Active substance:

One bottle contains 10 ATRA LLC (antitripsen units) of the APRETININA active substance obtained from the lungs of cattle.

Ancillary:

Mannitol

One ampoule with solvent contains 2 ml of isotonic sodium chloride solution.

Description

Basic physico-chemical properties:

active substance in bottles: a substance of white or almost white in the form of a lyophilisate.

Solvent in ampoules: transparent, colorless liquid

pharmachologic effect"Type \u003d" Checkbox "\u003e

pharmachologic effect

A polyvalent protease inhibitor has an antiproatic, antifibrinolytic and hemostatic effect.

Possessed wide spectrum Inhibitory actions and therefore can be used not only as an antifibrinolyticism, but also as a prophylactic and therapeutic agent for violations of other enzyme systems. APRETININA activity is expressed in the kallicrein inactivating units (KIE), as well as in antitripsene units (ATRA).

1 ATRA corresponds to 1.33 kie.

The presence of antiprotezine activity determines the efficiency of aprotinine under the affixes of the pancreas and other states accompanied by a high content of kallicrein and other proteases in plasma and tissues. Reduces the fibrinolytic activity of blood, inhibits fibrinolysis and has a hemostatic effect in coagulopathy. The blockade of the kallicrein-kinin system allows you to use it for prevention and treatment various shapes shock.

Pharmacokinetics

Indications for use

Acute pancreatitis;

Prevention of postoperative pancreatitis and fatty embolism;

Bleeding and hemorrhage due to hyperfibrinolysis: post-traumatic, postoperative; before, after and during childbirth; severe hemorogic complications during thrombolytic therapy;

Shock states.

Contraindications

Contracting should not be prescribed to patients with increased sensitivity to apricin. In patients with increased tendency to ultra-sensitive reactions or increased sensitivity to drugs, the contricane is applied only with great caution. In the first 3 months of pregnancy, the contrikal does not apply.

Pregnancy and lactation period

Method of application and dose

The contents of 1 vial are dissolved in 2 ml of isotonic sodium chloride solution. This solution is administered to a patient in the lying position of intravenously inkjet (slowly, maximum 5 ml in 1 minute) or by a brief or long drip infusion. Patients with acute pancreatic necrosis and effusion in abdominal cavitycontaining enzymes, conflict can be introduced further intraperitoneally.

Without the prescription, the doctor for conflict is valid the following dosing modes: with acute pancreatitis: Immediately intravenously (slowly) Patients are introduced 200,000 - 300 ATRA Pontical Ltd., then 200,000 - 300,000 ATRA contrikala are still injected intravenously. This treatment is carried out up to normalization. clinical picture Diseases and laboratory tests.

Prevention of postoperative pancreatitis: Slowly intravenously entered in a dose of 200,000 ATRU per day as auxiliary treatment.

For the treatment of shock states: Initially, slowly intravenously entered in a dose of 200,000 - 300,000 ATRA, then in a dose of 140, LLC every 4 hours.

Prevention of Euyremic Emmolia: First, slowly intravenously entered in a dose of 200,000 ATRA, then approximately 200,000 ATRA contrikala as auxiliary treatment, then somewhat slowly intravenously.

When bleeding: Initially, slowly intravenously entered in a dose of 300,000 ATRA, then every 4 hours slowly intravenously entered in a dose of 140,000 atre. Children of the contrikal are introduced in a daily dose of 14,000 aths per kg of body weight.

Side effect

It is possible, more likely after repeated administrations, skin rash, symptoms of anaphylactic reactions up to the development of anaphylactic shock. In addition, tachycardia, nausea, vomiting, arterial hypotension, pallor of skin, shortness of breath, abundant sweating are possible. With the appearance of the listed adverse Reactions Consult a doctor immediately. In the event of any unusual reactions, be sure to consult a doctor about further application Drug!

Overdose

In numerous trials carried out on different types Animals, even when applying aprotinine in doses, far exceeding therapeutic doses for people, no toxic influences were detected.

Interaction with other medicines

Pontrick reduces streptocinase and urchinase activity. If possible, the contricane should not be combined with other drugs, especially with R-lactam antibiotics.

If you take any other drugs, be sure to inform your doctor about it! During the treatment of 10,000, do not take any other medicines (including those that are released without a recipe) without prior consultation with the doctor. Uncontrolled treatment can harm your health.

Features of application

Precautions

A break in the treatment or premature cessation of the use of the drug reduces the likelihood of treatment success.

Pontrick is a drug for the treatment of acute pancreatitis.

pharmachologic effect

The active substance of the contrikala is an apricin, which is characteristic of inhibiting proteolytic enzymes.

Also, an apricin inhibits the kallicrein-kinine system, so it can be used at different shocks.

The drug is inactivating proteinases and plasmin, which makes it possible to use it during acute pancreatitis or coagulopathy.

The drug in the kidneys is metabolized, removed from the urine for two days.

Form release

Release in powder for dilution of the solution for the introduction of the drug intravenously. You can buy conficilla with a solvent, in a pack of 10 ampoules.

Analogs of Contrikal - Gordskos, Agex, Aprotinin, Inhiprol, Vero-Narkap, Trasilol 500 000, Ingitril, Traskolan, Aerub.

Indications for applying

According to the instructions, the contrikal is prescribed for treatment acute forms Pancreatitis (including pancreatic), to prevent pancreatitis occurrence after operations, fat embolism after fractures and operations.

Good feedback on conficilla used in complex therapy toxic, burn, hemorrhagic, traumatic shock.

Also, the use of conflict is effective during bleeding due to coagulopathy (blood coagulation disorders) provoked by hyperfibrinolysis.

Contraindications

According to the instructions, the contrikal cannot be used with hypersensitivity to the active substance, during pregnancy (for a period of up to 12). Caution should be observed when using conflict patients with polyvalent allergies.

After 12d. Pregnancy The drug can only be applied for special testimony.

It is impossible to take conflict simultaneously with the urchinase, streptokinase, it can brake their action. It is also not compatible with antibiotics and solutions containing lipids, amino acids, dextran.

You can only buy conficure by recipe.

If you need to use the analogues of the counterpart, you should familiarize yourself with their instructions, because Side effects and contraindications may differ.

Instructions for use of conficilla

You can buy conflict in ampoules 10,000, 30,000, 50000Ened.

For the treatment of acute pancreatitis, the remedy is administered intravenously and as early as possible, in the dosage of 200,000 - 300 000. After that, for 24 hours. Drip intravenously introduced the same dose of the means. Treatment usually lasts before improving the state of the patient and a positive change in these analyzes.

For the prevention of postoperative pancreatitis, a tool is prescribed in the initial dose of 200,000, after which the four rubles are introduced 100 000ied every 6h.

To eliminate shock, the contrikal begin to enter in a dose of 200,000 each per day, and after every 4h. - 140 000Ad.

To prevent fat embolism, the use of conflict starts with a dose of 200,000, which is injected at low speed intravenously. After that, 200,000-1d per day drip intravenously.

For the treatment of coagulopathy, the contrikal according to the instructions are prescribed to enter in a dose of 300 ° C at low speed intravenously, then every 4h. - Drip intravenously at 140 000.

Positive feedback on conficilla used to stop generic bleeding. Appointed for early 700,000 - 1 000 ° C intravenously and then 700 ° C each hour before elimination of bleeding.

The drug for children is prescribed at the rate of 14 000 to 1 kilogram of the child's weight. We introduce the drug to children in an intravenous or drip (at low speed, no more than 5 ml / min), in the position lying. Before use, the contricane is dissolved with a solution of sodium chloride 0.9%. Improve the solution immediately, it is impossible to store it.

Side effects

The tool can lead to allergic reactions, increasing heart Rhythm, sweating, weakness, shortness of breath, nausea, skin sonicity.

There are reviews about conficure, that there is a big risk of appearance side effects After re-administering the drug, but they may occur after the first introduction.

In the event of the appearance of side effects, it is necessary to cancel the drug and use the counterpart analogues.

Yours faithfully,

Lyophilized substance , in bottles 5 pcs. In the contour package and complete with a physiological solution for breeding powder.

This form, like pills, is not released.

pharmachologic effect

Medicine in its structure is polypeptide and prepares from the pulmonary fabric of cattle. Inhibits kallicrein-kinin system both in general and individual components. Blocks proteases that actively participate in fibrinolysis , plazmin , and other enzymes.

Contracyl inhibits fibrinolysis and used as coagulopathy as hemostatic .

1 Antitrypsin unit corresponds to 1.33 kallicrein inactivating units (KIE).

Pharmacodynamics and pharmacokinetics

Apricin in gastrointestinal Inactivated. Half-life up to 10 hours. Excreted by the kidneys.

Indications for the use of conficilla

• in acute phase;
• operations on the pancreas for prophylaxis outolyza;
• caused by activation of fibrinolysis (postoperative, postpartum, post-traumatic, polymenorrhea );
• all species shock (traumatic, hemorrhagic, toxic, burn);
• prevention of postoperative vapotitis;
• massive damage to the soft tissues due to injuries;
• prevention of postoperative bleeding and.

There are also indications for the use of conflict in complex therapy coagulopathy and bleeding.

Contraindications

• in the I and III trimester;
• DVS syndrome ;
• breastfeeding period;
• intolerance of cattle protein;
• individual sensitivity to the drug.

Side effects

In case of prolonged infusions - flebitis and.

Instructions for use of conficilla (method and dosage)

The dose depends on the severity of the condition and the clinical picture. Enter intravenously drip. In most cases, the initial dose is 500 thousand kie, to maintain - 50 thousand kiet per hour.

Overdose

Symptoms were not observed. Allegedly, side effects can enhance.

Interaction

Simultaneous use with increases blood coagulation time.

Combination S. reomakodex It is able to strengthen sensitization on both drugs.

Terms of sale

On prescription.

Storage conditions

Temperature that does not exceed 25 ° C.

Shelf life

3 years. .

Concrikala synonyms

Apricin , Gordoks , .

Children

Apply according to readings. Dose is determined according to body weight.

During pregnancy and lactation

Strict contraindication is the application in the I and III trimester of pregnancy. There is no data on the efficiency and safety of the application during the lactation period and in the II trimester of pregnancy.

Name:

Contrickle (Contrycal)

Pharmacological
act:

Polypeptidederived from lung cattle. Blocks the kallicrein-kinin system.
Inhibits both the total proteolytic activity and the activity of individual proteolytic enzymes.
It is a polyvalent protease inhibitor (including plasmin, kinningogenase, tripsin, chymotrypsin, kallicrein, including activating fibrinolysis).
Reduces the fibrinolytic activity of blood, inhibits fibrinolysis, has a hemostatic effect with coagulopathy.
The activity of the apricinine is expressed in the kallicrein inactivating units (KIE), in trypsin inactivating units of the European Pharmacopoeia (Ph.eur.u), as well as in antitripsene units (ATRA). 1 Ph.eur.u corresponds to 1800 kie. 1 ATRA corresponds to 1.33 kie.
Pharmacokinetics
Aprotinin, being a polypeptide, is inactivated in the gastrointestinal tract.
Displays with urine in the form of inactive decay products. T1 / 2 in the terminal phase is 7-10 hours.

Indications K.
application:

Pancreatitis (acute, exacerbation of chronic), pancreonenecosis;
- the implementation of diagnostic research and operations in the pancreas (prevention of the enzymatic autolysis of the pancreas during operations on it and nearby organs of the abdominal cavity);
- prevention of acute nonspecific postoperative vapotitis;
- bleeding against the background of hyperfibrinolysis: post-traumatic, postoperative (especially during operations on prostate gland, lungs), before, after and during childbirth (incl. with embolism of inchopulod water);
- Polymenia;
- angioedema edema;
- shock (toxic; traumatic, burn, hemorrhagic);
- extensive and deep traumatic damage to fabrics;
- as auxiliary therapy - coagulopathy, characterized by secondary hyperfibrinolysis (in the initial phase, before the effect of the effect after applying the heparin and replacement of coagulation factors); massive bleeding (during thrombolytic therapy), when conducting an extracorporeal blood circulation;
- prevention of postoperative pulmonary embolism and bleeding; Fat Emblem with polytrams, especially when fractures lower extremities and bones of the skull.

Mode of application:

With acute pancreatitis: The introduction of conficilla should begin as early as possible, the drug is administered intravenously, with a low speed, in a dose of 200,000 - 300,000 units, then during the day the same dose of the intravenously is injected drip.
Therapy continues until improving objective (analyzes data) and subjective symptoms (improvement of the patient's condition).
Prevention of pancreatitis in operational interventions: Initial dose of conficing 200000 units, then 100,000 units four times a day, every 6 hours.
Treatment of Shock: Initial dose of 200,000 units / day conficilla, then 140,000 e dayy every 4 hours.
Prevention of fat embolia: Initial dose of 200000 U intravenously at low speed, then 200000 UR / day intravenously drip.
Under coagulopathy: Initial dose of 300,000 units intravenously at low speed, then 140,000 units intravenously drip, every 4 hours.
Bleeding in kind: The initial dose of 700,000 is 10,000,000 units, then 700,000 units every hour before the bleeding stop.

For kids The daily dose of conflict is 14000 units per 1 kg of body weight of the child.
The conficilla is introduced intravenously inkjet (with low speed, no more than 5 ml / min) or drip, the drug should be entered when the patient is in the position of the lying. A 0.9% NaCl solution is added before administration to the contents of the vial.
The prepared solution should be entered immediately, the introduction after long-term storage is unacceptable.

Side effects:

From side immune system : Anaphylactic shock, angioedema swelling.
From the skin and subcutaneous fiber: Rash on the skin, maculopapulous rash, urticaria, itching, color change.
Gastroy violations: nausea, vomiting, especially with rapid administration.
From the hepatobiliary system: Violation of the liver function, jaundice, liver failure.
Cardial disorders: arrhythmia, tachycardia, ventricular tachycardia, atrial fibrillation, decline / increased blood pressure, shortness of breath, sore pain, ischemia myocardium, myocardial infarction, thrombosis coronary arteries, pericarditis.
Neurological violations: psychotic reactions, hallucinations, confusion of consciousness, tremor, excitation, dizziness, cramps.
From the urinary system: OPN, Anuria, neurosis of the renal tubules, an increase in creatinine in blood plasma.

Vascular disorders: embolism, thrombosis, arterial thrombosis, pulmonary artery embolism.
From the respiratory system, chest and mediastinal organs: shortness of breath, cough, bronchospasm, pain in chest, pulmonary edema.
From the musculoskeletal system and connective tissue : Arthralgia, Malgy.
Violation of metabolism, metabolism: hyperglycemia, hypokalemia, acidosis, hypervolemia.
From the blood system and lymphatic system: Syndrome of DVS, Coagulopathy, leukocytosis, thrombocytopenia, reduced prothrombin.
Others: total weakness, increased sweating, hyperthermia, thrombophlebitis at the place of infusion.
For re-administration APRETININA (for 6 months after the first administration) occasionally allergic reactions may occur various degrees severity.
Even when the second administration of aprotinine does not cause any symptoms, the third administration can lead to the emergence of reactions from allergic to anaphylactic. In such cases, the injection / infusion of apricinine should be immediately terminated.
If necessary, start anti-flipping therapy according to ordinary clinical standards.

Contraindications:

DVS syndrome (with the exception of the coagulopathy phase);
- I and III pregnancy trimesters, lactation period;
- increased sensitivity to apricin;
- Increased sensitivity to cattle protein.

Before starting therapy, it is desirable to conduct a skin test for the individual sensitivity of the patient to the apricin.
When indicating in history for allergic reactions before the start of therapy, aprotinin recommends the use of histamine H1 receptors and GCS blockers.
In hyperfibrinolysis and the engine, it is possible to use an aprotinin only after eliminating all the manifestations of the DVS syndrome and on the background of the prophylactic action of heparin.
Carefully To apply in patients to which minelaxants injected over the previous 2-3 days.