The drug grammidin indications for use. Grammidin tablets (Neo and Neo with anesthetic) for resorption: instructions, features of use in children and adults. What to choose - red or green Grammidin. Means "Grammidin neo" - what is it
Grammidin is an antibacterial combination drug for topical application in the mouth and pharynx. The active ingredient is Gramicidin S.
An antibacterial agent, has a bacteriostatic (Streptococcus pneumoniae, meningococci, gonococci, pathogens of anaerobic infections) and high concentrations bactericidal action on Streptococcus spp. and Staphylococcus spp.
Increases the permeability of the membrane of a microbial cell for inorganic cations due to the formation of a network of channels in the lipid structures of the membrane, which causes the development of osmotic instability of the cell.
The anesthetic included in the Grammidin tablet has a local anesthetic effect and effectively eliminates pain in the pharynx and oral mucosa. The remedy relieves pain quickly enough: relief can be felt almost immediately after the pill is completely absorbed.
When resorbed, it stimulates hypersalivation, which contributes to the mechanical cleansing of the oral cavity and pharynx from microorganisms, that is, enhances salivation, helping to cleanse the oropharynx from microorganisms and inflammatory exudate.
How is Grammidin NEO different?
Additional active substance Grammidin NEO - Cetyliridinium Chloride, helps to relieve discomfort in the throat.
Indications for use
What does Grammidin help with? According to the instructions, the drug is prescribed in the following cases:
- Tonsillitis is an acute inflammation of the tonsils.
- Stomatitis is an infectious process in the oral mucosa.
- Gingivitis is a bacterial inflammation of the gums.
- Periodontal disease is an inflammation of the tissues surrounding the tooth (periodontium).
- Angina is a purulent inflammation of the tonsils, often caused by streptococci or staphylococci.
- Tonsillitis is an inflammatory infectious process in the larynx.
- Pharyngitis is a bacterial pathological process in the pharynx.
The drug is used for infectious and inflammatory diseases of the upper respiratory tract and pharynx.
Instructions for use of Grammidin, dosages
The drug must be taken immediately after meals. The tablets are kept in the mouth until they are completely absorbed, they cannot be chewed. After each dose of the drug, you should refrain from drinking and eating for 1-2 hours.
Dosage of tablets Grammidin with anesthetic, according to the instructions for use - 1 tablet \ 3 or 4 times a day. With severe symptoms of the disease, the permissible dosage for adults is 2 tablets up to 4 times a day (the tablets are taken one after the other with an interval of 20-30 minutes).
Dosage of Grammidin for children:
- Children over 12 years old and adults - 2 tablets (they dissolve directly one after the other within half an hour) 4 times a day.
- Children under the age of 12 - 1-2 tablets 4 times a day.
The average duration of the course of therapy is 5-6 days. With ongoing symptoms inflammatory process, you need to see a doctor.
Instructions for use of Grammidin NEO
The drug is prescribed for adults and children (from 12 years old) 1 tablet 3-4 times a day.
Children from 4 to 12 years old - 1 tablet Grammidin NEO \ 1-2 times a day.
The duration of the course is 7 days. With absence therapeutic effect within 7 days of taking the drug, you must consult a doctor.
Side effects
The instruction warns of the possibility of the development of the following side effects when prescribing Grammidin:
- allergic reactions;
- temporary loss of sensitivity of the tongue.
Contraindications
It is contraindicated to prescribe Grammidin in the following cases:
- 1 trimester of pregnancy;
- children under 4 years of age;
- hypersensitivity to the components of the drug.
If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be resolved.
Overdose
Overdose cases have not been registered and described. Strengthening possible adverse reactions.
Analogues Grammidin, price in pharmacies
If necessary, you can replace Grammidin with an analogue for the active substance - these are drugs:
- Grammidin Neo.
According to the therapeutic effect:
- Gramicidin (from 112.00 rubles),
- Gramicidin C hydrochloride,
- Gramicidin C
When choosing analogues, it is important to understand that the instructions for the use of Grammidin, the price and reviews, do not apply to drugs of a similar action. It is important to consult a doctor and not make your own replacement of the drug.
Price in Russian pharmacies: Grammidin for children 1.5mg + 1mg 18 tablets for sucking - from 236 to 304 rubles, the cost of Grammidin NEO with anesthetic 3mg 18 tablets for sucking - from 215 to 310 rubles, according to 482 pharmacies.
Store in a dry, dark place at a temperature not exceeding 25 ° C. Keep out of the reach of children. Shelf life is 2 years.
Terms of dispensing from pharmacies - without a prescription.
Many people suffer various diseases oral cavity with infectious etiology... This is especially common in the cold season.
Grammidin tablets will come to the rescue and help to quickly get rid of a sore throat.
Instructions for use
The active ingredient of the drug "Grammidin" is the antibiotic gramicidin. "Grammidin" is an antibacterial, antiseptic and local anesthetic drug, which is intended for topical use, for absorption in the oral cavity.
The active substance provides a bactericidal effect due to which there is a noticeable improvement in the permeability of the cell wall of gram-negative and gram-positive bacteria.
This medicine acts on almost all pathogens that provoke the development of various infectious and inflammatory diseases of the oral cavity and pharynx.
As a result of damage to the cell wall, the microorganism dies almost instantly. Grammidin is non-addictive bacteria.
During resorption tablets profuse salivation occurs, which also contributes to the active cleansing of the oral cavity and pharynx from a variety of microorganisms and their waste products.
The anesthetic oxybuprocaine has a local analgesic effect on the mucous membrane of the mouth and throat almost instantly. It provides a reversible blockade of the spread and conduct nerve impulses through the axons of nerve cells.
Cetylpyridinium chloride belongs to the group of antiseptic agents. It is intended to suppress the growth and subsequent reproduction of pathogens infectious diseases oral cavity.
The drug has an analgesic effect, reduces inflammation, has an antimicrobial effect, softens discomfort in the throat, facilitates swallowing, and when absorbed, causes hypersalivation, which contributes to the mechanical cleansing of the oral cavity and pharynx from microorganisms.
Indications
The indications for the use of "Grammidin" are infectious lesions of the oral cavity and pharynx, which are accompanied by the prevalence of pain syndrome:
- acute pharyngitis, unspecified;
- angina agranulocytic (acute tonsillitis, unspecified);
- acute tonsillitis;
- gingivitis;
- periodontal disease;
- periodontitis;
- stomatitis, as well as related lesions.
Reception medication Grammidin is usually prescribed by your healthcare professional after a meal. The tablet must be sucked in the mouth. It is forbidden to chew it. After use, do not eat or drink for the next two hours.
Dosage for older people over twelve years old is 2 tablets (you need to take one after the other with a time interval of thirty minutes) - 4 times a day.
Children under twelve years old 1-2 tablets should be given 4 times a day. As a rule, the duration of the course of treatment is 5-6 days.
Interaction with other drugs
As for the interaction of "Grammidin" with other drugs, the drug is capable of enhancing the various effects of many other antibiotics, which are prescribed both locally and systemically.
The medication is produced pharmaceutical company in the form of tablets, which have either a white or white-yellowish color. One standard cardboard box contains two plastic blisters, ten small tablets each.
The drug contains an active substance, as well as several additional components. The antibiotic gramicidin C with the addition of cetylpyridinium chloride and oxybuprocaine is the main component of the tablets. Inactive substances include calcium stearate, milk sugar, sugar, and methylcellulose.
Side effects
In most cases, "Grammidin" does not cause various side effects. However, some patients sometimes show signs of allergic reactions.
In addition, this drug has a fairly strong anesthetic effect, which can cause a temporary violation of the sensitivity of the tongue.
"Grammidin" is contraindicated for people who are allergic to one or another component contained in the medicine.
Storage conditions and periods
Store "Grammidin" must be stored indoors at a temperature not exceeding 25 ° C, in a place that is reliably protected from direct sunlight. The drug should be kept out of the reach of children.
The shelf life of the tablets is no more than three years. It is forbidden to take an expired medicine, because it can lead to side effects.
Price
In Ukrainian pharmacies the drug "Grammidin" can be purchased at a price of 225 to 265 hryvnia.
In pharmacies within the territory of Russian Federation this medicine costs from seven hundred rubles.
Analogs
Today, many pharmaceutical companies produce drugs that are similar in action to Grammidin. Its counterparts include the following medicines:
1 tablet contains:
Active substances: gramicidin C - 3.00 mg (in the form of gramicidin C dihydrochloride - 3.20 mg), cetylpyridinium chloride - 1.00 mg (in the form of cetylpyridinium chloride monohydrate - 1.05 mg).
Excipients: colloidal silicon dioxide - 5.00 mg, talc - 60.00 mg, acesulfame potassium - 15.00 mg, mint flavor - 25.00 mg, sorbitol - 1065.75 mg, magnesium stearate - 25.00 mg.
Pharmacotherapeutic group
Means for the treatment of diseases of the larynx and pharynx. Other antiseptics.
ATX code: .
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Pharmacological properties
Pharmacodynamics
Combined drug for the treatment of infectious and inflammatory diseases of the pharynx and oral cavity. The drug contains the antimicrobial agent gramicidin C and the antiseptic agent cetylpyridinium chloride.
The mechanism of action of gramicidin C is associated with an increase in the permeability of the cytoplasmic membrane of the microbial cell, which disrupts its stability and causes cell death.
Cetylpyridinium chloride is an antiseptic from the group of quaternary ammonium compounds, has antimicrobial and antifungal (Candida albicans) action, does not affect mycobacteria.
Pharmacokinetics
The drug has local action and is practically not absorbed in the gastrointestinal tract.
Indications for use
Local symptomatic treatment of infectious and inflammatory diseases of the oral cavity and pharynx.
Method of administration and dosage
It is used after meals, by absorption in the mouth without chewing.
Immediately after using the drug, you should refrain from eating and drinking for 1-2 hours.
Dosage for adults and children over 12 years old: 1 tablet 3-4 times a day.
Dosage for children from 6 to 12 years old: 1 tablet 1-2 times a day.
The drug should not be taken for more than 7 days. If necessary, more long-term use or the lack of a therapeutic effect (including in case of worsening of the condition), it is recommended to consult a doctor.
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Side effect
The frequency of adverse reactions is determined using the following scale: very often (> 1/10), often (> 1/100 to<1/10), нечасто (>1/1000 to<1/100), редко (> 1/10000 <1/1000), очень редко (<1/10000), неизвестно (частота не может быть оценена на основании имеющихся данных).
Rarely: allergic reactions, changes in taste, irritation of the oral mucosa, delayed wound healing of the oral mucosa.
Frequency not known: nausea, vomiting.
In case of adverse reactions, including those not listed in this instruction, you should consult a doctor.
Contraindications
Hypersensitivity to the components that make up the drug;
- children under 6 years old;
- pregnancy.
Overdose
There is no information on overdose cases.
Given the amount of active and auxiliary substances contained in 1 tablet, the possibility of overdose is minimal.
Symptoms when the recommended doses for cetylpyridinium chloride are exceeded are gastrointestinal disturbances (nausea, vomiting, diarrhea).
Sorbitol, which is part of the drug, with a significant overdose (more than 30 g of sorbitol per day) can cause diarrhea, flatulence.
In case of overdose, consult a doctor.
Treatment: drug withdrawal, gastric lavage, symptomatic therapy.
Precautionary measures
If during the use of the drug the symptoms of the disease persist or the condition worsens (the temperature rises, there is a cough, headache, vomiting, etc.), you should consult a doctor.
In case of bacterial infections, in particular those caused by streptococcus, it is recommended to prescribe the main etiotropic therapy with an appropriate antibacterial agent of systemic action.
With the development of a viral infection, the use of the drug as monotherapy may not be effective enough, since the viral infection develops intracellularly.
It is not recommended to use cetylpyridinium chloride in case of damage to the mucous membrane due to the possible inhibition of repair processes.
Patients with contact allergies should not take the drug, as the likelihood of sensitization increases.
The use of the drug can temporarily change the taste sensation, but within 4 hours after taking the drug, the perception of taste is restored. It is recommended to take the drug after meals.
For some dosage forms of preparations containing cetylpyridinium chloride, it has been shown that their prolonged use can cause a slight temporary brown staining of the teeth and tongue, but these phenomena disappear after the drug is discontinued.
Due to the content of sorbitol, the drug is not recommended for patients with congenital fructose intolerance.
Due to the content of sorbitol, the drug may have a mild laxative effect.
Application in children:
Do not use in children under 6 years of age due to the risk of accidental ingestion of the tablet into the respiratory tract and aspiration.
Application during pregnancy and lactation
The drug is contraindicated for use during pregnancy due to the lack of sufficient data.
There are no data on the penetration of active ingredients into breast milk. Taking the drug is not recommended during breastfeeding.
The drug Grammidin is widely used for the active treatment of pathologies in the mouth, throat, inflammation and infection. The active ingredients have a detrimental effect on the pathogenic microflora and effectively fight stomatitis, tonsillitis and sore throat. In order to prevent serious negative consequences, it is important to study the instructions for use of the drug Grammidin.
The drug Grammidin is an antibacterial agent used for topical use in diseases of an infectious and inflammatory nature of the oral cavity and throat.
The main and active medicinal substance of the drug is grammidin C. Its content depends on the type of drug and varies from 1.5 to 3 milligrams. The composition of the medication includes other substances:
- lactose monohydrate;
- sugar;
- methylcellulose;
- calcium stearate.
What are the forms of release
A pharmaceutical company offers several forms of the popular remedy:
- Grammidin (spray, tablets). The dosage for the active compound is 1.5 milligrams. The second shape has a convex appearance, yellow or white.
- Grammidin Children's, is widely used in the treatment of diseases in children.
- Grammidin Neo is produced in the form of white tablets. It contains the maximum amount of active substance - 3 milligrams each. The package contains 6 to 9 pieces.
- Grammidin with anesthetic.
- Neo Grammidin with an active anesthetic.
There are only 5 types of medicine, they differ in the presence or absence of certain additional substances, since the active compound is one - Grammidin C. The main distinguishing feature is the color scale on the package. For example, red stands for Grammidin with anesthetic and Grammidin Neo, yellow for children. It is produced in the form of tablets intended for resorption.
For the convenience of treating the throat, the medication is available in the form of a spray. Regardless of the type of drug, the drug has the same analgesic and preventing the development, reproduction of pathogenic microflora.
Mechanism of action
The active compound of the drug is the antibiotic gramicidin. It has a detrimental effect on the pathogenic microflora that causes diseases in the oral cavity of an inflammatory nature. No drug addiction was found.
Correctly selected composition increases the secretion of saliva, thereby cleansing the oral cavity from the decay products of the vital activity of pathogenic microflora.
What properties does the drug have:
- antiseptic - treats the oral cavity, preventing the growth of bacteria and the development of the inflammatory process;
- the presence of lidocaine helps to eliminate discomfort during swallowing;
- the antibiotic acts as a disinfectant.
Indications and contraindications
What diseases is Grammidin most effective for? The medication is prescribed for severe sore throat, but there are other indications for prescribing a medication:
- periodontal disease - an inflammatory process in the tissues around the teeth;
- tonsillitis, in which purulent inflammation occurs in the tonsils, caused by streptococci and staphylococci;
- tonsillitis is an inflammatory process of an infectious nature that forms in the larynx;
- gingivitis - bacteria in the gums;
- with pharyngitis - the development of a bacterial process in the pharynx.
Also, the medication is effective for laryngitis (an inflammatory process that occurs on the mucous membranes of the larynx).
Despite the many positive properties, the drug has a number of contraindications:
- individual intolerance to the components;
- breastfeeding a newborn.
During pregnancy, the drug must be used very carefully and under the close supervision of a doctor. If you need to use Grammidin while breastfeeding, then you should stop breastfeeding your baby.
How to choose a variety of Grammidin?
The manufacturer offers several varieties of the drug. In this case, the question arises, how to choose the right medication, taking into account the characteristics and diseases of a person?
- For children under 12 years of age, it is recommended to use a preparation labeled "Children's" or simple, without additional components. Specialized, for schoolchildren and preschoolers, the drug is recommended for use in infections, inflammations. For patients from 12 to 18 years old, it is recommended to use the medication for adults.
- Simple Grammidin with anesthetic - for infections accompanied by an inflammatory process. The first option is suitable for the initial manifestations of signs of the disease, that is, when the pain in the oral cavity is small; but the second option is used for severe pain.
- At the first signs of an infectious disease (without pus in mucous secretions), Grammidin Neo or Grammidin Neo with an anesthetic are suitable. If the disease is accompanied by severe painful sensations in the throat, then it is worth using the second type.
The choice of a medication is based on the patient's condition and the degree of development of the pathological process. After the examination, the specialist can group several types of medicine to obtain the maximum result.
Instructions for use of the drug for adults
Adults are recommended to use the medication 1 tablet up to 4 times a day, but no more. They are absorbed in the oral cavity. Chewing is prohibited. After taking the medicine, it is required to refuse food and various liquids for 1.5-2.5 hours. After 7 days of regular admission, if the result of therapy with Grammidin does not appear, you should consult a doctor.
Features of admission to lactating and pregnant women
The use of Grammidin during pregnancy is acceptable, but there are some risks. In case of certain doubts, the medication should be replaced with a similar in action, but gentle.
Active substances are absorbed exclusively into the oral cavity, thus protecting the fetus from the adverse effects of the drug.
Before taking, a woman should make sure that there are no contraindications and intolerance to certain components. This can be done with your doctor. He will help you choose a sparing therapy regimen, necessarily lowering the dosage and frequency of administration.
If you exceed the indicated dosage, then it is imperative to visit the ultrasound office. This examination helps to find out whether the child has been harmed.
How to give Grammidin to children?
For children, the drug is allowed to be used from the age of 4. The tablet is dissolved after eating. To achieve maximum results, it is required to give up food and drink after taking the medication for 2 hours.
Up to 12 years, the permitted dosage is 1 tablet, the frequency of administration is up to 4 times a day. At an older age, it is allowed to take no more than 2 pieces, up to 4 times a day.
The lack of positive results from therapy after 7 days suggests that you should consult a doctor to replace the drug.
Side effect
If the specified dosage is exceeded or with individual intolerance to the components, the following adverse reactions may develop after using the medication:
- allergies - rash, itching, peeling, swelling;
- the tongue loses its sensitivity for a certain time.
Interaction with other drugs
When combining medications, be sure to consult with a specialist.
Terms of sale and storage of the drug
A drug is sold without a doctor's prescription in pharmacies. Store in a dry and dark place out of the reach of children. It is important to observe a temperature regime of no more than 25 degrees. It is valid for 3 years from the date of manufacture.
Similar means
The following tools are allowed to be used as analogues:
- - a drug with a combined effect. It is considered an antiseptic and pain reliever. It is produced in tablet form for resorption. Contraindications are: children's age up to 6 years, the period of natural feeding of the baby. It is forbidden to use during pregnancy for a period of 1 to 12 weeks, in the third trimester it is taken with extreme caution.
- Novosept Forte. It acts as an antiseptic, removes painful sensations in the throat. It is made in the form of lozenges for resorption, aerosol. It is forbidden to use for children, when carrying children and during breastfeeding.
- Grammidin C is a basic agent, similar in composition and action. Pharmaceutical companies are available in the form of an alcoholic concentrated solution, as well as in the form of tablets. The first type of agent is used internally and externally, and the second option is for treating the throat and oral cavity. There are no prohibitions on the use during the period of bearing a child, but with natural feeding, it is prohibited to take the drug.
- Septolet Neo. It is made in the form of sucking lozenges with various flavors: lemon, cherry, apple. It is used for pathologies of the throat in patients over 4 years old, it is allowed to use it during the bearing of children and with natural feeding.
The drug Grammidin and its varieties are popular antibacterial compounds for eliminating serious diseases of the ENT organs. It is used topically in dentistry, in the treatment of tonsillitis, pharyngitis, stomatitis. It is available in several forms, which makes it easy to choose a drug based on the signs of the disease.
It can be used while carrying a child and with natural feeding, but after consulting a specialist. For children, there is a special preparation marked "Children".
Remember that before treatment it is required to study the instructions for use in order not to cause serious harm to health.
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