Such manifestations in children have certain reasons. This is the imperfection of the secretory function of the digestive glands, and the insufficient development of the smooth muscles of the children's intestine, which is responsible for, as well as the absence or lack of enzymes involved in the digestion of food. Creon helps improve this process , but to prescribe a dose for each specific child, as well as to determine how many days you should drink the drug, you should consult a specialist.

Composition of the preparation

The composition of the medication includes pancreatin, which is obtained by extraction from the pancreas in pigs. Therapeutic effect from the use of this agent is achieved when it enters the stomach.

One capsule of the drug Creon, consisting of digestive enzymes, contains the recommended dose for children:

• lipase – 5000 units;
• protease - 200 units;
• amylase - 3600 U

Creon 10,000 is not a medicine as such, because it does not contribute to the development of a child, but simply supplies them in a finished form. This therapy is called substitution therapy. As soon as the drug is stopped, the problem can arise again, therefore, Creon capsules are usually given to children as part of complex therapy.

The active compound Creon 10,000 is a microsphere placed in a special gelatin capsule, which dissolves on contact with the internal environment of the gastrointestinal tract. After release, the microspheres are mixed with the gastric contents and then pass into small intestine, where the final dissolution of the drug takes place and its active enzymatic action begins, due to which the breakdown and absorption of proteins, carbohydrates and fats occurs.

Can Creon be given to a child?

The drug is suitable for the treatment of disorders in the digestive tract, not only in adults, but also in children. Naturally, for a one-year-old baby and older patients, the doctor can prescribe how many days to drink this remedy and in what quantity, only after preliminary diagnosis. The use of Creon capsules helps to improve digestion in case of insufficient enzymatic activity of substances secreted by cells.

Creon for a child under one year old

The first year of a baby's life is often accompanied by such an unpleasant condition as colic. In some situations, doctors recommend that young children drink Creon. The active compounds contained in it help food to be absorbed, however, the drug does not affect the production of pancreatic enzymes, therefore, after stopping the use, it may happen that unpleasant symptoms return.

There are some features of the appointment of Creon and its dosage for children under one year old . If the baby feeds only on breast milk, then it is necessary to offer him clean water to drink in order to provide protection from the appearance.

How to give Creon to a one-year-old child? The way of using the drug in this case will differ from that in an adult patient. The capsule of Creon 10000 must be carefully opened, mixed with liquid or baby puree only half of the total amount of microspheres and immediately given to the baby, since the drug can be inactivated, being unprotected by a gelatin capsule.

Indications and contraindications

According to the information specified in the instructions for use of the drug, Creon can be given to 10,000 children with the following diseases and conditions digestive system:

• Chronic inflammation of the pancreas ().
• Congenital hereditary disease cystic fibrosis.
• Functional deficiency of pancreatic enzymes, in which the use of Creon allows a 1-year-old child to fully eat and develop.
• Diarrhea symptoms . In this case, a small patient is assigned complex therapy, also doctors recommend drinking a lot of water, especially in summer , to prevent dehydration of the body.
• The use of Creon is indicated for colic in children under one year old.

The therapeutic dose of the drug, the regimen and the duration of treatment with Creon in childhood must comply with the recommendations specified in the instructions for use. It is not necessary to exceed the permissible period of use of the drug in infants and toddlers up to a year, this can adversely affect the synthesis of enzymatic substances in the pancreas.

Among the contraindications to the use of Creon, the following diseases can be distinguished, which must be excluded before taking the medicine for children:

• and exacerbation of its chronic course.
• Individual intolerance to the constituent components of the drug.

Instructions for use

Self-medication with Creon can lead to various side effects in children; only a doctor should prescribe therapy after diagnostic activities... Starting therapy with Creon for children, you should carefully read the instructions for use.

The dose of the drug is determined by the doctor depending on the severity of the disease, the characteristics of its course and the age of the child. Exceeding the recommended amount of Creon 10,000 for the treatment of children may cause an overdose.

Before starting therapy with Creon, you must pay attention that the instructions for use contain special instructions on how to give the drug to children under the age of three. The child must be sure to eat well and eat enough food per day so that the enzymatic substances can act and not harm the mucous membranes of the stomach and intestines. It is also required to ensure that the baby drinks a large amount of water, which is necessary to prevent constipation. The daily dosage of Creon for children should be divided into three equal parts and given to drink capsules before meals.

The main question that worries parents when a pediatrician prescribed Creon to a child under the age of one year is how to give the medicine. For babies who do not yet know how to swallow gelatin capsules, or it causes them to gag, it is allowed to open the shell and mix the contents of the pill with water or food. This has already been said above.

What are the features of using Creon and how many capsules should children take? The dosage depends on the age. Babies are prescribed Creon with a pancreatin content of 10,000 units . Take 1-2 capsules before each full meal. Babies should only mix half the contents of the pill with food.

Side effects

The use of the drug in children in some cases may be accompanied by the occurrence of side effects:

• a child's allergy to Creon previously not manifested;
• problems with bowel movements, such as constipation or diarrhea;
• pain and epigastric discomfort.

In order to avoid the occurrence of an overdose of the drug Creon in a child, it is necessary before taking it , carefully read the information leaflet on which the possible complications and contraindications. With extreme caution, it is necessary to approach the treatment of a child under one year old with Creon. Children exclusively on breastfeeding, you can take baby Creon, but strictly following all the doctor's recommendations.

Analogs

Creon is suitable for children of different ages, however, when individual intolerance arises, they give analog drugs, which have a similar composition and mechanism of action. The price for them is often lower.

The most famous analogs are:

They contain pancreatic enzymes that perform the same functions as the components of Creon, however, generics are not always suitable for a child who is not yet 2 years old, since they are tablet forms. This makes it difficult to swallow the medication at such an early age.

It is necessary to transfer the baby to an analogue of Creon in case of severe diarrhea or vomiting , arising from the intake of this medication, as well as due to individual intolerance. However, the appointment of another drug is carried out only by a doctor; an independent transition to cheaper analogs may not bring the desired therapeutic effect.

Creon is prescribed by the attending pediatrician in the presence of various digestive disorders provoked by insufficient enzymatic activity of the pancreas, for example, with diarrhea, colic, dysbiosis in a child. The drug is suitable for children of any age, the only difference will be in the dosage of the drug. Before giving Creon a drink to an infant, you should consult a pediatrician, and also establish an adequate drinking regimen.

Useful video about diseases of the pancreas in children

Against the background of unhealthy nutrition and bad ecology, digestive problems arise even in children. Against the background of complementary feeding, an imperfect digestive system of infants can malfunction due to a lack of enzymatic activity.

Diarrhea, pain, constipation, heartburn, increased gassing and flatulence - a similar symptomatology is considered the most typical for disorders of the gastrointestinal tract. In a similar situation, gastroenterologists recommend taking it to normalize digestion and eliminate pathological symptoms.

Can a child take this drug?

Digestive problems occur in patients of all ages, both adults and very young.

• , gastritis, cystic fibrosis and pancreatic pathologies are often found even in very young patients. It is for such patients that it is recommended to take Creon capsules, which are safe even for newborns and infants.
• Creon belongs to the most modern enzyme preparations the latest generation... It was developed to normalize digestion by replenishing the deficiency of enzymatic pancreatic-glandular activity.
• The drug has many advantages, because its main active ingredient is placed in microgranules, coated with a shell that is resistant to stomach acid.
• The microspheres are placed in a gelatin-based capsule. When the capsule reaches the stomach, it dissolves there, releasing hundreds of small microspheres. They mix evenly with food masses and penetrate with a lump of food into the intestinal cavity, where the shell of the microsphere dissolves, releasing pancreatic enzymes that will help food to be better broken down and absorbed.

Composition of the medicine

As part of the drug, the main active ingredient is pancreatin obtained by extract from the pancreas in pigs. Each capsule of Creon contains the amount of enzymes - amylase, protease and lipase, recommended and safe for children.

In fact, Creon is not a medicine in the generally accepted concept, because it does not force the children's body to produce the missing enzymes, but simply supplies them to the body in a ready-made form.

That is, in fact, Creon is prescribed for enzyme replacement therapy. When the child stops taking the drug, the lack of enzymes may reappear.

Indications and contraindications

• Babies need to be given only half the contents of the capsule at a time before each full meal.
• From a year old, children are prescribed one capsule also before a full meal.

Child over 3 years old

Children over 3 years of age can usually swallow the capsule on their own, but if it causes vomiting or difficulty swallowing, then the medicine should be given by analogy with children under three years of age, that is, by mixing microgranules with food or drink.

It is better to mix the microspheres from the capsule with something acidic that does not need to be chewed. For children, this can be yogurt, applesauce, or juice.

Before each full meal, the child is given 1-2 capsules of Creon. Usually, such children are prescribed to take the drug up to 3-5 times a day.

Also, parents need to know that pancreatin from Creon impairs the absorption of iron, therefore, with prolonged treatment, it may occur Iron-deficiency anemia... Against the background of treatment with Creon, you need to give the child more drink to avoid constipation.

Side effects

Failure to comply with the dosage, unreasonably long intake of Creon, or the presence of intolerance, the child may experience adverse reactions such as:

• Stool problems such as diarrhea or constipation
• Allergic reaction to the drug in the form of rashes, vomiting, etc.;
• Painful discomfort in the epigastric region.

To eliminate the likelihood of development adverse reactions, you must first familiarize yourself with the attached annotation, having studied the contraindications and possible reactions to the drug.

You should be especially careful when treating children under one year of age. It is allowed to take the drug by children who eat only breast milk, but only by medical prescription.

ABBOTT PRODUCTS, GmbH (Germany)

ATX: A09AA02 (Multienzymes (lipase, protease etc.))

Enzyme preparation

ICD: C25 Malignant neoplasm of the pancreas E84 Cystic fibrosis K83.1 Blockage of the bile duct K85 Acute pancreatitis K86.1 Other chronic pancreatitis K86.8 Other specified diseases of the pancreas (atrophy, stones, cirrhosis, pancreatic fibrosis) K90.3etetic .1 Syndromes of operated stomach K91.2 Malabsorption after surgery, not elsewhere classified

Enzyme preparation improving digestion processes. Pancreatic enzymes that make up the drug facilitate the digestion of proteins, fats, carbohydrates, which leads to their complete absorption into small intestine.
Creon 10,000 capsules, containing pancreatin in the form of enteric-coated minimicrospheres, dissolve quickly in the stomach, releasing hundreds of minimicrospheres. The aim of this principle is to mix the minimicrospheres with the intestinal contents and, ultimately, to better distribute the enzymes after their release within the intestinal contents.
When the minimicrospheres reach the small intestine, the enteric membrane is destroyed (at pH> 5.5), the release of pancreatic enzymes with lipolytic, amylolytic and proteolytic activity, which leads to the breakdown of fats, carbohydrates and proteins.
The digested substances are then either absorbed directly or further hydrolyzed by intestinal enzymes.

Indications

In animal studies, the lack of absorption of whole (uncleaved) enzymes has been demonstrated and, as a result, classical pharmacokinetic studies have not been performed. Preparations containing pancreatic enzymes are not ...

Contraindications

- hypersensitivity to any component of the drug.

Dosage

The drug is taken orally. The dose is determined individually, depending on the severity of the disease and the composition of the diet.
Capsules should be taken during or immediately after each meal (including snacks), swallowed whole, do not break ...

Overdose

Symptoms: hyperuricosuria and hyperuricemia.
Treatment: drug withdrawal, symptomatic therapy.

Drug interactions

Studies on the interaction of the drug Creon 10,000 with others medicines was not carried out.

Side effect

From the digestive system: very often (≥1 / 10) - pain in the abdomen; often (≥1 / 100, view in full

During pregnancy and breastfeeding

There are no clinical data on the use of preparations containing pancreatic enzymes during pregnancy. Prescribe the drug Creon 10,000 during pregnancy with caution if the intended benefit to the mother exceeds the potential ...

Application in children

Application is possible according to the dosage regimen.

special instructions

In patients with cystic fibrosis who received high-dose pancreatin preparations, strictures of the ileum and cecum and colon (fibrosing colonopathy) have been described. As a precautionary measure, if you experience unusual symptoms or changes in ...

Special conditions for admission

used with caution during pregnancy, may be used while breastfeeding, may be used for children

Pharmacokinetics

In animal studies, the lack of absorption of whole (uncleaved) enzymes has been demonstrated and, as a result, classical pharmacokinetic studies have not been performed. Preparations containing pancreatic enzymes are not ...

Conditions of dispensing from pharmacies

The drug is approved for use as a means of OTC.

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 25 ° C in a tightly closed container. Shelf life is 2 years.
After the first opening of the bottle, the shelf life is 3 months.

Release form

Enteric-soluble hard gelatin capsules, size No. 2, with a colorless transparent body and a brown opaque lid; the contents of the capsules are light brown minimicrospheres.
1 caps.
pancreatin
150 mg,
which matches ...

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Creon 10,000 - medicinal product to replenish the lack of pancreatic enzymes.

Release form and composition

The drug is available in the form of enteric capsules: hard gelatinous, with a transparent colorless body and an opaque brown lid, size 2; inside the capsules, light brown minimicrospheres are visible (20, 50 and 100 pcs. in white polyethylene bottles with a screw cap; in a cardboard box one bottle and instructions for use of Creon 10,000).

Composition for 1 capsule:

• active substance: pancreatin - 150 mg (corresponds to the content of protease - 600 U Ph.Eur., lipase - 10,000 U Ph.Eur., amylase - 8000 U Ph.Eur.);
• auxiliary components: hypromellose phthalate, cetyl alcohol, macrogol 4000, dimethicone, triethyl citrate;
• capsule body and cap: sodium lauryl sulfate, gelatin, black iron oxide dye, titanium dioxide, yellow iron oxide dye, red iron oxide dye.

Pharmacological properties

Pharmacodynamics

Creon 10,000 is enzyme agent, which improves the processes of food digestion in children and adults. As a result of the use of the drug, the severity of symptoms of enzyme deficiency is significantly reduced (the frequency and consistency of the stool changes, pain in the abdomen and flatulence disappears). Creon 10,000 enzymes facilitate the digestion of fats, proteins and carbohydrates, and this contributes to their more complete absorption in the small intestine.

Pork pancreatin is contained in capsules of the drug in the form of minimicrospheres, which are covered with an acid-resistant shell. After the capsules dissolve in the stomach, hundreds of minimicrospheres are released. Together with food, they enter the intestines, are thoroughly mixed with the intestinal contents, and then reach the small intestine, where the enteric membrane is rapidly destroyed. The released enzymes actively break down proteins, carbohydrates and fats. Then the resulting substances are absorbed directly or broken down by intestinal enzymes into smaller units.

Pharmacokinetics

Classical studies of the pharmacokinetics of the drug have not been carried out, since pancreatic enzymes show their therapeutic effect directly in the lumen of the small intestine before absorption. In terms of chemical structure, these are proteins that break down into gastrointestinal tract to amino acids and peptides, in the form of which they are absorbed into the intestinal wall.

Indications for use

Creon 10,000 is used in children and adults as a replacement therapy for pancreatic enzyme deficiency, resulting from a decrease in its enzymatic activity due to impaired production of pancreatic enzymes, regulation of their secretion, delivery to the site of action and also increased destruction in the intestine. The listed violations are caused various diseases digestive tract and are most often found in chronic pancreatitis, cystic fibrosis, pancreatic cancer, Schwachman-Diamond syndrome, obstruction of the common bile duct or pancreatic ducts, after complete or partial removal of the stomach, after surgery on the pancreas, in conditions after attacks of acute pancreatitis and subsequent resumption of nutrition.

Contraindications

Creon 10,000 is contraindicated in patients with hypersensitivity to pancreatin or any auxiliary component of the drug.

Creon 10 000: instructions for use (dosage and method)

Creon 10,000 capsules are taken orally, without chewing or breaking, with water or other liquid.

Doses are selected individually (the composition of the diet and the severity of the disease are taken into account). The drug should be taken with or after meals, at every meal, even with a light snack.

It is not always possible for small children or elderly patients to swallow the capsule whole. In such cases, it is opened and the contents are added to soft foods or sour-tasting drinks (yogurt, fruit juice, applesauce). The pH of the liquid or food should be less than 5.5. The prepared mixture of minimicrospheres with a drink or liquid cannot be stored and must be taken immediately after mixing.

Chewing capsules or using liquids or food with a pH of more than 5.5 to mix with the minimicrospheres can lead to destruction of the enteric membrane and early release of enzymes in oral cavity... As a result, the effectiveness of the drug decreases, and the mucous membranes of the oral cavity are irritated.

Patients should get enough fluids, especially when the need for it increases. Otherwise, you may experience or increase constipation.

With cystic fibrosis, the dose of Creon 10,000 depends on the patient's body weight. Children under 4 years of age at the beginning of therapy are prescribed 1000 lipase units per kg of body weight at each meal. For children over 4 years of age and adults, the starting dose is 500 lipase units per kg of body weight with each meal. In the future, the dose of the drug is increased, taking into account the severity of the symptoms of the disease, controlling steatorrhea and maintaining an adequate nutritional status. Usually, daily dose does not exceed 10,000 lipase units per kg of body weight or 4,000 lipase units per g of fat consumed.

In other conditions with enzyme deficiency of the pancreas, the dose of Creon 10,000 is set individually, taking into account the fat content of the food and the degree of insufficiency of digestion. In the main meal, the dose of pancreatin is 25,000–80,000 U of lipase, during or after a light snack - 1/2 of the individual dose.

Side effects

• digestive system: very often - abdominal pain; often - vomiting, nausea, bloating, diarrhea, or constipation; with an unknown frequency - fibrosing colonopathy (in patients with cystic fibrosis who received high doses of pancreatin);
• immune system: with an unknown frequency - anaphylactic reactions (mainly from the skin);
• skin and subcutaneous fat: infrequently - rash; with an unknown frequency - urticaria, pruritus.

Overdose

In case of an overdose of the drug in the blood and urine, increased content uric acid.

Creon 10,000 should be canceled and symptomatic treatment initiated.

special instructions

If, during drug therapy, the patient develops changes in abdominal cavity or other unusual symptoms, a medical examination should be done to rule out strictures of the blind, ileum, and colon. The likelihood of fibrosing colonopathy increases in patients with cystic fibrosis who receive Creon 10,000 in a daily dose of 10,000 IU of lipase or more.

Influence on the ability to drive vehicles and complex mechanisms

The effect of the drug on the ability to drive vehicles is insignificant or absent.

Application during pregnancy and lactation

Experimental studies have shown that pancreatin is not teratogenic. Despite this, the use of the drug during pregnancy is possible only in exceptional cases when the benefits of treatment for the mother exceed possible risk for the fetus.

Childhood use

In children, Creon 10,000 capsules are used according to indications, adhering to the recommended dosage regimen. The high activity of lipase, which is found in pancreatin, increases the risk of constipation in children.

Drug interactions

The effectiveness of pancreatin can be reduced in combination with antacids containing magnesium hydroxide and / or calcium carbonate.

Creon 10,000 can reduce iron absorption. It is theoretically possible to reduce the effectiveness of acarbose under the action of pancreatin.

Analogs

The analogues of Creon 10,000 are: Creon 25,000, Creon 40,000, Mezim 20,000, Mezim forte 10,000, Pangrol 25,000, Gastenorm forte 10,000, Gastenorm forte, Penzital, Pancreatin, PanziKam, Micrasim, Creon Micro, Pancreasim, Pancreatin- LekT, Mezim forte, Pancreatin forte, Hermital, Panzim forte, Enzistal-P, etc.

Terms and conditions of storage

Store in a tightly closed bottle at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Shelf life is 2 years. Capsules from an opened bottle must be used within 3 months.

Composition and release form of the drug

◊ Enteric capsules hard gelatinous, size No. 2, with a colorless transparent body and a brown opaque lid; the contents of the capsules are light brown minimicrospheres.

Excipients: macrogol 4000 - 37.5 mg, hypromellose phthalate - 56.34 mg, dimethicone 1000 - 1.35 mg, cetyl alcohol - 1.18 mg, triethyl citrate - 3.13 mg.

Composition of a hard gelatin capsule: gelatin - 60.44 mg, iron dye red oxide (E172) - 0.23 mg, iron dye yellow oxide (E172) - 0.05 mg, iron dye black oxide (E172) - 0.09 mg, titanium dioxide (E171) - 0.07 mg, sodium lauryl sulfate - 0.12 mg.

20 pcs. - bottles made of white high density polyethylene with a screw cap made of polypropylene (1) - packs of cardboard.
50 pcs. - bottles made of white high density polyethylene with a screw cap made of polypropylene (1) - packs of cardboard.
100 pieces. - bottles made of white high density polyethylene with a screw cap made of polypropylene (1) - packs of cardboard.

pharmachologic effect

Enzymatic agent. Contains pancreatic enzymes - amylase, lipase and proteases, which facilitate the digestion of carbohydrates, fats and proteins, which contributes to their more complete absorption in the small intestine. In diseases of the pancreas, it compensates for the insufficiency of its exocrine function and helps to improve the digestion process.

Pharmacokinetics

The pharmacokinetics of pancreatin have not been studied.

Indications

Lack of exocrine pancreatic function (including chronic cystic fibrosis).

Chronic inflammatory-dystrophic diseases of the stomach, intestines, liver, gallbladder; conditions after resection or irradiation of these organs, accompanied by impaired digestion of food, diarrhea (as part of combination therapy).

To improve the digestion of food in patients with normal gastrointestinal tract function in case of errors in nutrition, as well as in violation of chewing function, forced prolonged immobilization, a sedentary lifestyle.

Preparation for X-ray and ultrasound organs of the abdominal cavity.

Contraindications

Acute pancreatitis. Hypersensitivity to pancreatin.

Dosage

The dose (in terms of lipase) depends on the age and the degree of pancreatic insufficiency. The average dose for adults is 150,000 U / day. With complete insufficiency of the exocrine function of the pancreas - 400,000 U / day, which corresponds to the daily requirement of an adult for lipase.

Maximum daily dose is 15,000 U / kg.

Children under the age of 1.5 years - 50,000 U / day; over 1.5 years old - 100,000 U / day.

The duration of treatment can vary from several days (if the digestive process is disturbed due to dietary errors) to several months or even years (if constant substitution therapy is necessary).

Side effects

When used in medium therapeutic doses side effect observed in less than 1%.

From the digestive system: in some cases - constipation, discomfort in the stomach, nausea. The causal relationship between the development of these reactions and the action of pancreatin has not been established. these phenomena refer to the symptoms of exocrine pancreatic insufficiency.

Allergic reactions: in some cases - skin manifestations.

From the side of metabolism: at long-term use in high doses, the development of hyperuricosuria is possible, in excessively high doses - an increase in the level of uric acid in the blood.

Others: when using pancreatin in high doses in children, perianal irritation may occur.

Drug interactions

With simultaneous use with antacids containing calcium carbonate and / or magnesium hydroxide, it is possible to reduce the effectiveness of pancreatin.

With simultaneous use, it is theoretically possible to reduce the clinical efficacy of acarbose.

With simultaneous use with iron preparations, it is possible to reduce the absorption of iron.

special instructions

When the dose should be adequate to the amount of enzymes, which is necessary for the absorption of fat, taking into account the quality and quantity of food consumed.

In case of cystic fibrosis, the use of pancreatin in doses of more than 10,000 U / kg / day (in terms of lipase) is not recommended due to an increased risk of developing strictures (fibrous colonopathy) in the ileocecal region and in the ascending colon.

With a high activity of lipase contained in pancreatin, the likelihood of constipation in children increases. Increasing the dose of pancreatin in this category of patients should be carried out gradually.

Gastrointestinal disorders may occur in patients with hypersensitivity to pancreatin, or in patients with a history of meconium ileus or bowel resection.

Pregnancy and lactation

The safety of using pancreatin has not been studied enough. Application is possible in cases where the expected benefit to the mother outweighs the potential risk to the fetus.

In experimental research found that pancreatin has no teratogenic effect.

Childhood use

Application is possible according to the dosage regimen. With a high activity of lipase contained in pancreatin, the likelihood of constipation in children increases.