Viferon

Structure

Ointment 1 g contains:
Interferon Human recombinant alpha-2 - 40000ma;
Tocopherol acetate - 0.002 g;
Additional substances.

Viferon 150000MA suppositories for rectal application 1 suppository contains:
Interferon Human recombinant alpha-2 - 150000ME;
Tocopherol acetate - 0.055 g;
Ascorbic acid - 0.015 g;
Additional substances.

Viferon 500000MA Suppositories for rectal use 1 Suppository contains:
Interferon human recombinant alpha-2 - 500000ma;
Tocopherol acetate - 0.055 g;

Additional substances.

Viferon 1000000MA suppositories for rectal use 1 Suppository contains:
Interferon Human recombinant alpha-2 - 1000000ME;
Tocopherol acetate - 0.055 g;
Ascorbic acid - 0.022 g;
Additional substances.

Viferon 3000000MA Suppositories for rectal use 1 Suppository contains:
Interferon human recombinant alpha-2 - 3000000ME;
Tocopherol acetate - 0.055 g;
Ascorbic acid - 0.022 g;
Additional substances.

pharmachologic effect

Viferon is a complex drug containing interferon human recombinant alpha-2, ascorbic acid and alpha-tocopherol acetate. The drug has antiviral, immunomodulatory and antiproliferative effect. Interferon in the body enhances the activity of T-helpers, cytotoxic T-lymphocytes, increases phagocytic activity, intensity of differentiation of in-lymphocytes. Interferon does not have a direct antiviral effect, but causes a virus-affected cell in the cell in the surrounding cells, which prevent the breeding of the virus. It also contributes to the exit of viral particles from the affected cell, their inactivation by other immune agents. The drug also inhibits replication and transcription of not only viruses, but also some bacteria, for example chlamydia. Damage to cell membranes, violation of their permeability and elasticity, which irreversibly occurs in the development of an infectious process leads to a decrease in the effectiveness of interferon. Ascorbic acid and tocopherol acetate are powerful antioxidants and membrane-stabilizing components. In combination with them, the effectiveness of interferon increases 10-15 times. In addition, their presence enhances the immunomodulating effect of interferon on T- and B-lymphocytes, leads to the normalization of the content of immunoglobulin E, reduce the manifestation side Effects. When using Viferon, even for a long time is not formed antibodies that neutralize interferon.
The use of the drug allows to significantly reduce the dose and the duration of the course of treatment with antibiotic therapy, hormonal drugs and cytostatics.

Reducing the interferon concentration in blood during rectal use occurs
12 hours after use, which is much longer than when intravenous administration interferon, and necessitates re-administration Preparation Viferon after 12 hours. In prematurest children with gestational age less than 34 weeks, the drug is derived faster, and the need for re-administration occurs after 8 hours after applying the drug.
With the outer use of the drug Viferon, the system action is practically not manifested in connection with low adsorption of the drug.

Indications for use

Suppositories:
Complex therapy of various infectious inflammatory diseases in children and adults, including acute respiratory viral infections (flu, diseases respiratory tract complicated bacterial infection), Pneumonia (viral, bacterial, chlamydial), meningitis (bacterial, viral), sepsis. Intrauterine infections, including chlamydia, herpes, cytomegaly, candidiasis (including visceral), mycoplasmosis.
Complex therapy of hepatitis B, C and D, in children and adults, including in chronic viral hepatitis of the pronounced degree of activity and complicated by cirrhosis of the liver.
Complex therapy of urogenital infections in adults, including pregnant women, (chlamydia, cytomegalovirus infection, ureaplasmosis, trichomoniasis, gardnerellosis, papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis). Herpetic infection, including genital form.

Ointment:
Herpety lesions of the skin and mucous membranes, papillomavirus infection (vulgar warts, pointed wigs, bovenoid papulese).

Mode of application

Rectal suppositories:
IN complex therapy Different infectious-inflammatory diseases in children, including prematurely: newborn with a term of gestation For more than 34 weeks, visiferon 150000 meters are prescribed daily by 1 suppository 2 times a day. The course of treatment is 5 days. A premature newborn with a period of gestation is less than 34 weeks daily Viferon 150000MA 1 suppository 3 times a day after 8 hours. The course of treatment is 5 days. Repeated courses are possible when various diseasesBut the break between the courses should be at least 5 days. In children, including premature courses are carried out under sepsis 2-3 courses, with a herpetic infection of 2 courses, cytomegalovirus infection, mycoplasmosis, candidiasis of 2-3 courses. For ARVI and pneumonia, by decision of the doctor, a repeated course of treatment with Viferon can also be carried out.

With integrated therapy of chronic viral hepatitis in children and adults:
Children, depending on age, prescribe: up to 6 months - 300000-500000m per day; from 6 to 12 months - 500000mm per day; From 1 to 7 years - 300000mm to 1m2 body surface area per day. Children under the age of 7 years old - 500000mm at 1 m2 body surface area per day. The dose of the drug is divided into 2 receptions with a break of 12 hours the first 10 days daily, then three times a week every other day for 6-12 months.
Adults are prescribed Viferon 3000000MA 1 Suppository 2 times a day with a break of 12 hours the first 10 days daily, then three times a week every day for 6-12 months.

With comprehensive therapy of urogenital infections, including pregnant women:
Adults are prescribed Viferon 500000MA 1 suppository 2 times a day with a break of 12 hours. Course 5-10 days. According to the testimony, an additional course can be conducted after 5 days of the break. In herpetic infection, Viferon 1000000MA is prescribed 1 suppository 2 times a day with a break of 12 hours. Course of treatment 10 days. Treatment is advisable to start at the first signs of the development of the disease.
Pregnant women (from 14 weeks of pregnancy) Viferon 500000MA 1 Suppository 2 times a day after 12 hours daily for 10 days, then 1 Suppository 2 times a day twice a week for 10 days, then after 4 weeks it is necessary to conduct a preventive course Viferon 150000ME 1 Suppository 2 times a day for 5 days. Preventive courses are carried out every 4 weeks until childbirth.

Integrated therapy of infectious diseases in adults: Assigns Viferon 500000ME 1 Suppository 2 times a day after 12 hours. Course of treatment 5-10 days.

Ointment:
They apply a thin layer on the affected areas of the skin daily 3-4 times a day and carefully rubbing. Course of treatment 5-7 days.

Side effects

Suppositories: In isolated cases, skin development is possible allergic reactions, such as itching and urticaria, which go through 72 hours after the cancellation of the drug.
Ointment: side effects No detected.

Contraindications

Suppositories and ointment: Increased individual sensitivity to the components of the drug.

Pregnancy

Suppositories: Application is possible from 14 weeks of pregnancy, there are no restrictions for use during lactation.
Ointment: due to low systemic adsorption of the drug, it is possible to apply during periods of pregnancy and lactation.

Medicinal interaction

Suppositories: the drug is compatible and combined well with all drugs used to treat the above diseases (antibiotics, chemotherapy products, glucocorticosteroids).
Ointment: interactions with other drugs have not been detected.

Overdose

There are no reports on cases of overdose of the drug.

Form release

Suppositories for rectal use of 10pcs. In the contour cell packaging, 1 or 2 contour packages in the cardboard box.
Ointment in a bank of 12 g 1 bank in cardboard packaging.

Storage conditions

Store in a dry-protected place at a temperature of 2-8 degrees Celsius.
Shelf life:
Suppositories - 2 years.
Ointment - 1 year.

Nonological Classification (ICD-10)

Meningococcal infection (A39)

Streptococcal septicemia (A40)

Other septicemia (A41)

• stops the reproduction of viruses inside the cells, preventing the spread of infection by the body;
• increases the activity of lymphocytes in relation to the affected virus cells;
• activates macrophages - cells of the immune system.

Attraction of additional interferon is due to the fact that its own begins to be produced by the body after 3-5 days after the start of viral activity.

The use of the same suppositories makes it possible to stop a viral infection when the first symptoms appear or completely prevent its penetration into the cells (that is, the candles can be used to prevent the disease).

Suppositories 150,000 IU are used in children under 7 years old, including newborns and premature. The drug is prescribed by infants that appeared on the light for a period of less than 34 weeks of 1 candle 3 times a day, all other children 2 times a day.

Suppositories 500,000 meters are discharged by children over 7 years old, 1 candle 2 times a day.

The duration of therapy is 5 days, at the discretion of the pediatrician, the treatment diagram can be extended.

In case of infections in newborns, born on the period of more than 34 weeks, 150,000 IT suppositories are prescribed 1 candle 2 times a day, prematurely appeared on the light earlier than 34 weeks - 3 times a day for 5 days.

Number of courses in infections in newborns as follows:

• Blood infection, mycoplasmosis, cytomegalovirus infection - 2-3 courses
• Inflammation of brain shells, - 1-2 courses
• Infections caused by herpes virus - 2 courses

Between courses you need to withstand the interval of 5 days.

With chronic hepatitis B, C, D drug prescribe:

• infants under six months in a daily dosage of 300,000-500 000 meters;
• babies aged 0.5 to 1 year in a day dose - 500,000 me;
• patients aged from year to 7 years in a daily dose of 3,000,000 IU on 1M 2 surface area of \u200b\u200bthe body;
• patients who have reached 7 years in day dosage - 5 000 000 IU on 1M 2 surface area of \u200b\u200bthe body.

Candles are inserted 2 times a day for 10 days, then 3 times a week per day for half a year before a year. The duration of therapy depends on the well-being of the child and the results of laboratory research.

The daily dosage of the medication is calculated for each child by multiplying the recommended dosage for a given age group on the body surface area calculated by the GRUFDA nomogram, Terry and Hour. In order to calculate a one-time dosage, the daily dose is divided in half, and the result obtained is rounded to a dose of the candle in the most side.

Child, suffering from chronic aggressive viral hepatitis and cirrhosis, before carrying out plasmocytophoresis and hemosorption is prescribed in the following dosages:

• children under 7 years old are prescribed suppositories 150,000 me;
• patients over 7 years old - 500,000.

Insert the candles need rectally 2 times a day for 2 weeks.

Side effects

Side reactions to candles are very rare. It can be a rash around the anal hole and / or itching. If suddenly you noticed such manifestations in the child, the drug should be canceled. Symptoms pass for themselves for 3 days.

Cases of severe allergic reactions when applying suppositories were not marked.

Interaction with other medicines

Suppositories are perfectly combined with all medicinal preparationsthat are used in the treatment of diseases specified in the list of its testimony.

They are prescribed as an addition to the main therapy, good results gives in a complex and with antibiotics, and with hormonal preparations, and with medicines of other pharmaceutical groups.

special instructions

Candles are allowed to use during pregnancy in women, starting from the 2nd trimester. They are safe for use during lactation.

With the joint appointment of candles and antibacterial drugs, the recent increase is noted, which can be the basis for reducing the dosage of antibiotics or reduce the duration of treatment with them.

Candles do not have any effect on the rate of reactions and the concentration of attention.

The drug should be stored in the refrigerator at a temperature of from 2 to 8 degrees above 0. With room temperature Candles quickly softened and use them for the purpose becomes impossible. Therefore, the packaging is removed from the refrigerator immediately before applying the drug.

In pharmacies, suppositories are released without a recipe. But this should not be a reason for their mindless use. Parents should not be forgotten that

Instructions for use:

Viferon is a drug of immunomodulatory, antiproliferative and antiviral action.

Release form and composition

Viferon is released in the form:

• Ointment for local and outdoor use - homogeneous, viscous, yellowish-white or yellow, with a specific smell of lanoline (6 g or 12 g in aluminum tubes, 12 g in polystyrene banks, 1 tube or a bank in a cardboard pack);
• Gel for local and outdoor use - gel, opaque, homogeneous white mass with a grayish tint (12 g in aluminum tubes or in polystyrene banks, 1 tube or a jar in a cardboard pack);
• Suppositories for rectal use - bullet-shaped, homogeneous consistency, white with a yellowish color shade, with a diameter of up to 10 mm (10 pcs. In contour cellular packs, 1 or 2 packages in a cardboard pack).

The composition of 1 g of Mazi includes:

• Active substance: Human recombinant interferon alpha-2b - 40000 international units (IU);
• Auxiliary components: anhydrous lanolin - 0.34 g; tocopherol acetate - 0.02 g; peach oil - 0.12 g; Medical Vaseline - 0.45 g; Purified water - up to 1 g.

The composition of 1 g of gel includes:

• Active substance: Human recombinant interferon alpha-2b - 36000 IU;
• Auxiliary components: 95% ethanol - 0.055 g; alpha-tocopherol acetate - 0.055 g; methionine - 0.0012 g; benzoic acid - 0.00128 mg; citric acid monohydrate - 0.001 g; sodium chloride - 0.004 g; Sodium tetrabrate decahydrate - 0.0018 mg; distilled glycerol (glycerol) - 0.02 g; 10% solution of albumin serum human - 0.02 g; Sodium carmellosis - 0.02 g; Purified water - up to 1 g.

The following suppository includes:

• Active substance: Human recombinant alpha-2b - 150000, 500,000, 100,000,000 or 30,000,000, 1000000 or 30,000,000
• Auxiliary components: Ascorbic acid - 0.0054 / 0.0081 / 0.0081 / 0.0081 g, respectively; alpha-tocopherol acetate - 0.055 g; Dihydrate of Edptate Dinataria - 0.0001 g; Sodium ascorbate - 0.0108 / 0.0162 / 0,0162 / 0.0162 g, respectively; Polysorbate 80 - at 0.0001 g;
• Basis: Confectionery and cocoa oil - up to 1 g.

Indications for use

Viferon in the form of ointments is prescribed for the treatment of the following diseases:

• Acute respiratory viral infections (ARVI) and flu in children over 1 year;
• Viral (including herpes) lesions of mucous membranes and skin of various localization.

The gel preparation is shown to use:

• ORVI, including influenza, long and frequent ARVI, incl. flowing with complications with bacterial infections (prevention, simultaneously with other drugs);
• Recurring stenosing laryngotracybrees (prevention, simultaneously with other drugs);
• Herpety Cervicitis (simultaneously with other drugs);
• Herpety infection of mucous and skin (acute and aggravation of chronic recurrent), incl. The urogenital form of herpetic infection (simultaneously with other drugs).

Viferon in the form of suppositories is used simultaneously with other drugs in the treatment of diseases:

• ORVI, including influenza, incl. leakage with complications with bacterial infections, pneumonia (chlamydial, viral, bacterial) in adults and children;
• Chronic viral hepatitis B, C, D in adults and children, incl. in combination with the use of hemisorption and plasmapheresis in chronic viral hepatitis of pronounced activity, which are complicated by the cirrhosis of the liver;
• Infectious inflammatory diseases in newborns (including premature) children: sepsis, meningitis (viral, bacterial), intrauterine infection (enterovirus infection, chlamydia, CMV infection, herpes, mycoplasmosis, candidiasis, incl. Visceral);
• Recurrent or primary herpes infection of mucous membranes and leather, localized form, medium-heavy and lightweight flow, including urogenital form in adults;
• Infectious-inflammatory diseases of the urogenital tract (bacterial vaginosis, ureaplasmosis, chlamydia, papillomavirus infection, CMV infection, gardnerellosis, trichomoniasis, mycoplasmosis, recurrent vaginal candidiasis) in adults.

Contraindications

Hypersensitivity to the components of the drug.

Method of application and dosage

Ointment Viferon is used locally and externally.

Herpetic infection: Ointment should be applied 3-4 times a day with a thin layer on lesions and gently rub. The duration of therapy is from 5 to 7 days. The treatment is recommended to start when the first signs of the disease appears (redness, burning, itching). With a recurrent herpes, treatment is desirable to begin in the longitudinal period or when the first signs of recurrence appear.

Influenza and other ORVI: The ointment of the thin layer is applied to the mucous membrane of the nasal strokes 3-4 times a day during the entire period of the disease. The multiplicity of applications for children is 1-2 years old - 3 times a day, 2-12 years old - 4 times a day.

Gel Viferon is used locally and externally.

Comprehensive ARVI's therapy: gel (strip up to 5 mm long) should be applied to the surface of the nasal mucosa, which you need to pre-dry, and / or to the surface of the sky almonds using a spatula or cotton wand, 3-5 times a day. The duration of the healing course is 5 days, if necessary, therapy can be continued. For the prevention of ARVI during the rise of the morbidity 2 times a day, the gel strip is applied to 5 mm. The duration of the application of Viferon is 14-28 days.

Complex therapy of the recurrent stenosis laryngotracheobronchitis: On the surface of the sky almonds should be applied a gel strip up to 5 mm. In the acute period of the disease (the first 5-7 days) - 5 times a day, then within 21 days - 3 times a day. For the prevention of the disease, the gel is used within 21-28 days 2 times a day, the courses are recommended to repeat 2 times a year.

Complex therapy of acute and chronic recurrent herpetic infection (in the event of the first signs of the disease): A strip of gel to 5 mm should be applied using a cotton swab / cotton stick or spatula on the affected surface, pre-dried, 3-5 times a day for 5-6 days. The duration of the course can be enlarged before the disappearance of clinical manifestations.

Complex therapy of herpetic cervicitis: 1 ml of a cotton swab should be applied 2 times a day to the surface of the cervix, which you first need to be cleaned of mucus. The duration of the drug is 7-14 days.

The gel on the surface of the sky tonsils must be applied after half an hour after taking food, on the mucous membrane of the nasal cavity - after cleaning the nasal passages. When applying the viriferon on the affected areas of mucous membranes and skin for 30-40 minutes, a thin film is formed, to which the following dose is applied in the future. If desired, the film can be washed with water or delay.

Suppositories Viferon applied rectally.

Complex therapy of acute respiratory viral infections:

• Adults and children from 7 years - daily within 5 days (according to the indications it is possible longer). 2 times a day with a break of 12 hours of 1 Suppository 500000 IU;
• Children up to 7 years old, including newborns and premature ages from 34 weeks - daily 1 Suppository 150000 IM 2 times a day at an interval of 12 hours within 5 days (according to the testimony, treatment can be continued with a break of 5 days);
• Premature newborn children with gestational age up to 34 weeks - daily 1 1 suppository 150,000 meters, 3 times a day with an interval of 8 hours within 5 days (according to the testimony, treatment can be continued with a break of 5 days).

Complex therapy of infectious inflammatory diseases (sepsis, meningitis, intrauterine infections, including CMV infection, chlamydia, herpes, candidiasis, enterovirus infection) newborn children, incl. premature, with gestation age: Over 34 weeks - Daily 1 Suppository 150000 meters 2 times a day at a 12-hour interval, up to 34 weeks - daily 1 Suppository 150,000 meters 3 times a day with an interval of 8 hours. Therapeutic course - 5 days.

• Sepsis - 2-3 courses;
• CMV infection - 2-3 courses;
• Herpetic infection - 2 courses;
• Meningitis - 1-2 courses;
• Mycoplasmosis, candidiasis, incl. visceral - 2-3 courses;
• Enterovirus infection - 1-2 courses.

In the presence of clinical testimony, treatment can be continued.

Complex therapy of chronic virus hepatitis B, C, D: 10 days Viferon is used daily 2 times a day after 12 hours, then 6-12 months - 3 times a week every other day. The duration of therapy is determined by laboratory indicators and clinical efficacy. Daily dose Amount:

• Adults - 2 suppositories for 30,000,000 meters;
• Children from 7 years old - 500,000 meters per 1 m2 of the surface of the body surface;
• Children 1-7 years - 30,000 meters per 1 m2 surface of the body surface;
• Children 6-12 months - 500,000 me;
• Children under 6 months - 300000-500000 me.

Chronic viral hepatitis of pronounced activity and cirrhosis of the liver: Before carrying out hemosorption and / or plasmapheresis, children under 7 years old are recommended daily use of Viferon for 150,000 ME, for children over 7 years old - 500,000 meters 2 times a day with a break of 12 hours within 14 days.

Complex therapy of infectious-inflammatory diseases of the urogenital tract (mycoplasmosis, ureaplasmosis, papillomavirus infection, chlamydia, CMV infection, gardnerellosis, trichomoniasis, recurrent vaginal candidiasis, bacterial vaginosis): Adults - 5-10 days daily 1 Viferon Suppository 500000 IU. Multiplicity of application - 2 times a day (every 12 hours). In the presence of clinical testimony, treatment can be continued. According to the same scheme in the first 10 days of treatment, Viferon is prescribed pregnant women after 14 weeks gestation. In the next 10 days, the drug is prescribed 1 suppository 2 times a day with a break of 12 hours every 4th day. Next - every 28 days before the delivery of 1 Suppository 150000 IM 2 times a day with the same interval daily within 5 days. If necessary, before the delivery (from 38 weeks of gestation), for 10 days, 1 500,000 meters per day are prescribed.

Recurrent or primary herpetic infection of the skin and mucous membranes, localized shape (medium and lightweight): The recommended one-time dose for adults for 10 days is 10,000,000 me, pregnant women with 2 trimester - 500,000 meters. The drug is used daily 2 times a day (every 12 hours). In the presence of clinical readings, therapy can be continued. Pregnant women in the future viriferon can be applied according to the treatment of infectious and inflammatory diseases of the urogenital tract.

Side effects

Viferon in the form of ointments in most cases is moved well. Side effects when applied to the mucous membrane of the nose are usually transitional and weak and disappear independently after the cancellation of the drug.

In exceptionally rare cases, the use of gel in patients with increased sensitivity can develop local allergic reactions. When they appear, treatment is stopped.

When applying suppositories, Viferon in some cases is possible the development of allergic reactions (itching, skin rashes). These phenomena are reversible and disappear after 72 hours after the cessation of therapy.

special instructions

An opened tube with ointment can be stored in the refrigerator 1 month, with gel - 2 months.

Viferon in the form of suppository pregnant women can be used, starting from 14 weeks of pregnancy.

Medicinal interaction

Viferon is well combined with all drugs used in the therapy of viral and other diseases (chemotherapy products, antibiotics, glucocorticosteroids).

Analogs

Viferon Analogues are: Infogel, Vitaloferon, Genferon, Laferon, Laceniobion, Anaferon, Kipiferon, Pharmaceutical.

Terms and conditions of storage

Store in lightweight, dry, inaccessible for children, at a temperature of 2-8 ° C.

The shelf life of the drug in the form of gel and ointment - 1 year, suppositories - 2 years.

.
If you have questions about the use of candles Viferon during pregnancy, look at the article.
If you are not clear how to properly introduce rectal candles Viferon, look at the article.
Price Viferon: in Moscow, Ukraine, Belarus.
On the right selection of candle dosages Viferon in questions and answers read in the article

Information on how to properly store Viferon candles in the form of questions and answers, can be viewed in the article

Trade name of the medicinal product

Viferon (Viferon) ®

Manufacturer

Feron Ltd., Russia

International non-proprietary title

Interferon human recombinant alpha-2

Dosage form

Suppositories rectal

Form release

Suppositories (150000 me, 500,000 meters, 10,000,000 meters, 30,000,000 meters) weighing from 0.95 g to 1.05 g, 10 pieces in the contour cellular PVC packaging / paper or mass from 1.00 g to 1.10 g of 10 pieces in the contour cellular PVC PVC packaging. 1 or 2 Contour cell packaging with instructions for use in a pack of cardboard

Description

Suppository has a bullet form, yellowish-white color, homogeneous consistency. The inhomogeneity of the color in the form of marble and the presence on the cutting of a funnel-shaped deepening is allowed. The diameter of the suppository is not more than 10 mm.

Pharmacotherapeutic group

Immunomodulating and antiviral agent.

Active substance

1 Suppository Viferon 150000 I1 contains an active substance - interferon human recombinant alpha-2 150000 me;
1 Suppository Viferon 500000 IE Contains Active Substance - Interferon Human Recombinant Alpha-2 500000
1 Suppository Viferon 1000000 IA Contains Active Substance - Interferon Human Recombinant Alpha-2 10,000,000
1 Suppository Viferon 3000000 meters contains active substance - Interferon Human recombinant alpha-2 30,000,000

Excipients

Acid ascorbic 0.015 g, alpha - tocopherol acetate 0.055 g, base oil cocoa or solid fat

pharmachologic effect

Interferon Human recombinant alpha-2 has pronounced antiviral, immunomodulatory and antiproliferative properties. Comprehensive composition The drug determines the presence of a number of additional effects: in the presence of acid ascorbic and alfaracopherol Acetate increases the antiviral activity of interferon of human recombinant alpha-2, its immunomodulatory effect on T- and B-lymphocytes is enhanced, the level of immunoglobulin E is normalized, the functioning of the endogenous interferon system is restored. In addition, acid ascorbic and alpha-tocopherol acetate, being highly active antioxidants, possess anti-inflammatory, membrane-stabilizing, as well as regenerating properties. It was established that when using Viferon, there are no side effects arising from the parenteral administration of interferon preparations, and antibodies that neutralizing the antiviral activity of interferon are not formed.

Pharmacokinetics

After rectal administration after 12 hours, a decrease in serum concentration is observed, which causes the need for its re-administration.

Indications for use

In the complex therapy of various infectious and inflammatory diseases in children, including newborns and prematurely:

• acute respiratory viral infections (flu, ORVI, including complicated by bacterial infection),
• pneumonia (bacterial, viral, chlamydial),
• meningitis (bacterial, viral),
• sepsis,
• intrauterine infection (chlamydia, herpes, cytomegaly, enterovirus infection, candidiasis, including visceral, mycoplasmosis);

In complex therapy chronic viral hepatitis B, C, D in children and adults, including in combination with the use of plasmapheres and hemosorption,
with chronic viral hepatitis of the pronounced degree of activity and complicated by cirrhosis of the liver;
in comprehensive therapy in adults, including pregnant women, with urogenital infection (chlamydia, cytomegalovirus infection, ureaplasmosis, trichomoniasis, gardnerellosis, papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis),
primary or recurrent herpety skin and mucous infection, localized shape, light and medium-free current, including urogenital form;
in complex therapy, including complicated bacterial infection in adults.

Dosing mode

Suppositories containing the interferon human recombinant alpha-2 as an active substance in the indicated dosages (150,000 IU, 500,000 IU, 1,000,000 IU, 3000000 IU) apply rectally.
In comprehensive therapy of various infectious inflammatory diseases in newborns, including premature: newborn, including premature children with gestational age more than 34 weeks Assign Viferon 150000 IU * Daily 1 Suppository 2 times a day after 12 hours. Course treatment is 5 days.
Premature newborn children with gestation age less than 34 weeks Assign Viferon 150,000 me daily 1 suppository 3 times a day after 8 hours. Course treatment is 5 days.
The recommended number of courses at various infectious inflammatory diseases children, including newborn and premature:

• influenza, ARVI, including complicated by bacterial infection - 1-2 courses;
• pneumonia (bacterial, viral, chlamydial) - 1-2 courses,
• sepsis - 2-3 courses,
• meningitis - 1-2 courses,
• herpetic infection - 2nd courses,
• enterovirus infection - 1-2 courses,
• cytomegalovirus infection - 2-3 courses,
• mycoplasmosis, candidiasis, including visceral, - 2-3 courses.

The break between the courses is 5 days. By clinical indications Therapy can be continued.

In complex therapy chronic viral hepatitis B, C, D In children and adults: Chronicles with chronic viral hepatitis The drug is prescribed in the following age dosages: up to 6 months 300000-500000 IU per day; from 6 to 12 months - 500,000 meters per day. In age from 1 year to 7 years - 300,000 meters per 1 m2 of body surface area per day. In age over 7 years old - 500,000 meters per 1 m2 body surface area per day. For each particular patient produce by multiplying the dosage recommended for this age on the body surface area calculated by nomogram To calculate the surface area of \u200b\u200bthe body at height and mass according to Garford, Terry and the Pour, are divided into 2 administrations, rounded to the dosage of the corresponding suppository. Preparation applies 2 times a day after 12 h. The first 10 days daily, further three times a week every day for 6-12 months.
The duration of treatment is determined by clinical efficacy and laboratory indicators. Children with chronic viral hepatitis spent degree of activity and cirrhosis of the liver Before conducting plasmapheresis and / or hemosorption The use of the drug is shown during 14 days daily 1 Suppository 2 times a day after 12 hours (Children under 7 years old Viferon 150,000 ME, for children over 7 years old - Viferon 500000 IU).
Adults S. chronic viral hepatitis Assigns Viferon 3000000 IU 1 Suppository 2 times a day after 12 hours for 10 days daily, then three times a week after a day for 6-12 months. The duration of treatment is determined by clinical efficacy and laboratory indicators.
In comprehensive therapy adults, including pregnant women, from urogenital infection (chlamydia, cytomegalovirus infection, ureaplasmosis, trichomoniasis, gardnerellosis, papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis), with primary or recurrent herpetic infection Skin and mucous membranes (localized shape, light and medium-free current, including urogenital form).
Adults, with the above infections, except herpetic, visifers are prescribed 500,000 me by 1 Suppository 2 times a day after 12 hours. Course 5-10 days. For clinical indications, therapy can be continued with breaks between the courses of 5 days.
For herpetic infection Assign Viferon 1000,000 me 1 Suppository 2 times a day after 12 hours. Course of treatment 10 days or more with a recurrent infection. It is recommended to begin treatment immediately when the first signs of lesions of the skin and mucous membranes appear (itching, burning, redness). In the treatment of recurrent herpes, it is desirable to begin treatment in the longitudinal period or at the very beginning of the manifestation of signs of recurrence.
W. pregnant women with urogenital infection, including herpety, in the II trimester of pregnancy (starting from 14 weeks) - Viferon 500 000 me 1 Suppository after 12 hours (2 times a day) for 10 days, then 1 suppository after 12 hours (2 times a day) twice a week - 10 days. Next, after 4 weeks, preventive courses of the drug Viferon are held 150 000 me 1 Suppository every 12 hours - for 5 days, the preventive course is repeated every 4 weeks. If necessary, it is possible to conduct a medical course before childbirth.

Separate article. In comprehensive therapy influenza and other sharp respiratory viral diseases , including complicated bacterial infection in adults. Apply Viferon 500,000 me 1 Suppository 2 times a day after 12 hours daily. The course of treatment is 5-10 days.

Contraindications

Increased sensitivity to any of the components of the drug

Pregnancy and lactation

The drug is allowed to use from 14 weeks of pregnancy. It does not have restrictions on the application during lactation.

Side effect

In rare cases, the development of allergic reactions (skin rashes, itching) is possible. These phenomena are reversible and disappear 72 hours after the discretion of the drug

special instructions

It is possible to use as part of combination therapy with antibacterial drugs, GKS, immunosuppressive drugs, interferon inductors.

Overdose

Data is not provided

Medicinal interaction

Viferon, rectal suppositories, compatible and well combined with all drugs used in the treatment of the above diseases (antibiotics, chemotherapy products, glucocorticosteroids)

Shelf life

2 years. Do not apply the drug after the expiration date

Storage conditions

In a dark place, at temperatures from 2 to 8 ° C. Transportation and storage in accordance with the joint venture 3.3.2.1248-03 at a temperature of from 2 to 8º C. Store in places inaccessible to children

Conditions of vacation from pharmacies

Without a doctor's prescription

approximate price

Russia:150000 IU 5.3-7 $, 500,000 IU $ 7.9-9, 1000000MU 10.9-13.8 $, 3000000 IU 18.7-21.1
Belarus:150000 IU 10-14.3 $, 500000 IU 13.9-194 $

• Indications
• Contraindications
• pharmachologic effect
• Dosage

Candles Viferon is a drug that is characterized by high efficiency in the treatment of viral infections in children, adults and women during pregnancy. The instruction will avoid the emergence of such effects, familiarize yourself with the rules of admission and doses.

Composition of the medicinal product

Baby Suppositories Viferon 150000 as an active ingredient contain human interferon ALPHA-2B, Dosage 150,000 IU. As auxiliary substances are used tocopherol acetate, sodium ascorbate, ascorbic acid, polysorbat. The base of the suppository is cocoa butter, fat, the number of which does not exceed 1 g. The price is very democratic, so it will be able to afford to buy the bulk of the population.

Suppositories Viferon 500000 and Viferon 1000000 will have a similar composition, but the number of the main ingredient will be respectively 500 thousand and 1 million. The content of some auxiliary substances will be increased. Suitable for adult category of patients, even women during pregnancy.

Candles have a bullet form. They are produced white with a lemon yellow tint. Heterogeneity of staining is allowed up to marbling. On the longitudinal slice will be marked in the form of a funnel. The diameter of the candle should not exceed 10 mm. The instruction will help properly choose a dose and a course of treatment for any group of patients.

Back to the category

Indications

The main indication for use is the presence of infectious inflammatory lesions of viral nature. However, this tool will be ineffective for the treatment of AIDS. The price is available affordable, so it will be able to use people from any social group. Viferon managed to get positive feedback and found application for therapy:

• sharp respiratory diseases Viral origin (flu, pneumonia various etiology) in children and adults, even during pregnancy;
• infectious inflammatory pathologies in newborns (meningitis of different etiology, sepsis, enterovirus and intrauterine infections);
• herpety skin lesions, which is primary or recurrent in children and has urogenital forms in adults;
• chronic hepatitis viral etiology at any age within the framework of comprehensive treatment;
• infectious and inflammatory pathologies of the urogenital tract in an adult age group, including during pregnancy, within the framework of comprehensive treatment.

Back to the category

Contraindications

Candles have practically no contraindications. They cannot be used only in cases of the presence of individual intolerance to at least one component. The instruction of the drug will allow you to find out that the drug can be appointed even during pregnancy and for children. Thanks to this, Viferon has only positive feedback.

Back to the category

pharmachologic effect

Viferon represents medicine, whose basis was the human interferon recombinant alpha-2b. Candles possess such effects as antiviral, antiproliferative and immunomodulating. The immunomodulatory activity of the viriferon is associated with the possibility of enhancing the activity of phagocytes, an increase in the cytotoxicity of lymphocytes to each target cell, the candles are capable of indirectly exhibit bacterial activity.

Thanks to the presence in the preparation of vitamin C and tocopherol acetate, it became possible to increase the activity of interferon in tens of times. An enhancement of the immunomodulatory effect is noted, the effectiveness of the immune response to the appearance of pathogenic microorganisms and viruses increases. These substances are able to exhibit anti-inflammatory and membrane-stabilizing effect.

The use of the drug Viferon will contribute to the normalization of the level of immunoglobulin E, gradually restoring the operation of its own interferon. It was possible to establish that the use of visiferon 1 candles will fully prevent the occurrence of side effects, which are noted in parenteral administration of interferon.

Candles will significantly reduce therapeutic doses of antibiotics, hormones, therapy duration by these means. The preparation of Viferon includes cocoa, which makes it possible to eliminate the use for the production of toxic emulsifiers of synthetic origin. This allows you to widely and efficiently use the medicine in children and women during pregnancy.

Back to the category

Dosage

Candles apply rectally. Each suppository will contain the number of the main ingredient, which is indicated in the dose. Some diseases will require the use of the drug as monotherapy or complex treatment. Application with acute respiratory infections of viral nature is possible in children, and in adulthood, use during pregnancy is not excluded. In these cases, only the dose and price will differ.

For adults and children, since the seven years old, Viferon 500,000 uses. It is enough to install 1 candles twice per day, it is important to withstand a 12-hour interval. The drug is prescribed to apply every day to 5-7 days. If a viral infection is characterized by severity, the duration of the course doctor can increase.

For newborns, up to 7 years old are recommended to use the drug, the dose of which is 150,000 meters. It is prescribed twice a day, the interval between suppositories should be 12 hours. The duration of the course is 5 days, it is possible to increase it. The instruction involves the possibility of repetition of the course, but after a break for at least 5 days.

Babies and newborn children, whose gestational age does not exceed 34 weeks, use children's candles, the dose of which is also 150,000 meters. However, in this case, it is necessary to put the suppository 1 time three times a day every 8 hours. The duration of the course should also be 5 days.

The group of premature children, whose gestational age is more than 34 weeks, the candles must be used twice a day no more than 5 days.

Sophisticated infectious diseases Infants and premature babies involve the use of several courses of the drug Viferon, for example, during sepsis you need 2-3 courses, with meningitis - 1-2 courses, cytomegalovirus lesion will require 2-3 courses. It is important to keep a break between several courses within 5 days.

For therapy chronic hepatitis Use Viferon within comprehensive therapy. Adults, even during pregnancy, prescribe a dose of 300,000 meters on 1 candle twice a day. The duration of therapy is 10 days, then it is necessary to use the drug up to 3 times a week about 12 months. The duration of therapy should be determined by the results of clinical and laboratory research.

In children, the drug Viferon for treating hepatitis is used according to the following scheme:

1. Age up to 6 months - 300000-500000 IU per day;
2. Age 6-12 months - 500,000 meters per day;
3. Up to 7 years use 30,000,000 meters per day;
4. In children over 7 years old, 5,000,000 meters per day.

Candles must be used every 12 hours 10 days, and after three times a week for 12 months.

The instruction of the drug Viferon will be able to introduce with the formula for calculating daily doses for any patient. To do this, it is sufficient to multiply a dose that is peculiar to a certain age group, on the value of the surface area of \u200b\u200bthe body. The last parameter can be calculated using a normogram. Motherwise dose It should be half of the daily.

Preparation Viferon can be used during pregnancy. However, it is permitted only after 14 weeks. Candles are not restricted for use during breastfeeding period.

Back to the category

Special instructions and storage conditions

Information about efficiency was obtained using the drug Viferon at complex treatment diseases such as: Herpety and cytomegalovirus infection, chlamydia, toxoplasmosis in children, adults and women during pregnancy.

The drug is recommended to be stored in a dark place, which is characterized by inaccessibility for children. The optimal temperature regime is 2-8 ° C. Preparation Viferon, thanks to unique characteristics, managed to find widespread use in all age groups of patients. High efficiency, the lack of side effects are beneficial to allocate the drug among the analogues.

Comments

Megan92 () 2 weeks ago

Did anyone succeed at dirty with papil armpits? It's very much they prevent me, especially when you sweat.

Daria () 2 weeks ago

I have already tried so much and only after reading this article, I was able to get rid of papilocks (and very fiscal).

P.S. But here I am from the city itself and we did not find it on sale, ordered via the Internet.

Megan92 () 13 days ago

Daria () 12 days ago

megan92, so I wrote in my first comment) I duplicate just in case - link to the article..

Sonya 10 days ago

And this is not a divorce? Why sell on the Internet?

Jules26 (Tver) 10 days ago

Sonya, what country do you live in? On the Internet is sold, because shops and pharmacies put their markup of the brutal. To the same payment only after receiving, that is, first looked, checked and only then paid. And on the Internet now everything is sold - from clothes to televisions and furniture.

Edition response 10 days ago

Sonya, hello. This drug For the treatment of papilomirus infection is really not implemented through the pharmacy chain and retail stores to avoid overestimated prices. To date, order only on official website. Be healthy!

Sonya 10 days ago

I apologize, I did not notice the information about the cash on delivery. Then everything is in order for sure if the payment upon receipt.

Margo. (Ulyanovsk) 8 days ago

And someone tried folk Methodsto get rid of warts and papillom?

Andrey a week ago

I tried to catch a wart to my head with vinegar. The wart really sued, only in her place such a burrow was that his finger was sick. And the most annoying thing is that after a month and a half, two more warts were spoken (((

Catherine a week ago

I tried to learn the papillae, it did not help, it was only handled and became so terrible (((

Maria 5 days ago

Recently watched the transfer on the first channel, there also about this papifex spoke. Many doctors recommended for treatment. I ordered, I use it and indeed, papillomas are resolved one after another, only 2 pieces remained, the most lively.