Active substance

Clemastine (clemastine)

Release form, composition and packaging

Solution for intravenous and intramuscular administration clear, colorless or light yellow to pale greenish yellow.

Excipients: sorbitol - 90 mg, ethanol 96% - 140 mg, propylene glycol - 600 mg, sodium citrate dihydrate - up to pH 6.3, water for injection - up to 2 ml.

2 ml - glass ampoules (5) - plastic trays (1) - cardboard boxes.

pharmachologic effect

Blocker H 1 - histamine receptors, a derivative of ethanolamine. It has a strong antihistamine effect with a rapid onset of action and a duration of up to 12 hours, prevents the development of vasodilation and contraction of smooth muscles induced by histamine.

Possessing an anti-allergic effect, it reduces the permeability of blood vessels, capillaries, inhibits exudation and the formation of edema, reduces itching, and has an m-anticholinergic effect.

Pharmacokinetics

Communication with proteins is 95%. Excretion from plasma is biphasic, the corresponding T 1/2 are 3.6 ± 0.9 h and 37 ± 16 h.

It undergoes significant metabolism in the liver. Metabolites are mainly (45-65%) excreted through the kidneys with urine; unchanged active substance is found in the urine only in trace amounts.

During lactation, a small amount of clemastine can pass into breast milk.

Indications

- prevention or treatment of allergic and pseudo-allergic reactions (including administration, blood transfusion, diagnostic use of histamine);

- angioedema, anaphylactic or anaphylactoid shock (as an additional remedy).

Contraindications

- hypersensitivity;

- pregnancy;

- lactation period;

- taking MAO inhibitors;

- diseases of the lower respiratory tract(incl. bronchial asthma);

- intolerance to fructose;

— childhood up to 1 year.

Intra-arterial administration of the drug is not allowed!

Carefully: in patients with stenosing gastric ulcer, pyloroduodenal obstruction, with cervical obstruction Bladder as well as hypertrophy prostate accompanied by urinary retention, with increased intraocular pressure, hyperthyroidism, diseases of cardio-vascular system, including arterial hypertension.

Dosage

Adults: 2 mg (2 ml), that is, the contents of 1 ampoule, 2 times a day (morning and evening). FROM preventive purpose the drug is administered intravenously in a stream slowly (over 2-3 minutes or more) at a dose of 2 mg immediately before the possible occurrence of an anaphylactic reaction or a reaction in response to the use of histamine. The drug solution can be further diluted with isotonic solution or 5% glucose solution in a ratio of 1:5.

Children: 0.025 mg/kg/day IM divided into 2 injections.

Side effects

Frequency classification adverse reactions: very often (>1/10); often (>1/100,<1/10); нечасто (>1/1000, <1/100); редко (>1/10 000, <1/1000); очень редко (<1/10 000).

From the nervous system: often - increased fatigue, drowsiness, sedation, weakness, feeling of fatigue, lethargy, impaired coordination of movements; infrequently - dizziness; rarely - headache, tremor, stimulating effect.

From the gastrointestinal tract: rarely - dyspepsia, nausea, vomiting, gastralgia, dry mouth; very rarely - constipation.

From the sense organs: rarely - a violation of the clarity of visual perception, diplopia, acute labyrinthitis, tinnitus.

From the side of the kidneys and urinary tract: very rarely - frequent or difficult urination.

From the respiratory system: rarely - thickening of bronchial secretions and difficulty in expectoration of sputum, a feeling of pressure in the chest, respiratory failure, nasal congestion.

From the side of the cardiovascular system: rarely - a decrease in blood pressure (more often in elderly patients), extrasystole; very rarely - tachycardia.

From the blood and hematopoietic organs: rarely - hemolytic anemia, thrombocytopenia, agranulocytosis.

From the side of the skin and subcutaneous fat: rarely - skin rash.

From the immune system: infrequently - photosensitivity, shortness of breath; rarely - anaphylactic shock.

If any of the side effects listed in the instructions get worse, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

Symptoms. An overdose of antihistamines can lead to both inhibitory and stimulating effects on the central nervous system, more commonly observed in children. Phenomena of anticholinergic action may also develop: dry mouth, fixed pupil dilation, flushing of the upper half of the body, tachycardia, gastrointestinal disorders (nausea, epigastric pain, vomiting).

Treatment. Symptomatic therapy is shown.

Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Tavegil in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Tavegil in the presence of existing structural analogues. Use to treat allergies in adults, children, and pregnancy and lactation. Interaction of the drug with alcohol.

For the use of tablets:

• urticaria of various origins;
• itching, itchy dermatoses;
• drug allergy;
• insect bites and stings.

• drowsiness;
• increased fatigue;
• headache;
• dizziness;
• tremor;
• sedative effect;
• weakness;
• feeling tired;
• lethargy;
• dyspepsia;
• nausea, vomiting;
• pain in the epigastrium;
• constipation;
• dry mouth;
• loss of appetite;
• diarrhea;
• frequent urination;
• difficulty urinating;
• nasal congestion;
• heartbeat;
• extrasystole;
• hives;
• skin rash;
• anaphylactic shock;
• photosensitivity;
• noise in ears;

News edited by: admin16, 16:09

Tavegil /

Composition and form of release:

1 tablet contains clemastine fumarate 1 mg, 10 pcs in a blister, 2 blisters in a box.

1 ml solution for injection - 1 mg; in ampoules of 2 ml, in a box of 5 ampoules.

5 ml of syrup - 0.67 mg; in vials of 60 or 100 ml.

Tablets and syrup: hay fever and other allergic rhinopathy, urticaria, pruritus, pruritic dermatosis, eczema, contact dermatitis, skin reaction to medication or insect bites.

Solution for injection: anaphylactic or anaphylactoid shock, angioedema; prevention and treatment of allergic or pseudo-allergic reactions (with the introduction of radiopaque agents, blood transfusion, the use of histamine for diagnostic purposes).

Hypersensitivity, diseases of the lower respiratory tract (including bronchial asthma), breastfeeding, children's age (tablets - up to 6 years, injections - up to 1 year).

Use during pregnancy and lactation:

During pregnancy - only for health reasons. At the time of treatment should stop breastfeeding.

From the nervous system and sensory organs: fatigue, dizziness, sedation, drowsiness, in some cases (especially in children) a stimulating effect (anxiety, irritability, insomnia, tremor).

From the side of the cardiovascular system and blood (hematopoiesis, hemostasis): rarely - palpitations, lowering blood pressure, extrasystole.

On the part of the respiratory system: rarely - thickening of bronchial secretions and difficulty in separating sputum, a feeling of compression in the chest.

From the digestive tract: dyspepsia, rarely - dry mouth, nausea, epigastric pain, constipation, in some cases - lack of appetite, vomiting, diarrhea.

Allergic reactions: very rarely - urticaria, skin rash, photosensitivity; with intravenous administration in some cases, anaphylactic shock.

Other: very rarely - frequent or difficult urination.

Symptoms: depression or excitation of the central nervous system, dry mouth, persistent mydriasis, flushing, disorders of the gastrointestinal tract.

Treatment: induction of vomiting (with preserved consciousness), gastric lavage with isotonic sodium chloride solution (after no more than 3 hours after ingestion), the appointment of a saline laxative, symptomatic therapy.

Dosage and administration:

inside. Adults and children over 12 years old - 1 mg 2 times a day (morning and evening), before meals with water; in severe cases up to 6 mg / day. Children 6-12 years old - 0.5-1 mg before breakfast and at night. For children aged 1-6 years, a syrup of 0.67 mg (1 teaspoon) is recommended.

Injections. In / in a jet slowly or in / m - in a single dose of 2 mg in the morning or evening. Children - in / m 0.025 mg / kg / day in two divided doses. For the prevention of allergic reactions - in / in slowly 2 mg immediately before a possible anaphylactic reaction or a reaction in response to the use of histamine. For intravenous administration, the drug can be diluted with isotonic sodium chloride solution or 5% glucose solution in a ratio of 1:5.

Use with caution in diseases of the cardiovascular system (including arterial hypertension), increased intraocular pressure, angle-closure glaucoma, hyperthyroidism, stenosing gastric ulcer, obstructive processes in the pyloric and duodenal region, prostatic hypertrophy (accompanied by urinary retention), obstructive phenomena in the neck of the bladder.

It should not be used during work by drivers of vehicles and people whose profession is associated with increased concentration of attention.

Tavegil solution for injections 1 mg/ml, 2 ml in ampoule No. 5

Dosage form: Solutions for internal use

Composition

active ingredient: clemastine;

1 ml 1.34 mg clemastine hydrofumarate, equivalent to 1 mg clemastine;

excipients: sorbitol (E 420), ethanol 96%, propylene glycol, sodium citrate, water for injection.

Dosage form

Injection.

Basic physical and chemical properties: transparent, colorless or yellowish solution.

Pharmacological group

Antihistamines for systemic use.

ATC code R06A A04.

Pharmacological properties

Tavegil is an H1 receptor antagonist. Refers to antihistamines of the benzhydryl ether group. Tavegil selectively inhibits histamine H 1 receptors and reduces capillary permeability. It has a pronounced antihistamine and antiallergic effect, characterized by a rapid onset and a significant duration (up to 12:00).

The binding of clemastine to plasma proteins is approximately 95%.

Clemastine is metabolized in the liver. Elimination is carried out in two phases: the half-life of the first phase averages 3.6 hours; the second phase - 37 hours. Metabolites in large quantities (45-65%) are excreted by the kidneys in the urine. The modified active substance is found in the urine only in small quantities. In women during lactation, a small amount of the drug may pass into breast milk.

Indications

Prevention and treatment of allergic and pseudo-allergic reactions, including reactions to the introduction of contrast agents, blood transfusion, diagnostic use of histamine.

Secondary treatment (after the administration of adrenaline at a dose of 0.01 mg / kg) in case of anaphylactic or anaphylactoid shock and angioedema.

Contraindications

Hypersensitivity to clemastine or to excipients of the drug, as well as to antihistamines of a similar chemical structure. Porfiry.

Interaction with other medicinal products and other forms of interaction

Antihistamines potentiate the sedative effect of drugs that depress the central nervous system (hypnotics, MAO inhibitors, tricyclic antidepressants, anxiolytics, opioid analgesics and alcohol). During the use of the drug should avoid the use of alcoholic beverages.

Application features

The drug in this dosage form may have a pronounced sedative effect than oral administration, especially in young children. Intravenous injections should be carried out slowly (within 2-3 minutes).

Tavegil should be used with caution in angle-closure glaucoma, peptic ulcer in the presence of stenosis, pyloroduodenal stenosis, prostatic hypertrophy with urinary retention and obstruction of the bladder neck.

The drug contains sorbitol, so it should not be used in patients with hereditary fructose intolerance.

The drug contains ethanol 96% mg in 2 ml (1 ampoule). It may be harmful to those suffering from alcoholism. The ethanol content should be considered when using the drug in children and patients who belong to high-risk groups, such as patients with liver disease or epilepsy.

Use during pregnancy and lactation

Tavegil should not be used during pregnancy and lactation.

The ability to influence the reaction rate when driving vehicles or operating other mechanisms

Due to the antihistamine sedative effect of clemastine and possible adverse reactions from the nervous system, tavegil solution for injection may affect the ability to drive vehicles or other mechanisms.

Dosage and administration

For adults and children over 12 years of age, administer slowly (within 2-3 minutes) or intramuscularly in a single dose of 2 ml (contents of 1 ampoule) - 2 times a day (morning and evening). The introduction of the drug is strictly prohibited!

To prevent allergic reactions, inject 2 ml of tavegil slowly intravenously immediately before the possible development of an anaphylactic reaction or a reaction to histamine. The solution can be diluted with 0.9% sodium chloride solution or 5% glucose solution in a ratio of 1: 5. For children aged 1 to 12 years, enter intramuscularly at a dose of 0.025 mg / kg of body weight 2 times a day.

Tavegil should not be used in children under the age of 1 year.

Overdose

Symptoms of both depression and excitation of the central nervous system may occur, for example, depression of consciousness, agitation, hallucinations or convulsions. Anticholinergic symptoms such as dry mouth, fixed pupillary dilation, hyperemia, gastrointestinal disturbances, and tachycardia are also possible.

Treatment. Application features.

Adverse reactions

From the nervous system: often - a feeling of fatigue, sedation, drowsiness infrequently - dizziness; rarely - headache.

On the part of the psyche: rarely - arousal.

From the digestive system: rarely - gastrointestinal disorders, including epigastric pain, nausea, dry mouth; very rarely - constipation.

From the immune system: infrequently - hypersensitivity reactions, shortness of breath isolated cases - shock.

On the part of the skin: rarely - skin rashes.

From the side of the cardiovascular system: very rarely - tachycardia, palpitations.

General disorders: rarely - asthenia.

Best before date

Do not use after the expiry date stated on the package.

Storage conditions

Keep out of the reach of children at a temperature not exceeding 30 ° C.

Incompatibility

The drug should not be mixed with other solvents, except for those provided for in the instructions for use.

Package

2 ml solution in a glass ampoule; 5 or 10 ampoules in a carton.

Holiday category

Manufacturer

Takeda Austria GmbH / Takeda Austria GmbH.

Manufacturer's location and address of the place of business

Art. Peter-Straße 25, 4020 Linz, Austria /

St. Peter - Strasse 25, 4020 Linz, Austria.

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The information in the guide is provided for informational purposes only and is taken from open sources. If you have any questions regarding the nature of the disease and the correct method of diagnosis and treatment, we recommend that you consult a doctor.

Before purchasing and using drugs, it is HIGHLY recommended that you consult a doctor and familiarize yourself with the official annotation of the drug from the manufacturer. The final decision on the appointment of the drug and determining the size of the dose can only be taken by a specialist.

Our site is not responsible for the consequences caused by the use of posted information.

Tavegil injections and instructions for use: when, in what doses and how?

Allergy injections Tavegil are a quick way to eliminate the symptoms of this disease. Today, allergies affect every 3rd person. Allergy sufferers seize every opportunity to improve their quality of life. Before using this medicine, you must definitely consult a doctor, since the instructions for using Tavegil injections suggest the occurrence of side effects after injections.

What are the injections for?

According to the instructions for use, Tavegil in ampoules is prescribed for the treatment of the following diseases:

1. allergic dermatosis;
2. chronic or acute eczema;
3. atopic and contact dermatitis;
4. skin rash that occurs due to the presence of an allergen in food or medicine;
5. insect bites;
6. hives;
7. hemorrhagic vasculitis.

In addition, Tavegil is very often used for hay fever and colds as an additional medication to the main treatment.

Applications of Tavegil in ampoules

The medicine presented in ampoules is administered intravenously or intramuscularly. The required dose is calculated by the attending physician.

When administered intravenously, it must be diluted in saline. The proportion is 1 ml of Tavegil per 5 ml of solution.

The therapeutic effect of the drug

After the drug Tavegil has entered the physiological environment of the body, it begins to rapidly spread throughout the body. In places where mast cells accumulate, the components of the drug begin to have an antipruritic and blocking effect.

According to the instructions, after 20 minutes the following effect occurs:

1. the percentage permeability of the vascular wall of small capillaries is reduced;
2. excess interstitial fluid is eliminated;
3. calms the central nervous system.

It should be noted that Tavegil does not have a sedative effect on brain structures. Due to this, there is no inhibition of mental reactions and there is no drowsiness.

The therapeutic effect is achieved rather slowly. Allergic reactions decrease 5 hours after taking the medicine. The duration of action reaches 24 hours.

Instructions for use Tavegil provides for the use of the drug for women during breastfeeding. Clemastine, which is part of Tavegil, is absorbed in the small intestine within 2 hours. As soon as clemastine enters the bloodstream, it binds to plasma protein compounds. Therefore, it is not found in milk. As for the use of injections during pregnancy, they are allowed to be used individually.

The drug Tavegil is excreted from the body by the kidneys. In small quantities, the active substance is transformed in the liver cells. Therefore, in case of serious kidney and liver diseases, the dosage recommended by the attending physician should not be exceeded.

Contraindications to the use of the drug

According to the instructions for use of the presented medication, there are contraindications. This medicine must not be taken:

1. children up to a year;
2. at the time of relief of an attack of bronchial asthma;
3. in the presence of an allergic reaction in relation to any component of the drug.

Instructions for use of this remedy for allergies provides for a condition in which the medicine should be taken with extreme caution:

• during pregnancy;
• with a stomach ulcer and 12 duodenal ulcer;
• with stenosis of the stomach and bladder;
• with an enlarged prostate;
• with any diseases of the heart and blood vessels;
• with angle-closure glaucoma.

This medicine belongs to the first generation drugs in the treatment of allergies. Despite the fact that today there are new drugs, Tavegil is still popular in the treatment of this disease.

Tavegil for injections - official instructions for use

Registration number:

INN or grouping name:: clemastine

Chemical Name:: (2R)-2-(2-((R)-1-(4-chlorophenyl)-1-phenylethoxy)ethyl)-1-methylpyrrolidine (E)-butenedioate.

Dosage form:

Composition:

Active substance - 2.68 mg of clemastine hydrofumarate (equivalent to 2 mg of clemastine),

excipients - sorbitol 90 mg, ethanol 140 mg, propylene glycol 600 mg, sodium citrate dihydrate to pH 6.3, water for injection up to 2 ml.

Description: Clear, colorless or light yellow to pale greenish yellow liquid.

Antiallergic agent - H1-histamine receptor blocker.

H1-histamine receptor blocker, ethanolamine derivative. It has a strong antihistamine and antipruritic effect with a rapid onset of action and a duration of up to 12 hours, prevents the development of vasodilation and contraction of smooth muscles induced by histamine.

Possessing an anti-allergic effect, it reduces the permeability of blood vessels, capillaries, inhibits exudation and the formation of edema, reduces itching, and has an m-anticholinergic effect.

Communication with plasma proteins is 95%. Excretion from plasma is biphasic, the corresponding half-lives are 3.6 ± 0.9 hours and 37 ± 16 hours. Clemastine undergoes significant metabolism in the liver. Metabolites are mainly (%) excreted through the kidneys in the urine; unchanged Active substance is found in the urine only in trace amounts. During lactation, a small amount of clemastine can pass into breast milk.

Indications for use

Angioedema, anaphylactic or anaphylactoid shock (as an additional remedy).

Hypersensitivity, pregnancy, lactation, taking monoamine oxidase inhibitors (MAOIs), diseases of the lower respiratory tract (including bronchial asthma), fructose intolerance, children under 1 year of age.

Intra-arterial administration of the drug is not allowed!

In patients with stenosing gastric ulcer, pyloroduodenal obstruction, with obstruction of the bladder neck, as well as prostatic hypertrophy, accompanied by urinary retention, with increased intraocular pressure, hyperthyroidism, diseases of the cardiovascular system, including arterial hypertension.

Use during pregnancy and during breastfeeding

The use of the drug during pregnancy and during breastfeeding is contraindicated.

Adults: 2 mg (2 ml), that is, the contents of 1 ampoule, 2 times a day (morning and evening). For prophylactic purposes, the drug is administered intravenously in a stream slowly (over 2-3 minutes or more) at a dose of 2 mg immediately before the possible occurrence of an anaphylactic reaction or a reaction in response to the use of histamine. The drug solution can be further diluted with isotonic sodium chloride solution or 5% glucose solution in a ratio of 1:5.

Children: 0.025 mg/kg per day intramuscularly divided into 2 injections.

Classification of the frequency of occurrence of adverse reactions:

very often (≥1/10); often (≥1/100, ≤1/10); infrequently (≥1/1000, ≤1/100); rarely (≥1/10,000, ≤1/1000); very rare (≤1/10,000).

From the nervous system:

Often: increased fatigue, drowsiness, sedation, weakness, feeling of fatigue, lethargy, impaired coordination of movements;

Rare: headache, tremor, stimulant effect.

From the gastrointestinal tract:

Rare: dyspepsia, nausea, vomiting, gastralgia, dry mouth;

Very rare: constipation.

From the sense organs:

Rare: blurred vision, diplopia, acute labyrinthitis, tinnitus.

From the side of the kidneys and urinary tract:

Very rare: frequent or difficult urination.

From the respiratory system:

Rarely: thickening of bronchial secretions and difficulty in expectoration of sputum, a feeling of pressure in the chest, respiratory failure, nasal congestion.

From the side of the cardiovascular system:

Rarely: lowering blood pressure (more often in older patients), extrasystole.

Very rare: tachycardia.

From the blood and hematopoietic organs:

Rare: hemolytic anemia, thrombocytopenia, agranulocytosis.

From the side of the skin and subcutaneous fat:

Rare: skin rash.

From the immune system:

Uncommon: photosensitivity, shortness of breath;

Rare: anaphylactic shock.

If any of the side effects listed in the instructions get worse, or if you notice any other side effects not listed in the instructions, tell your doctor.

Symptoms. An overdose of antihistamines can lead to both inhibitory and stimulating effects on the central nervous system, more commonly observed in children. Phenomena of anticholinergic action may also develop: dry mouth, fixed pupil dilation, flushing of the upper half of the body, tachycardia, disorders of the gastrointestinal tract (nausea, epigastric pain, vomiting).

Treatment. Symptomatic therapy is shown.

Interaction with other drugs

Tavegil® enhances the effect of drugs that depress the central nervous system (hypnotics, sedatives, anxiolytics), m-anticholinergics, and alcohol. Incompatible with the simultaneous use of MAO inhibitors.

Clemastine has a slight sedative effect (from mild to moderate in intensity), therefore, people taking Tavegil® are advised to refrain from driving vehicles, working with mechanisms, as well as from other activities that require increased concentration and psychomotor speed.

Solution for intravenous and intramuscular administration 1 mg/ml.

2 ml solution in glass ampoules type 1 (Eur.F.). 5 ampoules in a plastic tray. One plastic pallet, together with instructions for use, is placed in a cardboard box.

At temperatures from 15 to 30 °C.

Keep out of the reach of children.

5 years. Do not use after the expiration date indicated on the package.

Registration certificate holder

Novartis Consumer Health SA

Rue de Letraz, 1260 Nyon, Switzerland

Nycomed Austria GmbH

St. Peter-Straße 25, 4020 Linz, Austria.

Representation in Russia / Address for submitting claims

Tavegil in injections instructions for use

An effective anti-allergic agent is Tavegil. What does this medicine help with? The drug has an anticholinergic effect. Tavegil instructions for use suggest using it for the treatment of urticaria, eczema, edema, rhinitis and other manifestations of allergies.

Composition and form of release

The drug is sold in tablet form, as a syrup, solution for injection. The composition of all forms of the drug Tavegil, which helps with allergy symptoms, includes the active substance clemastine in the form of clemastine hydrofumarate.

1 ml of solution contains 1 mg of active ingredient. Additional substances are: sodium citrate, ethanol, injection water, propylene glycol, sorbitol.

Tavegil tablets contain 1 mg of the active substance, as well as the following additional substances: povidone, lactose monohydrate, talc, magnesium stearate and corn starch.

Pharmacological properties

The active substance of Tavegil tablets, from which the antihistamine effect is manifested, reduces vascular permeability. In addition, this drug has a sedative effect on the human body and exhibits unexpressed anticholinergic activity. As for the hypnotic effect, this medicine does not have such an effect.

Tavegil (according to reviews of medical specialists) helps to reduce itching, swelling, inhibition of exudation, and also reduce capillary permeability.

After oral administration, Tavegil is almost completely absorbed from the gastrointestinal tract. The maximum concentration of the active ingredient of the drug in the blood plasma is observed two to four hours after ingestion. The drug is excreted from the body to a greater extent with urine.

Injections, Tavegil tablets: what does the medicine help with

An antihistamine is prescribed for:

• contact dermatitis;
• allergic urticaria;
• hay fever;
• allergic rhinitis;
• eczema;
• allergies to insect bites;
• itchy dermatosis;
• drug allergy.

What else does the medicine help with? Indications for the use of Tavegil are also:

• acute iridocyclitis;
• hemorrhagic vasculitis;
• serum sickness;
• pseudo-allergic reaction;
• anaphylactic shock.

Contraindications

According to the instructions, the use of Tavegil (including analogues of the drug) is unacceptable in situations such as:

• Bronchial asthma.
• Reception of MAO inhibitors.
• Individual intolerance to the drug Tavegil, from which these tablets can cause allergies.
• Children's age up to one year.
• Pregnancy.
• The period of lactation (breastfeeding).
• Diseases of the lower respiratory tract.

Judging by the reviews, Tavegil should be taken with caution by people suffering from the following pathologies:

• Arterial hypertension.
• Obstruction of the bladder neck.
• Narrowing (stenosis) of the pylorus of the stomach.
• Angle-closure glaucoma.
• Hyperplasia of the prostate, accompanied by urinary retention.
• Diseases of the cardiovascular system.

Tavegil: instructions for use

How to take pills

The tablet form is taken orally twice a day at a dosage of 1 mg. The maximum allowable daily amount of Tavegil is 6 mg. Children: 0.5 mg twice a day. For children from 1 to 6 years old, the medicine is prescribed in the form of syrup, 1 teaspoon. It is not recommended to use the drug under 1 year of age.

Application instruction of Tavegil in ampoules

Intravenous and intramuscular administration of the drug is carried out twice a day, 2 mg, children from 1 to 12 years old are injected with injections of 12.5 mcg / kg 2 times. In order to prevent allergies, 2 mg of clemastine is slowly injected intravenously once. The contents of the ampoule must be dissolved in 0.9% NaCl.

The drug is not available in the form of an ointment.

Side effects

The use of Tavegil, according to patients, can provoke the occurrence of such undesirable reactions as:

• extrasystole, lowering blood pressure, palpitations;
• nasal congestion, difficulty breathing;
• thickening of bronchial secretions;
• feeling of pressure in the chest area;
• difficulty in separating sputum;
• difficult and frequent urination;
• photosensitivity, skin rash;
• anaphylactic shock, agranulocytosis;
• thrombocytopenia, hemolytic anemia;
• tinnitus, diplopia;
• violation of the clarity of visual perception;
• nausea, dyspepsia;
• gastralgia, vomiting;
• dry mouth;
• constipation or diarrhea;
• loss of appetite;
• drowsiness, increased fatigue;
• weakness, sedation;
• lethargy, feeling tired;
• impaired coordination of movements;
• tremor, headache, dizziness.

special instructions

Tavegil can distort the results of skin prick tests for allergens, so it is necessary to stop taking it no later than 72 hours before the start of allergy testing. If symptoms of the development of undesirable effects appear, you should consult a doctor.

During the period of use of clemastine, patients are advised to refrain from driving vehicles and mechanisms.

Interaction with other drugs

Tavegil enhances the effect of drugs that depress the central nervous system (hypnotics, sedatives, anxiolytics), m-anticholinergics, and alcohol. Incompatible with the simultaneous use of MAO inhibitors.

Application in Pediatrics

Children under 1 year of age should not take the drug.

How to take from 1 to 6 years? The medicine is prescribed in the form of syrup, 1 teaspoon. A solution from 1 year to 12 years old is administered by injections of 12.5 mcg / kg 2 times a day.

During pregnancy and breastfeeding

Do not use Tavegil during pregnancy and breastfeeding.

Analogues

Currently, the most effective analogues of Tavegil in terms of pharmacological action are the following drugs:

Before using Tavegil analogues, it is necessary to consult with your doctor (in order to avoid unforeseen adverse reactions).

Price where to buy

In Moscow, St. Petersburg and other cities of Russia, you can buy Tavegil, the price of which is 159 rubles, at a pharmacy without a prescription. In Kiev, tablets are sold for 76 hryvnia. In Minsk, medicine can be purchased for 6-8 bel. rubles. Price in Kazakhstan tenge.

Reviews

Quickly act against allergic reactions, inexpensive drug. However, there are strong side effects, in particular drowsiness, the hypnotic effect is very pronounced.

Injections are generally effective in helping to cope with allergies. There is also a strong hypnotic effect. There are reviews that people became ill after injections, pressure drops, dizziness, tachycardia appeared.

“The dermatologist advised me to buy Tavegil tablets and drink them to me 1 tablet 1 time per day (preferably at night). milk, but it was precisely this effect that we needed. And already in the morning the effect was noticeable. My daughter's cheeks became less red and the rash on the leg decreased. "

“I was helped a lot once, I can even say they saved me! Excellent pills, but I didn’t have any side effects.”

"Compared to suprastin, it is rather weak. But we also use it, because we need to alternate such drugs, since they are addictive."

“My wife had a serious skin itch. Redness appeared in the neck, on the elbows and knees, stomach and even on the face. Even two tablets a day were enough to get rid of itching first, and a day later from allergic dermatitis. The wife noted only one side effect: it causes drowsiness, but it was even in her favor, because before that she could not sleep peacefully.

When allergic symptoms have been tormenting for a long time, I want to find a remedy that helps quickly and without many side effects. This description is fully consistent with Tavegil - an antihistamine drug with a long (prolonged) action.

Tavegil - composition and effect produced

The active ingredient in the drug in question is clemastine fumarate. The substance is derived from ethanolamine, has the following properties:

• decreased permeability of blood vessels and capillaries;
• reduction of itching;
• stop the formation of puffiness;
• sedative effect;
• inhibition of exudation;
• prevention of smooth muscle contraction;
• local anesthetic action.

For most people, it is important that the drug does not produce a hypnotic effect. In this case, Tavegil is excellent - indications for use allow it to be taken even by drivers, employees of various industries and operators of mechanisms.

The described drug is produced in three types:

Each form contains a different concentration of clemastine fumarate per single dose.

One tablet of Tavegil contains 1 mg of active ingredient. This amount is more than enough to quickly eliminate allergy symptoms for 8-10 hours.

Tavegil injections in ampoules of 2 ml are more suitable for emergency cases, when signs of the disease lead to shortness of breath or suffocation, it is urgent to relieve swelling and tension of smooth muscles. The concentration of clemastine is 1 mg in 1 ml of solution.

Tavegil syrup has a pleasant taste and smell, so it is often used in the treatment of children. In addition, the content of the active ingredient in it is less: 0.67 mg per spoon (5 ml) of syrup.

Indications for Tavegil's use

For injections, the indications are as follows:

• serum sickness;
• angioedema;
• hemorrhagic vasculitis;
• anaphylactoid reactions, including anaphylactic shock;
• acute iridocyclitis;
• pseudo-allergic and allergic reactions.

In the form of tablets, this medication is used twice a day (morning and evening), 1 mg at a time. In severe allergies, you can increase the daily dosage, but do not exceed 4 mg. Therapy for children from 6 to 12 years old involves reducing the portion - half a capsule in the morning and at bedtime. Tablets should be taken regularly, preferably at the same time, before meals, with a small amount of clean water.

If you prefer syrup, then adults are prescribed 10 ml of the drug twice a day. Children from 3 to 12 years old are recommended half the amount of Tavegil, 5 ml at a time. For children under 3 years old, it is advisable to take the remedy no more than 2-2.5 ml of syrup in the morning and evening.

Injections of the drug must be performed intravenously or intramuscularly, slowly injecting the solution. A single dose for adults is 2 ml. In the case of treating a child, the amount of Tavegil should be reduced to 0.25 ml and divided into 2 injections.

The following diseases do not allow the use of this remedy:

• diseases of the lower respiratory tract;
• bronchial asthma;
• prostatic hyperplasia;

You can not take Tavegil during pregnancy and lactation. You can use the drug for the treatment of children only from 1 year in the form of syrup, tablets and ampoules for injection - only from 6 years.

It is also undesirable to combine Tavegil and alcohol, while drinking monoamine oxidase inhibitors.

In this article, you can read the instructions for using the drug Tavegil. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Tavegil in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Tavegil in the presence of existing structural analogues. Use to treat allergies in adults, children, and pregnancy and lactation. Interaction of the drug with alcohol.

Tavegil is a blocker of histamine H1 receptors, a derivative of ethanolamine. It has anti-allergic and antipruritic effects, reduces vascular permeability, has a sedative and m-anticholinergic effect, does not have hypnotic activity. Prevents the development of vasodilation and contraction of smooth muscles induced by histamine. Reduces capillary permeability, inhibits exudation and edema formation, reduces itching.

The antihistamine activity of the drug when taken orally reaches a maximum after 5-7 hours, persists for hours, and in some cases up to 24 hours.

Clemastine hydrofumarate + excipients.

After oral administration, Tavegil is almost completely absorbed from the gastrointestinal tract. It is excreted in breast milk in small quantities. Clemastine undergoes significant metabolism in the liver. Metabolites are mainly (45-65%) excreted in the urine; unchanged active substance is found in the urine only in trace amounts.

For the use of tablets:

• hay fever and other allergic rhinopathy;
• urticaria of various origins;
• itching, itchy dermatoses;
• acute and chronic eczema, contact dermatitis;
• drug allergy;
• insect bites and stings.

To use the solution for injection:

• anaphylactic or anaphylactoid shock and angioedema (as an additional remedy);
• prevention or treatment of allergic and pseudo-allergic reactions (including the administration of contrast agents, blood transfusion, diagnostic use of histamine).

Solution for intravenous and intramuscular administration (injections in ampoules for injection).

Instructions for use and dosage

Inside, adults and children over 12 years of age are prescribed 1 tablet (1 mg) in the morning and evening. In cases that are difficult to treat, the daily dose may be up to 6 tablets (6 mg).

Children aged 6-12 years are prescribed 1/2-1 tablet before breakfast and at night.

Tablets should be taken before meals with water.

Adults and children over 12 years of age are prescribed 10 ml of syrup (1 mg) in the morning and evening. In cases that are difficult to treat, the daily dose can be up to 60 ml of syrup (6 mg).

Children aged 6 to 12 years are prescribed 5-10 ml of syrup before breakfast and at night.

Children aged 3 to 6 years are prescribed 5 ml 2 times a day before breakfast and at night.

Children aged 1 to 3 years are prescribed 2-2.5 ml 2 times a day before breakfast and at night.

Intramuscularly or intravenously, adults are prescribed 2 mg (2 ml, i.e. the contents of one ampoule).

For the purpose of prevention, immediately before the possible occurrence of an anaphylactic reaction or a reaction in response to the use of histamine, the drug is administered intravenously in a jet at a dose of 2 mg (2 ml). Solution for injection in an ampoule can be further diluted with isotonic sodium chloride solution or 5% glucose solution in a ratio of 1:5. In / in the injection of Tavegil should be carried out slowly, for more than 2-3 minutes.

Children are prescribed at a dose of 25 mcg / kg per day in 2 injections.

• drowsiness;
• increased fatigue;
• headache;
• dizziness;
• tremor;
• sedative effect;
• weakness;
• feeling tired;
• lethargy;
• impaired coordination of movements;
• rarely, especially in children, there is a stimulating effect on the central nervous system, manifested by anxiety, increased irritability, agitation, nervousness, insomnia, hysteria, euphoria, convulsions, paresthesia;
• dyspepsia;
• nausea, vomiting;
• pain in the epigastrium;
• constipation;
• dry mouth;
• loss of appetite;
• diarrhea;
• frequent urination;
• difficulty urinating;
• thickening of bronchial secretions and difficulty in sputum separation;
• feeling of pressure in the chest and difficulty breathing;
• nasal congestion;
• lowering blood pressure (more often in older patients);
• heartbeat;
• extrasystole;
• hives;
• skin rash;
• anaphylactic shock;
• photosensitivity;
• violation of the clarity of visual perception;
• noise in ears;
• hemolytic anemia, thrombocytopenia, agranulocytosis.

• diseases of the lower respiratory tract (including bronchial asthma);
• simultaneous use of MAO inhibitors;
• children under 1 year of age (tablets should not be used in children under 6 years of age);
• lactation (breastfeeding);
• hypersensitivity to the components of the drug.

Use during pregnancy and lactation

During pregnancy, Tavegil is used only if the expected benefit of therapy for the mother outweighs the potential risk to the fetus.

Tavegil should not be used during lactation, because. clemastine is excreted in small amounts in breast milk.

Contraindicated in children under 1 year old.

Children over 1 year old: 0.025 mg/kg per day intramuscularly divided into 2 injections.

Intra-arterial administration of the drug Tavegil is not allowed.

To prevent distortion of the results of skin prick tests for allergens, the drug must be discontinued 72 hours before allergy testing.

Influence on the ability to drive vehicles and control mechanisms

Tavegil potentiates the action of drugs that depress the central nervous system (hypnotics, sedatives, tranquilizers), m-anticholinergics, and ethanol (alcohol).

Analogues of the drug Tavegil

Structural analogues for the active substance:

general description

Tavegil is considered an antiallergic drug related to first-generation antihistamines. The drug is produced by the Swiss company Novartis Consumer Health.

The active substance that has a general antihistamine effect is clemastine hydrofumarate.

Indications for appointment

Tavegil has pronounced anti-allergic qualities, so this medicine is prescribed to relieve the symptoms of various types of allergies, the most basic of which include:

• Angioedema;
• Allergic diseases, accompanied by the appearance of rashes on the body;
• Urticaria;
• Allergic reactions that occur in response to the introduction of vaccines.
• Seasonal allergorinitis and conjunctivitis;
• contact dermatoses;
• Atopic form of dermatitis;
• Allergic reactions that develop after the introduction of drugs, insect bites;
• food allergy.

The drug Tavegil is often included in the complex treatment of serum sickness, hemorrhagic vasculitis, acute iridocyclitis, anaphylaxis. The drug is also used in the treatment of pseudo-allergy.

Release form

Tavegil is produced in tablet form, in the form of a sterile solution intended for injection, and also in the form of a syrup for children.

The shape is flat, round, on one side there is an engraving in the form of the letters "OT" and a risk. There are 10 or 5 tablets in a blister.

Injections in ampoules are available in 2 ml. For each milliliter of solution, there is 1 mg of Clemastine, from the auxiliary components there is ethanol, sodium citrate dihydrate, injection water, propylene glycol, sorbitol.

A transparent, pale yellowish or colorless solution of Tavegil is placed in transparent glass ampoules, 5 pieces in a package.

Tavegil in the form of a syrup is available in dark bottles with a dispenser with a capacity of 60 and 100 ml.

1 ml of syrup contains 0.134 mg of clemastine fumarate, which corresponds to 0.1 mg of the active ingredient of clemastine.

Additional substances: ethanol, flavors ("peach", "lemon"), purified water, potassium dihydroorthophosphate KH2PO4, propylene glycol, sodium saccharin, sorbitol solution 70%, disodium hydrogen phosphate anhydrous, methylparaben, sodium saccharin, propylparaben.

pharmachologic effect

The drug is a blocker of histamine receptors, refers to ethanolamine derivatives.

The main action is antipruritic and antiallergic.

• Reduces the permeability of capillary walls;
• It inhibits the release of fluid from the intercellular spaces, thereby preventing the development of edema;
• Reduces spasm of smooth muscles;
• Has a sedative effect.

The maximum antihistamine activity of the drug reaches when taken orally after 5-7 hours, it lasts mainly for 12 hours, although in some cases the therapeutic effect of Tavegil can last about a day.

Pharmacokinetics

Metabolism of clemastine occurs in the liver tissues, the drug is almost completely absorbed from the gastrointestinal tract when taken orally. Cmax is determined in plasma 2-4 hours after administration.

Clemastine is 95% bound to plasma proteins. In a small amount, it is excreted along with breast milk.

The metabolites of Tavegil are mainly excreted in the urine, the active active substance in the biological fluid is detected only in the form of traces.

Instructions for use and standard dosages

A single and daily dose of Tavegil for patients with allergic reactions is selected by a doctor based on the age of the patient, the severity of the reaction, body weight and individual characteristics.

Tablets

Tavegil in the form of tablets for children from 12 years old, adolescents and adults is prescribed 1 mg (one tablet) in the morning and evening.

It is possible to increase the daily dose of the drug to 6 mg, usually this dosage is used for only a few days in severe allergic conditions.

When treating children aged 6 years and over, Tavegil is given half a tablet in the morning and evening. The maximum dose per day should not exceed three milligrams.

The medicine should be drunk immediately before meals with clean water.

Injections in ampoules

The injectable preparation can be used in the treatment of children from one year old. Injections in ampoules are placed in a vein or intramuscularly. The drug is prescribed 2 ml twice a day.

For children older than one year, injections of the drug are placed only in the muscle. The dosage is selected based on body weight. For every kilogram of weight, the introduction of 0.025 mg is necessary. The daily dose is divided into two single doses, which are given in the morning and in the evening.

Syrup

Tavegil syrup is prescribed for children not younger than 1 year old. The dosage is carried out according to the measured spoon supplied in the kit.

1. From 1 to 3 years - 4-5 ml;
2. From 3 to 6 years -10 ml;
3. From 6 to 12 years - from 10 to 20 ml;
4. Children over 12 years of age and adults are prescribed 20 ml of the drug per day. In severe cases - 60 ml.

All daily dosages are divided into two doses at night and before breakfast.

Contraindications

Tavegil is not used in the treatment of allergies:

• With pathologies of the lower respiratory organs, including if the patient has bronchial asthma, do not confuse with allergic asthma;
• With simultaneous treatment with MAO inhibitors;
• In children under the age of one year, this applies to the solution for injection. Until 6 years of age, it is not recommended to treat allergies with a drug in tablet form;
• With hypersensitivity to the active or auxiliary components of the drug.

It is prescribed with caution if the patient has a history of the following diseases:

• Stenosing peptic ulcer of the stomach;
• Pyloroduodenal obstruction;
• Obstruction of the neck of the urinary bladder;
• Increased intraocular pressure;
• Hyperthyroidism;
• Diseases of the heart and blood vessels, including hypertension.

Side effects

The risk of developing adverse reactions is minimal in those patients who strictly adhere to the doctor's recommendations regarding the dosage of Tavegil and the total duration of treatment for the underlying disease.

Side effects are more common in patients with hypersensitivity to the components of the drug. The likelihood of their occurrence increases with a long course of therapy.

When treating with Tavegil, it is possible:

• Violation of the National Assembly, expressed by lethargy, apathy, drowsiness, periodic pain and dizziness;
• Impaired respiratory function, up to shortness of breath. Dryness of the mucous membrane of the oropharynx causes a debilitating paroxysmal cough;
• Changes in the heart and blood vessels. Some patients note intense thirst during treatment, dry mouth, pain in different parts of the abdomen, nausea, and occasional vomiting. Blood tests show increased activity of liver transaminases;
• Tachycardia, hypotension, cardiac arrhythmias.

If adverse reactions are strongly pronounced and negatively affect the general well-being and performance, then the attending doctor should be told about this.

Overdose

An overdose of Tavegil occurs if a single dose of the drug is increased by 4 or more times.

In children, an overdose often leads to stimulation of the central nervous system, which is manifested by strong excitement, irritability. Hyperactivity turns into lethargy.

In adult patients, an overdose has a greater effect on enhancing the anticholinergic effect of the drug. It is manifested by increasing dryness in the mouth, dilated pupils, nausea or vomiting, pain in the abdomen, flushing of blood to the body.

If signs resembling an overdose appear, the patient should be immediately taken to the hospital.

It is necessary to start providing help on your own - you need to induce vomiting, give as much to drink as possible.

In the event that no more than three hours have passed since the poisoning, gastric lavage should be combined with an enema and with the use of laxatives.

In a hospital, symptomatic therapy is prescribed - drugs are selected based on the identified changes.

Instruction

for medical use

medicinal product

TavegilT

Tradename

Tavegil T

International non-proprietary name

clemastine

Dosage form

Solution for intravenous and intramuscular injection 1 mg / 1 ml, 2 ml

Composition

2 ml of solution contain

active substance- 2.68 mg clemastine hydrofumarate, equivalent to 2 mg clemastine

Excipients: sorbitol, ethanol 96%, propylene glycol, sodium citrate, water for injection.

Description

Clear, colorless to pale yellow or pale green-yellow solution.

Pharmacotherapeutic group

Antihistamines of systemic action.

Aminoalkyl ethers

ATX code R06AA04

Pharmacological properties

Pharmacokinetics

Communication with plasma proteins is 95%.

Clemastine undergoes significant metabolism in the liver. Metabolites are mainly (45-65%) excreted through the kidneys with urine; unchanged active substance is found in the urine only in trace amounts.

During lactation, a small amount of clemastine can pass into breast milk.

Pharmacodynamics

Tavegil® is an H1 receptor antagonist.

Refers to antihistamines from the group of benzohydryl ethers, reduces capillary permeability, has anti-allergic and antipruritic effects, characterized by a rapid onset and a significant duration of action, up to 12 hours.

Indications for use

Prevention or treatment of allergic and pseudo-allergic reactions, including administration of contrast agents, blood transfusion, diagnostic use of histamine

Angioedema, anaphylactic shock or anaphylactoid reactions, as an adjunct

Dosage and administration

Adults: the average dose is 2 mg / 2 ml, that is, the contents of 1 ampoule. The drug is administered intravenously or intramuscularly in the morning and evening.

For prophylactic purposes, the drug is administered slowly intravenously at a dose of 2 ml immediately before the possible occurrence of an anaphylactic reaction or a reaction in response to the use of histamine. The drug solution can be further diluted with isotonic sodium chloride solution or 5% glucose solution in a ratio of 1:5

Children: 0.025 mg / kg per day intramuscularly, preliminarily dividing the dosage into two injections.

Side effects

Often (from ≥ 1/100 to< 1/10)

Fatigue

Sedation, lethargy

Sometimes (from ≥ 1/1000 to< 1/100)

Dizziness

Hypersensitivity reactions

Rare (≥ 1/10,000 to< 1/1000)

Headache

Increased irritability

Nausea, epigastric pain, dry mouth

Urticaria, skin rash

Very rarely (< 1/10000)

Tachycardia

Anaphylactic shock.

Contraindications

Hypersensitivity to clemastine and other antihistamines of a similar chemical structure or to any of the excipients

Rare hereditary fructose intolerance, due to the content of sorbitol in the medicinal product

porfiria

Pregnancy and lactation

Children's age up to 1 year

Carefully:

In patients with stenosing gastric and duodenal ulcers, pyloroduodenal obstruction, bladder neck obstruction, prostatic hypertrophy accompanied by urinary retention, increased intraocular pressure and angle-closure glaucoma.

Drug Interactions

Tavegil® enhances the effect of drugs that depress the central nervous system (hypnotics, sedatives, anxiolytics, tricyclic antidepressants, opioid analgesics), M-anticholinergics, and alcohol. Not compatible with concomitant use of monoamine oxidase inhibitors. Enhances the effect of warfarin (anticoagulant).

special instructions

Intra-arterial administration of the drug is not allowed!

IV administration should be slow (over 2-3 minutes)

Special care should be taken when using Tavegil® in patients with stenosing gastric ulcer, pyloroduodenal obstruction, obstruction of the bladder neck, as well as prostatic hypertrophy, accompanied by urinary retention, increased intraocular pressure and angle-closure glaucoma.

The composition of the drug includes ethanol, in this regard, it is not recommended to be taken by people suffering from alcoholism. It is also necessary to take into account the presence of ethanol when prescribing to children and patients at high risk (liver disease, epilepsy).

Features of the effect of the drug on the ability to drive a vehicle or any other potentially dangerous mechanisms.

Tavegil® has a slight or moderate sedative effect, therefore it is recommended to refrain from driving a vehicle and working with any other potentially dangerous mechanisms.

Overdose

Symptoms. An overdose of antihistamines can lead to both a depressant and a stimulating effect on the central nervous system, which is expressed in depression of consciousness, increased irritability, hallucinations and convulsions. Anticholinergic effects may also develop: dry mouth, fixed pupillary dilation, upper body flushing, gastrointestinal disorders (nausea, epigastric pain, vomiting), and possibly tachycardia.

Treatment: Symptomatic therapy.

Release form and packaging

2 ml of the drug in ampoules of colorless hydrolytic glass

5 ampoules in a plastic tray, together with instructions for medical use in the state and Russian languages, are placed in a cardboard box.

Storage conditions

Store at a temperature not exceeding 30 0 С.

Keep out of the reach of children!

Shelf life

Do not use after the expiration date indicated on the package.

Terms of dispensing from pharmacies

On prescription

Name and country of the manufacturing organization

Takeda Austria GmbH, Austria.

St-Peter-Straße 25, A-4020 Linz, Austria.

Name and country of the marketing authorization holder

Novartis Consumer Health SA, Switzerland

Name and country of the packaging organization

Takeda Austria GmbH, Austria

Address of the organization that accepts claims from the consumer on the quality of the product on the territory of the Republic of Kazakhstan

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Tavegil injections and instructions for use: when, in what doses and how?

Allergy injections Tavegil are a quick way to eliminate the symptoms of this disease. Today, allergies affect every 3rd person. Allergy sufferers seize every opportunity to improve their quality of life. Before using this medicine, you must definitely consult a doctor, since the instructions for using Tavegil injections suggest the occurrence of side effects after injections.

What are the injections for?

According to the instructions for use, Tavegil in ampoules is prescribed for the treatment of the following diseases:

1. allergic dermatosis;
2. chronic or acute eczema;
3. atopic and contact dermatitis;
4. skin rash that occurs due to the presence of an allergen in food or medicine;
5. insect bites;
6. hives;
7. hemorrhagic vasculitis.

In addition, Tavegil is very often used for hay fever and colds as an additional medication to the main treatment.

Applications of Tavegil in ampoules

The medicine presented in ampoules is administered intravenously or intramuscularly. The required dose is calculated by the attending physician.

Attention! A doctor's consultation is required!
When administered intravenously, it must be diluted in saline. The proportion is 1 ml of Tavegil per 5 ml of solution.

The therapeutic effect of the drug

After the drug Tavegil has entered the physiological environment of the body, it begins to rapidly spread throughout the body. In places where mast cells accumulate, the components of the drug begin to have an antipruritic and blocking effect.

According to the instructions, after 20 minutes the following effect occurs:

1. the percentage permeability of the vascular wall of small capillaries is reduced;
2. excess interstitial fluid is eliminated;
3. calms the central nervous system.

It should be noted that Tavegil does not have a sedative effect on brain structures. Due to this, there is no inhibition of mental reactions and there is no drowsiness.

The therapeutic effect is achieved rather slowly. Allergic reactions decrease 5 hours after taking the medicine. The duration of action reaches 24 hours.

Instructions for use Tavegil provides for the use of the drug for women during breastfeeding. Clemastine, which is part of Tavegil, is absorbed in the small intestine within 2 hours. As soon as clemastine enters the bloodstream, it binds to plasma protein compounds. Therefore, it is not found in milk. As for the use of injections during pregnancy, they are allowed to be used individually.

The drug Tavegil is excreted from the body by the kidneys. In small quantities, the active substance is transformed in the liver cells. Therefore, in case of serious kidney and liver diseases, the dosage recommended by the attending physician should not be exceeded.

Contraindications to the use of the drug

According to the instructions for use of the presented medication, there are contraindications. This medicine must not be taken:

1. children up to a year;
2. at the time of relief of an attack of bronchial asthma;
3. in the presence of an allergic reaction in relation to any component of the drug.

Instructions for use of this remedy for allergies provides for a condition in which the medicine should be taken with extreme caution:

• during pregnancy;
• with a stomach ulcer and 12 duodenal ulcer;
• with stenosis of the stomach and bladder;
• with an enlarged prostate;
• with any diseases of the heart and blood vessels;
• with angle-closure glaucoma.

This medicine belongs to the first generation drugs in the treatment of allergies. Despite the fact that today there are new drugs, Tavegil is still popular in the treatment of this disease.

In this article, you can read the instructions for using the drug Tavegil. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Tavegil in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Tavegil in the presence of existing structural analogues. Use to treat allergies in adults, children, and pregnancy and lactation. Interaction of the drug with alcohol.

Tavegil- a blocker of histamine H1 receptors, a derivative of ethanolamine. It has anti-allergic and antipruritic effects, reduces vascular permeability, has a sedative and m-anticholinergic effect, does not have hypnotic activity. Prevents the development of vasodilation and contraction of smooth muscles induced by histamine. Reduces capillary permeability, inhibits exudation and edema formation, reduces itching.

The antihistamine activity of the drug when taken orally reaches a maximum after 5-7 hours, persists for 10-12 hours, and in some cases up to 24 hours.

Composition

Clemastine hydrofumarate + excipients.

Pharmacokinetics

After oral administration, Tavegil is almost completely absorbed from the gastrointestinal tract. It is excreted in breast milk in small quantities. Clemastine undergoes significant metabolism in the liver. Metabolites are mainly (45-65%) excreted in the urine; unchanged active substance is found in the urine only in trace amounts.

Indications

For the use of tablets:

• hay fever and other allergic rhinopathy;
• urticaria of various origins;
• itching, itchy dermatoses;
• acute and chronic eczema, contact dermatitis;
• drug allergy;
• insect bites and stings.

To use the solution for injection:

• anaphylactic or anaphylactoid shock and angioedema (as an additional remedy);
• prevention or treatment of allergic and pseudo-allergic reactions (including the administration of contrast agents, blood transfusion, diagnostic use of histamine).

Release form

Tablets 1 mg.

Solution for intravenous and intramuscular administration (injections in ampoules for injection).

Instructions for use and dosage

Tablets

Inside, adults and children over 12 years of age are prescribed 1 tablet (1 mg) in the morning and evening. In cases that are difficult to treat, the daily dose may be up to 6 tablets (6 mg).

Children aged 6-12 years are prescribed 1/2-1 tablet before breakfast and at night.

Tablets should be taken before meals with water.

Syrup

Adults and children over 12 years of age are prescribed 10 ml of syrup (1 mg) in the morning and evening. In cases that are difficult to treat, the daily dose can be up to 60 ml of syrup (6 mg).

Children aged 6 to 12 years are prescribed 5-10 ml of syrup before breakfast and at night.

Children aged 3 to 6 years are prescribed 5 ml 2 times a day before breakfast and at night.

Children aged 1 to 3 years are prescribed 2-2.5 ml 2 times a day before breakfast and at night.

Ampoules

Intramuscularly or intravenously, adults are prescribed 2 mg (2 ml, i.e. the contents of one ampoule).

For the purpose of prevention, immediately before the possible occurrence of an anaphylactic reaction or a reaction in response to the use of histamine, the drug is administered intravenously in a jet at a dose of 2 mg (2 ml). Solution for injection in an ampoule can be further diluted with isotonic sodium chloride solution or 5% glucose solution in a ratio of 1:5. In / in the injection of Tavegil should be carried out slowly, for more than 2-3 minutes.

Children are prescribed at a dose of 25 mcg / kg per day in 2 injections.

Side effect

• drowsiness;
• increased fatigue;
• headache;
• dizziness;
• tremor;
• sedative effect;
• weakness;
• feeling tired;
• lethargy;
• impaired coordination of movements;
• rarely, especially in children, there is a stimulating effect on the central nervous system, manifested by anxiety, increased irritability, agitation, nervousness, insomnia, hysteria, euphoria, convulsions, paresthesia;
• dyspepsia;
• nausea, vomiting;
• pain in the epigastrium;
• constipation;
• dry mouth;
• loss of appetite;
• diarrhea;
• frequent urination;
• difficulty urinating;
• thickening of bronchial secretions and difficulty in sputum separation;
• feeling of pressure in the chest and difficulty breathing;
• nasal congestion;
• lowering blood pressure (more often in older patients);
• heartbeat;
• extrasystole;
• hives;
• skin rash;
• anaphylactic shock;
• photosensitivity;
• violation of the clarity of visual perception;
• noise in ears;
• hemolytic anemia, thrombocytopenia, agranulocytosis.

Contraindications

• diseases of the lower respiratory tract (including bronchial asthma);
• simultaneous use of MAO inhibitors;
• children under 1 year of age (tablets should not be used in children under 6 years of age);
• lactation (breastfeeding);
• hypersensitivity to the components of the drug.

Use during pregnancy and lactation

During pregnancy, Tavegil is used only if the expected benefit of therapy for the mother outweighs the potential risk to the fetus.

Tavegil should not be used during lactation, because. clemastine is excreted in small amounts in breast milk.

Use in children

Contraindicated in children under 1 year old.

Children over 1 year old: 0.025 mg/kg per day intramuscularly divided into 2 injections.

special instructions

Intra-arterial administration of the drug Tavegil is not allowed.

To prevent distortion of the results of skin prick tests for allergens, the drug must be discontinued 72 hours before allergy testing.

Influence on the ability to drive vehicles and control mechanisms

drug interaction

Tavegil potentiates the action of drugs that depress the central nervous system (hypnotics, sedatives, tranquilizers), m-anticholinergics, and ethanol (alcohol).

Analogues of the drug Tavegil

Structural analogues for the active substance:

• clemastine;
• Clemastin-Eskom;
• Rivtagil.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.