Manufacturer: FSUE NPO "Microgen" Russia

PBX code: j07bd51

Farm Group:

Release form: Liquid medicinal forms. Injection.

General characteristics. Structure:

Indications for use:

Method of use and dose:

Features of application:

Side effects:

Interaction with other drugs:

Contraindications:

Storage conditions:

In accordance with the joint venture 3.3.2.1248-03 at a temperature of from 2 to 8 ° C, stored in an inaccessible place for children. Freezing is not allowed. Shelf life - 1 year.

Transport in accordance with the joint venture 3.3.2.1248-03 at a temperature of from 2 to 8 ° C. It is allowed short-term (no more than 24 hours) transportation at a temperature of from 9 to 20 ° C. Freezing is not allowed.

Leave terms:

On prescription

Packaging:

Lyophilisate for the preparation of a solution for subcutaneous administration. 1 or 2 doses in ampoule. In a pack of 10 ampoules with instructions for use and insert with the stacker number.

Composition and form of release of the drug

5 doses - ampoules (10) - packs cardboard.

pharmachologic effect

The attenuated strain of the virus of Corey Leningrad-16 and Moscow-5 are obtained by cultivation in the primary culture of Japanese quail embryos cells followed by purification and lyophilization. Stimulates the production of anticornel antibodies to 95% of seronegative persons on 21-28 days after vaccination, immunity remains at least 18 years.

Hyperactureted schwarz measles virus strain is cultivated on chicken embryos. Specific immunity is evolving for 15 years and, in accordance with the available data, is maintained at least 20 years.

Indications

Active prevention of measles: in children 12 months, who did not slander; In older people, not vaccinated and did not pain in epidemiasis; At the grafted earlier children, in the serum whose antibodies to the measles virus were not detected.

Contraindications

Congenital or acquired immunodeficiency (including HIV infection); Introduction at least within 6 weeks before vaccination. To use the vaccine obtained from the strain of the virus of Corey Leningrad-16 or Moscow-5 :. Live vaccines can not be used in pregnant women, as well as in persons with acquired or congenital immunodeficiency, because It is possible to develop a disease caused by vaccine strain.

Dosage

Immediately before use, the vaccine is divorced at the rate of 0.5 ml of the solvent on 1 vaccine dose of the vaccine. The method of administration (p / k or in / m) depends on the dosage form used.

Side effects

Part of patients in terms of 5 to 18 days can be observed temperature reactions, zea hyperemia, rhinitis, sometimes - shaking and; In rare cases, king rash joins. Very rare complications from the CNS - Encephalitis, convulsions arising after 6-10 days after vaccination usually against the background of high temperature. Allergic reactions in individuals with intolerance to alien. Local reactions - hyperemia, swelling at the place of introduction for 1-3 days.

special instructions

The specific dosage form of the vaccine should be applied strictly according to the indications and in accordance with the instructions for use. Cheering against measles can be carried out no earlier than 2 months after vaccination against other infections, as well as not earlier than 3 months after or 3 weeks before the introduction of immunoglobulins.

Pregnancy and lactation

Pregnancy is a contraindication to the use of a vaccine obtained from the strain of Corey Leningrad-16 virus or Moscow-5 (living vaccines cannot be used in pregnant women, since it is possible to develop a disease caused by vaccine strain).

Before the beginning of the immunoprophylaxis, Kor was one of the most severe childhood infections. The severity of this viral disease is due to high mortality, the risk of developing complications, which are registered with more than 30% of those who have suffered. In most cases, they appear in children under 5 years and young people over 20 years old. The most difficult consequences include the average otitis, pneumonia, acute encephalitis, subacute sclerosing pankenefalitis (presumably occurs 7 years after the suffered disease as a result of the persistence of measles virus in the tissues of the brain), unbeasting pregnancy, congenital malformations. For the period from 2000 to 2010, the anticorrheal vaccination led to a decrease in the overall world mortality from measles by 74%.

General information about vaccination

The main information about the measles is presented in the picture below.

For the immunoprophylaxis of measles are used:

• monopreparata - Live Koreary Vaccine (HCB);
• trivaccine - against measles, epidemic vapor and rubella (PDA);
• human immunoglobulin is normal.

The first two vaccine preparations are used for active immunization.

The LCD contains in its composition the Vaccine strain of the measles virus, which is grown in the culture of the Japanese quail embryos cell. The drug contains a slight amount of kanamycin or neomycin (antibiotics from the aminoglycoside group) and the trail amount of egg protein. The vaccine immediately before injection is bred by a special solvent, which is attached to each bottle or ampoule. Divorced LCD is used immediately or within 20 minutes.

This vaccine ensures the production of antibodies (that is, forms sufficient immunity) in 95% of vaccinated during the first 12 weeks. It holds for more than 25 years. The absence of antibody generation can be explained by the following reasons:

• primary (non-standard of individual production series of vaccines, non-compliance with the rules of storage and transportation);
• secondary (immunization of children up to 12 months. Against the background of circulation of maternal antibodies, the simultaneous administration of immunoglobulin, the development of acute disease, the presence of individual characteristics of the body).

The complex vaccine of the CCP is a drug that includes live vaccine strains of viruses of these infections. It contains the minimum amount of neomycin. Vaccines of various production, having different trade names (Trimovaks, MMR 2, Priorix, etc.) are used. The advantage of this vaccination lies in the fact that in this drug there are 3 viruses at once, that is, it is not necessary to make 3 injections. The PDA complex vaccine is allowed to be administered simultaneously from any other other than the BCH-M and BCG.

The human immunoglobulin is normal represents an active protein fraction that is isolated from serum or plasma of donors or sera of placental blood and contains antibodies to measles virus. Used for passive immunoprophylaxis.

When is vaccination?

Vaccinations are subject to kids regardless of their gender, according to the national calendar of preventive vaccinations, at the age of 12 months. Revacitation is shown to all children at the age of 6, before entering school.

There is one feature of the revaccination of the PDA complex vaccine - it is carried out if the child did not have any of these infections. If the kid robbed any of them before reaching the vaccination age, then it is immunized by monovaccines in the deadlines that are installed by vaccinations calendar.

The drug is administered 1 time in a dose of 0.5 ml subcutaneously to the shoulder area or under the blade.

Immunization tactics should be thought out individually for each child. At the discretion of vaccination parents, it is possible to perform separately with an interval of 1 month.

Emergency prevention of measles

Emergency (postcontact) Corey prevention in an epidemic focus is necessary when there is a risk of developing this infection. In order to prevent the emergence of subsequent cases of the disease, vaccination (revaccination) of the LCD is carried out by the following categories of persons aged 9 months to 40 years, if from the moment of detection of the patient no more than 72 hours passed:

• Not grafted against measles.
• Which have one vaccination against this infection (if not less than 4 years).
• With an unknown vaccine history of measles.
• In which the serological examination did not detected antibodies in protective titers (levels) to this virus.

Children and adolescents up to 18 years old are immunized with a complex vaccine of the PDAs, and adults - the RPC. In the absence of the latter - trivaccin.

For emergency core prevention among non-birds and unsecured, which have contraindications to vaccination, a single introduction of human immunoglobulin is applied no later than 5 days from the moment of contact with the patient:

• children from 3 months of age at a dose of 1.5 ml (3 ml) depending on the state of health and time from the moment of contact;
• adults at a dose of 3 ml.

After the introduction of human immunoglobulin vaccinations against measles is performed no earlier than 2-3 months.

PostAscital complications and reactions

Most children have anticorrheal vaccination at all is not clinically manifested. Although up to 15% of the grafts have a specific post-validity reaction between the 6th and 18th day from the moment of immunization. It can be accompanied by an increase in body temperature (37.5-38 degrees), catarrhal (runny nose, conjunctivitis (eye redness), cough), even a nonophiceal pale pink covenotic rash may occur. Usually these manifestations are preserved no more than 2-3 days.

Even and have developed any post-specific reactions, then for others, the child is not contagious. That is, it does not highlight the pathogen in the environment.

At the grafted korea vaccine complications are rarely recorded. In children with intolerance to any component of the vaccination drug, various allergic manifestations may occur (more often rashes, less often swelling, urticaria, anaphylactic shock), as well as hemorrhagic vasculitis syndrome, increase in lymph nodes and thrombocytopenic purpura (on time from 7th to 30 - day from the moment of injection).

Rarely with a vaccine reaction against the background of an increase in body temperature (up to 39-40 degrees), febrile cramps may occur. They are usually characterized by a duration of 1-2 minutes and are celebrated for 15 days from the moment of injection. In this case, the appointment of antipyretic drugs is shown. Further forecast of this phenomenon is favorable, residual phenomena are extremely rare. More serious lesions of the central nervous system can be associated with vaccination, if noted for 5-15 days after it. They are observed extremely rare - 1 case per million people.

According to the results of studies of American scientists, the frequency of encephalitis in the grafts lower than among the population as a whole.

The combined vaccine of children is moved well. Side effects are similar to the press. Includes various post-specific reactions characteristic of each monovaccin (anti-phoned, anti-optical and anti-penette).

It is the opinion that the CCP's comprehensive vaccine is able to cause autism in children. This is due to the erroneous publication in one authoritative medical journal of the study indicating the development of this ailment as a side effect of this vaccination. After this event, a huge number of tests were conducted. And there was no reliable connection between the complex vaccine and autism. Therefore, you can safely spend your babies vaccination against these infections.

Contraindications

Contraindications to immunization with anticorrement vaccines (monopreparations and complex) are:

• Heavy forms of allergic reactions to antibiotics from the group of aminoglycosides (neomycin, monomitin, canamycin, etc.) and on egg protein.
• Various immunodeficiency states (primary and secondary) are the reception of glucocorticosteroids or cytostatics, oncological, mainly malignant, diseases (lymphoma, leukemia, etc.).
• Strong reaction (body temperature rise above 40 degrees, swelling and redness more than 8 cm in diameter at the injection site) or complication on the previous dose.

Contraindication to immunization is not HIV infection.

Although the Vaccine Vaccine is usually introduced in the absence of acute disease or exacerbation of chronic, in special situations (communication with the core patient, an extreme situation) Immunization can be carried out to persons with light formations of ARVI (redness of the language, runny nose) and recovering even if there are subfebrile temperatures .

Cheering against measles can be carried out no earlier than 3 months after or 6 weeks before the introduction of immunoglobulin, plasma or other blood products that contain antibodies. For the same reason, they should not be applied for 2 weeks after vaccination. If you need to enter them earlier, the anti-zero vaccination must be repeated.

Filtered list

Active substance:

Medical Instructions

Cory vaccine alive attenuated
Medical Instructions - RU No. LSR-005239/09

Last Change Date: 27.04.2017

Dosage form

Lyophilisate for the preparation of a solution for subcutaneous administration

Structure

One vaccination dose of the drug (0.5 ml) contains:

• at least 1000 TCD 50 (tissue cytopathogenic doses) measles virus;
• stabilizer - sorbitol - 25 mg, gelatin - 12.5 mg.

Description of the dosage form

The drug is a homogeneous porous, loose mass of white or white-yellow color, hygroscopic.

Characteristic

Cory vaccines lively attenuated, lyophilisate for the preparation of a solution for subcutaneous administration, made from a strain of measles virus EDMONSTON-ZAGREB on human diploid cells MR C -5.

Pharmacological (immunobiological) properties

The vaccine stimulates the production of antibodies to measles virus, which reach the maximum level after 3-4 weeks after vaccination.

The drug complies with WHO requirements.

Indications

The vaccine is intended for the planned prevention of measles.

Planned vaccinations are conducted twice aged 12-15 months and 6 years old children who did not pain.

Children born from Seronegative to Corey Mothers virus vaccinate at the age of 8 months and further - at 14-15 months and 6 years.

The interval between vaccination and re-vaccination must be at least 6 months.

Contraindications

• Primary immunodeficiency states, malignant blood and neoplasm diseases;
• a strong reaction (temperature rise above 40 ° C, swelling, hyperemia more than 8 cm in diameter at the injection site) or complication on the previous introduction of the vaccine;
• severe renal impairment;
• heart disease in decompensation;
• pregnancy.

Method of application and dose

Immediately before use, the vaccine is divorced only by the attached solvent (water for injection) using a sterile syringe at the rate of 0.5 ml of the solvent per vaccination dose of the vaccine.

The vaccine must be completely dissolved for 3 minutes to form a transparent colorless or light yellow solution.

Not suitable for the use of vaccine and solvent in bottles and ampoules with impaired integrity, labeling, as well as when changing their physical properties (colors, transparency, etc.), with an expired shelf life, incorrectly stored.

The opening of the vials, ampoules and vaccination procedure is carried out with strict compliance with the rules of asepsis and antiseptics. The ampoules in the place of the feet are treated with 70 º alcohol and rolled, not allowing the alcohol in the ampoule.

For breeding vaccine, a sterile syringe takes the entire required volume of the solvent and transfer it to the bottle with a dry vaccine. After stirring, they change the needle, pick up a vaccine into a syringe and make injection.

The vaccine is introduced deep subcutaneously in the volume of 0.5 ml under the blade or to the shoulder area (on the border between the lower and middle third shoulder from the outside), pre-processing the skin at the injection site of the vaccine 70 º alcohol.

The diluted vaccine is not subject to storage.

The attached solvent is specifically made for this vaccine. The use of solvents for other vaccines and for core vaccines from other manufacturers is not allowed. The use of non-compliant solvents can lead to a change in vaccine properties and severe reactions in recipients.

Side effects

Reaction to Introduction

In the next 24 hours after the administration of measles vaccine, moderate pain in the injection site may appear. In most cases, pain passes within 2-3 days without treatment. 5-15% of vaccinated 7-12 days after vaccination can be a moderate increase in temperature duration of 1-2 days. In 2% of vaccinated 7-10 days after vaccination, the appearance of rash, duration up to 2 days. Moderate adverse reactions arise with a lesser frequency after the introduction of the second dose of the vaccine. In the post-specific period, the development of encephalitis with a frequency of 1: 100,000,000 introduced doses was registered, while the causal relationship with vaccination was not proven.

Complications that develop extremely rarely include convulsive reactions arising, most often after 6-10 days after vaccination, usually against the background of high temperature, and allergic reactions arising in the first 24-48 hours in children with allergy-changed reactivity.

Note. The temperature increases above 38.5 ° C in the post-specific period is an indication for the purpose of antipirectrics.

Interaction

After the introduction of drugs of immunoglobulin, human vaccinations against measles are carried out no earlier than 2 months. After the introduction of the Korele vaccine, the drugs of immunoglobulin can be administered no earlier than after 2 weeks; If it is necessary to use Immunoglobulin earlier than this period, measles vaccination should be repeated.

After vaccination, the transient inversion of a tuberculin-positive reaction to tuberculin-negative reaction may be observed.

Cinema vaccination can be carried out simultaneously (one day) with other vaccinations of the national calendar (against epidemic vapor, rubella, polio, hepatitis B, cough, diphtheria, tetanus) or not earlier than 1 month after the preceding vaccination.

Precautions

Vaccinations are held:

• after acute infectious and non-infectious diseases, with exacerbation of chronic diseases - at the end of the acute manifestations of the disease;
• with non-heavy forms of ORVI acute intestinal diseases, etc. - immediately after normalization of temperature;
• after immunosuppressive therapy - after 3-6 months after the end of treatment.

Persons temporarily liberated from vaccinations should be taken under observation and grafted after removing contraindications.

With the introduction of a vaccine to patients receiving corticosteroids, immunosuppressive drugs or undergoing radiotherapy, an adequate immune response may not be obtained.

The vaccine can be assigned to children with an established or alleged diagnosis of HIV infection. Although the available data is insufficient and additional research is required, today it does not have evidence of the participation of adverse reactions in the introduction of this vaccine or other measles vaccines with clinical or asymptomatic treatment of HIV infection. The vaccine should not be prescribed with other immunodeficiency states with a violation of cellular immunity.

special instructions

ATTENTION! The vaccine should be administered only subcutaneously. Vaccinated should be under medical supervision at least 30 minutes after immunization. The venues of vaccinations must be equipped with anti-shock therapy. To relieve anaphylactic reactions that may occur in children with allergically modified reactivity to introduce not only measles vaccines, but also other vaccines, a solution of adrenaline 1: 1000 is ready to have ready. Adrenaline's injection should be made at first suspicion to the beginning of the development of a shock reaction.

Form release

Vaccine - 1 or 10 doses in a dark glass bottle, 10 bottles with 1 dose of vaccine with instructions for use in a cardboard pack or 50 bottles with 1 or 10 doses of vaccine with 5 copies of instructions for use in a cardboard pack.

The solvent is 0.5 ml (per 1 dose of vaccine) or 5.0 ml (by 10 doses of the vaccine) in an ampoule of colorless transparent glass. 10 ampoules of 0.5 ml in a blister from PVC / aluminum foil, 1 or 5 blisters in a cardboard pack. 10 ampoules 5.0 ml per PVC blister / aluminum foil, 5 blisters in a cardboard pack.

Horizontal orange bands are applied to the vaccine bottles and on cardboard packs (Pantone 151c Orange).

Storage conditions

Transportation of vaccine and solvent:

At temperatures from 2ºС to 8ºС.

Storage:

Vaccines - at a temperature of from 2 ° C to 8ºС in a place protected from light, inaccessible to children.

Solvent - at a temperature of from 5 ºС to 30ºС. Do not freeze

Shelf life

Vaccines - 2 years; Solvent - 5 years.

The preparation with an expired application is not subject to use.

Conditions of vacation from pharmacies

For therapeutic and preventive and sanitary and preventive institutions

Cory vaccines Live attenuated - Instructions for medical use - RU No.

For many decades, Cort has been practically not diagnosed in children and adults. However, in 2014 there was a fixed outbreak of the disease, which led to the infection of more than 100 people. Therefore, the question of the need to vaccinate the population arose. Conduct with this challenge allows measles vaccine that can be used in children and adult patients. It is worth considering it more detailed, which represents the GCV vaccination, deciphering its name, vaccination features.

What is the danger of measles?

Cort is a contagious infectious disease that is transmitted by air-droplet. At the same time, patients are distinguished into the air of the causative agent even in the long period. The first symptoms of measles are similar to a banal cold. Patients celebrate cough, the appearance of sore throat, runny nose, temperature increase.

As infection progresses, patients have a characteristic rash on the face, which gradually spreads to the whole body. Cort requires immediate therapy, otherwise dangerous complications may develop:

• Pathology of respiratory authorities: multicellular pneumonia, laryngotrachites, bronchitis, plerites, bronchiolites;
• Nervous System Diseases: Encephalitis, Meningoencephalitis, Panensephalitis, Meningitis;
• Diseases of digestive organs: colitis, enterocolites.

Important! In adult age, the infectious disease is heavier, often provokes the development of complications.

Features Cory vaccinations

The abbreviation of the LCD is decoded as a lively vaccine. Vaccine drug is produced in Moscow. As part of the GCV vaccine are:

• Live weakened viral particles (Serotype Leningrad-16), which are grown on a special culture of Japanese quail embryos;
• Auxiliary compounds - antibiotics - aminoglycosides (kanamycin, gentamicin);
• LS-18 and gelatin that is used as stabilizers.

A core culture fluid vaccine is produced in the form of lyophilisate for the preparation of injection solutions in ampoules or bottles. The vaccine drug is widely used to immunize patients up to 35 years. Conducting the GCV vaccination contributes to the formation of a pronounced immune response after 1 month in 95% of the grafted people. The duration of immunity reaches 20 years.

Vaccination schedule

The vaccination is carried out, according to the national vaccination calendar:

• Babies from 1 to 1.5 years, which previously did not hurt the infectious disease;
• Graft children in the absence of antibodies to measles;
• Revaccination is carried out at 6 years.

This scheme allows you to create reliable immunity in a child against measles for 18-20 years. Vaccination of preschoolers is aimed at preventing a mass epidemic of measles, quarantine. Repere HCD vaccine is introduced to adult patients up to 35 years. If a child over 15 years old or an adult has not been immunized in childhood or there are no data on vaccinations, then a double introduction of a vaccine drug with an interval of 6 months is shown.

If the mother has a child of a seronegative reaction to the measles virus, two-time HCB vaccination is shown:

• The first dose of vaccine is introduced at 8 months;
• The second vaccination is 1.5 years;
• Revaccination is shown for children at a six-year-old age.

If the patient, regardless of age, in contact with sick cortex, shows the emergency prevention of the disease. In this case, the korevaya culture living vaccine is introduced within 3 days from the date of contact. Children under 12 months additionally shows the introduction of 1-2 doses of human immunoglobulin to prevent infection.

Features of the introduction of vaccine

The bottle with lyophilisate contains 5 familiar doses of the vaccine preparation, 1 dose is in Ampoule. The dry substance should be dissolved before administration in a special solvent, which is in each package. The diluted solution has a pinkish tint, should not have extraneous inclusions (flakes, sediment).

The GCV vaccination is subcutaneously into the upper part of the shoulder, it is possible to introduce in the field of the blade. Immunization in childhood is often combined with vaccination against other infections. This goal is used combined vaccine drugs.

Important! With separate use, the vaccination of the RPG is made 30 days after the previous immunization.

Rules of behavior before and after vaccination

The vaccine drug was created using quail proteins and antibiotics-aminoglycosides, therefore, patients often occur allergic reactions. To prevent allergies in allergy persons, it is recommended for 3-4 days before vaccination take antihistamines. On the day of the vaccination, the GCV should be consulted from a specialist, measure the temperature. In some cases, a clinical study of blood and urine is shown.

After vaccination should not immediately leave the clinic. Doctors recommend to remain on the territory of the institution up to 30 minutes, so that in the development of anaphylaxia, the patient can get the necessary medical care. Within a few days, it is recommended not to water the injection site, do not wear close clothes.

Important! Cinema virus is inactivated by alcohol and other antiseptic solutions, so the injection site should not be treated with similar drugs.

Side effects of the GCV vaccine

Many parents refuse to vaccinate the child, fearing the development of severe adverse reactions. However, after the vaccination of the RPG, unwanted symptoms rarely arise - vaccination is usually well tolerated. Only in rare cases there is such symptoms:

• Increased temperature;
• Development of convulsion;
• Pale pink rash;
• Cough;
• An increase in the size and soreness of lymph nodes;
• Swelling, redness of the injection site;
• Allergic reactions: rash, urticaria.

The listed symptoms usually do not require special therapy, however, you can use antipyretic and antihistamines for facilitating the patient's condition.

Possible complications and contraindications

The Koreawny vaccine refers to small-acting drugs, so most patients are not developing post-specific reactions. However, with a burdened allergological history, after vaccination, allergic reactions may arise (the appearance of rash, swelling). Complications include pronounced post-glacial reactions: an increase in body temperature to 40 0 \u200b\u200bs, the appearance of symptoms of intoxication, seizure. However, these states are diagnosed extremely rarely.

Reduced the risk of developing complications allows a medical examination at which the doctor must determine the contraindications. Refuse to vaccinate recommend in such cases:

• Pregnancy period or pregnancy planning;
• Acute period of diseases of infectious and noncommunicable nature;
• Pathologies that are characterized by a long flow: viral hepatitis, pancreatitis, tuberculosis, nervous system pathology;
• Aggravation of chronic pathologies;
• Heavy allergies to antibiotics, anamnesis eggs;
• Oncopathology;
• Malignant blood pathology;
• Blood transfusion for 3 months;
• Severe post-prevention reactions to last immunization;
• Contacts with infectious patients. Vaccination can be done only at the end of quarantine;
• Against the background of long-term radiation or chemotherapy;
• Pronounced immunodeficiency.

The introduction of a living hole vaccine allows you to form a reliable immunity against a dangerous viral infection in a patient. Vaccination is usually easily transferred, rarely provokes the development of adverse reactions. However, before vaccination, you need to consult a doctor to assess the patient's condition, determine the need for immunization.