Papaverin destination. From what the pills are prescribed Papaverin men and how to use them. Dosage and methods of reception
"Papaverin", from which this antszmolitik helps? The medicine effectively lowers the tone and the contractile operation of the smooth muscles. The remedy has antihypertensive and analgesic effect. The drug "Papaverin" instructions for use prescribes use with cholecystitis, renal colic, angina.
Composition and form of release
Medication "Papaverin", from which it helps in spasms and colic to various groups of patients, is made in the following forms:
- Tablets with an active element of 10 or 40 mg.
- Solution for injection. It is implemented in 2 ml ampoules with 2% by incorporating the active substance.
- Rectal suppositories of 20 mg.
The active element is papaverine hydrochloride, from which the drug helps the patient according to the testimony. Auxiliary components depending on the variety of drugs are: Dinatari Edetat, sugar, methionine, talc, stearin and other substances.
The box with the drug introduced instructions for use.
Pharmacological properties
The effect of the drug "Papaverin", from which its effectiveness depends, is due to anticonvulsant, painkillers and antihypertensive properties of the active element. After applying the medication, the muscle tone of the internal organs decreases, the blood flow is improving, arteries and vessels are expanding.
Instructions for the use of the preparation "Papaverin" indicates its ability to reduce blood pressure. When taking large doses, a sedative effect is observed, intracardiac conductivity is slowed down, the excitability of myocardium decreases. In small amounts, the medicine has a weak effect on the nervous system.
Solution, candles, pills "papaverin": from what helps
The medicine is shown to use when: 
- spasms of the muscles of the abdominal organs;
- renal colic;
- the treatment of a hypertensive crisis is also prescribed a means of "Papaverin", from which it helps in the composition of comprehensive treatment;
- cholecystitis;
- spastic colitis;
- endarteritis;
- pylorosphazma;
- angina;
- spasms of the peripheral vessels;
- urine delay spastic etiology;
- bronchospasm;
- reducing the scope of the brain vessels;
- reduced arterial renal influx.
The drug is used in front of surgical interventions on the internal organs, when the relaxation of the smooth muscles of the patient is required.
Preparation "Papaverin": instructions for use
Tablets are taken inside 3-4 times a day. The dosage for adult patients is 0.04 - 0.06. Papaverin tablets for children are given in the amount, calculated depending on age. One-time amount is:
- Up to 2 years - 5 mg.
- Up to 4 years - 5-10 mg.
- Up to 6 years - 10 mg.
- Up to 9 years - 10-15 mg.
- Up to 14 years - 15 - 20 mg.
How to use Papaverin injeces
The solution can be administered to a muscular fabric or under the skin up to 4 times a day. The unit dose is 1-2 ml. Intravenous injections are performed slowly, while the solution must be in advance to dissolve 0.9% by saline in proportion 1 to 1.
Application of candles
Suppositories are shown only to adult patients. You can use Papaverin candles up to 3 times in the knocks.
Side effects
The preparation "Papaverin" can provoke negative reactions of the body from the side of the blood, heart, vascular, gastric, intestinal, nervous systems. Sourgeous reactions include: 
- drop pressure;
- nausea;
- drowsiness;
- Av - blockade;
- conservation;
- eosinophilia;
- ventricular tachycardia;
- bloating;
- allergies;
- increase the activity of hepatic transaminases.
In disruption, diplopia, weakness, drowsiness, pressure decrease can be observed in the patient.
Contraindications
Means "Papaverin" instructions for use prohibits prescribing when:
- increased sensitivity of the patient to the components;
- low arterial pressure;
- acute lack of kidney;
- glaucoma;
- atrioventricular conductivity;
- children up to 6 months;
- people in old age.
Application of the drug "Papaverin" during pregnancy
According to the instructions, the effect of the Papaverin medication during pregnancy is not fully studied. The provisions of the annotation are recommended to refrain from the reception of the medication. However, doctors prescribe this tool for several decades. They set the dosage and the duration of therapy individually for each patient.
At the same time, no undesirable consequences are observed. Reviews of women awaiting the birth of a child also indicate that disorders did not occur after use. What is the candle "Papaverin" help during pregnancy? The main indication is the hypertonus of the uterus, which is the cause of premature genera and miscarriage.
The price and analogues
Simple antispasmodic effects are provided by drugs: "" and "drootaverine hydrochloride". Buy tablets "Papaverin" can be for 10 - 15 rubles. The price of 10 injections is 40 rubles. For candles will have to give 60 - 70 rubles.
Conditions of holiday and storage
Papaverin refers to the antispasmodic preparations of prescription leave. The shelf life of the tablets is 5 years, injection mortars - 24 months.
Gross formula
C 20 H 21 NO 4Pharmacological group of Papaverin substance
Nonological Classification (ICD-10)
CAS code
58-74-2Characteristics of substance Papaverin
Papaverin hydrochloride - white crystalline powder without smell, slightly bitter taste. Slowly soluble in water (1:40), little - in ethanol, soluble in chloroform, practically insoluble on the air. Molecular weight 375.85.
Pharmacology
pharmachologic effect - antispasmodic, hypotensive.Inhibits phosphodiesterase and causes the accumulation of cyclic 3 ", 5" -amf and a decrease in Ca 2+ levels. Reduces the tone and relaxes the smooth muscles of internal organs (gastrointestinal tract, respiratory, urinary system) and vessels. In large doses reduces the excitability of the heart muscle and slows down intracardiac conductivity.
Quickly and fully absorbed with any ways of administration. Plasma is associated with proteins. Easily passes through histohematic barriers, biotransformation is subjected in the liver. T 1/2 - 0.5-2 hours is displayed by the kidneys mainly in the form of metabolites.
Application of substance Papaverin
Spasm of smooth muscles: abdominal organs (cholecystitis, pylorospasm, spastic colitis, renal colic), peripheral vessels (endartinguritis), brain vessels, hearts - angina (as part of complex therapy), bronchospasm; As auxiliary drugs for premedication.
Contraindications
Hypersensitivity, AV blockade, glaucoma, heavy liver failure, elderly age (risk of developing hyperthermia), children's age (up to 6 months).
Restrictions on application
Condition after CMT, shock conditions, chronic renal failure, insufficiency of adrenal function, hypothyroidism, prostate hyperplasia, religative tachycardia.
Application in pregnancy and breastfeeding
Safety of use during pregnancy and in breastfeeding period is not installed.
Side effects Papaverin substance
From the side of the cardiovascular system and blood (blood formation, hemostasis): AV blockade, ventricular extrasystole, decrease in blood pressure.
From the head of the gastrointestinal authorities: constipation, increased activity of hepatic transaminases.
Others: Sleepiness, eosinophilia, allergic reactions.
Interaction
In combination with barbiturates, the antispasmodic effect of papaverine is enhanced. With joint use with tricyclic antidepressants, procanamide, reserpine, quinidine, it is possible to strengthen the hypotensive effect of papaverin.
Overdose
Symptoms: Violation of vision (shots in the eyes), weakness, drowsiness, decreased blood pressure.
Treatment: Stomach wash (milk, activated carbon), maintenance of blood pressure.
Ways of administration
Inside, p / k, in / m, rectally.
Precautions Substance Papaverin
It should be borne in mind that efficiency is reduced during smoking.
Interactions with other active substances
Trade names
| Name | Validation of the Vyshkovsky index ® |
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The site provides reference information solely to familiarize yourself. Diagnosis and treatment of diseases must be under the supervision of a specialist. All drugs have contraindications. Consultation of a specialist is obligatory!
Papaverine (Latin - Papaverine) is a widespread medicinal substance with antispasmodic, vasodilatory and hypotensive effects. By origin and chemical structure, Papaverin is alkaloid Opium poppy, that is, it turns out from the poppy straw, but is not a narcotic substance.Varieties, titles, form of release and composition of papaverin preparations
Papaverin is simultaneously the trade name of some drugs, and the international name (MNN) of the active substance that is part of many drugs. Preparations with the trading name "Papaverin" are the same with the active substance "Papaverin". This substance is called either just papaverine or papaverin hydrochloride. Moreover, papaverine hydrochloride is the chemical name of papaverine, and from the point of view of a doctor or patient between these terms there is no difference. Currently, in the countries of the former USSR, drugs, which include only Papaverin, are usually called "Papaverin" as an active ingredient. In some cases, letters or abbreviations, encrypting the name of the manufacturer of the manufacturer of the drug, for example, "Papaverin MS", "Papaverin Buffus", and others can be added to the word Papaverin, and others. However, in all cases, we are talking about the same drug produced by different plants. but containing the active component of Papaverin.
In addition, there are multicomponent drugs with other names containing simultaneously several active substances, among which there are papaverine. These are drugs such as Papazole, Andipal, TEOODIBAVERIN, etc. However, in this article we will consider exclusively monocomponent drugs containing only papaverin as an active substance and having the same name accordingly. To distinguish and not to confuse the active substance and the name of the drug, the first will write with a small letter, and the second - with a big one.
Monocomponent preparations containing only papaverine as an active substance are currently being produced under the following commercial names:
- Papaverine;
- Papaverin buffus;
- Papaverin MS;
- Papaverin hydrochloride.
Accordingly, the composition of three dosage forms as an active substance contains papaverine hydrochloride in the following dosages:
- Adult tablets - 40 mg;
- Tablets for children - 10 mg;
- Injection solution - 20 mg per 1 ml;
- Rectal suppositories - 20 mg per candle.
Since the pharmacological effect of papaverine is multidirectional, it is attributed simultaneously to two groups of drugs, such as vasodilators (vasodilators) and spasmolytiki. Accordingly, papaverine is used as a spaspolytic to the treatment of functional disorders of the gastrointestinal tract, and as a vasodilator - in the therapy of erection violations.
Therapeutic effects of Papaverin
Papaverin due to blocking the work of a number of enzymes reduces the tone and relaxes the smooth muscles of all internal organs. The fact is that internal organs (stomach, intestines, blood and lymphatic vessels, bronchi, light, urethra, etc.) are equipped with exceptionally smooth muscles, due to the work of which their total tone rises or decreases. With an increase in the tone, the organ is compressed, that is, its spasm arises, and when it decreases, on the contrary, there is relaxation and expansion of the existing lumen. For example, with increasing the tone of the smooth muscles of the intestines, the bronchi or gallbladder, the organs are strongly compressed, characteristic spastic pain appear and the promotion of their enlightenment is disturbed. That is, the intestine is delayed the promotion of the food lump, it ceases to relete the bile from the gallbladder, and the required amount of air cannot pass through the bronchi. In addition, any spasm of internal organs is accompanied by pain syndrome of various intensity. Papaverin removes spasm, relaxes organs, thereby restoring their function and binding pain syndrome. Since the drug is not elected, he effectively stops spasm and pain of any internal organ, and therefore applied very widely. In principle, Papaverin has the same properties and therapeutic effects as the well-known but-shp.
Papaverin has a relaxing effect on the internal organs, since it affects smooth muscles and does not affect the transverse-striped. The fact is that on the human body and in the heart there are only cross-striped muscles, which have other properties and react to completely different irritants and substances. Therefore, antispasmodics acting on smooth muscles do not affect the reduction of skeletal and heart muscles. Thus, Papaverin is able to remove spasm and relax the muscles of internal organs without affecting myocardium and muscles of the body.
Summing up the effects described, the following main therapeutic effects of papaverine can be distinguished:
- Relaxes smooth muscles and removes the spasms of smooth muscles of blood vessels, organs of the digestive, respiratory and urogenital system;
- Due to the relaxation of the muscles of blood vessels and their subsequent expansion reduces blood pressure;
- High doses reduce the excitability of the heart muscle and slow down the healing of the heart;
- In high dosages, has a sedative effect on the central nervous system.
Papaverin is quickly absorbed into the bloodstream at any route of administration (tablets, rectal candles, intramuscular injections) and is excreted by the kidneys. Half of the administered dose of the drug is output after 0.5 - 2 hours.
Papaverin (tablets and injections) - Indications for use
Indications for the use of pills, injections and rectal papaverine suppositories are completely the same, since regardless of the dosage form, the drug is absorbed into the blood and has systemic therapeutic effects.Tablets, injections and pipaverin suppositories are shown in use in the following diseases and states:
- Spasms of smooth muscle elements of the gastrointestinal tract organs with various diseases, such as pylorospasm, colitis, cholecystitis, cholangitis, etc.;
- Spastic pains (for example, with colitis, meteorism, menstruation, irritable intestinal syndrome (CRC), constipation, etc.);
- As part of the complex therapy of cholecystitis and renal colic, as an anesthetic and removable spasm of the drug organ;
- Spasms and pain in the organs of the urogenital system (cystitis, pylitis, kidney stones or in urethra, etc.);
- Bronchospasm;
- Spasm of brain vessels;
- Spasm of peripheral vessels, for example, with endarting and other diseases;
- As part of the complex therapy of angina;
- As an auxiliary drug during preliminary preparation (premedication).
Papaverin (papaverine hydrochloride) - instructions for use
Consider the rules and nuances of the use of each dosage form of papaverine (tablets, candles and injection solutions) separately.Papaverin Tablets - Instructions for use
Tablets should be taken inside, swallowing entirely, not chewing, not scholarsing and non-shredding in other ways, but drinking enough water (approximately 200 ml). Papaverin can be taken regardless of food, and as needed, that is, when spastic pains or painful spasms arise. However, if there are spastic pains in the organs of the gastrointestinal tract, it is better to take Papaverin for 15 - 30 minutes before meals so that the drug stopped the symptoms, and the person could easily eat and drink. In case of spasms and spastic pains of internal organs, adults and adolescents are recommended to take papaverin at 40 - 60 mg (1 - 1.5 tablets) 3-4 times a day. Children should give pills with a special children's dosage of 10 mg. And the dosage of papaverine for children is determined by age:
- 6 - 24 months - 5 mg (1/2 of a children's tablet) 3-4 times a day;
- 2 - 4 years - at 5 - 10 mg (1/2 - 1 children's tablet) 3-4 times a day;
- 5 - 6 years - 10 mg (1 children's tablet) 3-4 times a day;
- 7 - years - 10 - 15 mg (1 - 1.5 children's pills) 3-4 times a day;
- 10 - 14 years - 15-20 mg (1.5 - 2 children's tablets) 3-4 times a day.
Papaverin in ampoules - instructions for injection
The ampoules contains a sterile-ready for the introduction of a 2% solution of papaverine, containing 20 mg of active substance in 1 ml. Since there are 2 ml of solution in Ampoule, the total dosage of papaverine in a whole ampoule is 40 mg, which is equivalent to one adult tablet. The solution can be administered in solid form subcutaneously or intramuscularly, and after dilution - intravenously. Adults and adolescents over 10 years old, the solution is introduced 2 - 4 times a day, and for children under 10 years old - 2 times a day. The single dosage of papaverine is determined by age:
- 6 - 24 months - 0.25 ml of a solution of 2-4 times a day;
- 2 - 4 years - 0.25 - 0.5 ml of solution;
- 5 - 6 years - 0.5 ml of solution;
- 7 - years - 0.5 - 0.75 ml of solution;
- 10 - 14 years - 0.75 - 1 ml of solution;
- 15 years and older - 1 - 2 ml of solution.
For subcutaneous or intramuscular administration, primarily choose the injection site. Intramuscularly optimally enter the solution into the upper-block outer surface of the hip or the outer upper part of the shoulder, and subcutaneously to the area around the navel. Before performing injection, the skin is wiped with an antiseptic, after which the desired amount of solution is gained into the syringe and introduced into the prepared place. For intramuscular injection, the needle is introduced deep into the fabric perpendicular to the surface of the skin. And for subcutaneous injections, first capture approximately 1 cm of the skin with a large and index finger, making a fold from it. After that, the syringe needle is set to approximately at an angle of 45 o to the skin surface and introduced into this fold. The solution is released in the tissue and gently take out the needle, after which the injection site is again wiped with an antiseptic. Each time you can enter a solution to a point, which is at a distance of at least 1 cm from other traces from past injections.
For intravenous administration, it is necessary first the desired amount of papaverine dilute in 10-20 ml of physiological solution. Then this mixture is administered intravenously, slowly. Intravenous injections should be performed only in the hospital, and the subcutaneous or intramuscular can be done at home on their own, if a person has mastered their technique and does not experience fear.
Papaverin - Instructions for the use of candles
Candles are injected into the rectum, carefully pushing the index finger through the anus. Introducing the candles should be definitely clean, just flushed with soap hands or in sterile gloves. Dosage of suppositories with various diseases accompanied by spasms and spastic pains is determined by age and amounts to 1 - 2 candles 2 - 3 times a day for adults, and 1 candle 2 times a day for children over 10 years. Children under 10 years old candles are cut into 2 or 4 equal parts and administered with these pieces containing the required amount of active substance. So, children under 4 are administered by quarter or half a candle, and from 5 to 10 years old - half a suppository 2 times a day. Dosage for various diseases
Dosage of papaverine in all dosage forms is the same with various diseases and conditions, and differs only depending on the age of a person using the drug. So, one-time dosages of the solution, suppository and Papaverin tablets for people of different ages are as follows:- 6 - 24 months - 5 mg;
- 2 - 4 years - 5 - 10 mg;
- 5 - 6 years - 10 mg;
- 7 - years - 10 - 15 mg;
- 10 - 14 years - 15-20 mg;
- Over 14 years old - at 20 - 60 mg.
The maximum allowable single dosage of papaverine is the greatest dose specified for each age multiplied by four. That is, for an adult, the maximum allowable one-time dosage is 60 * 4 \u003d 240 mg, for a child from 10 to 14 years - 20 * 4 \u003d 80 mg, etc. The maximum allowable daily dosage is equal to the maximum one-time multiplied by three.
special instructions
With any diseases that are indicated to use Papaverin, you can choose that dosage, the form that seems to be the most convenient time. For example, if a person is most convenient to take tablets, you should choose this particular form.If it is necessary to quickly achieve the therapeutic effect, especially in the first days of exacerbation of the disease, then injections should be used. After 2 - 3 days, if a person can swallow, should be replaced by the injections with pills or rectal candles. The entire course of therapy is not recommended using subcutaneous or intramuscular injections, as it entails large risks compared to the reception of tablets. Therefore, injections should be set only if the candles and tablets cannot be applied for any reason. In general, doctors recommend to be guided by a simple rule in the choice of the form of the drug - always use either candles, or tablets, and shots apply only if it is necessary to obtain a rapid therapeutic effect, but at the first opportunity to replace them with pills or suppositories.
If a person suffers from the gastrointestinal spasms, it can use papaverine both in candles and in tablets, based exclusively on personal preferences. However, it should be remembered that when using Papaverin candles, the clinical effect comes faster than from tablets. Therefore, if you need to get a quick effect, it is better to use candles. It is also recommended to choose candles if a person for any reason cannot swallow pills.
In spastic pains in the urinary system organs, the optimal option is papaverine suppositories, since when they were introduced into the rectum, the active substance very quickly reaches the affected tissues and has a powerful therapeutic effect. If for some reason the candles are impossible to enter the rectum or difficult, then it should be replaced with pills.
In children, it is recommended to use papaverine in the form of suppositories or special children's tablets with a low dosage of active substance in 10 mg. Do not have children to give halves or quarters of papaverine pills for adults, which contain 40 mg of active substance.
Papaverin is not a drug intended for long term applications, so it is used exclusively for one-time removal of spastic pains against the background of the exacerbation of the disease or state. This means that independently tablets, candles or injections of papaverine can be used within 2 - 3 days, after which the improvement is required to appear, expressed in the decrease in spastic pains and unpleasant sensations in the localization of the pathological process. If there is no improvement, then immediately consult a doctor, as this may indicate the development of severe surgical pathology, for example, appendicitis, bleeding, peritonitis, etc.
For the purpose of the doctor, Papaverin is usually used within 7 - 14 days or a little longer, right up to completely relieve painful spastic pain. If a person has been suffering from any chronic disease for a long time, for example, cholecystitis, it perfectly knows the symptoms of its exacerbation and the dynamics of improvements advancing against the background of admission of papaverine, and therefore can independently determine the duration of the drug.
If a person faced spastic pain for the first time, then the first course of therapy should be carried out exclusively under the supervision of a doctor and independently fix their own sensations, as well as a positive trend. In the future, when aggravating the disease, the relief of spasms will also be made by antispasmodics, and their dynamics will not differ fundamentally from the one that was fixed for the first time. And a person who remembers the dynamics of reducing spastic pain and normalization of the state, during periods of exacerbation in the future will be able to independently control how correctly the treatment is going, without visiting the doctor for this and does not go to the hospital. In addition, he will be able to record any distinctive manifestations of treatment dynamics and report them to a doctor who, in turn, will be aiming to look for their cause and engage in the problem of diagnosing a combined or atypical pathology.
Overdose
Papaverin overdose is possible and manifests itself by the appearance of two eyes, weakness, drowsiness and a decrease in pressure. For the treatment of overdose, stomach washing, after which it gives a sorbent (activated carbon, polysorb, etc.) and milk, and maintain pressure at a normal level.Interaction with other medicines
Papaverin reduces the therapeutic effect of Levodopa and methyldopes.In addition, but-shap with papaverine is often used to prepare the cervix to childbirth, for which women take 1 tablet or administer 1 candle of each drug 2 times a day for 2 weeks before the expected date of delivery. This practice is widespread, however, these drug preparation drugs are more harmful than good, since just before childbirth, when the uterus should actively shrink and prepare, it is artificially "inhibited by" spasmolitis, relaxing muscles and reducing the tone. As a result of the use of but-ships with papaverine "For the preparation of the cervix" increases the likelihood of the weakness of generic activity and, accordingly, the use of rhodtle, relativesexpension and the imposition of obstetric tongs or vacuum. That is, there is no preparation of the cervix, but the oppression of generic activity.
The use of but-ships with papaverine does not reduce the risk of breaks, which in most cases depend only on competent knowledge of the childhood by the doctor. And for the preparation of the cervix to childbirth, which is carried out only during the rejunction or necessity of urgent delivery against the background of the threat of mothers's life, completely different drugs are used (soda, etc.) and non-drugs (laminaries, Foley catheter, etc.).
Papaverin Children
Papaverin in any dosage form can be used in babies from three months. The instructions usually indicate that the drug is allowed to use from 6 months, but Pediatrician practitioners based on perennial observations for the use of papaverine are considered justified and secure its application from 3 months. Indeed, the composition of the popular drug of the Ofonna, used for childbing, also includes papaverin.The kids of the first year of life, Papaverin is used mainly to relieve spastic pain and intestinal colic, and in children of older age - for removing bronchospasm, as well as in complex therapy of pancreatitis, liver colic and urethra spasms. In addition, if a child has a high temperature and white, cold hands and legs, then papaverin is given to expand the vessels for 15 to 20 minutes to the antipyretic drug. In a situation where the hands and feet are cold, and the temperature is very high, antipyretic without prior admission of antispasmodics (papaverine, but-shops, drootaverine, etc.) will not act, because the narrowed, spashed vessels will not give excess warmth and cool the body .
Papaverin in children is used in all three dosage forms in the dosages depending on age:
- 6 - 24 months - 5 mg (1/2 of a children's tablet, 0.25 ml of solution or 1/4 candles) 2 times a day;
- 24 years - at 5 - 10 mg (1/2 - 1 children's tablet, 0.25 - 0.5 ml of solution or 1/4 - 1/2 candles) 2 times a day;
- 5 - 6 years - 10 mg (1 children's tablet, 0.5 ml of solution or half of the candle) 2 times a day;
- 7 - 9 years - 10-15 mg (1 - 1.5 children's tablets, 0.5 - 0.75 ml of solution or 1/2 - 2/3 of the candles) 2 - 3 times a day;
- 10 - 14 years - 15-20 mg (1.5 - 2 children's tablets, 0.75 - 1 ml of solution, 2/3 - 1 candle) 2 - 3 times a day;
- Teens older than 14 years - 20 to 40 mg (1 adult tablet, 1 - 2 ml of solution or 1 - 2 candles) 3-4 times a day.
Papaverin from pressure
Papaverin expands blood vessels and moderately reduces blood pressure, but it does not use it as a specific antihypertensive drug for long-term treatment courses. Papaverin in combination with dibazole is usually injected with hypertensive crisis - Increased sensitivity to components of drugs;
- AV blockade;
- Liver failure;
- Old age over 65 years old;
- Children's age under 6 months.
- Transferred over the past 6 months the cranopy and brain injury;
- Shock states;
- Chronic renal failure; 1.
Biospa pills;
2. Vero-drootaverin pills;
3. Dwarvery solution for injections, tablets;
4. DROTAVERINA MS, DROTAVERIN FORTER, DROTAVERIN-UFF, DROTAVERIN-TEVA AND DROTAVERIN-FPO - Tablets;
5. DROTAVERIN-ELLARA Solution for injections;
6. Nikoverin pills;
7. But-ship tablets and injection mortar;
8. But shpa forte pills;
9. Nos-sray solution for injections and tablets;
10. Papazole and papazole-UFF pills;
11. Platifillin with papaverine pills;
12. Ple Spa Tablets;
13. Spasp solution for injection and tablet;
14. Spasmodes and spasmodes forte pills;
15. Spaser tablets;
16. Spakoving solution for injection and tablet.Composition and form of release of the drug
Injection Greenish yellow transparent solution.
Auxiliary substances: Water D / and - up to 1 ml, Dinatari Edettat Dihydrate - 0.05 mg - 0.1 mg.
2 ml - neutral glass ampoules (5) - contour cellular packaging (1) - packs cardboard.
2 ml - neutral glass ampoules (5) - contour cell packaging (2) - packs cardboard.
2 ml - neutral glass ampoules (5) - cardboard packs.
2 ml - neutral glass ampoules (10) - cardboard packs.
2 ml - neutral glass ampoules (5) - Packaging Contour cells (4) - Cardboard packs (for hospitals).
2 ml - neutral glass ampoules (5) - contour cell packages (5) - cardboard packs (for hospitals).
2 ml - neutral glass ampoules (5) - Packaging Contour cells (10) - Cardboard packs (for hospitals).
2 ml - neutral glass ampoules (5) - Packages Contour cells (50) - Cardboard packs (for hospitals).
2 ml - neutral glass ampoules (5) - contour cell packaging (100) - cardboard packs (for hospitals).pharmachologic effect
Dosage
Inside - 40-60 mg 3-5 times / day. Rectally - at 20-40 mg 2-3 times / day.
At a / m, n / k or in / in administration, a single dose for adults is 10-20 mg; The interval between the introductions is at least 4 hours. For elderly patients, the initial one-time dose is not more than 10 mg. For children aged 1 to 12 years, the maximum one-time dose is 200-300 μg / kg.
Side effects
Maybe: Nausea, constipation, drowsiness, increased sweating, arterial hypotension, increase in activity of hepatic transaminases.
With quick / in the introduction, as well as when applying in high doses: Development of AV blockade, rhythm disorders.
Medicinal interaction
With simultaneous use with anticholinergic agents, it is possible to enhance anticholinergic effects.
It is believed that with simultaneous use with alprostadyl, there is a risk of developing priapism.
There are reports of reducing the efficiency of levodopes during its simultaneous use.
Reduces the hypotensive effect.
Composition of a solution of 2 ml:
The active substance is papaverine hydrochloride - 40 mg.
Auxiliary substances - DL methionine, disodium salt of ethylenediaminetetraacetic acid, water.
Characteristic release
The shape of the release of papaverine in ampoules is cardboard boxes with glass ampulus, the solution content is the same.
pharmachologic effect
Drug, effectively eliminating the reduction in the smooth muscles of all organs without exception. Strong spasmolitic. Inhibits phosphodiesterase, excites the cluster in the cyclically adenosine monophosphate cell (CAMF), and lowers the calcium level contained inside the cells.
- It struggles with an increased tone, actively and effectively normalizing the condition of the smooth muscles of internal organs, various organism systems - the gastrointestinal tract (gallbladder, stomach), respiratory (bronchi), cardiovascular, sexual and urinary systems.
- Promotes the expansion of arteries, improvement and acceleration of blood flow (and cerebral).
- Promotes a decrease in blood pressure (hypotensive action).
- Middle doses of the drug are slightly reflected on the central nervous system.
High doses, in particular, the active substance of the drug gives the likelihood of the sedative effect, slowing the intracardiac conductivity and reduced myocardial excitability.
Pharmacodynamics and pharmacokinetics
The bioavailability of the drug, or the ability of the drug to reach the place of its main impact on the body - 54%. Binds to plasma proteins - up to 90%.
It is quickly and evenly distributed throughout the body, it is easily overcoming histohematic obstacles.
The splitting process, metabolization occurs in the liver, which does not allow the medicine to accumulate in the body.
It is excreted together with the urine, the kidneys in the form of metabolites, in the process of dialysis is completely derived from the blood.
Indications for the use of papaverine
In most cases, papaverin is used in the treatment - endartareitis, bronchospasm, pylorospasm, cholecystitis, angina and spastic colitis.
Papaverin is shown
- Prevention of muscle spasms of smooth structures of internal organs (with inflammation of the gallbladder, irritable colon syndrome, stomach spa), bronchi.
- Elimination of sharp pain and during biliary and renal spasms.
- Treatment of potency disorders (erectile disorder of vascular origin).
- Spasms, vascular diseases, in particular oblique entarteritic, involuntary reductions of brain vessels and lower limbs.
- Angina (in organized therapy).
- It is practiced as an additional medication to prepare a patient to a general anesthesia (reduces the degree of anxiety, enhances the anesthetic drugs).
Contraindications
Forbidden Papaverin
- Children up to 6 months of life.
- People are able to coma.
- With oppressed respiratory states.
- In the presence of pathologies in the form of blockade (atrioventicular, disorder of the wired function of the nervous impulse).
- Glaucoma of different types and stages.
- Age more than 75 years.
- Fibroplastic intercourse of penis (Peyroni).
- Hepatic insufficiency in the heavy stage.
- Individual intolerance to the components of the medication.
Side effects
The response picture of the use of papaverine can be represented by several deviations:
- From the digestive system, it is possible: nausea, vomiting, chair disorders (in particular constipation).
- From the side of the cardiovascular system: lowering blood pressure, development of atrioventricular (AV) blockade, violation of the rhythm of ventricular abbreviations.
- Drowsiness.
- Increase sweating.
- Hyperactivity of hepatic enzyme proteins (transaminase).
Instructions for the use of papaverine
Papaverin in ampoules instruction, on the use of which should strictly be observed, is released from sales points only by special recipes, with the seal of the medical institution and the signature of the doctor.
The prescription describes in detail the most important nuances of the prescription of the medication. Compliance with which ensures the effectiveness and effectiveness of the drug.
Method and dosage
Papaverin in ampoules is used for intramuscular, intravenous and subcutaneous administration.
Adult appointed dosage by the attending physician, in accordance with the state of its health, age and clinical picture of concomitant diseases.
One-time administration is prescribed from 1 to 2 ml (the solution is divorced in sodium chloride 0.9%), the following injection is produced at least after 4 hours.
The duration and dosage of treatment is appointed by a doctor.
Intravenous administration is carried out extremely slow and under the supervision of the physician.
Patients, the older age group, the introduced fraction of the drug should not be more than 10 mg.
Overdose
The overdose of the drug is likely exclusively with incorrectly administered, exceeded, uncontrolled doses. Overdose is also possible in the existing kidney and liver diseases.
Elimination of consequences of overdose includes a set of procedures
The drug is directly canceled, then the operational washing of the stomach is followed by milk and activated carbon, and the supporting and symptomatic therapy is assigned, eliminating the complications and disorders.
There is no definite antidote from papaver.
With the appearance of a persistent pathological (not associated with sexual act), the erection, mainly as a result of the addition of the drug by intracable, therapy is made in exactly the same method of administration of adrenaline, phenylephrine.
In extremely difficult situations, a shunt operation may be required on the vessels of the sexual organ.
Interaction with other drugs
The simultaneous admission of papaverin with anticholinergic drugs increases the impact of the latter.
The simultaneous reception of papaverine with alprostadyl (in the variation of intracar-free administration) increases the likelihood of recapination (persistent pathological erection).
The simultaneous admission of papaverine with anti-parkinsonic means reduces the effectiveness of Levodopa.
The simultaneous admission of papaverin with reduced blood pressure drugs, reduces the effectiveness of the action of methyldop.
Excellent results gives the integrated use of Papaverin, Analgin and Dimedrol in the form of an urgent injection for first aid in a variety of pathologies.
Papaverin in childhood
The purpose of papaverine is prohibited for therapy in children who have not reached 6 months of age, as the likelihood of the formation of hyperthermia increases.
Papaverin in old age
Assigned with careful dressing and in small doses. Control from the doctor must be systematic.
Persons over 60 should be consulted with a doctor, in no case should not be engaged in self-medication.
Papaverin during pregnancy and lactation
The use of papaverine during pregnancy and the lactation period is not fully understood, the control studies did not pass.
Nevertheless, the drug is practiced in the therapy of pregnant women, only under the strict observation of the doctor. Appointed in serious situations when there is no other treatment option. If the expected benefits exceeds the likely threats for a child.
Papaverin injections are permissible during breastfeeding period, but strictly under the monitoring of specialists. Practice did not reveal the occurrence of side effects rendered to the infant.
In no case cannot be independently assigned to themselves.
Storage conditions
The drug must be stored in a place protected from light and inaccessible to children, to observe the temperature limit - not higher than 25 degrees of heat.
Shelf life
Storage of the drug - 24 months from the date of manufacture. After the expiration date specified on the package is not used in any purposes.
special instructions
Systematic control of a doctor and excessive caution in the use of a solution of papaverine:
- During the post-traumatic period, in the presence of brain bruises, injuries.
- With the renal insufficiency of chronic flow.
- In case of lack of functioning of adrenal glands.
- With a persistent shortage of thyroid hormones (hypothyroidism).
- With insane, benign formations of prostate.
- Violations of the conductivity of electrical signals, pulses and heart rate (tachycardia belgorithing).
- Weak patients.
The use of alcoholic beverages during papaverine therapy should be discontinued!
Analogs
Papaverin analogues are very much, they are mainly not particularly different, the only difference goes in the grams of the active substance and auxiliary firm.
Virtually identical to the composition and process of exposure - drochlorine hydrochloride (solution).
Therapeutic effects are allocated analogs.
- But-shpa in the form of a solution.
- Papaverin buffet in the form of a solution.
