Name:

Remantadinum

Pharmacological
action:

Remantadine- a specific chemotherapeutic agent with a well-pronounced antiviral activity. Chemical structure- cc-methyl-1-adamantylmethylamine hydrochloride (adamantane derivative). In the early stages of development, it inhibits the replication of viruses. Probably, it also inhibits the synthesis of the virus envelope. Effective against influenza viruses, including influenza caused by the B virus. Virological genetic studies have shown that Remantadine affects Nega M2, a specific protein of the virion of the influenza A virus. ).
A drug undergoes active metabolism in the liver... About 1/5 of the administered dose within 72 hours after administration is excreted in the urine in unchanged form. Pharmacokinetics in chronic liver diseases characterized by stable cirrhosis does not change significantly compared to healthy volunteers (provided that 200 mg of Remantadine is taken as a single oral dose).

Indications for
application:

Applicable for kids school age(from 7 years old) and adults for early treatment of influenza.
Adults used as a preventive measure during a flu epidemic. It is also used for the prevention of tick-borne viral encephalitis.

Indications:
- early treatment and prevention of influenza in adults and children over 7 years old;
- prevention of influenza during epidemics in adults;
- prevention of tick-borne encephalitis of viral etiology.

Special instructions!
When using Remantadine, exacerbation of chronic concomitant diseases is possible. In elderly patients with arterial hypertension the risk of developing hemorrhagic stroke increases.

In influenza caused by the B virus, rimantadine has an antitoxic effect. Prophylactic reception is effective in contact with patients, with the spread of infection in closed groups and with a high risk of illness during an influenza epidemic. The emergence of drug-resistant viruses is possible.

Mode of application:

Prevention of influenza
Adults within 1 month, 1 tablet (50 mg) 1 time per day. If, for any reason, a pill is missed, the next pill should be taken in normal mode without carrying out an increase in dosage. It is recommended to consult a doctor before starting the appointment.

Treating influenza in the early stages
Childhood: from 7 to 10 years old, the drug is prescribed 2 times a day, 1 tablet (50 mg); from 11 to 14 years old - 1 tablet (50 mg) 3 times a day. For adults, during the first day of the disease, 2 tablets (100 mg) 3 times a day. Can daily dose take immediately - 6 tablets (once) or divide the daily dose into 2 doses (3 tablets 2 times a day). On the 2nd and 3rd day of the disease - 2 tablets (100 mg) 2 times a day. During the fourth and fifth days - 2 tablets (100 mg) 1 time per day.
The duration of the course of treatment with Remantadine is 5 days.

Prevention of tick-borne viral encephalitis
For children the drug is prescribed only by a doctor. The drug should be taken immediately after a tick bite. Adults- 2 tablets (100 mg) 2 times a day for 3 days. On the recommendation of a doctor, in some cases, it is allowed to take it for 5 days. It is inappropriate to take Remantadine if more than 48 hours have passed since the bite. People at risk, as well as those who participate in hikes in areas covered with plants or forests, living in tents are allowed to prevent tick-borne viral encephalitis and without a tick bite for 15 days, 50 mg (1 tablet) 2 times a day (this scheme is for adults only).

Side effects:

Remantadine is well tolerated. Possible side effects include:
- Violations from the outside organs gastrointestinal tract : diarrhea, dyspepsia;
- violations by skin: rash;
- violations by nervous system : drowsiness, attention deficit, ataxia, agitation, swinging gait disturbances, hyperkinesis, depression;
- hearing disorders: tinnitus;
- violations by respiratory system: hoarseness of the voice.

If others appear side effects, the doctor should be notified of this.

Contraindications:

Chronic and acute diseases kidney;
- acute liver disease;
- pregnancy and breastfeeding;
- hypersensitivity to adamantane derivatives, active substance or other components of Remantadine;
- thyrotoxicosis.

Interaction
other medicinal
by means of:

Recommended do not use alcohol during treatment with Remantadine, although there is no information on unwanted interactions between alcohol and Remantadine. The combination of Remantadine with alcohol can cause various reactions from the nervous system. Acetylsalicylic acid and paracetamol reduce the effectiveness of the drug.

Remantadine tablets are antiviral drugs. The drug has been used for a long period of time, and has proven itself to be excellent both in the treatment of children and adult patients.

The active ingredient, remantadine hydrochloride, is well studied and has practically no side effects on the human body. 1 tablet contains 50 mg of active ingredient, this must be taken into account when calculating the therapeutic dosage.

In this article, we will consider why doctors prescribe Remantadine, including instructions for use, analogs and prices for it. medicine in pharmacies. Real REVIEWS of people who have already used Remantadin can be read in the comments.

Composition and form of release

The drug Remantadine is produced exclusively in the form of tablets.

• Composition of 1 tablet: rimantadine 50 mg. Lactose monohydrate, calcium stearate, talc, potato starch as auxiliary substances.

Rimantadine is active against various strains of influenza A.

What is Remantadine used for?

The main indications for the use of rimantadine include groups viral infections affecting the upper respiratory tract.
Direct indications include:

• influenza type A;
• acute respiratory viral infections;
• frequent colds;
• flu prevention;
• treatment and prevention of tick-borne encephalitis after the bite of an infected tick.

• recurrent shingles;
• herpetic eruptions on the lips;
• herpes infection in the external genital area.

In some cases, the instructions for use advise the use of remantadine in immunological practice in persons suffering from herpetic forms of infections.

pharmachologic effect

The principle of action of rimantadine in the body:

• prevents the penetration of the virus into healthy cells - this gives reason to consider the considered medicinal product an effective prophylactic agent;
• blocks the release of viruses from the cell - this contributes to a significant reduction in the total amount of viral agents in the body.

Thus, the drug has antiviral and antitoxic effects.

Instructions for use

Remantadine should be taken orally after meals: swallow tablets / capsules whole and drink plenty of water.
The recommended doses are individual, depending on the indications, the patient's age and the treatment regimen used:

1. For the treatment of influenza in the early stages of the disease, children 7–10 years old are prescribed the drug twice a day, 50 mg (1 tablet); children 11-14 years old - 50 mg (1 tablet) 3 times / day. For adults, during the first day of the disease, 100 mg (2 tablets) are used 3 times / day. Adults can take a daily dose at once - 6 tablets (once) or divide the daily dose into two doses (3 tablets 2 times / day). On the 2nd and 3rd day of illness, take 100 mg (2 tablets) 2 times / day. During the 4th and 5th days - 100 mg (2 tablets) 1 time / day. The duration of the course of therapy with Remantadine is 5 days.
2. As prophylactic this drug assigned only to adults. You will have to drink one tablet once a day. Beforehand, it is better, nevertheless, to consult a doctor. If the pill was not taken on time, there is no need to increase the dose. The drug should be taken as usual - no more than 1 pill every 24 hours.
3. Prevention of viral tick-borne encephalitis. In this case, this drug should be prescribed only by a doctor. Especially when it comes to children. The medicine should be taken immediately after the tick bite. Adult dosage- two tablets twice a day. However, the doctor may prescribe a long-term intake of this remedy - for 5 days. It should also be noted that if two days have passed after the bite, taking the drug will already be useless.
4. Prevention of infection with viral tick-borne encephalitis, that is, in fields, forests, tall grasses, this drug can be taken prophylactically for 15 days. The dosage in this case is one pill twice a day.

Contraindications

You can not use the drug in such cases:

1. Children under 7 years old - for tablets, up to 14 years old - for capsules;
2. Thyrotoxicosis;
3. Sharp and chronic diseases kidney;
4. Acute liver disease;
5. Glucose-galactose malabsorption, lactose intolerance, lactase deficiency;
6. Pregnancy and lactation period;
7. Individual hypersensitivity to the components of the drug.

Carefully:

1. Epilepsy, including a history of;
2. Arterial hypertension;
3. Diseases of the gastrointestinal tract;
4. Liver failure;
5. Chronic renal failure
6. Atherosclerosis of the vessels of the brain.

Side effects

When using Remantadine, side effects may develop, manifested in the form of:

1. Headache, insomnia, nervousness, dizziness, impaired concentration, drowsiness, anxiety, increased excitability fatigue (central nervous system);
2. Pain in the epigastrium, flatulence, increased levels of bilirubin in the blood, dry mouth, anorexia, nausea, vomiting, gastralgia (digestive system);
3. Allergic reactions.

Application features

The use of Remantadine can provoke an increased manifestation of concomitant diseases that are chronic in nature;
The use of the drug in patients with functional impairment the activity of the liver and kidneys leads to the development of poisoning;
The use of Remantadine in elderly patients can lead to accumulations of the drug.

During pregnancy and lactation

Remantadine is categorically contraindicated for use at any stage of pregnancy. If an urgent need arises, it is possible to use Remantadine during the period breastfeeding(only after a complete refusal to breastfeed for the entire duration of treatment, including complete elimination of the drug from the body).

Analogs

Analogs with one active ingredient and a similar antiviral effect: Remantadin Sti, Olvirem, Remantidine Aktitab, Polirem, Algirem, Arbidol, Kagocel, Tamiflu.

Prices

The average price of Remantadine in pharmacies (Moscow) is 80 rubles.

Remantadine - antiviral drug, a derivative of adamantane. Instructions for use of Remantadine indicate its effectiveness against different strains of influenza A virus, tick-borne encephalitis, herpes viruses. The medicine has an immunomodulatory and antitoxic effect. Therapeutic effect achieved by the ability of certain components of Remantadin to inhibit the reproductive function of the virus and infect pathogenic microbes on early stage their development. The main indications for the use of Remantadine are influenza diseases. The drug stops the process of infection and promotes the fastest recovery organism. Instructions for the use of Remantadin tablets especially recommends their use in the early stages of the development of the disease, as well as with preventive purpose... It should be noted that the medicine should not be taken by children.

The price of a flu remedy depends on the manufacturer and the packaging option.

1. Pharmacological action

Antiviral drug. The mechanism of the therapeutic effect is associated with blocking the processes of viral reproduction and the synthesis of proteins necessary for their vital activity.

Absorption of Remantadine occurs in the intestine at a fairly low rate. Neutralization of the drug occurs in the liver, excretion - with the help of the kidneys. The maximum concentration is observed in the nasal secretion.

Bacterial activity:

• Group A viruses;
• Group B influenza viruses;
• Tick-borne virus.

2.indications for use

• Prevention and treatment of influenza in patients childhood from 7 years old;
• in adult patients;
• Prevention of the occurrence of tick-borne viral origin;
• Prevention of influenza during epidemics and in case of forced contact with patients.

3. Method of application

:

Before taking Remantadine, you should consult your doctor.

If there are gaps in treatment, the drug continues to be taken as usual, without increasing the dose.

Treatment for the early stages of influenza:
The dosage of the drug depends on the age of the patients:

• Pediatric patients in the range of 7-10 years: 1 tablet of Remantadine twice a day;
• Pediatric patients in the range of 11-14 years: 1 tablet of Remantadine three times a day.

Adult patients take the drug according to the following scheme:

• The first day of illness: 2 tablets of Remantadine three times a day or 6 tablets of Remantadine at one time or 3 tablets of Remantadine twice a day;
• The next two days of illness: 2 tablets of Remantadine twice a day;
• 4 and 5 days of illness: 2 tablets of Remantadine once a day.

The duration of treatment is no more than 5 days.

Prevention of tick-borne viral origin:

Pediatric patients are allowed to take Remantadine only as directed by a doctor.

In the case of an insect bite (provided that no more than two days have passed since the bite), the drug is taken 2 tablets twice a day for 3 or 5 days.

For the prevention of the disease, adults at risk (living or spending sufficient time in the forest) are recommended to take the drug in a dosage of 1 tablet twice a day for 15 days.

In all cases, Remantadine is taken after meals and washed down with a sufficient amount of warm drinking water. The tablets must be swallowed without chewing or breaking its integrity in any way possible.

Application features:

• The use of Remantadine can provoke an increased manifestation of concomitant diseases that are chronic in nature;
• The use of the drug in patients with functional disorders of the liver and kidneys leads to the development of poisoning;
• The use of Remantadine in elderly patients can lead to accumulations of the drug.

The drug should be used with caution in the following conditions:

• High blood pressure;
• Presence of epilepsy in the medical history;

4. Side effects

• Disorders of the senses (sensation of tinnitus);
• Organ disorders digestive system(upset stools, pain in the stomach, pain in the abdomen, nausea, vomiting, increased bilirubin levels, a feeling of dry mouth, decreased appetite);
• Respiratory system disorders (difficulty breathing, hoarseness);
• Various allergic reactions(skin rashes, itchy skin);
• Disorders of the nervous system (sleep disturbances, causeless anxiety, confusion, distraction of attention, dizziness, headaches, increased nervous excitability, general fatigue).

5. Contraindications

• Acute and chronic kidney disease;
• Hypersensitivity to the drug and its components;
• Acute and chronic liver diseases;
• Pregnancy and lactation period;
• Persistent increase in the content of thyroid hormones;
• Individual intolerance to the drug and its components.

6. During pregnancy and lactation

Remantadine is categorically contraindicated for use at any stage of pregnancy. If an urgent need arises, it is possible to use Remantadine during breastfeeding (only after a complete refusal of breastfeeding throughout the entire duration of treatment, including complete elimination of the drug from the body).

7. Interaction with other medicinal products

• Simultaneous use with drugs that alleviate the course of epileptic seizures, there is a decrease in the effectiveness of the latter;
• Simultaneous use with Paracetamol or Acetylsalicylic acid leads to a decrease in the maximum concentration of Remantadine;
• Simultaneous use with drugs whose therapeutic effect is associated with enveloping the mucous membrane of the digestive system or the ability to bind and remove unwanted chemical compounds, leads to a significant decrease in the absorption of Remantadine;
• Simultaneous use with drugs, whose healing effect associated with a change in the acid-base balance of urine to the acidic side, there is a decrease in the effectiveness of Remantadine;
• Simultaneous use with drugs, whose therapeutic effect is associated with a change in the acid-base balance of urine to the alkaline side, leads to an increase in the effectiveness of Remantadine;
• Simultaneous use with Cimetidine leads to a decrease in the excretion of Remantadine from the body.

8. Overdose

Cases of overdose with Remantadine at this time not described... In cases of overdose with similar drugs, disturbances in the activity of the central nervous system, disturbances heart rate and death.

In case of an overdose of Remantadine, the main actions medical staff should be aimed at maintaining all vital functions of the body. It is also recommended to administer Physostigmine at the following dosage:

• For pediatric patients - 0.5 mg of the drug;
• For adult patients - 1-2 mg of the drug.

The maximum dosage of Physostigmine should not exceed 2 mg of the drug per hour.

9. Release form

Tablets, 50 mg - 10, 20, 30, 40 or 50 pcs.

10. Storage conditions

It is recommended to store remantadine in a dry place, sufficiently protected from light.
Recommended temperature regime- not exceeding room temperature.
Shelf life is no more than 5 years.

11. Composition

1 tablet:

• rimantadine hydrochloride - 50 mg.

12. Terms of dispensing from pharmacies

The drug is dispensed without a prescription.

The indication for taking Remantadin is influenza - an insidious infection that not only deprives us of our ability to work, but often also leads to much more dire consequences (including paralysis of the facial muscles and even death). The number of new types of this virus reaches hundreds, and new "versions" are constantly appearing, so it is very important to carefully study the indications for taking pills, they must affect a specific infection.

For some time, the population was actively encouraged to get vaccinated against the flu, but then much more effective vaccine analogues such as Remantadin appeared. It is difficult to say when exactly the medicine was created and why it was not previously in demand, despite the affordable cost of the tablets. The drug is contraindicated for children, but is indispensable for adult patients in the treatment of:

• early stages of influenza;
• to prevent the development of influenza viruses;
• for the prevention of viral tick-borne;
• to prevent influenza during an epidemic or through contact with infected people.

Today, the drug is widely available and can be used by everyone (except for a child under 7 years old, since instructions for using Remantadine for children younger age does not exist).

On our website you can find the current price of the drug, as well as the price of other antiviral drugs.

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* Instructions for medical use to the drug Remantadin is published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USING IT IS NECESSARY TO CONSULT A SPECIALIST

Composition and release form of the drug

10 pieces. - contour cell packaging (1) - cardboard packs.
10 pieces. - contour cell packaging (2) - cardboard packs.
20 pcs. - cans of dark glass (1) - packs of cardboard.

pharmachologic effect

Adsorbents, astringents and coating agents reduce the absorption of rimantadine.

Urine acidifying agents (ammonium chloride, ascorbic acid) reduce the effectiveness of rimantadine (due to increased renal excretion).

Urine alkalizing agents (acetazolamide) enhance its effectiveness (decrease in renal excretion).

Paracetamol and acetylsalicylic acid reduce the C max of rimantadine by 11%.

Cimetidine reduces the clearance of rimantadine by 18%.

special instructions

Rimantadine is used with caution in arterial hypertension, epilepsy (including history), cerebral atherosclerosis.

When using rimantadine, exacerbation of chronic concomitant diseases is possible. In elderly patients with arterial hypertension the risk of developing hemorrhagic stroke increases. With indications of a history of epilepsy and ongoing anticonvulsant therapy, with the use of rimantadine, the risk of developing an epileptic seizure increases. In such cases, rimantadine is used at a dose of up to 100 mg / day simultaneously with anticonvulsant therapy.

Remantadine- an antiviral drug for systemic use.

Remantadine is effective against various strains of influenza A virus (especially type A 2). It is active against tick-borne encephalitis viruses (Central European and Russian spring-summer), which belong to the group of arboviruses of the Flaviviridae family. The main mechanism of antiviral action is inhibition of the early stage of specific reproduction after the penetration of the virus into the cell and before the initial transcription of RNA. The pharmacological efficacy of the drug is ensured by inhibiting the reproduction of the virus in initial stage infectious process. Remantadine has an antitoxic effect in influenza caused by the B virus. It is not effective in other acute respiratory viral infections.

Pharmacokinetics

.

Remantadine is well, but slowly absorbed from the gastrointestinal tract. Most of the drug is extensively metabolized. The half-life from blood plasma is 24-36 hours. It is excreted in the urine: less than 15% of the dose - unchanged, about 20% - in the form of hydroxyl metabolites. At renal failure the half-life is increased by approximately 2 times.

Indications for use

A drug Remantadine used in children from 7 years of age and adults for the treatment of influenza. Adults are used as a preventive measure during an influenza epidemic, for the prevention of tick-borne viral encephalitis.

Mode of application

The tablets are swallowed with water. Should take Remantadine after meal.

Prevention of influenza

Adults for 1 month, 1 tablet (50 mg) 1 time per day. If, for any reason, a pill is missed, take the next pill as usual, without increasing the dosage. It is recommended to consult a doctor before starting the appointment.

Treating influenza in the early stages

Children's age: from 7 to 10 years, the drug is prescribed 2 times a day, 1 tablet (50 mg); from 11 to 14 years old - 1 tablet (50 mg) 3 times a day. For adults, during the first day of the disease, 2 tablets (100 mg) 3 times a day. You can take the daily dose at once - 6 tablets (once) or divide the daily dose into 2 doses (3 tablets 2 times a day). On the 2nd and 3rd day of the disease - 2 tablets (100 mg) 2 times a day. During the fourth and fifth days - 2 tablets (100 mg) 1 time per day.

Prevention of tick-borne viral encephalitis

For children, the drug is prescribed only by a doctor. The drug should be taken immediately after a tick bite. Adults - 2 tablets (100 mg) 2 times a day for 3 days. On the recommendation of a doctor, in some cases, it is allowed to take it for 5 days. It is inappropriate to take Remantadine if more than 48 hours have passed since the bite. People at risk, as well as those who participate in hikes in areas covered with plants or forests, living in tents are allowed to prevent tick-borne viral encephalitis and without a tick bite for 15 days, 50 mg (1 tablet) 2 times a day (this scheme is for adults only).

Side effects

Remantadine well tolerated. Possible side effects include:

Disturbances from the organs of the gastrointestinal tract: diarrhea, dyspepsia.

Skin disorders: rash.

Disturbances from the nervous system: drowsiness, attention disturbances, ataxia, agitation, swinging gait disturbances, hyperkinesis, depression.

Hearing disorders: tinnitus.

Respiratory system disorders: hoarseness.

If other side effects appear, notify the doctor about this.

Contraindications

:

Contraindications to the use of the drug Remantadine are: chronic and acute kidney disease; acute liver disease; pregnancy and breastfeeding; hypersensitivity to adamantane derivatives, the active substance or other components of Remantadine; thyrotoxicosis.

Pregnancy

:

Remantadine contraindicated for pregnant women in any trimester.

Interaction with other medicinal products

It is recommended not to consume alcohol during treatment Remantadine, although there is no information on unwanted interactions between alcohol and Remantadine. The combination of Remantadine with alcohol can cause various reactions from the nervous system. Acetylsalicylic acid and paracetamol reduce the effectiveness of the drug.

Overdose

If poisoning occurs Remantadine, it is necessary to maintain the functions of vital organs and systems. The literature does not describe cases of overdose with Remantadine, but there is information about poisoning with adamantane derivatives - adamantadine. In this case, hallucinations, agitation, cardiac arrhythmias and death were observed. If poisoning with Remantadine is accompanied by reactions from the nervous system, treatment with physostigmine at a dose of 1-2 mg for adults and 0.5 mg for children is recommended. If necessary, the introduction of physostigmine can be repeated, but at a dosage of no more than 2 mg of physostigmine per hour.