High Activity:
Low activity:
Bonding with plasma proteins of blood:
Almost complete (about 90%).
Election: kidneys, intestines.
Should not be above 25 degrees.
Not for 5 years.
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* Instructions for medical use to the drug Unidox Solyutab published in free translation. There are contraindications. Before use, you must consult with a specialist.
Dispersible pills Round, double-screw, from light yellow or gray-yellow color to brown with enclosures, with engraving "173" (tablet code) on one side and risk to another.
Auxiliary substances: microcrystalline cellulose - 45 mg, saccharine - 10 mg, hypronomes (low-developed) - 18.75 mg, hypimosellos - 3.75 mg, silicon colloidal dioxide (anhydrous) - 0.625 mg, magnesium stearate - 2 mg, monohydrate lactose - up to 250 mg.
10 pieces. - PVC blisters / aluminum foil (1) - Cardboard packs.
Semi-synthetic antibiotic group of a wide range of action. It has a bacteriostatic effect by suppressing the synthesis of protein of pathogens.
Active in relation to aerobic gram-positive bacteria: Staphylococcus SPP. (including penicillinase strains), Streptococcus SPP. (including Streptococcus Pneumoniae), Bacillus Anthracis, Listeria Monocytogenes; Anaerobic bacteria: Clostridium SPP.
Doxycycline is also active with respect to aerobic gram-negative bacteria: Neisseria Gonorrhoeae, Escherichia Coli, Shigella SPP., Salmonella SPP., Enterobacter SPP., Klebsiella SPP., Bordetella Pertussis, as well as in relation to Rickettsia SPP., Treponema SPP., Mycoplasma SPP. and chlamydia spp.
Doxycycline Sustainable Pseudomonas Aeruginosa, Proteus SPP., Serratia SPP., Most of the strains of Bacteroides Fragilis.
After receiving inside quickly and almost completely absorbed from the gastrointestinal tract. Food reception slightly affects Doxycycline absorption. Widely distributed in the tissues and body fluids. Proteins binding is 80-95%. T 1/2 is 12-22 hours. Excreted with urine unchanged (40%), but the main part of the dose is excreted unchanged with the feces due to the secretion of bile.
Infectious inflammatory diseases caused by microorganisms sensitive to doxycycline, incl. infections of respiratory and ENT organs; PCT infection; purulent infections of the skin and soft tissues (including angry rash); infections of the urogenital system (including gonorrhea, primary and secondary syphilis); Ricketsiosis, brucellosis, rickettsiosis, osteomyelitis, trachoma, chlamydia.
Pregnancy, child age up to 8 years (the possibility of forming insoluble complexes with calcium in the bone skeleton, enamels and dentine teeth), increased sensitivity to tetracycline, porphyria, severe liver failure, leukopenia, lactation period, miastic (for in / in administration).
Adults are prescribed 200 mg / day on the first day of treatment, in subsequent days - 100-200 mg / day. Multiplicity of reception (or in / in infusions) - 1-2 times / day. For children over 8 years old and body weight, more than 50 kg Daily dose for intake or introduction in / in (drip) is 4 mg / kg. In the following days - 2-4 mg / kg / day, depending on the severity of the clinical course of the disease. Multiplicity of reception (or in / in infusion) - 1-2 times / day. The recommended minimum time for in / in infusion is 100 mg of doxycycline (at a concentration of an infusion solution of 0.5 mg / ml) is 1 h.
Maximum doses: for adults for intake - 300 mg / day or 600 mg / day (depending on the etiology of the causative agent); For in / in administration - 300 mg / day.
From the digestive system: Nausea, vomiting, anorexia, diarrhea, constipation, dysphagia, glossite, esophagitis, transient increase in the blood content of hepatic transaminases, SHF, bilirubin.
From the hematopopitation system: neutropenia, thrombocytopenia, hemolytic anemia.
Allergic reactions: skin rash, itching, eosinophilia; Rarely - Svinke, photosensitization.
Others: An increase in residual nitrogen, candidiasis, intestinal dysbacteriosis, a change in the color of the teeth in children.
Preparations containing metal ions (, preparations containing iron, magnesium, calcium) are formed with doxycycline inactive chelates, and therefore it is necessary to avoid simultaneous purposes.
With simultaneous use with barbiturates, phenyoline, the concentration of doxycycline in the blood plasma decreases due to the induction of microsomal liver enzymes, which may cause a decrease in its antibacterial action.
It is necessary to avoid combination with penicillins, cephalosporins that have a bactericidal effect and which are antagonists of bacteriostatic antibiotics (including doxycycline).
Doxycycline absorption reduce kolhesistramin and bears (observe the interval between receiving at least 3 hours).
Due to the suppression of intestinal microflora, doxycycline reduces the prothrombin index, which requires a dose correction of indirect.
The reception of doxycycline reduces the reliability of contraception and increases the frequency of breakthrough bleeding against the background of taking estrogen-containing oral contraceptives.
The simultaneous use of retinol contributes to an increase in intracranial pressure.
Doxycycline is used with caution when impaired liver function. With violations of the kidney function, the dose correction is not required.
To prevent the ceiling action (esophagitis, gastritis, ultraceration of the gastrointestinal tract), it is recommended to receive in daytime clock with plenty of liquid, food or milk. In connection with the possible development of photosensibination, it is necessary to limit the insolation during treatment and within 4-5 days after it.
A solution of doxycycline for in / in administration should be used no later than 72 hours after its preparation.
Doxycycline is contraindicated to use during pregnancy and during lactation. Doxycycline penetrates through a placental barrier. It can cause a long-term change in the color of the teeth, the enamel hypoplasia, the increase in the growth of the fetal skeleton bones, as well as the development of liver fatty infiltration.
If you need to use during lactation, it is necessary to stop breastfeeding.
Doxycycline does not apply in children up to 8 years, because Tetracyclines (including doxycycline) cause a long-term change in the color of the teeth, the enamel hypoplasia and slowing the longitudinal growth of the skeleton bones in this category of patients.
With violations of the kidney function, the dose correction is not required.
Contraindicated in severe liver failure. Doxycycline is used with caution when impaired liver function.
In infectious diseases, doctors are often prescribed a new generation antibiotic "Unidox". The instruction recommends that this agent is used in inflammatory processes caused by various microorganisms. The drug belongs to the group of tetracyclines and is able to influence a wide range of pathogens of diseases. The medicine not only destroys bacteria, but also prevents their further reproduction.
The acting component of the drug "Unidox" tetracycline antibiotic doxycycline. The composition of each tablet includes 100 mg of this substance, it is precisely an antibacterial effect on the body.
The drug also contains additional components: magnesium stearate, microcrystalline cellulose, hyprolosis, monohydrate lactose, silicon colloidal dioxide. These substances do not have the therapeutic effect, but contribute to the best absorption of doxycycline.
The medicine is released only in tablet form. In the pharmacy network you can meet the drugs "Unidox" and "Unidox Solutab". The difference between the only consists of the fact that the pills "Unidox Soluteab" can be crushed, dissolve in water and prepare a suspension. This form is convenient when treating children. In the rest of the rest, these drugs are absolutely identical.
The medication looks like round pills, convex on both sides. The number 173 is engraved on them - this is the code of the drug.
The medicine affects the microorganisms at the cellular level. Doxycycline affects the RNA of malicious bacteria and suppresses the formation of microbial proteins. It is effective against many gram-positive and gram-negative bacteria: streptococci, staphylococci, treponam, salmonella, pathogens of many intestinal and urinary infections. In addition, it is able to destroy some simple microorganisms - a dysenteric amebe and plasmodium (malaria causative agent).
However, in some infections, there will be no effect on the use of the Junidox medication. The manual suggests that doxycycline does not affect all types of viral and fungal microfursions, as well as on proteins, enterococci and blue sticks.
Unidox does not affect the harmfulness of the natural microflora of the digestive organs and does not reduce immunity.
If the patient is diagnosed with an infectious disease, the pathogen of which is amenable to doxycycline, then the doctor may assign the Tablets "Unidox". The use of the antibiotic is shown in the following pathologies:
These are the most common indications for the appointment of an antibiotic "Unidox". In addition, the drug is effective against particularly dangerous infections and brown tropical diseases, such as:
In some cases, it is possible to use with the prophylactic objectives of Junidox tablets. The instruction recommends appointing the drug to people leaving for tropical countries to prevent infection with malaria and leptospirosis.
However, such an effective antibiotic as "Unidox" is suitable not to all groups of patients. First of all, it cannot be taken to people with increased sensitivity to doxycycline and the auxiliary components of the tablets. It should not be used by them and the patients who had previously observed allergies to tetracycline drugs.
There are other cases when the drug is categorically contraindicated. Tablets "Unidox" can not be taken pregnant and nursing mothers. Doxycycline is able to overcome and also penetrate breast milk. If a woman needs to undergo a course of treatment during lactation, then breastfeeding must be stopped. This antibiotic is not prescribed to children under 8 years old. Contraindications are related to the fact that doxycycline can accumulate in the bones and lead to calcium sediments in the skeleton of the fetus and a small child. In addition, the drug may adversely affect the formation of teeth in children under 8 years.
Medicines with doxycycline are contraindicated patients with severe liver and kidney pathologies and patients who are diagnosed with porphyria.
The organism of some patients can negatively respond to the reception of the drug "Unidox". Side effects may arise from the following organs and systems:
In case of such manifestations, you need to report them to your doctor. After a reduction in the dose or abolition of the antibiotic, all side effects disappear.
The attending physician, depending on the nature of the disease, determines the necessary dose of the antibiotic. Reception "Unidox" is recommended during meals. Tablets wash with water. If the Dosage form "Unidox Soluteab" is used, then you can pre-grind and dissolve tablets in 20 ml of water.
The following antibiotic treatment diagram is usually applied:
Treatment with the drug usually lasts from 5 to 10 days. In some diseases, the duration of the course of therapy and the dosage "Unidox" has its own characteristics:
It must be remembered that doxycycline strongly increases skin sensitivity to ultraviolet. Therefore, during the course of treatment, a tan should be abandoned or use the creams with a high degree of protection.
Some drugs may disrupt the suction of doxycycline. These include antacids, iron preparations, laxatives with magnesium. Therefore, it is necessary to withstand the interval of 3 hours between the admission of "Unidox" and these medicines.
During treatment with an antibiotic undesirable to take vitamin A (Retinol). This can provoke a headache due to an increase in intracranial pressure. And one should not combine the treatment of "Unidox" with the reception of penicillin and cephalosporinic antibiotics. These drugs will reduce the action of doxycycline.
Women receiving hormonal contraceptives must be remembered that doxycycline reduces the contraceptive effect of these drugs and increases the likelihood of non-cyclic uterine bleeding.
Patients should know that Unidox and alcohol are incompatible. The drinking alcohol enhances the metabolism of the medication, as a result, the concentration of the antibiotic in the blood plasma drops, and the therapeutic effect is reduced to zero. At the same time, a double load falls on the liver, which manifests itself in nausea, vomiting, pain in the abdomen, diarrhea, dizziness.
Barbiturates, "carbamazepine", "phenytoin", "rifampicin" can also reduce the therapeutic effects of the antibiotic.
The drug is released by a doctor's prescription. It is impossible to carry out independent treatment with an antibiotic "Unidox".
The instruction recommends keeping tablets at a temperature of +15 to +25 degrees. In order to avoid poisoning, the medicine must be kept in such a place where children cannot detect it. In compliance with the storage rules, the drug is suitable for use for 5 years. After this period, the tablet cannot be taken.
The price of "Unidox" in Moscow pharmacies - from 280 to 370 rubles. Currently, on sale can be found in the main tablet "Unidox Solutab", which are a soluble formulation.
Patients are often interested in the analogues of Junidox. You can choose preparations with the same active substance - doxycycline. The following drugs include such a category:
Of these drugs "Doxycycline" is the most common analogue of "Unidoxa". The price of his very low - from 12 to 32 rubles.
Is it possible to consider "doxycycline" with a full-fledged substitute for soluble pills "Unidox Soluteab"? If we consider the chemical composition of these drugs, they contain different modifications of the same drug substance. "Doxycycline" is produced on the basis of hydrochloride, and Unidox Solutab - on the basis of the monohydrate. They have the same therapeutic effect, but there are also small differences:
It can be concluded that "doxycycline" is a cheap analogue of "Unidoxa" and is somewhat heavier tolerated by the body.
Dispersible pills From light yellow to gray-yellow, round, double-screw, with engraving "173" on one side and risk - to another.
Excipients: Cellulose microcrystalline, saccharin, hypronzes (low-access), hypimloose, silicon colloidal dioxide, magnesium stearate, monohydrate lactose.
10 pieces. - Blister (1) - cardboard boxes.
Description of the medicinal preparation Unidox Soluteab ®. Based on officially approved instructions for the use of the drug and made in 2011. Renewal date: 25.11.2011
A wide spectrum antibiotic action from a tetracycline group. Bacteriostatically acts, suppresses protein synthesis in a microbial cell by interacting with 30s subunit ribosomes.
Active in relation to gram-positive and gram-negative aerobic and anaerobic bacteria: Streptococcus SPP., Staphylococcus SPP., Klebsiella SPP., Enterobacter SPP. (Including Enterobacter aerugenes), Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Chlamydia spp., Mycoplasma spp., Ureaplasma urealyticum, Listeria monocytogenes, Rickettsia spp., Escherichia coli, Shigella spp., Campylobacter fetus, Vibrio cholerae, Yersinia spp. (including Yersinia Pestis), Brucella SPP., Francisella Tularensis, Bacillus Anthracis, Bartonella Bacilliformis, Pasteurella Multocida, Borrelia Recurrentis, Clostridium SPP. (except Clostridium difficile), Actinomyces SPP., Fusobacterium Fusiforme, Calymmatobacterium Granulomatosis, PropioniBacterium Acnes, Treponema SPP., Typhus Exanthematicus; Some simplest: Entamoeba SPP., Plasmodium Falciparum.
Usually, not active in relation to Acinetobacter SPP., Proteus SPP., Pseudomonas SPP., Serratia SPP., Providencia SPP., Enterococcus SPP.
The possibility of acquired sustainability to doxycycline in a number of pathogens should be taken into account, which is often cross-in-group (i.e., strains resistant to doxycycline will simultaneously be resistant to the entire tetracycline group).
Suction
Absorption is fast and high (100%). Food reception slightly affects the absorption of the drug, which has no clinical value.
C Max doxycycline in blood plasma (2.6-3 μg / ml) is achieved 2 hours after taking 200 mg, after 24 hours, the concentration of the active substance in the blood plasma decreases to 1.5 μg / ml.
After receiving 200 mg on the first day of treatment and 100 mg / day in the following days, the concentration of doxycycline in the blood plasma is 1.5-3 μg / ml.
Distribution
Doxycycline reversibly binds to plasma proteins (80-90%), penetrates well in the tissue, poorly into the spinal fluid (10-20% of the blood plasma concentration), but the concentration of doxycycline in the spinal fluid increases with inflammation of the spinal shell.
V D - 1.58 l / kg. 30-45 minutes after intake, doxycycline is found in therapeutic concentrations in the liver, kidney, lungs, spleen, bones, teeth, prostate gland, eye tissues, in the pleural and ascitic fluids, bile, synovial exudate, exudate hymic and frontal sinuses, Liquid gum grooves.
With normal liver function, the level of the drug in bile is 5-10 times higher than in plasma.
The saliva determines 5-27% of the value of the concentration of doxycycline in the blood plasma.
Doxycycline penetrates a placental barrier, in small quantities secreted into breast milk.
Accumulates in dentine and bone tissue.
Metabolism
Metabolized only a minor part of doxycycline.
Election
T 1/2 after one-time intake is 16-18 hours, after receiving repeated doses - 22-23 hours.
Approximately 40% of the adopted dose is derived in a biologically active form by the tubular secretion in the kidneys, 20-40% is excreted through the intestine in the form of inactive forms (chelates).
Pharmacokinetics in special clinical cases
T 1/2 of doxycycline in patients with impaired kidney function does not change, because It increases his removal through the intestines.
Hemodialysis and peritoneal dialysis do not affect the concentration of doxycycline in blood plasma.
Infectious-inflammatory diseases caused by microorganisms sensitive to the drug:
Prevention of postoperative purulent complications and malaria caused by Plasmodium Falciparum, with short-term travel (less than 4 months) in the territory where strains resistant to chlorochine and / or pyrimetamine sulfadoxin are distributed.
The drug is preferably taken during the meal (for the pretting of dyspeptic phenomena). Tablets are dissolved in a small amount of water (about 20 ml) to obtain a suspension. Tablets can also be swallowed entirely, divided into parts or dear, drinking water. Preferably, taking tablets sitting or standing, which reduces the likelihood of esophagitis and esophagus ulcers. The drug should not be taken immediately before bedtime.
Typically, the duration of treatment is 5-10 days.
Adults and children over 12 years oldon the first day of treatment, 200 mg / day in 1 or 2 receptions are prescribed, in the following days of treatment - 100 mg / day daily. When heavy infections Assign 200 mg / day daily during the entire treatment period.
For infections caused by Streptococcus Pyogenes, The duration of treatment is at least 10 days.
For Uncomplicated gonor. (except for anorectal infections in men) adults Assign 100 mg 2 times / day to complete cure (on average for 7 days), or 600 mg is prescribed for one day - 300 mg in 2 receptions (the second reception after 1 hour after the first).
For primary syphilis prescribed 100 mg 2 times / day for 14 days, with secondary syphilis - 100 mg 2 times / day for 28 days.
For uncomplicated urogenital infections caused by chlamydia trachomatis, Cervicitis, Neuborokokkoy Urealiticum caused by Ureaplasma urealiticumare prescribed 100 mg 2 times / day for 7 days.
For acne Assign 50 mg / day, the course of treatment is 6-12 weeks.
For malaria Prevention Assign 100 mg 1 time / day 1-2 days before the trip, then daily during the trip and within 4 weeks after returning; children over 8 years old - 2 mg / kg 1 time / day.
For preventing diarrhea travelers - 200 mg on the first day of the trip to 1 or 2 receptions, hereinafter - 100 mg 1 time / day during the entire stay in the region (no more than 3 weeks).
For treatment of leptospirosis - 100 mg inside 2 times / day for 7 days; for leptospirosis prevention - 200 mg 1 time / week during stay in a dysfunctional area and 200 mg - after departure. Data on the use of the drug in prophylactic purposes is absent longer than 21 days.
FROM the purpose of the prevention of infections in medical abortion Assign 100 mg per 1 hour to and 200 mg after intervention.
Maximum daily doses for adults - up to 300 mg / day or up to 600 mg / day for 5 days heavy gonduct infections. For children over 8 years old with body weight more than 50 kg - up to 200 mg for children 8-12 years old with body weight less than 50 kg - 4 mg / kg daily throughout the treatment.
For renal (QC less than 60 ml / min) and / or liver failure A decrease in the daily dose of doxycycline is required, since it takes a gradual accumulation of it in the body (the risk of hepatotoxic action).
From the digestive system: anorexia, nausea, vomiting, dysphagia, diarrhea, esophagitis, esophagus ulcer, enterocolitis, pseudo-membrane colitis, liver damage (during long-term intake or in patients with renal or liver failure);
Dermatological and allergic reactions: Photosensitization, urticaria, maculopapulous and erythematous rash, angioedema swelling, anaphylactic reactions, pericarditis, exacerbation of systemic red lupus, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necroliz.
From the hematopopitation system: Hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia.
From the side of the coagulation system of blood: Reducing the activity of Protromina.
From the endocrine system: In patients who have long received doxycycline, it is possible to reversible dark brown scokeering of the tissue of the thyroid gland.
From the nervous system and sense organs: a benign increase in intracranial pressure (anorexia, vomiting, headache, swelling of an optic nerve), vestibular disorders (dizziness or instability), ringing in the ears.
From the urinary system: The increase in the residual nitrogen of urea (due to the anti-canceric effect of the drug).
On the side of the musculoskeletal system: Doxycycline slows down osteogenesis, violates the normal development of teeth in children (irreversibly changes the color of the teeth, the enamel hypoplasia is developing).
Others: Candidiasis (glossitis, stomatitis, damn, vaginitis) as manifestation of superinfection.
Application in pregnancy and breastfeeding
Unidox Soluteab ® is contraindicated to use during pregnancy and during lactation (breastfeeding). Doxycycline in small quantities secreted into breast milk.
Application with violations of liver function
Contraindicated with expressed liver disorders.
Patients with violations of the liver function Unidox Soluteab ® are prescribed only in case of impossibility of treatment with other drugs.
For violations of the functions of the liver It is necessary to reduce the dose of the drug.
There is the possibility of cross-stability and hypersensitivity with other tetracycline drugs.
Tetracycles can increase prothrombin time, the purpose of tetracyclines in patients with coagulopathy should be carefully monitored.
The antanabolic effect of tetracycline can lead to an increase in the level of residual urea nitrogen in the blood. As a rule, it does not have a significant value for patients with normal kidney function. However, patients with renal failure can occur azotemia growth. The use of tetracyclines in patients with impaired kidney function requires medical control.
With long-term use of the drug, periodic control of blood laboratory indicators, liver and kidney functions are required.
In connection with the possible development of photodermatitis, it is necessary to limit the insolation during treatment and within 4-5 days after it.
Reception of antibiotics can cause excess growth of insensitive organisms, including mushrooms of the genus Candida. In this case, the drug should be discontinued and to begin proper therapy.
Cases of pseudommable colitis are described when taking almost all antibacterial drugs, including doxycycline. The degree of gravity varied from light to the threatening life of the state. It is important to keep in mind this diagnosis in patients with diarrhea, developed on the background or after receiving antibacterial drugs. It is necessary to carefully collecting anamnesis, since diarrhea caused by Clostridium difficile can develop within 2 months after the end of the reception of antibacterial drugs.
Due to the possibility of the development of neuro-muscular blockade, caution should be exercised when prescribing tetracycline patients with Miasthenia Gravis (MYASTHENIA GRAVIS).
Tetracyclines can cause aggravation of systemic red lupus.
Impact on the ability to driving vehicles and control mechanisms
Features of the influence on the ability to drive a car and manage the mechanisms were not studied.
Symptoms: Strengthening adverse reactions caused by damage to the liver - vomiting, feverish condition, jaundice, azotemia, increasing the level of transaminases, an increase in prothrombin time.
Treatment: Immediately after taking large doses, it is recommended to wash the stomach, abundant drink, if necessary - induction of vomiting. Take activated carbon and osmotic laxatives. Hemodialysis and peritoneal dialysis is not recommended due to low efficiency.
Due to the suppression of doxycycline intestinal microflora, the prothrombin index is reduced, which requires a dose correction of indirect anticoagulants.
With a combination of doxycycline with bactericidal antibiotics, violating the synthesis of the cell wall (penicillins, cephalosporins), the efficiency of the latter decreases.
Doxycycline reduces the reliability of contraception and increases the frequency of acyclic bleeding when taking estrogen-containing hormonal contraceptives.
Ethanol, barbiturates, rifampicin, carbamazepine, phenytoin, accelerating doxycycline metabolism, reduce its concentration in blood plasma.
The simultaneous use of doxycycline and retinol contributes to an increase in intracranial pressure.
ASTELLAS PHARMA EUROPE B.V. in the Republic of Belarus
Some facts about the product:
Price in the Internet pharmacy Site: from 327
The drug Unidox Solyutab has an antibacterial and bacteriostatic effect, it is referred to as semi-synthetic antibiotic substances having a wide range of action and included in the tetracycline group. The main active substance of the drug - doxycycline monohydrate, which blocks the production of protein compounds in microbes cells, violating these connections of transport ribonucleic membranes. The drug Unidox exhibits increased activity when exposed to aerobic gram-negative and gram-positive bacteria. Exception is resistant to doxycycline bacteria: Singny stick (Pseudomonas Aeruginosa), Proteus (Proteus SPP), Section (Serratia SPP), Fragilis Bacteroids (Bacteroides Fragilis). The drug has rapid and complete absorption from the gastrointestinal tract and is actively associated with protein compounds in the blood plasma. Eating is practically no effect on the absorption process of the active substance. The removal of the drug occurs with urine and feces (in the process of bile) unchanged.
Unidox Soluteab means is subject to use in infectious and inflammatory diseases caused by pathogens having sensitivity to the active substance of medication.
The restrictions on the use of Junidox Medical Preparation is:
The drug Unidox Soluteab is used by an oral method, in which it is possible to divide the tablet on the part, chewing or dissolving it in water. The length of the therapeutic course is about five to seven days. Standard dose for patients, over eight years old and weighing more than fifty kilograms is 200 mg of active substance in the first day, which can be divided into two receptions. Subsequent 100 mg daily. In case of infectious diseases in heavy form - 200mg every period. In patients of children's age, from eight to twelve years, with weight of less than 50 kilograms, use 4 mg per kilogram in the first day and then 2 mg per kilogram of weight. The dose can be divided into two receptions. In case of infectious diseases in heavy form - 4mg / kg daily. Dosing in some infectious diseases. In the case of a gonorial disease, adult patients use 100 mg of active substance twice a day, for a week or with the length of treatment in one day it is possible to use one-time 600 mg of doxycycline. The dose is divided into two receptions at an interval at one time. In syphilis disease (primary), 100 mg of the active substance is used twice a day, the length of therapy is two weeks. With a secondary disease, the course of treatment is extended to four weeks. With infectious diseases caused by chlamydia and urepary, in uncomplicated form, 100 mg of doxycycline is used twice a day. The duration of treatment is one week. Heavy forms of acne is 100 mg per day for six to twelve weeks. 100 mg is appointed 100 mg of disposable per day for preventive measures for malaria, a few days before departure, then daily during the journey and on the four-week period after it. For childcare patients, one hundred and eight years is scheduled for 2 mg per kilogram of body mass, once a day. The disease leptospirosis is prescribed by 100 mg of the drug Unidox Soluteab twice a day, the duration of therapy is one week. For prophylactic treatment of 200 mg of once seven days before the end of finding in disadvantaged areas. In the case of a pregnancy interruption operation, it is necessary to use the active substance in sixty minutes to surgical intervention and 200 mg after it. Maximum daily doses for adult patients allowed to use up to 600 mg per day, for the treatment of severe infectious diseases. For childhood patients from eight years and weighing more than fifty kilograms 200 mg. Children from eight to twelve years, weight less than fifty kilograms - 4 mg per kilogram weight. In the case of kidney pathologies, the creatinine clearance is less than 60, as well as with hepatic failure, it is necessary to reduce the amount of active substance.
In the case of a dose of active substance greater than the maximum, it is possible to strengthen the negative symptoms of side effects that may be caused by hepatic intoxication:
Negative manifestations of side effects during the treatment of Junidox drug therapy may be as follows. Gastrointestinal tract.
Preparations that contain in their composition aluminum, magnesium, calcium, iron-containing, sodium substances can reduce the process of absorption of the active substance. It is necessary to divide the time of consumption of them with a doxycycline interval equal to three hours. With simultaneous use with anticoagulant drugs, the dose correction is required. When combined with antibiotic means, which violate the synthesis of cell walls, their impact can be reduced. Unidox can reduce the effectiveness of contraceptive drugs. Co-use with retinol can increase intracranial pressure in the patient.
The drug has a negative impact on the intrauterine development of the fetus, affects the process of forming bone tissue, as well as provoke the occurrence of fat infiltration in the liver. The tool is prohibited from pregnant patients. At the occurrence of pregnancy, it is necessary to immediately stop using doxycycline. If you need to use medication during the lactation, you should immediately stop breastfeeding.
Since one of their symptoms of side effects is dizziness, it is recommended to treat the car and other vehicles with caution. Also to carry out work requiring increased attention and concentration.
Alcohol can not be taken with drugs with antibiotic properties. Since this can cause negative reactions up to a severe form.
Requirements for the storage of Junidox Solutab Medical Means prescribe temperature regime from fifteen to twenty-five degrees of heat. The tool must be maintained in production packaging in places inaccessible to children and animals. In compliance with the storage rules, the shelf life is five years. After this period, the drug cannot be used and must be disposed of.
The drug can be purchased in the pharmacy network without the presentation of the recipe from the doctor.