Dispersible (water-soluble) tablets contain amoxicillin in the form of amoxicillin trihydrate (Amoxicillin trihydrate), microcrystalline and dispersible cellulose, vanillin, crospovidone, flavors (lemon and tangerine), magnesium stearate, saccharin.

Release form

Flemoxin Solutab dispersible tablets:

• 125, 250, 500 or 1000 mg package No. 20 (blisters of 5 pcs., 4 blisters per pack);
• 125 mg package No. 14 (blisters of 7 pcs., 2 blisters per package).

Tablets are oval, white or white with a yellowish tint, with a separating risk on one side, and a digital designation (231, 232, 234 and 236) and the manufacturer's logo on the other.

pharmachologic effect

Antibacterial , bactericidal .

Pharmacodynamics and pharmacokinetics

Amoxicillin is a semi-synthetic β-lactam antibiotic of the penicillin group with a wide spectrum of antimicrobial activity.

Bactericidal properties The drug is due to the ability to suppress transpeptidase, disrupt the production of peptidoglycan (the supporting protein of the cell walls) during periods of division and growth, and provoke the lysis of microorganisms.

Shows activity against Gram (+) aerobes, including Staphylococcus spp. (with the exception of penicillinase-producing strains) and Streptococcus spp. (including Str.pneumoniae and faecalis); Gram (-) aerobes (gonococci, meningococci, Escherichia and Haemophilus influenzae, Proteus mirabilis; individual strains of Klebsiella, Shigella and Salmonella, as well as against H. pylori.

It is ineffective against strains of Proteus P. rettgeri and vulgaris (they are indole-positive), serrations, pseudomonads, enterobacteria, morganella morgani. Resistant to the action of amoxicillin mycoplasma, rickettsia and viruses.

A feature of the dosage form is that the tablets are easily dispersed in water to form a dispersion. Due to this, the drug is quickly and as completely as possible (more than 93% of the dose taken) absorbed from the alimentary canal.

Eating does not affect the absorption of the substance. TCmax - ranging from 60 to 120 minutes. When taking dispersible tablets, the plasma concentration of amoxicillin is higher than when taking insoluble forms of the drug. The active substance is resistant to acids.

TCmax when taking 500 mg of amoxicillin - 120 minutes. When taking twice the or half the dose of the drug, the Cmax also changes twice.

Approximately 20% of the dose taken is bound to plasma proteins. amoxicillin . The substance in therapeutically effective concentrations penetrates well into bone tissue, mucous membranes, sputum and intraocular fluid. Its concentration in bile is 2-4 times higher than the plasma concentration, in the amniotic fluid - from 25 to 30% of the plasma concentration in the body of a pregnant woman.

Through the BBB amoxicillin goes badly, but inflammation of the meninges its concentration in the cerebrospinal fluid is about ⅕ of the plasma concentration.

The substance is metabolized partially, most of the metabolic products are inactive in relation to pathogenic microflora .

Excretion is carried out by the kidneys. In patients with healthy kidneys T1 / 2 - from 60 to 90 minutes, in children under the age of six months (including premature babies and newborns) - from 3 to 4 hours. In case of violations of liver function, the indicator does not change, if kidney function is impaired, it can increase up to 8.5 hours (this is T1 / 2 of amoxicillin in anuria).

Indications for use: from what tablets Flemoxin Solutab?

Indications for the use of the drug - bacterial infections of the organs of the external respiratory system ( , pneumonia , , , , acute inflammation of the middle ear ), organs of the genitourinary system ( ,pyelitis , , , , ), skin and/or soft tissues ( impetigo , erysipelas , secondarily infected dermatoses ), digestive organs and abdominal infections ( angiocholitis , peritonitis , typhoid fever , , salmonellosis , , salmonella carriage ), if they are caused by bacteria sensitive to Flemoxin.

Flemoxin - what is it used for in pediatrics?

Flemoxin Solutab is the most commonly used penicillin drug in pediatric practice. Most often it is prescribed for bacterial infections of the respiratory system.

The experience of practical application proves the high efficiency of Flemoxin in sinusitis , acute nonpurulent otitis media , bronchitis , bronchopneumonia , tonsillitis , sore throat .

The drug is safe, well tolerated by young patients of any age and, which is no less important when it comes to the treatment of children, has excellent organoleptic properties.

Contraindications

Flemoxin is not prescribed for hypersensitivity to amoxicillin , other β-lactams or tablet excipients.

Relative contraindications for the antibiotic Flemoxin Solutab:

• kidney failure ;
• history of gastrointestinal pathology (especially antibiotic-associated colitis);
• pregnancy;
• lactation;
• breastfeeding period;
• polyvalent hypersensitivity to chemicals foreign to the body (xenobiotics).

Side effects

Side effects appear as:

• nausea, taste changes, diarrhea, vomiting, moderate increase in liver enzymes (sometimes), hemorrhagic and pseudomembranous colitis (rarely);
• interstitial nephritis (rarely);
• hemolytic anemia , neutropenia , ,thrombocytopenia .

When using the drug in the form of dispersible tablets, no adverse events from the nervous system were noted.

The use of the drug may be accompanied by the development of hypersensitivity reactions, which are expressed in the form of a rash (mainly specific maculopapular), erythema multiforme exudative (seldom), And (in exceptional cases).

Tablets Flemoxin Solutab: instructions for use

How to take Flemoxin tablets for adults?

The drug is taken orally, without being tied to the time of the meal.

The tablet can be dissolved in 20 ml of water until a syrup is obtained or in 100 ml of water until a suspension is obtained, it can be swallowed whole or taken in crushed form.

For mild and moderate infections, 250 mg tablets are taken in 2-3 pcs. 2 rubles / day, 500 mg tablets - 1-1.5 pcs. 2 rubles / day, tablets 1000 mg - half 3 rubles / day.

In the treatment of severe diseases, as well as infections with hard-to-reach foci, it is considered preferable to take the drug three times a day.

Daily dose antibiotic with severe infections, relapses and chronic pathologies - 1.5-2 tab. 500 mg 3 r./day

When flowing without complications acute shows a single dose of Flemoxin C (dose, respectively, 3 and 1 g).

In severe infections and chronic pathologies, the treatment regimen is selected taking into account the characteristics of the clinical picture of the disease.

In case of kidney damage, in which the Clcr indicator is in the range from 15 to 40 ml / min, the interval between taking the tablets should be increased to 12 hours. If the Clcr does not exceed 10 ml / min, the dosage of amoxicillin should be reduced by 15-50%. With anuria, the highest daily dose of amoxicillin is 2 g.

How to take Flemoxin tablets for children?

Children's Flemoxin are tablets with a dosage amoxicillin 125 and 250 mg. The instructions for children indicate that it is more convenient for a younger child to give a syrup or suspension, older children can swallow the tablet whole or after chewing it.

Instructions for the use of Flemoxin for children over 10 years of age are similar to instructions for adults: for infections of a mild and moderate course, the child is given 3-4 tablets. 125 mg 3 rubles / day.

Flemoxin Solutab for children over 3 years old is prescribed to take 3 tablets. 125 mg 2 r./day. or 2 tab. 125 mg 3 rubles / day.

For children under 3 years old, according to the instructions for use, Flemoxin Solutab 125 mg, tablets are given two 2 times a day. or one 3 rubles / day.

Dosage of Flemoxin Solutab for children, which contains 250 mg amoxicillin next:

• 2-3 tab. 2 rubles / day - patients older than 10 years;
• 1 tab. 3 rubles / day - patients 3-10 years old;
• 1 tab. 2 rubles / day or 0.5 tab. 3 rubles / day - Patients younger than 3 years of age.

The daily dose of Flemoxin Solutab for children of all age groups (including children of the first year of life) is from 30 to 60 mg / kg, divided into 2 or 3 doses. If the disease is severe or the pathological focus is difficult to access, it is preferable to take the drug 3 times a day.

For severe infections (including those with hard-to-reach foci), the recommended dose of the antibiotic is 60 mg / kg / day, divided into three doses.

Duration of treatment

The course duration for mild and moderate infections is from 5 days to 1 week. If the causative agent of the infection is Str. pyogenes, treatment lasts at least 10 days.

For severe infections, the medication should be continued for 48 hours after the symptoms disappear.

Antibiotic Flemoxin Solutab for angina

Angina - is common acute infectious disease , local manifestations of which are lesions tonsils (mainly the first and second - palatine). The most common pathogens sore throats - B-hemolytic streptococci of group A. Staphylococci provoke it much less often.

Untreated or undertreated angina gets complicated paratonsillitis , jade , myocarditis , paratonsillar abscess , tonsilogenic sepsis .

Given the bacterial nature of the disease, timely application is very important. antibiotics . If at catarrhal angina in some cases, the patient is enough antibiotics local action, then follicular and lacunar angina the doctor without fail prescribes drugs of systemic action.

Research results and practical experience have shown that the most effective means for sore throat are drugs of the penicillin group.

The advantages of Flemoxin over analogues are:

• unique dosage form (Solutab);
• the presence of tablets with a "child" dosage of the active substance;
• the possibility of using the drug without being tied to the time of eating.

Adults at sore throat the drug is recommended to take 2 rubles / day. 500-700 mg. At sore throat in children, children's Flemoxin Solutab is used - tablets with a minimum dosage of the active substance. The dose is selected by the doctor depending on the age of the patient and the characteristics of the course of the disease.

After the symptoms have subsided sore throats (the body temperature will decrease, the pustules on the tonsils will disappear, the sore throat will disappear, the condition of the lymph nodes will normalize), Flemoxin should be continued for at least two more days.

If treatment is stopped immediately, the risk of recurrence of the disease is high. Moreover, the symptoms can appear with a vengeance.

The use of the drug for sinusitis

Sinusitis - this inflammation of the paranasal sinuses .

Application antibiotic at sinusitis it is advisable if the disease is caused by bacteria that are sensitive to its action. When associated with a viral or fungal infection, as well as when allergic sinusitis , antibiotic therapy is not only ineffective, but can also aggravate the course of the disease.

Acute bacterial sinusitis appears first:

• hyperthermia (temperature febrile and above);
• violation of nasal respiration and phonation;
• soreness and swelling of the skin in the projection of the maxillary cavities;
• decreased sense of smell;
• the presence of pains radiating to different parts of the face (pains gradually lose their specific location);
• symptoms of general intoxication (sleep disturbances, headache, aching joints, etc.);
• the characteristic color of the pathological secretion discharged from the sinuses (its color in bacterial infections usually varies from yellow to dark green).

The choice of antibiotic is carried out taking into account:

• the results of a microbiological study of a biomaterial taken from the paranasal sinuses and an express test for staining the pathogen using the Gram method;
• characteristics of the patient's body;
• possible allergic reactions to the drug;
• the presence of comorbidities.

If the cause of the disease is staphylococci, streptococci or Haemophilus influenzae, the most preferable is the appointment of penicillin group drugs to the patient.

Application amoxicillin at bacterial sinusitis (including with complicated forms of the disease) gives a pronounced positive effect already in the first 7 days of treatment: the patient's symptoms of intoxication and pain in the paranasal sinuses decrease / disappear, the temperature decreases and nasal breathing is facilitated.

The effectiveness of Flemoxin Solutab is explained by the fact that this drug:

• affects a large number of strains of infectious agents;
• quickly and in high concentrations absorbed from the digestive tract;
• resistant to the action of gastric juice;
• available in an easy-to-use form.

Overdose

Symptoms of an overdose of Flemoxin Solutab: nausea, diarrhea, vomiting, impaired water-salt balance.

Treatment: gastric lavage, the appointment of enterosorbents, saline laxatives, taking measures aimed at correcting the balance of water and electrolytes.

Interaction

Phenylbutazone , probenecid , oxyphenbutazone and, to a lesser extent, sulfinpyrazone and ASA inhibit secretion antibiotics of the penicillin group , which leads to an increase in T1 / 2 and an increase in plasma concentration amoxicillin .

Bactericidal antibiotics (including , , cephalosporins And aminoglycosides ) render synergistic action in the case of their use in combination with Flemoxin.

When taken simultaneously with certain bacteriostatic agents ( sulfonamides , chloramphenicol etc.) antagonism is possible.

The use of oral contraceptives containing estrogen may lead to a decrease in the effectiveness of the latter and an increase in the risk of rupture bleeding.

Use in combination with allopurine as opposed to combination from allopurine does not increase the frequency of skin reactions.

Terms of sale

On prescription.

Storage conditions

Store below 25°C.

Best before date

Five years.

special instructions

Having a history erythroderma is not a contraindication to the use of the drug.

The possibility of developing cross-resistance with cephalosporins And antibiotics of the penicillin group .

As in the case of the use of other drugs of the penicillin group, the development of superinfection is possible.

Characteristic for pseudomembranous colitis severe diarrhea during treatment with the drug is a reason for the abolition of Flemoxin.

In patients with lymphocytic leukemia And infectious mononucleosis , but - and this is the difference between him and Flemoxin - to enhance its action, the drug also includes clavulanate (or clavulanic acid ) is a substance that inhibits bacterial beta-lactamase enzymes.

I.e Flemoklav is active against sensitive amoxicillin microorganisms, as well as against bacterial strains that produce some chromosomal and most plasmid β-lactamases.

clavulanate inhibits type II, III, IV and V beta-lactamases, but is inactive against those produced by enterobacteria, Pseudomonas aeruginosa, acinetobacteria, serrations (type I beta-lactamases).

Having a high affinity for antibiotics penicillin groups clavulanate significantly expands the spectrum of activity and, consequently, the application amoxicillin .

Flemoxin Solutab and alcohol

For patients who are prescribed antibiotic therapy, alcohol consumption is contraindicated.

Flemoxin Solutab during pregnancy

The appointment of the drug during pregnancy and breastfeeding (HB) is possible if the expected effect of its use exceeds the risk of developing unwanted side reactions.

A small amount of amoxicillin is excreted in breast milk, which can provoke the development of sensitization phenomena in a child who is on breastfeeding.

Flemoxin Solutab is a new generation antibiotic with a wide spectrum of action. The pharmacological composition of the drug includes an antibiotic from the penicillin series - amoxicillin trihydrate.

Flemoxin Solutab is a product of the pharmacological company Astellas Pharma, the country of origin of the drug is Japan. This drug is designed to fight infectious diseases in the body.

Susceptibility of the drug to bacteria and viruses

The following bacteria react to the drug Flemoxin Salutab:

• streptococci;
• golden staphylococcus aureus;
• listeria;
• coli infection;
• bacterium enterococcus;
• bacteria that provoke peptic ulcer of the stomach and intestines;
• staphylococcal bacteria;
• helibacteria;
• Klebsiella microbes;
• influenza;
• gonococci;
• salmonella.

According to Flemoxin Solutab indications for use, the drug does not affect viruses and fungal diseases in the human body.

Properties of the drug Flemoxin Solutab

Flemoxin Solutab has received great application in pediatrics and has the following properties:

• absolutely non-toxic - can be used by children from the moment of birth;
• bioavailability properties - the drug is absorbed in the intestine, which gives a good effect from taking tablets and suspensions, as well as from injections;
• acid resistance - does not respond to an increased acidic environment inside the stomach;
• wide distribution - a wide spectrum of action in the human body;
• does not accumulate in the body - it is quickly excreted from the body by the kidneys;
• does not pass through the blood-brain barrier - the antibiotic is not effective in inflammatory processes of the brain.

At what diseases sensitivity to the antibiotic Flemoxin Solutab

What does the antibiotic Flemoxin Solutab help with?

Diseases in the child's body that cause infections, the causative agents of which are bacteria and microbes that are quite sensitive to the antibiotic Flemoxin Solutab:

• otitis of ENT organs;
• inflammation of the nasopharynx (sinusitis, sinusitis);
• infectious angina, pharyngitis, tonsillitis;
• ARI (bronchitis, tracheitis);
• infectious pneumonia;
• diseases pyelonephritis;
• bacterial cystitis;
• acute and latent form of urethritis;
• diseases caused by Escherichia coli;
• purulent diseases of the skin.

Flemoxin from what? The drug has a negative effect on microbes at the level of diseased cells, while it protects healthy cells in the body from the negative effects of bacteria.

The therapeutic effect of the use of this drug shows a positive result - already from the second day of taking the medicine, there is a positive trend

The drug does not decompose in the gastric acidic environment, which is its distinguishing feature.

Use of a medicinal product for a child's body

The children's drug Flemoxin Solutab is a tablet form of a drug in which the dosage of the active substance is 125 mg, and there is also a dosage of 250 mg.

Flemoxin Salutab instructions for use indicate that children from 10 years of age can be given medications according to the instructions for adults at least 3-4 times a day with a dose of 125 mg.

Children from 3 years of age are prescribed the use of the drug 2 times a day, 1 tablet, Flemoxin Solutab 125 mg.

The dosage of the drug Flemoxin Solutab 250 mg is allowed for children from 10 years of age, but not more than 3 tablets per day. Children under the age of 10 years: 1 tablet per day with a dosage of 250 mg.

The daily dosage of the drug Flemoxin for children of all ages should not exceed 60 mg per kilogram of the child's weight and should be divided into several doses of use, preferably 3-4 doses. You can take tablets of 125 mg, as well as 250 mg.

When curing bacteria and infections in a child's body with this remedy, strict adherence to the instructions for use for children is necessary.

The use of a drug for the human body

How to take the drug for adults before meals or after meals?

The antibiotic Flemoxin Solutab is used orally, not tied to the time of eating. It is desirable to drink antibiotics at the same time. The tablet is swallowed whole or chewed, or prepared from a suspension, after dissolving it in 50-100 ml of water.

In infectious diseases of a mild nature of the disease and the course of an illness of moderate severity, Flemoxin tablets 250 milligrams are taken 2 to 3 times a day, one tablet.

Flemoxin Solutab 500 mg - 2 - 3 times a day, one tablet. Flemoxin Solutab 1000 mg - 2 - 3 times a day, 0.5 tablets.

In severe infectious diseases, it is necessary to increase the frequency of administration up to 4 times a day.

With gonorrhea in the acute form of the disease, it is necessary to drink Flemoxin Solutab together with the drug Probenecid and other antibacterial agents:

• Cefixime - taken orally, one tablet of 400 mg. It is possible to use during the period of bearing a child.
• Ciprofloxacin - orally, once 500 mg for gonorrhea at the initial stage of infection. It is not recommended to take this drug during pregnancy.
• Ofloxacin - orally, once 400 mg. If, in addition to gonococcal infection, diseases caused by other infections are observed in the body, treatment is carried out for 10-15 days. When carrying a child, the drug is not taken.

The use of Flemoxin Solutab when carrying a child and breastfeeding a child

Flemoxin Solutab instruction of the pharmacological company does not recommend taking flemoxin during the period of bearing a child and when breastfeeding a small child.

Flemoxin during pregnancy is prescribed in an extreme situation, if the benefit of taking the drug is much higher than the threat of adverse pathologies for the developing fetus.

When taking this drug, a special doctoral control over the state of the body of the expectant mother and the state of the fetus is necessary.

Flemoxin contains amoxicillin, and during lactation, a woman has a small amount of amoxicillin in her breast milk. When taking an antibiotic by a woman in labor, the child may experience an overdose of the drug.

If there is an urgent need to take an antibiotic during lactation, then you need to stop breastfeeding.

Side effects from the use of Flemoxin Solutab

After using the antibiotic Flemoxin Solutab, a number of side effects occur:

• change in taste buds;
• constant nausea, after eating - vomiting;
• painful diarrhea, constipation;
• acute form of dysbacteriosis;
• stomatitis with bright pain sensations;
• overexcitation;
• anxiety state;
• insomnia;
• state of confused consciousness partial loss of memory;
• manic depressive state;
• sharp pain in the head;
• morning strong circling of the head;
• acute conjunctivitis;
• anaphylactic shock and possibly coma;
• candidomycosis of the vaginal mucosa.

Before you start taking this medication, be sure to consult with your doctor.

The reaction to the drug from allergies is manifested in angioedema, rash on the skin, anaphylactic shock, as well as conjunctivitis and rhinitis. Dyspeptic indicators are disturbances in the state of appetite, severe nausea, belching, vomiting after ingestion or during meals.

Side effects on disorders in the work of hematopoietic organs and systems are quite rare if the correct dosage of the drug is followed.

Complications from taking the drug Flemoxin Solutab

Complications after taking the drug Flemoxin Solutab usually develop with an overdose or improper use.

The action of the drug is aimed at suppressing microbes and, together with harmful infections, beneficial microbes in the microflora of the stomach and intestines can die, and against the background of this indicator, dysbacteriosis develops in the body with pronounced symptoms:

• abdominal pain;
• frequent and loose stools;
• nausea and possibly vomiting.

If there is pain in the abdomen, this is the first sign of dysbacteriosis. Taking probiotics during this period is a must.

The consequences of dysbacteriosis can be fungal infections, and if the microflora is disturbed, these infections tend to multiply quickly enough. Symptoms of a fungal infection in the body:

• thrush in children of breastfeeding age;
• vaginitis or thrush in girls, which causes pain when urinating;
• itching of the genital organs with redness of the vulva;

Before taking this drug, it is necessary to consult with your doctor.

Formation of resistance of infections and bacteria to Flemoxin Solutab

The reason for the formation of resistance to Flemoxin Solutab in the body is the incorrect intake of these antibiotics:

• taking the funds for other purposes;
• the principle of sensitivity to the drug is not respected;
• low doses of medication;
• violation of the regularity of taking the drug;
• interruption of the course of treatment;
• too long treatment without a doctor's recommendation.

Drink antibiotics Flemoxin Solutab, you need no more than the period prescribed by the doctor.

Interaction of Flemoxin Solutab with other medications

The combined use of an antibiotic with diuretic drugs, medicines allopurinol, sulfinpyrazone - suppress the effect of antibiotics on the infection and contribute to the accumulation of amoxicillin in the blood.

Taking bactericidal antibiotics together with Flemoxin can cause synergism.

Antagonism is provoked when taking Flemoxin and bacteriostatic drugs.

Simultaneous use of Flemoxin with oral contraceptives may reduce the effect of contraceptives and increase the risk of uterine bleeding.

Antacids, as well as laxative drugs, aminoglycoside drugs and Flemoxin, taken at the same time, reduce the absorption of the body.

Ascorbic acid and Flemoxin increase absorption in the body.

Increases the therapeutic effect of taking Flemoxin and anticoagulants, their combined use.

Flemoxin enhances the body's absorption of digoxin.

Taking amoxicillin simultaneously with the drug allopurinol provokes a rash on the skin of the entire body of the patient.

Contraindications to the use of the drug

• intolerance to the Flemoxin component;
• acute inflammation of the stomach ulcer and ulcerative colitis disease;
• bronchial asthma caused by an allergy to antibiotics;
• exacerbated manifestation of allergy to various substances;
• lymphocytic leukemia;
• hemophilia;
• infectious mononucleosis;
• allergic reaction to amoxicillin;
• high blood pressure;
• insomnia;
• myocardial infarction and heart failure;
• epilepsy;
• nervous excitability;
• convulsions;
• chronic and acute liver diseases;
• cirrhosis of the liver;
• diseases of the kidneys and adrenal glands;
• alcoholism;
• bearing and feeding a child.

If you have diseases for which it is contraindicated to use this remedy, then you need to weigh the benefits of using it and the threat of side effects. In any case, the medication should be started after consultation with a personal doctor.

Do not forget that the list of side effects of the drug includes: nausea, vomiting, diarrhea, constipation, flatulence. It is not excluded: severe headache, heartburn, severe dizziness, sleep disturbance.

Flemoxin and alcohol are not compatible.

Overdose with Flemoxin Solutab

With an overdose of a drug, symptoms occur: nausea, vomiting, cutting pain in the abdomen and stomach cramps. Signs in the nervous system: inhibited actions, groundless drowsiness, depressive and irritable state are manifested. Noise and pain in the ears. From the side of the cardiac system, tachycardia, atrial dysfunction, bradycardia, and arrhythmia are observed. The possibility of a strong drop in blood pressure, both in the direction of its sharp increase, and in the direction of a strong decrease. In this case, there is a possibility of respiratory arrest and a coma.

On the part of the internal organs, acute renal and hepatic failure is observed, which can lead to long-term drug treatment.

If an overdose occurs, you should immediately flush the stomach with a large amount of liquid using potassium permanganate.

After that, take activated charcoal in a dose calculated according to the weight of the patient. It is also necessary to take an alkaline liquid until the symptoms are completely relieved, which were provoked by an overdose of the drug.

Reasonable use of Flemoxin Solutab has a positive effect on the patient's well-being and contributes to a quick recovery.

Analogues of the drug Flemoxin Solutab

Medication Flemoxin analogues with a similar spectrum of effects on bacteria and produced by various pharmaceutical companies:

• antibiotic Amoxicar;
• Amoxicillin;
• enhanced antibiotic Amoxicillin DS;
• drug Amosin;
• antibiotic Gonoform;
• drug Grunamox;
• medicine Danemox;
• drug Ospamox;
• Hyconcil;
• Ecoball.

These medicines contain the active substance amoxicillin in different doses.

In pharmacies, there are Flemoxin Solutab analogues cheaper. To buy or not to buy cheaper drugs is everyone's business.

Cheap medicines may contain not very high-quality substances, which weakens their action. Substitutes for amoxicillin in such products do not give the desired result in the fight against a bacterial infection.

wmedik.ru

The drug "Flemoclav Solutab". Reviews of specialists. Instruction

The drug "Flemoklav Solutab" is an antibiotic with a wide spectrum of action. It is active against gram-negative, gram-positive organisms, including bacteria producing beta-lactamase. The tool includes a combination of amoxicillin and clavulanic acid. This combination makes it possible to increase the spectrum of action in comparison with monotherapy.

Amoxicillin is inactivated by beta-lactamases, as a result of which it is inactive in monotherapy with respect to beta-lactamase-producing strains. Clavulanic acid produces a slight antimicrobial effect.

Indications for the use of "Flemoklav Solutab"

Reviews of experts testify to the effectiveness of the drug in the treatment of infections of varying severity and localization caused by microflora susceptible to the combination of clavulanic acid and amoxicillin. In particular, in otolaryngological practice, the drug is prescribed for infections of soft tissues, organs of the genitourinary system, skin, respiratory tract. The drug "Flemoklav Solutab", the doctors' reviews of which are very positive, is also used for osteomyelitis, postoperative infections, sepsis, peritonitis.

Release form and composition

The drug is available in the form of dispersed tablets. Each unit contains amoxicillin and clavulanic acid, respectively, in the amount of 125 and 31.25 mg, 250 and 62.5 mg, 500 and 125 mg, 875 and 125 mg. The tablets are packaged in cell packs of five or seven units. One box of product may include two or four packages. Auxiliary components in the preparation are saccharin, vanillin and others.

How to use the "Flemoklav Solutab"

Should Flemoxin be taken before or after meals?

Good afternoon. Flemoxin is an antibiotic commonly used to treat various infections in children.

According to the instructions, the drug can be taken both before meals, during meals, and after.

Since it is still an antibiotic, it is better to take it with food.

This drug is usually given to children and it is better not to take it on your own, but only after the prescription of this medication by your doctor, since any organism is individual, and can be harmful if you start taking it yourself.

Also, the doctor will determine the required dose for you.

This antibiotic is taken an hour before meals, or two after. In addition, it is dispersible, that is, soluble, and can be easily dissolved in a teaspoon of water and drunk as a suspension for those who cannot swallow tablets. Never drink milk. Only pure water.

As we can see from the instructions for the use of Flemoxin, you can take it at any time - before meals, during meals, and after meals.

It also does not matter in what form - the whole tablet is washed down with water, in the form of a powder, or even dissolved in syrup.

Flemoxin Solutab should be taken between meals.

Antibiotics are generally prescribed according to the scheme, at certain hours, and if you don’t feel like eating, then you don’t need to.

Flemoxin Solutab - cheek tablets, pleasant taste, quickly disintegrate in the oral cavity. They are not swallowed or washed down.

After taking half an hour, do not drink and do not eat so that the drug is absorbed into the oral cavity.

In the instructions for use Flemoxin Solutab it is said that:

In addition, the composition of each tablet knowingly includes:

• vanillin - 0.5 mg,
• tangerine flavor - 4.5 mg,
• lemon flavor - 5.6 mg and
• saccharin - 6.6 mg.

And it's not just that, the point is. what it is - Dispersible tablets, that is, they dissolve in the mouth and do not require swallowing or drinking.

You should also pay attention to this:

From the foregoing, it becomes clear that it is better to take Flemoxin Solutab strictly in time, dissolving them in the mouth (behind the cheek). As for the time of combining with food, it is better that you eat an hour before taking the pill, because allergies, pregnancy and lactation are rare, but almost every third person has gastritis and colitis.

Flemoxin is the most common and used antibiotic in recent times, and therefore all issues related to it are very relevant.

This drug belongs to the penicillin group and is very effective for bacterial infections of many diseases, and as for taking it, it is applicable before meals, during meals, and after meals - it doesn’t matter, the main thing is to follow the medication regimen, which prescribed by a doctor.

The annotation to the drug states that it can be used regardless of food intake. The composition of Flemoxin includes the antibiotic amoxicillin. And if you look at other preparations in which it is contained, then everywhere it is indicated that this substance has no attachment to food. Flemoxin tablets come in a soluble form. Therefore, they do not irritate the stomach and are absorbed relatively quickly, regardless of whether there is food in the intestines. The only indication that is given when taking is the need to consume a significant amount of water in order to avoid crystalluria, which may develop during the use of the drug.

It is fashionable to take a bactericidal acid-resistant broad-spectrum antibiotic Flemoxin Solutab before, during or after a meal. Due to the fact that the drug is acid-resistant, food intake practically does not affect its absorption. So, here you can choose what is more convenient for moms.

Flemoxin Solutab is a broad-spectrum penicillin antibiotic.

It is Flemoxin that can be taken, according to the instructions, before, during, or after eating. Tablets can be swallowed whole, divided into parts, chewed or dissolved in water to form a suspension.

During the reception, the medicine should be washed down with a sufficient amount of clean water.

Flemoxin is a type of antibiotic that can be taken at any time: before meals, during meals, or after meals. It will not affect his performance in any way. It is better to swallow the only tablet whole and it is necessary to observe the interval of taking the tablet. If you need to take 2 times a day, then we take it every 12 hours, but if the drug is prescribed for 3 doses, then you need to take it every 8 hours.

Flemoxin Solutab: instructions for use, description of the drug, indications and contraindications

The active substance Flemoxin Solutaba, as stated in the instructions for use, is represented by amoxicillin trihydrate.

Amoxicillin trihydrate is synthesized by a semi-synthetic penicillin substance with an antimicrobial, bactericidal effect on microorganisms.

Amoxicillin trihydrate is acid-stable, is not destroyed by the acidic contents of the stomach, and is activated immediately after ingestion in a short period of time.

The use of food, drinks does not cause a negative impact on the effectiveness of amoxicillin trihydrate, the achievement of the maximum effective concentration occurs after one hour. Due to the rapid interaction with blood transport proteins, Flemoxin is evenly distributed over the structural units of the whole body.

Flemoxin is highly effective against the following microbial organisms:

• streptococci (Str.pyogenes, Str.pneumonia);
• staphylococci (St.aureus);
• neisseria (N.meningitides, N.gonorrhoeae);
• hemophilic bacillus (H.influenza);
• clostridia (Cl.tetani, Cl.perfringens);
• helicobacter (Hel.pylori);
• listeria (Lis.monocytogenes).

The low efficacy of the drug has been proven by clinical studies in infections caused by Pr. Mirabilis, Sh.sonnei, En.faecalis, V.cholhere, Es.colli, Sal.typhii.

If we compare the drug with other antibiotics, Flemoxin is evenly distributed in the cell membranes of the mucous membranes, muscle structures, musculoskeletal system, bronchopulmonary secretion, achieving effective therapeutic accessibility. The active substance is relatively poorly absorbed through the membrane of the blood-brain barrier of the brain, however, in cases of development of purulent meningitis, an infectious lesion of the anatomical structures of the central nervous system, the concentration of amoxicillin trihydrate is determined in the cerebrospinal fluid of about 20%.

The metabolism of the drug is not very different from the antibiotics of the penicillin series. Partially, the drug is metabolized by cells of the hepatic beams - hepatocytes, the formed metabolites of amoxicillin trihydrate do not have a toxic effect. The bacteriostatic activity of derivatives-metabolites of amoxicillin trihydrate after disintegration in hepatocytes is low.

Elimination of Flemoxin Solutab is carried out by the kidneys, of which 80% is tubular excretion, 20% is glomerular filtration of metabolites. If the patient does not have a violation of the filtration capacity of the renal tissue, the primary half-life of the drug takes no more than one and a half hours. In children with immature renal parenchyma, the elimination half-life is about three and a half hours.

The uniqueness of the pharmacological subspecies "Solutab" is rapid absorption in the organs of the digestive system, absolute absorption (more than 94%).

Release form. Flemoxin is available in the form of white or yellowish dispersible tablets of 125, 250, 500 milligrams, 1 gram.

In addition to the active, excipients are presented in the form of:

• dispersible cellulose;
• lemon flavoring;
• crospovidone;
• saccharin;
• micro-crystalline cellulose;
• tangerine flavor additive;
• vanillin;
• magnesium stearate.

Dosing of the drug Flemoxin Solutab, instructions for use describes as follows: the drug is intended for oral administration, regardless of the time of planned food intake, before, during or after meals.

The dosage is divided into two halves, you can take the tablet completely, crush it to a powder state. Powder for children is recommended to be diluted with water to a state of suspension or syrup.

The antibiotic is prescribed strictly upon consultation of the supervising doctor, who takes into account the manifestations of the patient's allergic reactions, drug intolerance to certain substances that make up the drug Flemoxin Solutab.

Instructions for use suggests adjusting the dosage of the drug depending on:

• the severity of the course of the disease;
• antibiotic sensitivity of the pathogen;
• weight;
• age;
• gender of the patient.

In cases of progression, the spread of primary inflammation for the distribution of Flemoxin to hard-to-reach localizations of the infection, three times the use of the drug is recommended. For example, with a purulent lesion of the eardrum of the outer ear. During various chronic infectious diseases, frequent relapses, severe course of the disease, to reduce the risk of complications, adults are prescribed Flemoxin gram three times, and children 65 mg / kg per day.

Indications for the use of the drug are infectious and inflammatory diseases caused by microorganisms sensitive to Flemoxin Solutab:

• lesions of the skin, subcutaneous fat, soft muscle tissue, joints;
• pathology of the urinary, reproductive systems;
• infection of the upper, lower respiratory tract, lung tissue;
• disorders of the digestive system.

Contraindications to the use of the antibiotic Flemoxin Solutab are few due to the uniform distribution with the bloodstream through the organs and tissues of the body. The breakdown of amoxicillin into derivatives and metabolites significantly reduces the toxic effects on the liver and kidneys.

Absolute contraindications are:

• individual intolerance to the drug (anaphylactic shock);
• increased allergic sensitivity to the active substance of the drug (urticaria, pruritus, peeling);
• increased sensitivity to beta-lactam antibiotics, penicillins, cephalosporins, carbapenems.

The metabolism of amoxicillin by liver cells causes caution in the use of Flemoxin Solutab in the following conditions:

• alcohol abuse;
• chronic alcoholism;
• cirrhosis;
• acute and chronic liver failure;
• acute and chronic hepatitis;
• cholelithiasis;
• cholecystitis.

Excretion of the drug by the kidneys requires compliance with the dose of the drug, since a violation of the filtration function of the kidneys leads to the accumulation of the active substance and its metabolites, and the risk of overdose increases.

Pathology from the kidneys:

• acute and chronic renal failure;
• pyelonephritis;
• glomerulonephritis;
• circulatory disorders.

• lactation period;
• pregnancy;
• polyvalent hypersensitivity to xenobiotics;
• diseases of the gastrointestinal tract in history;
• lymphocytic leukemia;
• renal failure;
• infectious mononucleosis;
• history of allergic reactions.

For pregnant women or mothers during lactation, doctors prescribe the drug only in cases where the expected predicted benefit of treatment for a woman outweighs the risk of side effects in the fetus or infant. Flemoxin Solutab is excreted in small amounts with breast milk, this can lead to sensitization in a child, the development of allergic reactions.

Antibiotic Flemoxin Solutab and its therapeutic effect

The therapeutic bactericidal effect of the antibiotic Flemoxin Solutaba consists in the complete destruction of the infectious focus formed by gram-negative or gram-positive bacteria. After entering the human body, an acid-resistant antibiotic destroys most groups of infectious microorganisms, except for individual bacterial species capable of synthesizing the enzyme penicillinase.

Flemoxin Solutab is not used when the body is infected with indole-positive groups of the Proteus; in this case, a change in the drug is required for treatment.

The bactericidal effect of amoxicillin has been proven by domestic and foreign clinical studies.

Treatment of prostatitis with the antibiotic Flemoxin Solutab is widely used in urological practice. This is due to the rapid elimination of the inflammatory process of the prostate tissue, the removal of inflammatory edema, and the complete destruction of the pathogen. The effectiveness of the drug is achieved by individual selection of the daily dosage, a long course of therapy.

As a rule, with an infectious lesion of the prostate gland, the antibiotic Flemoxin Solutab is prescribed to men for a course of at least 14 days, depending on the titer of pathogenic bacteria, general symptoms.

The drug quickly relieves the symptoms of general intoxication:

Symptoms begin to disappear after the second dose of the drug, with an unfavorable prognosis of infection, the appointment of additional symptomatic therapy, anti-inflammatory non-steroidal drugs is required. In acute prostatitis, the antibiotic Flemoxin Solutab is prescribed after bacterial seeding to accurately identify the pathogen.

The use of the drug for the treatment of other diseases, such as upper respiratory tract infections, is used quite often among general practitioners and otolaryngologists.

Good bioavailability of the drug in the mucous membranes of the nasopharynx allows you to treat diseases such as:

• purulent rhinitis;
• sinusitis (sinusitis, ethmoiditis, frontal sinusitis);
• polyposis;
• adenoiditis;
• acute and chronic tonsillitis;
• various types of angina.

The antibiotic Flemoxin Solutab is prescribed both in childhood and in adulthood, after nasopharyngeal operations for a prophylactic effect, reducing the risk of infection. After opening the paratonsillar abscess, the drug is prescribed by a doctor to prevent secondary infection.

Flemoxin Solutab: dosage for adults and children

After the appointment of the drug Flemoxin Solutab, the dosage is determined by the attending physician, based on several criteria. Self-administration of drugs leads to the emergence of resistance in bacteria to antibiotics, persistent antibiotic resistance, which leads to the development of various complications and life-threatening pathologies.

This is due to non-compliance with dosing, fractional intake during the day, violation of the course of taking amoxicillin trihydrate. In inflammatory diseases of mild to moderate severity, doctors recommend using Flemoxin Solutab, regardless of meals, according to the scheme, depending on the course of the disease:

• with a mild adult, children from ten years of age helped 3 times / day;
• with moderate adults, children from ten years of age, 2 times / day;
• children from three to ten years old with a lung, 250 mg 3 times / day;
• children from three to ten years old with moderate 375 mg 2 times / day;
• children of the first three with a lung, 125 mg 3 times / day;
• children of the first three years with moderate severity are prescribed 250 mg 2 times / day.

On average, the calculation of the drug per day is mg amoxicillin per kilogram of the child's weight.

The resulting dosage is recommended to be divided into two or three doses, which improves the bioavailability of Flemoxin Solutab, increases its effectiveness, and the overall therapeutic effect. A triple dose is especially indicated for severe infections.

After the doctor's recommendations, the dosage of amoxicillin trihydrate can be increased by 1 kg per kilogram, this happens with extremely severe infections that are difficult to classical treatment. In such situations, pediatricians often combine Flemoxin Solutab in a dosage according to age with other representatives of antibiotic drugs.

In elderly people, amoxicillin trigdrate is dosed after a carefully collected anamnesis for pathology of the kidneys or the hepatocellular system. Depending on the degree of renal failure, which develops in many elderly people, the doctor adjusts the daily dose of the drug.

This avoids pathological toxic effects on body tissues, the occurrence of side effects. If there are complaints of feeling unwell, nausea, vomiting associated with the last use of the drug, it is necessary to urgently seek advice from the supervising doctor to cancel it.

Pregnant women and mothers during lactation are prescribed Flemoxin Solutab after adjusting the dosage, assessing the rationality of the intake. Wide distribution in the tissues of the mother's body leads to the penetration of the active substance through the uteroplacental bloodstream to the fetus.

This significantly increases the development of allergic reactions in a child after birth. According to the results of foreign clinical studies, no teratogenic effect on the fetus when taking the drug during pregnancy has been identified.

Flemoxin Solutab: how to take, analogues, prices

Amoxicillin trigdrate is widely used among men suffering from prostatitis, which leads to a high absorption of Flemoxin Solutab by the prostate tissue. How to take this drug is advised in detail by a urologist immediately after laboratory tests, a general examination of the patient.

Prostatitis is characterized by a recurrent course with frequent exacerbations during the year. This is due to the poor absorption of the drugs used, antibiotics of the penicillin group. The positive effects in patients of the drug Flemoxin Solutab, which can be taken individually - orally in the form of tablets, powder for syrup or suspension, are achieved due to the complete destruction of bacterial cells.

The high effectiveness of the drug is evidenced by the long-term remission of prostatitis without exacerbations after administration. The next relapse, as a rule, develops after hypothermia of the patient, secondary infection, and acute respiratory viral infections.

The drug is especially effective in the treatment of prostatitis caused by Neisseria or Escherichia coli. A pronounced bactericidal effect blocks the production of microbial enzymes, completely eliminates the consequences of an infection of the prostate tissue.

In the treatment of otitis media, otolaryngologists prefer the drug because of its absorption by the tissues of the outer, middle and inner ear. While other antibiotics are not able to fight the infection qualitatively, Flemoxin Solutab blocks the reproduction of bacteria and quickly eliminates the unpleasant symptoms of otitis media.

In the treatment of bronchitis, the drug is used to quickly get rid of a wet cough with a discharge of purulent viscous sputum. Suitable for the prevention of exacerbations of chronic obstructive pulmonary disease. Does not violate the mucociliary clearance of the ciliated epithelium of the bronchi, does not cause allergic reactions. It is prescribed with caution to patients with bronchial asthma to avoid allergic reactions.

The analogues of the original drug are:

Analogues are much cheaper, for example, the Austrian drug Hikoncil in 250 mg capsules costs about 30 rubles. The domestic drug Amosin Synthesis in capsules of 250 mg costs 68 rubles.

Prices for the original drug vary depending on the region, form of release, dosage of the drug. The cost of the drug Flemoxin Solutab Ortat in tablets of 125 mg N20 starts from 230 rubles per pack. For a dosage of the drug 1000 mg of the same manufacturer, you can pay up to 560 rubles.

Reviews after treatment with this antibiotic are usually positive. Minimal risk of side effects, low price relative to other antibiotics, pronounced therapeutic effect makes Flemoxin Solutab the drug of choice in the treatment of many infectious diseases.

The use of the drug in children from one year has positive reviews among parents. Reducing the risk of recurrent exacerbations, low risk of intestinal dysbacteriosis and good drug tolerance allow it to be widely used in pediatric practice.

Specialty: Urologist Work experience: 21 years

Specialty: Urologist-andrologist Work experience: 26 years

Flemoxin - a well-known antibiotic in an innovative form

Flemoxin is a generic of one of the most popular antibiotics in the world - Amoxicillin. The original drug was developed by British pharmacists in the 60s of the last century. Amoxicillin appeared on the pharmaceutical market in the early 70s.

Before you continue reading: If you are looking for an effective method of getting rid of a runny nose, pharyngitis, tonsillitis, bronchitis or colds, then be sure to check out this section of the site after reading this article. This information has helped so many people, we hope it will help you too! So, now back to the article.

Amoxicillin is without a doubt one of the safest broad-spectrum antibacterial drugs. According to some reports, this penicillin antibiotic is almost the most prescribed medicine in pediatrics. Almost every reputable pharmaceutical company considers it their duty to release their "Amoxicillin". The Japanese corporation Astellas Pharma also succeeded in this matter by developing Flemoxin.

Flemoxin Solutab stands out against the monotonous background of Amoxicillins due to its release form. After all, the drug is available in the form of dispersible tablets, which have a lot of advantages compared to the pills we are used to.

In this article, we will try to understand how Flemoxin differs from analogues, as well as to clarify the positive aspects of the drug. And we will not bypass the negative qualities, which, of course, are also present.

Astellas Pharma: new life for antibiotics

Astellas Pharma is the largest Japanese pharmaceutical concern. It appeared in 2005 through the merger of two well-known Japanese companies: Fujisawa Pharmaceutical Co and Yamanouchi Pharmaceutical Co.

Today, Astellas Pharma works in various areas of medicine, creating both original drugs and analogues of well-known brands. The company also produces several antibiotics, which have become widely known due to the dispersible form of release.

Each of these medicines has an additional word in the name, indicating a special form - solyutab. Dispersible preparations include:

• cephalosporin antibiotic Ceforal Solutab;
• Unidox Solutab, widely known in Russia;
• Wilprafen Solutab;
• Flemoxin Solutab and Flemoklav Solutab are two related drugs containing Amoxicillin as an active ingredient.

I would like to note that Flemoxin Solutab is registered only in Germany, Iceland, Portugal and the CIS countries.

Flemoxin solutab: composition of the drug

So, the composition of Flemoxin includes, as you already understood, the only active ingredient - Amoxicillin - in the form of a stable compound (trihydrate).

Amoxicillin is a semi-synthetic penicillin, which is very similar in chemical structure and spectrum of activity to Ampicillin.

As additional substances, the composition of Flemoxin includes chemical substances, which, in fact, ensure its solubility in the minimum volume of solvent. These include cellulose and MCC - microcrystalline cellulose.

Note that Flemoxin tablets have a pleasant citrus taste due to the addition of tangerine and lemon flavors.

The color of the tablet may vary from pure white to yellowish or even light yellow. A change in color does not mean that the drug was stored incorrectly. Or, more than that, it is a gross fake. The color variations of Flemoxin are associated with the presence of cellulose compounds in it, in which color changes are allowed.

Flemoxin release forms - for both children and adults

A wide range of Flemoxin includes both children's and adult forms of release, which differ only in dosage.

Unlike conventional oral antibiotics, Flemoxin is not presented in the form of a powder for the preparation of a pediatric suspension. Therefore, parents of small patients are practically deprived of the opportunity to show their hidden pharmaceutical abilities, calculating the volume of water and diluting the white powder with trembling hands.

So, let's list the release forms of Flemoxin Solutab.

Children's release forms:

• Flemoxin solutab with a dosage of 125 mg;
• Flemoxin solutab at a dose of 250 mg.

Adult forms of release:

• Flemoxin Solutab 500 mg;
• Flemoxin solutab at a dose of 1000 mg.

Why can't you split a Flemoxin tablet?

A transverse risk is applied to the oblong tablet of Flemoxin. Most patients believe that the risk is needed in order to split the tablet in half. And get the dosage exactly two times less than the original.

I would like to explain to readers why, nevertheless, experts persistently warn patients against such a division.

There are two reasons why you should not split a tablet into two parts. First, many tablets are coated with a protective coating that protects against the destructive properties of hydrochloric acid. However, this does not apply to Flemoxin - it is not coated, so we can go further.

The second and main reason is that when separating a tablet, it is technically impossible to know the dosage of the resulting parts. Even if you have a pharmacy scale at hand, and you were able to accurately divide a Flemoxin tablet weighing 1000 milligrams into two equal parts, the amount of the active substance remains unknown. Why do you think?

Take another look at the packaging of the drug or the instructions for Flemoxin. The composition of any tablet preparation (as, by the way, most others), in addition to the main active ingredient, often contains many other substances. Using the example of Flemoxin Solutab at a dosage of 125 mg, we see that the content of cellulose, microcellulose (or MCC), as well as flavors and saccharin, is about 17% of the share of Amoxicillin. In this case, the active substance is unevenly distributed, and therefore in the left half of the tablet there can be N percent more active substance than in the right. Or vice versa.

Accordingly, the effectiveness of different parts of the Flemoxin tablet can be, to put it mildly, not the same. And the side effects too.

And now let's remember that we are not dealing with ascorbic vitamins, but with a drug, the dose of which is carefully selected depending on the age and severity of the infection. And remember the unshakable rule of pharmaceutics: it is simply forbidden to divide a pill in order to reduce the dosage!

Exceptions may be some cardiac drugs. In such cases, the manufacturers themselves take into account all the nuances and technologically achieve a uniform distribution of all the components of the tablet.

Dispersible tablet: what is it?

Many patients, when faced with the name “dispersible tablet” for the first time, have a hard time imagining what it is. Meanwhile, a growing number of pharmaceutical companies are trying to wrap older drugs in dispersible form. Dispersible vitamins, antibiotics, and even erection-enhancing drugs are on the market.

Initially, dispersible tablets were created for patients who have difficulty swallowing. This condition, medically called dysphagia, occurs in 35% of the general population and 60% of the elderly.

The first dispersible tablets dissolved in the mouth with the formation of gas. Subsequently, new forms were developed, which include cellulose and its compounds. We have already mentioned that Flemoxin Solutab refers to such drugs.

Advantages of the dispersible form

So, let's see how Flemoxin dispersible tablets differ from regular Amoxicillin and what is their advantage.

So, the dispersible form of Flemoxin:

Flemoxin dispersible tablets are absorbed in the oral cavity directly into the bloodstream, bypassing the gastrointestinal tract. Due to this, the bioavailability of oral-soluble tablets is an order of magnitude higher than oral ones;

• quickly reaches peak concentration.

Oral tablets begin to be absorbed into the blood at best 15-20 minutes after ingestion. Dispersible dosage forms (including Flemoxin) are absorbed within 5 minutes after dissolution in the mouth;

• more suitable for pharmaceutical substances unstable in water.

An excellent example is children's Flemoxin Solutab 125 mg, which is much more convenient in the form of soluble tablets than amoxicillin suspension;

• can be used for newborns and infants;
• does not require additional manipulations before use, unlike, for example, a suspension that needs to be prepared;
• may be dissolved in breast milk;
• Requires very little water to dissolve.

Every parent knows how important it is that the medicine is not only effective, but also tasty. A mother who is trying to pour a hated bitter medicine on a sick child while dad is holding the child by the arms and legs is a very sad picture. And not so rare.

Astellas Pharma masked the traditionally bitter taste of Amoxicillin with citrus flavors and saccharin. Therefore, Flemoxin Solutab is a tasty medicine for children.

Flemoxin pharmacokinetic data - strong evidence of its benefits

The pharmacokinetic properties of drugs largely determine their effectiveness. This is an axiom that does not require proof.

So, for example, one of the most negative aspects of the predecessor of Flemoxin - Ampicillin - is low absorption and a short half-life. Imagine that two-thirds of the antibiotic is not absorbed at all. That is, you drink one gram of not the safest drug, and only 300 mg enters the bloodstream. The rest is excreted from the body, along the way, having “worked” in the intestines on your previously quite viable microflora. Not the most pleasant prospect, is it?

Therefore, one of the main tasks of modern pharmaceuticals is the search for new drugs and forms that have a high level of bioavailability. And Flemoxin Solutab, without any doubt, can be called one of these drugs.

Flemoxin is absorbed into the blood very quickly - within 5-10 minutes - and almost completely. The bioavailability index of dispersible Amoxicillin approaches 93%. Note that for oral dosage forms, such figures are practically record-breaking. In comparison with oral Amoxicillin, Flemoxin also clearly wins in this indicator. Thus, the bioavailability of conventional tablet forms of Amoxicillin rarely exceeds 75-80%.

Flemoxin packaging: tightness - a condition of safety

Flemoxin dispersible tablets are extremely sensitive to moisture. To protect the tablet from moisture contained in the air, it is necessary to ensure the complete tightness of the package. Flemoxin is packaged in aluminum blisters, which guarantee the protection of the antibiotic from premature decay.

If you accidentally squeezed a Flemoxin tablet out of the cell, it is better to either take it immediately or dispose of it, that is, mercilessly betray it to the trash can.

It should be remembered that due to the high content of cellulose, there is a possibility of gradual dissolution of the tablet in the moisture of the air. And we know that any antibiotic, including Flemoxin, is unstable in a dissolved state.

Therefore, a Flemoxin tablet, which was stored in a broken package or, even worse, without it, may at best be a harmless pacifier.

Flemoxin solutab: spectrum of pharmacological activity

Amoxicillin - the active substance of Flemoxin - is active against many gram-positive and gram-negative bacteria. Among them:

• streptococci - Streptococcus pyogenes and Streptococcus pneumonia;
• staphylococci, including Staphylococcus aureus;
• clostridia;
• causative agents of gonorrhea Neisseria gonorrhoeae;
• listeria;
• the causative agent of peptic ulcer Helicobacter pylori.

The low activity of Flemoxin is recorded against most pathogens of intestinal infections:

And finally, Proteus, enterobacteria, as well as microorganisms that produce beta-lactamases are absolutely insensitive to the action of Flemoxin.

Beta-lactamases and Flemoxin: the fight is not for life

In the instructions for Flemoxin and other penicillins, as well as cephalosporin antibiotics, the term "beta-lactamase" is often found. Usually, patients who carefully study the annotations intuitively understand that lactamase is probably something very bad. But it is not always possible to clearly understand what it is and what, in fact, is the harm of beta-lacatmaz.

Let's try to find out who or what this beta-lactamase is. And we will start by remembering when the first penicillins began to be used.

The history of antibiotics goes back over 70 years. During this period, many microorganisms have learned to recognize the destructive antibacterial substance. At least two groups of antibiotics - penicillins and cephalosporins - modern strains of bacteria already synthesize antidotes. In the role of an "antidote" are special enzymes from the group of beta-lactamases (penicillinase), which destroy the beta-lactam ring of the antibiotic. As a result, the drug is completely inactivated and has no antibacterial effect.

The first bacteria that learned to produce penicillinase were staphylococci. And, if in 1944 only 5% of strains of Staphylococcus aureus produced the enzyme, now this figure has increased many times and is almost 90%!

In addition, beta-lactamase-producing bacteria include streptococci, as well as many gram-negative microorganisms, including Klebsiella, Enterobacteria, Pseudomonas, and other pathogens.

So, when infected with microorganisms that produce beta-lactamase, neither Flemoxin, nor other analogs of Amoxicillin, nor Ampicillin are absolutely effective.

Therefore, the correct assessment of the doctor is so important when prescribing unprotected penicillins. The task of a specialist is to differentiate the pathogen and “not to miss” in the choice of an antibiotic.

Flemoxin or Flemoclav, which is better?

Astellas Pharma releases another antibiotic containing Amoxicillin, Flemoklav. Both the name and the packaging of the drug are very similar to Flemoxin, but there is a significant difference between these drugs. Let's see how these seemingly similar antibiotics differ.

We have already found out that some strains of microorganisms produce beta-lactamase, which inactivates Flemoxin. Therefore, in many infectious diseases, Amoxicillin, the active ingredient of Flemoxin, is absolutely ineffective.

Researchers at the British company Beecham, which developed Amoxicillin, were able to find a substance that blocks beta-lactamase. This substance was clavulanic acid. Scientists have proven that the combination of clavulanic acid and penicillin antibiotics is effective against strains of bacteria that produce beta-lactamase.

So there was already a new antibacterial drug with an extended spectrum of action. The original antibiotic was released by Glaxo under the name Augmentin. By the way, due to the protective action of clavulanates, complex antibiotics began to be called protected. After all, clavulanic acid really serves as a real protection of the lactam penicillin ring from destruction!

The Japanese corporation Astellas Pharma has developed a dispersible form of protected Amoxicillin - Flemoclav.

Often, patients ask themselves the question: which antibiotic is preferable - Flemoxin or Flemoklav? Only a specialist who relies not only on theoretical, but also on practical knowledge can resolve this dilemma.

The doctor, when deciding on the selection of one or another antibiotic, evaluates the history of the current disease, as well as the experience of treating previous infections. The most important stage in the selection of an antibiotic is the differentiation of the pathogen. An error leads to incorrect prescription of the drug, and, therefore, to ineffective treatment.

Complicating the decision is the fact that in the vast majority of cases the pathogen is calculated empirically, that is, based on the symptoms of the disease. A qualified doctor will undoubtedly be able to do this. But an amateur from medicine is definitely not able to do it. Therefore, patients should remember: the decision to prescribe antibiotics and the choice of a specific drug should be entrusted to a doctor or clinical pharmacist. And no one else!

Flemoxin Solutab: when to take?

Indications for the appointment of Flemoxin are primarily associated with the spectrum of pharmacological activity of the drug. Note that Amoxicillin is included in the protocols for the treatment of many infectious diseases.

Modern semi-synthetic penicillin - Flemoxin Solutab - is the drug of choice for uncomplicated pathologies of the respiratory tract of bacterial origin. I would like to place special emphasis on the word "uncomplicated". In case of a moderately severe disease or a severe, complicated infection, protected penicillins or antibiotics of other groups are preferred to Flemoxin.

So, let's list the main diseases in which Flemoxin Solutab is indicated:

Acute otitis media is inflammation of the middle ear.

In the initial treatment of acute otitis media, Flemoxin is the first-line drug, i.e. the preferred antibiotic. However, if the disease is aggravated by severe otalgia (pain in the ear), a temperature above 39 degrees, then the doctor may suspect infection of beta-lactamase producing strains of Haemophilus influenzae and Moraxella catarrhalis. In such cases, the drug of choice is Flemoklav, that is, protected Amoxicillin.

Pharyngitis and tonsillitis - inflammation of the pharynx and tonsils.

As a rule, these diseases are caused by Streptococcus pyogenes, which are highly sensitive to Amoxicillin. The standard treatment protocols indicate that Flemoxin Solutab is the drug of choice for bacterial angina. However, if the disease is recurrent in nature, i.e. recurs periodically within, for example, one year, then preference is given to a combination with clavulanates, as well as macrolides or cephalosporins.

Infections of the lower respiratory tract.

The main causative agents of pneumonia and bacterial bronchitis - alpha- and beta-hemolytic streptococci, Streptococcus pneumoniae, Staphylococcus aureus and hemophilus influenza - are sensitive to Flemoxin. Therefore, with uncomplicated bronchitis and pneumonia, Flemoxin solutab can be used.

Skin infections caused by susceptible streptococci, Staphylococcus aureus and Escherichia coli.

Urinary tract infections.

Flemoxin is effective in inflammatory diseases of the kidneys and bladder if they are caused by sensitive enterococci Enterococcus faecalis, Escherichia coli or Proteus. For the treatment of uncomplicated enterococcal urinary tract infections, Flemoxin is the drug of choice.

However, it should be borne in mind that some strains of E. coli are resistant, that is, absolutely insensitive to Amoxicillin. Meanwhile, cystitis - inflammation of the bladder - in most cases is caused by Escherichia coli. Therefore, Flemoxin in urological infections is prescribed with caution.

Typhoid fever and salmonellosis.

Flemoxin is considered an alternative antibiotic for these infections and is used when first-line drugs are contraindicated. Note that the drugs of choice are fluoroquinolone antibiotics and third-generation cephalosporins.

Flemoxin is used in cases of early localized Lyme disease.

Treatment of peptic ulcer with Flemoxin

Gone are the days when peptic ulcer was considered an incurable chronic disease that really aggravated the patient's life. Ulcers no longer need to be teetotalers, drink potato juice on an empty stomach, or poison themselves with vinyline. And even more so to lie down on the operating table.

Thanks to the discovery of the role of a banal infection in the formation of an ulcer in the wall of the stomach or duodenum, a quick and effective therapy for these diseases has become possible. Helicobacter pylori infection, the causative agent of which is the microorganism Helicobacter pylori, is the cause of peptic ulcer in almost 90% of cases. In addition, Helicobacter provokes the development of atrophic gastritis, a dangerous inflammatory disease of the stomach wall, which is a risk factor for ulcers and even stomach cancer.

For a long time, scientists could not even imagine that something living could survive in a sharply hydrochloric acid environment. It turned out that Helicobacter pylori not only survives, but also actively reproduces. The bacterium synthesizes a special enzyme that neutralizes the hydrochloric acid of the stomach - that's the whole secret of survival.

Meanwhile, Helicobacter responds well to therapy. The complex scheme for the treatment of infection includes two antibacterial drugs (one of which is Flemoxin), as well as a proton load inhibitor. The last remedy is necessary in order to completely neutralize the hydrochloric acid in the stomach. Indeed, otherwise, the healing of the inflamed area is simply impossible.

So, one of the most effective peptic ulcer treatment regimens includes Amoxicillin (Flemoxin Solutab), Clarithromycin, and a proton pump inhibitor (eg, Omeprazole, Lanzaprozol, and other drugs). In case of intolerance to Clarithromycin, a two-component scheme is used or Metronidazole is added as an antimicrobial agent.

STD treatment

Under the abbreviation STDs, not the most pleasant diseases are hidden - diseases that are sexually transmitted.

Flemoxin is used only for two infections, and even then in special cases. Let's consider them in more detail:

In the past, Amoxicillin was widely used to treat uncomplicated cases of gonorrhea. But recently, penicillin-resistant strains of Neisseria gonorrhoeae have formed, so Flemoxin is more often replaced with another antibiotic.

Flemoxin is a first line treatment for uncomplicated urethritis (inflammation of the urethra) and cervicitis (inflammation of the cervix) during pregnancy. Note that in most cases with chlamydia in pregnant women, instead of Flemoxin or other Amoxicillin, Sumamed is still used, which is considered the drug of choice.

Flemoxin is usually prescribed in case of individual intolerance to macrolides.

Standard dosages of Flemoxin according to the instructions for use

Immediately, we emphasize that any antibacterial drug is dosed individually. And Flemoxin is no exception to the rule. In each case, the doctor evaluates the severity of the disease, the history data, that is, the medical history, as well as concomitant diseases. And based on this information selects the correct dosage.

However, there are still standard dosages of Flemoxin - something like the average body temperature in the ward. We emphasize that they are necessary for the doctor, and not for the patient. And even more so, you should not rely on this information in order to prescribe the most correct treatment regimen for yourself.

So, according to the instructions for the use of Flemoxin, the following dosages are recommended:

• for children from 1 to 3 years old, use Flemoxin 250 mg tablets twice a day. An alternative appointment may be 125 mg of Flemoxin three times a day at regular intervals;
• The maximum dose of Flemoxin for a child is 60 mg per kilogram of body weight per day. This dosage is indicated for severe infectious processes;
• for children from 3 to 10 years old, 375 mg of Flemoxin is prescribed twice or 250 mg three times a day;
• for children over 10 years of age and adults, the average dosage of Flemoxin is 500-750 mg twice or 375-500 mg three times a day.

In severe infections, it is allowed to use Flemoxin up to 3 grams per day, necessarily divided into three doses.

The duration of treatment, as well as the dosage of Flemoxin, is selected individually. Note that the minimum course of therapy should not be less than five days. The standard treatment regimen consists of a weekly course of antibiotics. If the infection is caused by streptococcus Streptococcus pyogenes, Flemoxin is used for at least 10 days.

It is worth emphasizing that antibiotic treatment should not be stopped immediately after the disappearance of the symptoms of the disease. This haste is fraught with the formation of resistant strains from selected and strong bacteria, which Flemoxin simply does not have time to act on.

In order to avoid complications, it is necessary to continue treatment with Flemoxin for two days after the manifestations of the infection stop. At the same time, we must not forget that the minimum course should not be less than five days.

We chew, swallow, dissolve, or How is it better to take Flemoxin?

When faced with dispersible tablets for the first time, many patients are wondering how best to take Flemoxin. Let's try to answer this question and clarify whether there is a difference between the methods of taking this drug.

So, one of the most significant advantages of Flemoxin Solutab is the ability to choose a method of application that is convenient for the patient.

Depending on the individual characteristics and personal preferences of each Flemoxin tablet, you can:

• chew in the mouth;
• suck like a lollipop;
• dissolve in a small amount of cool boiled or simply purified water;
• dissolve in breast milk - for babies;
• dissolve in any juice, compote, tea and other drink. The only condition is that the drink should not be hot.

Immediately, we note that there is no fundamental difference in the methods of application. The absorption rate, bioavailability and metabolism of Flemoxin do not depend on how long you chewed the tablet or how much juice you diluted.

In addition, the pharmacokinetic properties of Flemoxin are not affected by food intake. You can take a tablet before meals, during lunch or after dinner, and in all cases, the bioavailability of the antibiotic will be the same.

Contraindications to taking Flemoxin

Do not forget that Flemoxin is an antibacterial drug that has both side effects and contraindications. However, in fairness it should be noted that Amoxicillin is one of the safest antibiotics.

So, we list the absolute contraindications to taking Flemoxin:

Individual sensitivity to penicillin antibiotics.

The likelihood of an allergic reaction to Flemoxin is low. However, if you have an allergy to medications, and even more so to antibiotics, do not forget to notify your doctor about this. The specialist will be able to assess the risk and choose the right antibacterial agent.

In addition, do not forget about cross-sensitivity between penicillins and cephalosporins. If you have had an allergic reaction, for example, to ceftriaxone or any other antibiotic from the cephalosporin group, then it is also better to replace Flemoxin.

The erroneous appointment of Flemoxin and other penicillins in this disease leads to the appearance of an erythematous rash. Note that the symptoms of infectious mononucleosis are similar to those of bacterial pharyngitis and tonsillitis. However, mononucleosis is caused by a virus and does not require antibiotic therapy. Only a doctor can make a correct diagnosis and prescribe the correct drug.

Flemoxin during pregnancy: risk and benefit

Flemoxin is one of the antibiotics conditionally approved for use during pregnancy. The instructions for Flemoxin indicate that the drug can be used in cases where the risk to the child is less than the expected benefit to the mother.

Do not be afraid of this wording. It is caused solely by the fact that clinical trials of Flemoxin in pregnant women have not been conducted, and it is unlikely that they will ever be carried out for obvious reasons.

Nevertheless, Flemoxin is considered one of the safest antibiotics that can be used during pregnancy. And quite a long experience of its use is an excellent proof of this. But we emphasize once again that any antibiotic, including Flemoxin, can only be prescribed by a doctor. Think about your health and the health of your unborn child.

Side effects associated with Flemoxin treatment

Flemoxin is one of the antibiotics that is well tolerated. However, there is a possibility of adverse events during or after drug treatment. Among them:

in 1-10% of cases are registered:

• development of a vulvovaginal fungal infection (in 2% of patients). In such situations, against the background of treatment with Flemoxin, the parallel use of antimycotic drugs, for example, Fluconazole, is recommended;
• diarrhea (in 1.7% of patients). As a rule, this symptom does not require the abolition of Flemoxin and disappears on its own;
• nausea (in 1.3% of patients);
• headache (in 1% of cases).

less than 1% of cases are possible:

Less than 1% of cases of treatment with Flemoxin may develop a rather serious side effect - pseudomembranous colitis. The cause of this condition is a change in the composition of the intestinal flora and the reproduction of conditionally pathogenic microorganisms Clostridium difficile. Clinically, pseudomembranous colitis is manifested by severe diarrhea, which is fraught with general dehydration of the body.

When such symptoms appear, the first thing the patient should do is to immediately notify the attending physician. Usually in such cases, the only possible way out is the abolition of Flemoxin and the appointment of another antibiotic or antimicrobial drug to which clostridia are sensitive. In addition, an important role is played by the restoration of water-salt balance in the body.

Flemoxin solutab - analogues

The pharmaceutical market is full of Amoxicillin generics from various manufacturers. Let's try to list those analogues of Flemoxin that have earned positive reviews from doctors:

• Amoxicillin produced by the Serbian company Hemofarm;
• Amoxicillin Sandoz, which is produced by the French corporation Sandoz;
• Hikoncil, a drug from the Slovak company KRKA;
• Ospamox produced by the Austrian pharmaceutical concern Biochemi;
• Amosin, Russian pharmaceutical company Sintez.

Despite the abundance of analogues of Flemoxin Solutab, very few preparations have the same dispersible form. These include the Austrian Ospamox DT.

And the last thing I would like to note. Despite the wide selection of Flemoxin analogues, one should not forget that the prerogative of both prescribing an antibiotic and choosing a generic belongs exclusively to the doctor.

The article above and comments written by readers are for informational purposes only and do not call for self-treatment. Consult with a specialist about your own symptoms and diseases. When treating with any medicine, you should always use the leaflet that comes with it in the package, as well as the advice of your doctor, as the main guideline.

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It is also worth paying attention to other drugs:

I did not notice any side effects: we did not have diarrhea, although we did not take Linex. The doctor said that Flemoxin does not cause dysbacteriosis, and he was right.

Be careful! Especially with children!

By the way, having exceeded the dose of the drug (it happened (((, a strong cough with vomiting, I thought that the drug was not absorbed and repeated the medication again.) We were sprinkled with a rash, recalculated the dose for that day and that's it, the rash went away and we were treated for 5 days.

Mother of two sons (2.5 and 5 years old).

Repeated intake caused anaphylactic shock. Pale face, blue lips, leg and arm cramps, respiratory arrest and loss of consciousness. Unfortunately, there are doctors who "work their bread" in front of the companies producing medical preparations, without thinking about the life and safety of little patients.

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Unidox Solutab, what is the drug for? Tablets are used for therapeutic purposes for the treatment of various chronic, infectious and skin diseases, which contains tetracycline.

Tetracycline, in turn, is a broad-spectrum antibiotic and has a bacteriological effect on microbes inside the cell. It has a detrimental effect on gram-positive and gram-negative microorganisms.

Some varieties of strains and diseases are resistant to the doxycycline group. Today we will tell you what helps, how to take it correctly, whether it is possible to combine Unidox Solutab and alcohol, and what are the side effects.

Instructions for use

The drug is used in medical practice of various directions - dermatology, gynecology, urology, venereology.

It is successfully used by cosmetologists for the treatment of acne, furunculosis, acne. The drug has a number of side effects due to its toxicity, so read the instructions before use.

Solutab Unidox: is it an antibiotic or not. In the drug, the main component is doxycycline (Doxycycline). It belongs to the tetracycline group and is a semi-synthetic antibiotic. This combination gives a double effect when penetrating the microbe, destroying it inside the cell membrane, blocking protein synthesis.

As a result, the growth of harmful bacteria stops, and its growth and reproduction in the body slows down. It can be concluded that the drug is a broad-spectrum antibacterial drug.

The composition of the antibiotic includes substances that suppress gram-negative and gram-positive stimuli of the disease. The tetracycline group prevents the reproduction of the simplest viruses and bacteria:

Pathologies of the genitourinary system:

• Salpingoophoritis (infectious inflammation of the ovary and fallopian tubes);
• Adnexitis;
• endometritis;
• Actinomycosis (actinomycosis);
• Acute dacryocystitis;
• With cystitis;
• With candidiasis.

Intestinal infections:

• Yersiniosis;
• Cholera;
• Wound infection and its complications;
• Benign lymphoreticulosis;
• Prevention of malaria.

The composition of the drug

The main component of the drug is tetracycline (Tetracyclinum), which is included in dispersible tablets. Doxycycline, based on a water molecule, promotes a gentle passage through the gastrointestinal mucosa, where it is further dissolved in the intestine.

The composition of auxiliary ingredients:

• Taste aromatics;
• MCC (microcrystalline cellulose);
• Hypromellosum (hypromellose);
• Giproloza;
• o-Sulfobenzoic acid imide;
• Silica;
• Natural sugar (lactose monohydrate);
• Magnesium stearate (E572).

Taking the tablet inside, it is quickly absorbed in the intestine, completely dissolving. Even if taken after meals, the absorption and action of the drug is not affected. It is considered a bad combination to take an antibiotic simultaneously with fermented milk products.

The action of the drug:

• Evenly distributed throughout all organs and tissues, without affecting the cerebrospinal fluid;
• Can pass through the placenta to the embryo;
• Absorbed into mother's milk;
• Accumulates in tissues, joints and bones;

The liver passes a small amount of the drug through itself, which does not have a detrimental effect on the cells of the liver parenchyma. That allows you to combine with alcohol in small quantities.

The antibiotic comes out naturally, through feces and urinary secretions. Patients with renal insufficiency need to be extremely careful with the drug, it can be excreted through the gastrointestinal tract and not fully exit the body.

The biological half-life is 15-16 hours with the primary use, the secondary one increases the elimination period to 24.

Release form

The manufacturer of the antibiotic produces a tablet preparation in a yellow shell and is delimited in half by a strip. The medicine has its own special code number 173, which is also indicated on the pill.

The average size allows you not to chew, which is very convenient when prescribing to children. The tablet contains 0.1 g of doxycycline. The package contains a plate of the drug with 10 pcs. pills of 100 mg each antibiotic.

For what

The wide spectrum of action of the drug allows it to be used in all areas of medicine. Given the possible side effects and contraindications, doctors prescribe it to destroy bacteria that cause inflammation, infection of various human organs.

Application :

In gynecology, for example, with thrush. Treatment of many diseases associated with urological infections. With chlamydia, they are prescribed by a doctor, the scheme is simple and designed for 7 days.

Abnormal processes of the urinary and reproductive system:

• With ureaplasma, the dose of the drug is increased, taken in the first 24 hours - 2 tablets each, the next days 1 table each;
• Treatment of cystitis, prostatitis, inflammation of the appendages;
• Venereal, STIs - chlamydia, gonorrhea, syphilis, lymphogranuloma.
• Respiratory disease;
• Infectious severe - coxiellosis, typhoid fever of various etiologies, bubonic infection (plague), blood poisoning (sepsis), inflammation of the endocardial membrane (heart), bone osteomyelitis, peritonitis (peritoneum);
• Deviations of the gastrointestinal tract;
• Cosmetic defects of the skin - pimples, acne, boils, blackheads;
• Prevention of complications in the postoperative period.

Dosage

The use of the drug is prescribed exclusively by the attending therapist. Best taken during or immediately after a meal. Adults drink a small amount of liquid, children can be crushed.

The course should not exceed 10 days. If it does not help, you should seek the advice of a doctor.

Application:

• The antibiotic is used as prescribed by the doctor;
• Based on 1 kg of weight: 2 mg * 1 kg;
• The daily norm on the first day is 2 tab. 0.1 g of antibiotic;
• From the second to 1 tab. ;
• Severe diseases are eliminated by an increased dosage of doxycycline.

With prostatitis: a treatment regimen

The drug is prescribed by the urologist according to the scheme. It differs from the standard treatment of diseases with this medication. You need to take 0.2 g (2 tablets) per day, the course is up to 1 month.

The duration is determined individually based on the characteristics of the organism and the presence of other chronic ailments. Do not self-medicate, the antibiotic is quite toxic.

What is taken into account when appointing:

• The severity of the pathology;
• Age category and kilograms of the patient;
• Antibiotic reactions and immune status;
• Inflammatory or acute ailments.

Before prescribing a medicine, a number of studies and diagnostics are carried out. Taken under the supervision of a doctor, this will help cure the prostate and not harm the body.

Venereal diseases

The drug Unidox Solutab treats ureaplasma, urethritis, chlamydia, gonorrhea (gonorrhea), syphilis and other STIs. Depending on the severity, the course of therapy varies from 2-4 weeks. Use the medicine for 1 table. * 2 p. a day after meals.

Self-medication is not worth it, only the doctor will prescribe the drug individually for each case. The antibiotic has side effects, so you need to use it very carefully, taking into account all the indications and restrictions.

Prevention

In order to prevent many diseases associated with flight and departure from the country, especially to hot Asian and African states, the medicine is taken in 1 table * 1 r. in a day. Starting 2 days before the flight, continuing the journey and a month after it, you need to take an antibiotic.

This applies to everyone who often flies on business trips or just travels. For prophylaxis after surgery or abortion, 1 table is prescribed. the day before the procedure and 1 tab. later.

In cosmetology and dermatology

The antibiotic copes well with skin diseases, rashes of youthful and transitional age. For the treatment of furunculosis, acne should be taken for 2-3 months, depending on the severity of the disease, 1 tab. per day. Streptococcal infections that have affected the area of ​​\u200b\u200bthe skin should be taken no more than 7-10 days according to the scheme.

Side effects

An antibiotic can cause such negative effects:

• Lack of appetite (anorexia);
• Nausea, vomiting, migraine, dizziness (fainting);
• Dysphagia, gastrointestinal upset;
• Urticaria, allergic reactions;
• Quincke's edema;
• Anaphylactic shock (anaphylaxis);
• Erythema (sharp reddening of the skin);
• Inflammation of the lining of the heart (pericarditis);
• Autoimmune hemolytic anemia (anaemia haemolytica);
• Destruction of tooth enamel;
• Thrush (candidiasis), vaginitis (colpitis), stomatitis (gingivitis, periodontitis);
• Yellowness of the cornea of ​​the eye, chills.

Alcohol compatibility

Many believe that you can take alcohol in parallel, since it is not absorbed into the liver. Do not drink alcohol while taking any antibiotics.

Flemoxin Solutab

Flemoxin Solutab(lat. Flemoxin Solutab

• Helicobacter pylori

Helicobacter pylori Helicobacter pylori

Helicobacter pylori.

Streptococcus pyogenes. - at least 10 days.

Helicobacter pylori

general information

Helicobacter pylori. antibiotic resistance Helicobacter pylori

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Flemoxin for children: how to take it correctly?

Bacterial infections are quite common among both adults and children. In some cases, antibiotics are the only way to quickly and effectively treat. Flemoxin for children is considered a fairly effective antibacterial agent. This drug was developed on the basis of amoxicillin, a substance from the group of semi-synthetic penicillins.

Flemoxin for children: composition and properties

As already mentioned, the main active ingredient of the drug is amoxicillin, which is a broad-spectrum antibiotic. It quickly affects pathogens, relieves the symptoms of the disease.

After taking the medicine, the intestinal mucosa is absorbed quite quickly and almost completely (tablets resistant to the effects of the acidic environment of the stomach). Approximately one fifth of amoxicillin binds to plasma proteins and penetrates into all organs, tissues and foci of inflammation. The excretion of the antibiotic and its metabolites is carried out through the urinary system.

Flemoxin for children: indications for use

This drug is used to treat a bacterial infection and only if the pathogens are susceptible to amoxicillin.

In most cases, these are diseases of the respiratory tract (tonsillitis, bronchitis, etc.), the genitourinary system, the digestive tract and the skin. It is worth recalling that it is strictly forbidden to arbitrarily prescribe antibiotics to a child - if you have alarming symptoms, be sure to consult a doctor.

• Children aged one to three years should take 125 milligrams of amoxicillin three times a day (see how many milligrams of the antibiotic are in one tablet and divide it into appropriate parts).
• Children from three to ten years old are recommended to take two hundred and fifty milligrams three times a day.
• Children over the age of ten can take five hundred milligrams three times a day.

The disease of moderate and mild severity, as a rule, is treated for 5-7 days. The only exception is a persistent streptococcal infection - the course of admission should last at least 10 days. Tablets must be taken for another two days after all symptoms have disappeared - this will prevent the occurrence of a recurrent infection.

The medicine can be taken with or without food. The tablet can be swallowed whole and washed down with the required amount of liquid. If necessary, it can be dissolved in 100 ml of warm water - a sweet solution with a pleasant lemon smell is formed (this is very convenient if a small child is sick).

Flemoxin for children: contraindications and side effects

The drug should not be used to treat a child who has developed an allergy to penicillin. Infectious mononucleosis is considered a contraindication.

Adverse reactions do not occur very often. In most cases, either a reaction occurs from the skin (rash, itching, redness), or from the digestive system (diarrhea, nausea, itching in the anus, vomiting). Sometimes anemia develops. Children may become overly active and irritable, or, conversely, drowsy and tired.

It is worth recalling that antibiotics kill not only pathogens, but also beneficial microorganisms. For a small child, this is fraught with dysbacteriosis and disorders in the liver. Therefore, ask your pediatrician about the drugs that you need to take to protect the microflora and hepatocytes. As a rule, lacto- and bifidocultures, as well as homeopathic preparations for the liver, are prescribed for this purpose.

Flemoxin Solutab

Flemoxin Solutab(lat. Flemoxin Solutab) is an antibiotic of the penicillin class. The active substance is amoxicillin.

Dosage forms of flemoxin solutab Flemoxin Solutab is available as dispersible (soluble) tablets containing 125, 250, 500 or 1000 mg of amoxicillin (as amoxicillin trihydrate). Tablets are white to light yellow, oval, from white to light yellow in color with the company's logo and digital designation on one side and a line dividing the tablet in half on the other side. The number on the tablet indicates the content of amoxicillin:

• 231 - tablet contains 125 mg of amoxicillin
• 232 - tablet contains 250 mg of amoxicillin
• 234 - tablet contains 500 mg of amoxicillin
• 236 - tablet contains 1000 mg of amoxicillin

Indications for use of flemoxin solutab Flemoxin solutab is used in the treatment of infectious and inflammatory diseases caused by microbes sensitive to flemoxin slyutab, including:

• respiratory infections
• infectious diseases of the genitourinary system
• infectious diseases of the skin and soft tissues
• infectious diseases of the gastrointestinal tract. including Helicobacter pylori-associated ulcers of the stomach and duodenum. atrophic gastritis. MALToms.

Flemoxin solutab in gastroenterology

Gastroenterologists most often use flemoxin solutab as one of the antibiotics as part of complex therapy for eradication Helicobacter pylori. Flemoxin solutab is not used for eradication Helicobacter pylori outside special schemes, without drugs that reduce the acidity of the stomach. The doses and procedure for taking flemoxin solutab depends on the eradication scheme used (see the article Amoxicillin or Standards for the diagnosis and treatment of acid-dependent and Helicobacter pylori-associated diseases (fourth Moscow agreement))

Flemoxin solutab is also not used in any form for the treatment of peptic ulcer of the stomach and duodenum or gastritis in the absence of Helicobacter pylori.

Method of application of flemoxin solutab and doses

Flemoxin Solutab is taken orally, before, during or after a meal, swallowed whole, or divided into parts or chewed, washed down with a glass of water or diluted in water to form a syrup (in 20 ml) or suspension (in 100 ml).

Adults and children over 10 years old, with mild to moderate infections - 500-750 mg 2 times a day or 375-500 mg 3 times a day.

Children from 3 to 10 years - 375 mg 2 times a day or 250 mg 3 times a day; from 1 to 3 years - 250 mg 2 times a day or 125 mg 3 times a day. The daily dose of flemoxin solutab for children under 1 year old is 30–60 mg per kg of body weight, divided into 2–3 doses.

In the treatment of severe infections and with hard-to-reach foci, it is desirable to take flemoxin solutab three times.

In chronic diseases, relapses, severe infections: adults - 0.75–1 g 3 times a day, children - up to 60 mg per kg per day; the dose calculated in this way is divided into 3 doses.

In acute uncomplicated gonorrhea - 3 g once, in combination with 1 g of probenecid.

For infections of mild and moderate severity, treatment with flemoxin solutab is 5–7 days, for infections caused by Streptococcus pyogenes. - at least 10 days.

In the treatment of chronic diseases, severe infections, the dose of flemoxin solutab should be determined by the clinical picture of the disease. Reception of flemoxin solutab is continued for two days after the disappearance of the symptoms of the disease.

With a creatinine clearance of less than 10 ml per minute, the dose of flemoxin solutab is reduced by 15–50%.

Professional medical articles regarding the use of flemoxin solutab in eradicationHelicobacter pylori Other medicines containing the active ingredient amoxicillin

Amoxicillin, Amoxicillin, Amoxicillin capsules 0.25 g, Amoxicillin DS, Amoxicillin sodium sterile, Amoxicillin Sandoz, Amoxicillin-ratiopharm, Amoxicillin-ratiopharm 250 TS, Amoxicillin powder for suspension 5 g, Amoxicillin tablets, Amoxicillin trihydrate, Amoxicillin trihydrate (Purimox) , Amosin Gonoform, Gramox-D, Grunamox, Danemox, Ospamox, Hiconcil. Ecoball.

general information

According to the pharmacological index, flemoxin solutab belongs to the Penicillins group, according to ATC - to the broad-spectrum Penicillins group and has the code J01CA04 Amoxicillin.

Flemoxin solutab is a generic of amoxicillin and therefore information on its medicinal properties, including: indications for use, dosing regimen, a list of microorganisms against which flemoxin solutab is active, flemoxin solutab in eradication schemes Helicobacter pylori. antibiotic resistance Helicobacter pylori to flemoxin solutab (amoxicillin), preservation of the intestinal microflora during therapy with flemoxin solutab, pharmacokinetics of flemoxin solutab, interaction of flemoxin solutab with other drugs, contraindications when taking flemoxin solutab - see the article Amoxicillin.

The manufacturer of Flemoxin Solutab is Astellas Pharma Europe B.V. (Astellas Pharma Europe B.V.), Holland.

Flemoxin Solutab has contraindications and features of use, consultation with a specialist is necessary before starting therapy.

How to take Flemoxin Solutab

"Flemoxin Solutab": instructions for use of the drug

The drug "Flemoxin Solutab" is prescribed for diseases caused by microorganisms sensitive to the active substance: diseases of the gastrointestinal tract, infections of the respiratory system, infections of the urinary system, infectious diseases of the skin and soft tissues. The agent has a bactericidal effect. "Flemoxin Solutab" is taken regardless of the meal time. The tablet should be taken with plenty of water. The highest concentration of the active substance in the blood plasma is reached after one to two hours. Excretion of the drug occurs only by the kidneys.

In infectious diseases of mild and moderate severity, the drug is prescribed in the following doses. Adults and children over the age of 10 years should take 500-750 mg twice a day or 500 mg three times a day. Children 3-10 years old are given 250 mg of the drug three times a day, children aged one to three years are given 250 mg twice a day or 150 mg three times a day. The daily dose of "Flemoxin Solutab" for children, on average, is 30 mg / kg. In severe infections, in cases of chronic diseases, it can be increased. For infections with mild or moderate severity, the drug is taken for five to seven days, for infections caused by streptococcus, the course of treatment should be at least ten days.

Contraindications and side effects "Flemoxin Solutab"

"Flemoxin Solutab" is contraindicated in case of hypersensitivity to cephalosporins and penicillins, with leukemoid reactions of the lymphatic type, infectious mononucleosis. While taking the drug, the following side effects may occur: nausea, vomiting, diarrhea, antibiotic-associated colitis, urticaria, skin itching, interstitial nephritis, severe allergic reactions (erythema multiforme, Stevens-Johnson syndrome, epidermal toxic necrolysis). There is a significant risk of anaphylaxis in patients with a history of severe allergic disease.

In patients with infectious mononucleosis, while taking this drug, a rash appears that is not associated with hypersensitivity to the agent; such episodes are not a contraindication to the use of Flemoxin Solutab. The use of this drug during pregnancy is possible according to the indications and under the supervision of the attending physician. The analogues of Flemoxin Solutab are Amoxicillin, Amoxisar, Amosis, Gramox-D, Gonoform, Grunamox, Ospamox, Danemox, Hikoncil, Ecobol.

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Flemoxin Solutab is one of the broad-spectrum oral antibacterial agents from the penicillin group. It has proven itself in various fields of medicine as an effective medicine against inflammation caused by pathogenic microflora. Often prescribed by doctors in case of infections of the respiratory tract, pelvic organs and digestive tract, skin, soft tissues. Suitable for both adults and children from the first years of life, has a minimum of contraindications and unwanted side effects.

Flemoxin Solutab 500 mg - instructions for use

The peculiarity of this drug is a water-soluble dosage form that increases the bioavailability of the active substance and makes it easier for patients of any age to take it. However, before taking it, you should definitely consult with a doctor of the appropriate profile: despite the low toxicity, which even allows you to prescribe Flemoxin Solutab during pregnancy, there are still restrictions on use and the risk of complications. The instruction will help to understand the specifics of the drug and responsibly approach the treatment.

The composition of the drug

The active active ingredient of dispersible tablets is the long-known semi-synthetic antibiotic penicillin Amoxicillin, characterized by increased acid resistance and high absorption rate. It has been used in medicine for many years and has an excellent therapeutic effect in the antibiotic treatment of infections caused by the following pathogens:

• Gram-positive varieties of the family of staphylo- and streptococci (however, with Staphylococcus aureus, which produces the enzyme penicillinase, it is ineffective).
• Aerobic gram-negative meningo- and gonococci, Escherichia coli, Salmonella, Klebsiella and Shigella.

The bactericidal action of the antibiotic is based on the inhibition of the synthesis of peptidoglycan, a structural component of the cell wall of the pathogen, due to which it is destroyed and dies.

Release form

The manufacturer and patent holder is the well-known pharmaceutical company from the Netherlands Astellas Pharma Inc. The drug is available in the form of special dispersible (soluble) tablets. That is, you can take them either as usual - swallowing and drinking, or after mixing in a small amount of water. Each yellowish-white oval tablet has a transverse line and its own marking indicating the amount of active ingredient:

• "231" - this is the designation of a drug containing 125 mg of amoxicillin;
• "232" - corresponds to 250 milligrams of the antibiotic;
• "234" - 500 mg;
• "236" - 1 gram or 1000 mg (maximum dosage).

Other ingredients include microcrystalline and dispersible cellulose, crospovidone, citrus flavors, saccharin, vanillin, and magnesium stearate. Packed tablets are five pieces in a blister and, accordingly, 20 in a cardboard box. For the 125 mg version, a version of 2 blisters of 7 tablets each is also available.

Indications and contraindications

Flemoxin Solutab is prescribed for sinusitis and other sinusitis, otitis media, infections of all parts of the respiratory tract (from tonsillitis to pneumonia), inflammatory diseases of the urogenital area caused by the corresponding microflora, infectious lesions of the digestive tract, soft tissues and skin.

The list of conditions requiring careful use includes such physiological and pathological conditions of the body as:

• pregnancy;
• lactation period;
• Infectious mononucleosis;
• liver or kidney failure;
• lymphocytic leukemia;
• previously transferred diseases of the gastrointestinal tract (especially colitis provoked by antibiotic therapy);
• bronchial asthma;
• allergic diathesis.

The only strict forbidden for use is individual hypersensitivity to both penicillins (as well as cephalosporins and carbapenems), and to any of the auxiliary ingredients of the tablets.

Flemoxin Solutab - dosage for children

This drug can be given to a child from the first year of life, with little or no fear of side effects.

• up to a year - from 30 to 60 mg of amoxicillin per day for each kg of body weight (in 2-3 doses);
• at the age of 1 to 3 years - 250 milligrams twice or 125 three times a day;
• from three to ten years of age, a double dose of 375 mg or 250 mg three times a day is indicated.

The interval between doses of Flemoxin Solutab depends on the nature of the disease: the more severe it is, the more often you need to give the medicine (every 8 hours). If the disease recurs or its chronic form worsens, a daily dose of 3 doses should be taken.

As for the question of how many days an antibiotic should be given to a child, pediatricians advise doing this for 5-7 days (in case of infection with a Streptococcus pyogenes strain, at least 10). The best option is to continue taking it for 48 hours after all the symptoms of the disease have disappeared.

Dosage for adults

Absorption and assimilation of the drug do not depend on food intake, so Flemoxin Solutab tablets can be drunk at any time, simply by swallowing or chewing, or dissolving in water. For infections that are not too severe, children and adults who have reached the age of ten are usually prescribed a daily dose of 500-750 mg twice a day or three times 375-500. The maximum dose - 3,000 mg of amoxicillin per day - is indicated for severe conditions.

Gonorrhea in uncomplicated form is treated with 3 grams of an antibiotic in combination with 1 g of the anti-gout drug Probenecid, taken once. If the patient has a significant decrease in values ​​​​(less than 10 ml per minute) of creatinine clearance, then the dosage can be halved.

Side effects of Flemoxin Solutab

Since this drug has only one strict contraindication, negative reactions of the body to the antibiotic are extremely rare. For example, on the part of the central nervous system, such cases have not been registered at all, and such side effects characteristic of many antibacterial agents as pseudomembranous colitis, interstitial nephritis, changes in the blood count, exudative erythema or anaphylaxis are isolated.

A little more often, dyspeptic disorders (nausea, vomiting, taste distortions and diarrhea) are recorded, which quickly disappear. Allergy to Flemoxin Solutab in a child or adult patient is also rare and mostly in a mild form of a specific maculopapular rash. Dysbacteriosis practically does not manifest itself and quickly disappears after the end of the course of antibiotic therapy, even without maintenance treatment with probiotics.

Flemoxin Solutab during pregnancy and breastfeeding

Despite the fact that the active substance of the drug is completely absorbed by the body and is very quickly distributed throughout it, overcoming the placental barrier, no negative effect on the fetus has been identified. Thus, pregnant women can take the drug, but caution (that is, doing it strictly according to the doctor's prescription in the absence of alternatives) is necessary. The degree of penetration of the antibiotic into breast milk is negligible, so sensitization in infants is very rare. However, for safety reasons, breastfeeding can be suspended for the duration of treatment.

Flemoxin Solutab and alcohol - compatibility

The detailed annotation to the drug mentions the interaction of this ABP with other medicines. For example, NSAIDs, probenecid increase the concentration of the antibiotic in the blood plasma; laxatives, antacids and aminoglycosides slow down absorption, and bactericidal drugs act synergistically. Ethanol is not on this list, however, combining Flemoxin Solutab and alcohol is unacceptable for several reasons.

Side effects increase, especially dyspeptic disorders - nausea and vomiting. The load on hepatocytes (liver cells) increases many times over, which metabolize all chemical compounds, including alcohol and drugs that enter the bloodstream. The resulting toxins accumulate in the body and destroy it, causing hepatitis and cirrhosis. In addition, the diuretic effect of alcohol contributes to the rapid removal of the antibiotic from the body. As a result, antibiotic therapy does not have a therapeutic effect, and complications appear.

Main article: Understanding the compatibility and consequences of alcohol and antibiotics

Diseases and their treatment

Each infection requires an individual approach to treatment. Only a qualified doctor can determine the type of pathogen, assess the severity of the patient's condition, the characteristics of his body, and make the appropriate appointment, so self-medication is unacceptable.

Flemoxin Solutab with sinusitis

The cause of inflammatory processes in the paranasal sinuses in most cases are strepto- and staphylococci. These pathogens are included in the spectrum of antimicrobial activity of amoxicillin, so preparations based on it are prescribed for sinusitis first. The specificity of the pharmacokinetics of Flemoxin Solutab allows it to be distributed very quickly to all organs and tissues, which is an indisputable advantage in case of inflammation of the paranasal sinuses.

Usually, relief occurs already on the second day of antibiotic therapy, and a week is enough for a complete cure. If the symptoms do not disappear within 48 hours, the disease is caused by a strain resistant to amoxicillin, which requires a change in the drug.

Flemoxin Solutab for otitis media

The treatment of inflammation of the middle ear with this drug has its own characteristics. By localization, the focus is difficult to access, so the duration of the course should not be minimal - this will help prevent relapses. In addition, the pill regimen must be three times a day: the daily dose prescribed by the doctor must be divided by three and taken every 8 hours. As a result, the optimal concentration of the antibiotic in the blood plasma and, accordingly, a quick recovery will be achieved.

Flemoxin Solutab for pneumonia

The most common causative agent of pneumonia is Streptococcus pneumoniae, which is part of the spectrum of antimicrobial activity of aminopenicillins. Amoxicillin and drugs based on it are first-line drugs in the treatment of pneumonia. They provide a therapeutic effect in 90% of cases, the course of treatment lasts from a week to ten days. The remaining 10% is a disease caused by strains that produce penicillinase, so antibiotic replacement is indicated.

Flemoxin Solutab for angina in children

Tonsillitis is diagnosed by pediatricians quite often, and since it is caused mainly by staphylo- and streptococci, amoxicillin preparations are most often prescribed. Dispersible tablets are an excellent dosage form for children of any age. They are easy to take, painful symptoms disappear quickly, and the full course of treatment usually does not exceed a week (2 times a day, according to age and weight).

Analogues and comparison

There are several antibacterial agents similar in antimicrobial activity and indications that can replace Flemoxin. However, the question of the appropriateness of such a step should be decided by the attending physician in order to take into account all possible risks and benefits.

Flemoxin or Sumamed - which is better

The macrolide antibiotic Sumamed is an azithromycin-based medicine produced in the form of a tablet, suspension, capsules and lyophilisate for the manufacture of an infusion solution. The advantage of analogue is a short course of antibiotic therapy, prolonged mechanism of action, minimal toxicity and good tolerability. If necessary, after consultation with the attending physician, Sumamed can be used to treat women who are carrying a child. When administered during breastfeeding, a temporary cessation of breastfeeding may also be recommended.

From six months, you can use the Sumamed suspension, tab. 125 mg from 3 years old, tab. 500 mg and 250 mg capsules from 12 years old. Parenteral administration is allowed from the age of 16.

In diseases caused by streptococci, it is preferable to use Flemoxin. For the eradication of intracellular pathogens (chlamydia, mycoplasma, legionella) - Azithromycin.

Flemoxin Solutab and Flemoklav Solutab - what is the difference

These two antibacterial agents with a similar name have much in common: the dosage form in the form of water-soluble tablets, amoxicillin as an active ingredient and dosage. The main difference is the presence of potassium clavulanate in Flemoclav, which protects the antibiotic from destruction by beta-lactamases. That is, the resistance of the drug increases, the spectrum of its activity against pathogens expands and, accordingly, the effectiveness increases. However, it is contraindicated for children under 2 years of age and pregnant women in the 1st trimester.

Flemoxin Solutab - reviews for children

Pediatricians unequivocally and unanimously consider the drug one of the best to date for the treatment of bacterial infections of the ENT organs and respiratory tract. What do parents say about this? They also in the vast majority of cases confirm the effectiveness of the antibiotic in angina, bronchitis in children, inflammation of the middle ear and pneumonia. There is a rapid elimination of painful symptoms, ease of use (can be diluted to the consistency of syrup or suspension), the almost complete absence of side effects. Negative reviews are rare and are usually associated with intolerance to penicillins or improper intake.

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How many days to drink Flemoxin Solutab and how to take it correctly? Such questions are always relevant when prescribing an antibiotic. The drug and its analogues can be prescribed for children, adults with tonsillitis, bronchitis, some diseases of the gastrointestinal tract, the genitourinary system. The list of diseases that can be eliminated with Flemoxin Solutab is quite large due to the fact that it has a wide spectrum of action.

It should be noted right away that it is impossible to take an antibacterial drug on its own.. It has contraindications and can cause side effects.

Duration of taking Flemoxin Solutab

Take Flemoxin Solutab for at least 5 days. Sometimes the dosage is calculated for 7, 10 and 14 it. A two-week reception is prescribed only if the pathology stage is running and requires a "nuclear strike" on the infection. Flemoxin Solutab should not be drunk for 1, 2 or 3 days.

In addition, it is impossible to violate the duration of treatment with the drug, which was established by the doctor. And you can not both reduce the number of days and increase.

The thing is that after exposure to amoxicillin (active ingredient), bacteria begin to die rapidly. In this case, the symptoms of the disease begin to gradually disappear. For many, this moment becomes a turning point. After all, it becomes easier, the temperature disappears, strength is added.

People stop taking pills, explaining this by the fact that “it has become easier!”. People write about it in multiple reviews. But bacteria are so insidious that they can resume their reproduction. As a result, a few days after the person stopped drinking Flemoxin Solutab, signs of the disease reappear.

For reference. When treating a sore throat in a child, you need to drink Flemoxin for 10 days; pneumonia - 14 days, tuberculosis - 7-12 months. And a disease such as cystic fibrosis, in which the bronchi and lungs are affected, is treated with an antibiotic for a very long time.

The established duration of administration and the calculated dosage of the drug for 5, 7, 10, 14 days is not a whim of a doctor. This is the dosage that was calculated during the studies.

How much to drink Flemoxin - dosage

When prescribing a dose of Flemoxin, doctors are guided by the state of human health, the types of pathology, its severity and, of course, age. The dosage is individual for each person.

For example, the treatment of gonorrhea involves a single dose of the antibiotic Flemoxin Solutab in the amount of 3000 mg, it does not require repetition.

For pathologies that occur in mild to moderate degrees, the following scheme of application is prescribed:

• adults and children over 12 years old should take the medicine 500 mg 3 times a day or 500-750 mg 2 times a day;
• children from 3 to 10 years - 250 mg 3 times a day;
• children from 1 year to 3 years - 250 mg 2 times a day;

Important! The dosage should be prescribed exclusively by the attending physician! Do not self-medicate!

In chronic pathologies, frequent relapses of diseases, the drug is prescribed, according to the instructions, 1000 mg for adults. Dosage of Flemoxin for children: 50-60 mg / kg / 3 times a day.

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In this article, you can read the instructions for using the drug Flemoxin Solutab. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Flemoxin Solutab in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Flemoxin Solutab in the presence of existing structural analogues. Use for the treatment of tonsillitis, sinusitis and other infections in adults, children, as well as during pregnancy and lactation.

Flemoxin Solutab- an antibiotic of the group of semi-synthetic penicillins with a wide spectrum of action. It is a 4-hydroxy analogue of ampicillin. It has a bactericidal effect. Active against aerobic Gram-positive and Gram-negative bacteria.

Microorganisms that produce penicillinase are resistant to amoxicillin (the active substance of the drug Flemoxin Solutab).

In combination with metronidazole, it is active against Helicobacter pylori. Amoxicillin is believed to inhibit the development of Helicobacter pylori resistance to metronidazole.

Cross-resistance exists between amoxicillin and ampicillin.

The spectrum of antibacterial action is expanded with the simultaneous use of amoxicillin and the beta-lactamase inhibitor clavulanic acid. This combination increases the activity of Flemoxin Solutab against Bacteroides spp., Legionella spp., Nocardia spp., Pseudomonas (Burkholderia) pseudomallei. However, Pseudomonas aeruginosa, Serratia marcescens and many other Gram-negative bacteria remain resistant.

Pharmacokinetics

When taken orally, Flemoxin Solutab is rapidly and completely absorbed from the gastrointestinal tract, is not destroyed in the acidic environment of the stomach. When the dose is increased by 2 times, the concentration also increases by 2 times. In the presence of food in the stomach does not reduce overall absorption. Widely distributed in tissues and body fluids. High concentrations of amoxicillin in the liver have been reported (therefore, the simultaneous intake of ethanol (alcohol) negatively affects this organ with the possibility of developing liver failure).

About 60% of an oral dose is excreted unchanged in the urine by glomerular filtration and tubular secretion. Some amount of amoxicillin is determined in the feces.

In small amounts, amoxicillin penetrates the BBB during inflammation of the pia mater.

Indications

• infectious and inflammatory diseases (respiratory, genitourinary, skin) caused by susceptible microorganisms, incl. bronchitis, pneumonia, tonsillitis, pyelonephritis, urethritis, gastrointestinal infections, gynecological infections, infectious diseases of the skin and soft tissues, listeriosis, leptospirosis, gonorrhea;
• For use in combination with metronidazole: chronic gastritis in the acute phase, peptic ulcer of the stomach and duodenum in the acute phase, associated with Helicobacter pylori.

Release form

Dispersible tablets 125 mg, 250 mg, 500 mg and 1000 mg.

Instructions for use and dosage

The drug is taken orally. The drug is prescribed before, during or after a meal. The tablet can be swallowed whole, divided into parts or chewed with a glass of water, and can also be diluted in water to form a syrup (in 20 ml) or suspension (in 100 ml) with a pleasant fruity taste.

The dosage regimen is set individually, taking into account the severity of the course of the disease, the sensitivity of the pathogen to the drug, the age of the patient.

In case of infectious and inflammatory diseases of mild and moderate severity, it is recommended to use the drug according to the following scheme: adults and children over 10 years old are prescribed 500-750 mg 2 times a day or 375-500 mg 3 times a day; children aged 3 to 10 years are prescribed 375 mg 2 times a day or 250 mg 3 times a day; children aged 1 to 3 years are prescribed 250 mg 2 times a day or 125 mg 3 times a day.

The daily dose of the drug for children (including children under 1 year old) is 30-60 mg / kg per day, divided into 2-3 doses.

In the treatment of severe infections, as well as in hard-to-reach foci of infection (for example, acute otitis media), a triple dose is recommended.

In chronic diseases, recurrent infections, severe infections, adults are prescribed 0.75-1 g 3 times a day; children - 60 mg / kg per day, divided into 3 doses.

In acute uncomplicated gonorrhea, 3 g of the drug is prescribed in 1 dose in combination with 1 g of probenecid.

For patients with impaired renal function with CC≤10 ml / min, the dose of the drug is reduced by 15-50%.

In case of infections of mild and moderate severity, the drug is taken for 5-7 days. However, for infections caused by Streptococcus pyogenes, the duration of treatment should be at least 10 days.

The drug should be continued for 48 hours after the disappearance of the symptoms of the disease.

Side effect

• taste change;
• nausea, vomiting;
• diarrhea;
• dysbacteriosis;
• stomatitis, glossitis;
• hepatic cholestasis;
• pseudomembranous and hemorrhagic colitis;
• leukopenia, neutropenia, thrombocytopenic purpura, eosinophilia, thrombocytopenia, agranulocytosis, hemolytic anemia;
• excitement, anxiety;
• insomnia;
• ataxia;
• confusion;
• behavior change;
• depression;
• peripheral neuropathy;
• headache;
• dizziness;
• skin reactions, mainly in the form of a specific maculo-papular rash;
• hives;
• skin hyperemia;
• erythematous rashes;
• rhinitis;
• conjunctivitis;
• arthralgia;
• toxic epidermal necrolysis;
• allergic vasculitis;
• anaphylactic shock;
• angioedema;
• labored breathing;
• vaginal candidiasis;
• superinfection (especially in patients with chronic diseases or reduced body resistance).

Contraindications

• hypersensitivity to the components of the drug;
• hypersensitivity to other beta-lactam antibiotics, incl. to other penicillins, cephalosporins, carbapenems.

Use during pregnancy and lactation

The use of the drug Flemoxin Solutab during pregnancy and lactation is possible if the expected benefit of therapy for the mother outweighs the risk of side effects in the fetus and infant.

In small amounts, amoxicillin is excreted in breast milk, which can lead to the development of sensitization phenomena in an infant.

Use in children

It is used in children according to indications according to the dosing regimen (including infants and newborns).

special instructions

Prescribe the drug to patients with infectious mononucleosis and lymphocytic leukemia should be used with caution, since there is a high probability of non-allergic exanthema.

The presence of erythroderma in history is not a contraindication for the appointment of the drug Flemoxin Solutab.

Cross-resistance with penicillins and cephalosporins is possible.

The appearance of severe diarrhea, characteristic of pseudomembranous colitis, is an indication for discontinuation of the drug.

During the course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

Perhaps the development of superinfection due to the growth of microflora insensitive to the drug, which requires a corresponding change in antibiotic therapy.

With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, other or additional methods of contraception should, if possible, be used.

Influence on the ability to drive vehicles and control mechanisms

There were no reports of adverse effects of the drug on the ability to drive vehicles or work with mechanisms.

drug interaction

Probenecid, phenylbutazone, oxyphenbutazone, diuretics, allopurinol, NSAIDs, to a lesser extent - acetylsalicylic acid and sulfinpyrazone inhibit the tubular secretion of penicillins, which leads to an increase in T1 / 2 and an increase in the concentration of amoxicillin in the blood plasma.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) show synergism when taken simultaneously.

Possible antagonism when taken with some bacteriostatic drugs (eg, chloramphenicol, sulfonamides).

Simultaneous administration of Flemoxin Solutab with estrogen-containing oral contraceptives may reduce the effectiveness of the latter and increase the risk of acyclic bleeding.

Antacids, glucosamine, laxative drugs, aminoglycosides, food reduce absorption. Ascorbic acid increases absorption.

Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index); enhances the absorption of digoxin.

The simultaneous use of amoxicillin with allopurinol increases the risk of skin rash.

Analogues of the drug Flemoxin Solutab

Structural analogues for the active substance:

• Amoxisar;
• Amoxicillin;
• Amoxicillin DS;
• Amoxicillin sodium sterile;
• Amoxicillin Sandoz;
• Amoxicillin-ratiopharm;
• Amoxicillin trihydrate;
• Amosin;
• Gonoform;
• Grunamox;
• Danemox;
• Ospamox;
• Hyconcil;
• Ecoball.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases from which the corresponding drug helps and see the available analogues for the therapeutic effect.