calendar (except for BCG and BCG-M) and inactivated vaccines of the vaccination schedule for epidemic indications (except for rabies). In this case, contraindications to each of the vaccines used must be taken into account; drugs should be injected into different parts of the body with different syringes.


The vaccine can be administered against the background of basic therapy for the underlying disease. Vaccination of patients receiving immunosuppressive therapy (corticosteroids, cytotoxic drugs, radiotherapy) may be less effective.

special instructions

On the day of vaccination, the vaccinated must be examined by a doctor (paramedic) with compulsory thermometry. Vaccination is not carried out at temperatures above 37.0 ° C.

The drug is not suitable for use in ampoules, vials, syringes with impaired integrity or labeling, with a change in physical properties (color, transparency), with an expired shelf life, violation of the requirements for storage conditions.

The vaccine must not be administered intravenously.

In the offices where vaccination is carried out, it is necessary to have anti-shock therapy means.

The vaccinated person must be under the supervision of a health worker for 30 minutes after immunization.

Influence on the ability to drive vehicles and use mechanisms

Grippol plus does not affect the ability to drive a car or control machines and mechanisms.

Pregnancy and lactation

Preclinical studies have shown that the inactivated polymer-subunit influenza vaccine does not have embryotoxic and teratogenic effects. The doctor makes the decision to vaccinate pregnant women individually, taking into account the risk of contracting influenza and possible complications of influenza infection. The safest vaccination is in the II and III trimesters of pregnancy.

Breastfeeding is not a contraindication for vaccination.

Conditions of dispensing from pharmacies

The drug is available with a prescription.

Storage conditions and periods

The drug should be stored out of the reach of children, protected from light at a temperature of 2 ° to 8 ° C; do not freeze. The drug, which has been frozen, cannot be used. Expiration date - 1 year.

The vaccine is transported by all types of covered transport in light-tight containers at a temperature of 2 ° to 8 ° C, under conditions that exclude freezing. Transportation is allowed at temperatures up to 25 ° C for 6 hours.

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