Why is it worth taking it in the form of a solution and how exactly to take this vitamin? And, most importantly, is it worth introducing it into the body artificially? People concerned about these issues are looking for answers in specialized publications. But in order to understand all the features of an aqueous solution of vitamin D3, it is enough to open an anatomy school textbook.

What is Vitamin D3

As the name implies, this vitamin belongs to group D. Vitamin D3 is found in large quantities in fat-soluble compounds and is formed in the body under the influence of ultraviolet rays, in other words, under the light of the sun. Therefore, the lack of vitamins of group D in the body can be replenished by taking natural or artificial ultraviolet baths. Or, in case of sunlight deficiency, with foods such as:

• lactose-containing products (cheese, butter, milk, etc.);
• fish fat;
• fish caviar;
• parsley and similar herbs.

In some, especially advanced cases, people are prescribed aqueous solutions containing vitamin D2 or D3, depending on what type of elements are lacking in the body.

Why is the vitamin D group so important, and why does a person need to carefully monitor the amount of this element in the body? The fact is that extremely important systems of the body and its internal organs need these trace elements. Vitamins belonging to the D group have a beneficial effect on:

• bones;
• cell growth process;
• the quality of the immune system;
• work of the nervous system.

First of all, all D vitamins, including D3, affect the absorption of calcium, magnesium and other minerals necessary for the proper formation of human bone and tooth tissues. Vitamin D3 is involved in the exchange of phosphorus and calcium. It regulates their amount in the body, controlling the level of concentration. A large amount of D vitamins in the body leads to the strengthening of the human musculoskeletal system. But do not forget that an excessive amount of these elements can adversely affect health. It is important to control the intake within the daily allowance.

In addition, vitamins of group D are actively involved in the processes of vital activity, development and restoration of the body at the level of the cellular structure. Scientists have shown that vitamins D3, for example, can slow down the rate of development of cancer cells that affect the breasts and intestines.

In addition, vitamin D3 has a general strengthening effect on human immunity. A sufficient concentration of this element helps the development and functioning of the human bone marrow, which plays an important role in the immune system.

Not infrequently, vitamin D3 is used in the treatment of organs of the musculoskeletal system. Calcium in human blood is responsible for the quality of transmission of nerve impulses, and D3, which is involved in the absorption of calcium and magnesium minerals, maintains the quality of this connection and helps the nervous system recover after serious damage or disease.

Consequences of vitamin D deficiency in the human body

It is very important to maintain the concentration of vitamin D3 at the proper level. Its deficiency in the human body can lead to extremely serious consequences. Especially detrimental deficiency of this element affects children and pregnant women. To prevent this, it is important to remember the first symptoms of vitamin D deficiency. These include signs such as:

• rapid fatigue of a person;
• decrease in its performance;
• deterioration in general well-being;
• delayed healing of fractures;
• a decrease in the concentration of minerals in the bones.

First of all, the risk of vitamin D deficiency is high in people who rarely get exposed to sunlight, i.e. homebodies, residents of the northern regions and the like.

The lack of these vitamins is especially serious in children, whose body is still being formed and needs a large amount of “building material”.

They have a deficiency of vitamins of group D leads to the development of rickets and diseases of the musculoskeletal system. Parents should start to worry if a child develops symptoms such as:

• slow and long teething;
• flattening of the occipital part of the skull (children's nape becomes flat);
• decrease in tissue density;
• change in the shape of the dome of the skull and facial bones;
• curvature of the legs and deformation of the pelvis;
• changes in the shape of the chest;
• development of hyperhidrosis;
• the appearance of excessive irritation and deterioration of sleep.

All these symptoms are signs of the development of such a serious disease in a child as rickets. It is for this reason that it is extremely important to prevent a deficiency of vitamins of group D in the body.

If it is difficult to replenish these elements naturally, you should take specialized preparations and an aqueous solution of vitamin D3. But remember that their excess in the body can also adversely affect its work. To avoid possible complications, it is worth remembering the daily intake of the solution.

1. Healthy and adult people should take no more than 600 IU of vitamin D per day.
2. The norm for growing children is IU per day.
3. For the elderly and patients who are prescribed vitamin therapy as a general tonic, the attending physician calculates the dose depending on the individual characteristics of the patient.

Due to the weakening of the body and the characteristics of the growing fetus, pregnant women should take an increased amount of group D elements. To prevent the development of insufficiency and complications of fetal development, it is enough to take up to 800 IU of an aqueous solution of vitamin D3.

Features of an aqueous solution of vitamin

D3 is one of the active forms of vitamin D. It affects the metabolism of the minerals calcium and phosphorus in the body, ensuring the proper functioning of the parathyroid glands. D3 is responsible for the absorption of mineral salts, helping to absorb calcium, phosphorus and magnesium in the body.

In addition, it regulates the excretion of these minerals during the work of the urinary system. In case of a lack of vitamin D3 in the body, doctors prescribe its aqueous or oily solutions. It is important to remember that only in this form can vitamin D3 be absorbed in the body.

An aqueous solution of vitamin D3 is prescribed if the patient has the following symptoms:

• avitaminosis;
• hypovitaminosis;
• osteoporosis;
• rickets;
• non-standard nutrition (for example, a vegetarian diet);
• liver failure, cirrhosis and other liver diseases;
• sudden weight loss of various origins;
• pregnancy;
• period of lactation and breastfeeding;
• pathology of the digestive tract;
• recovery period after surgery.

It is important to remember to follow the doses indicated by the doctor. Otherwise, an excess of vitamin D3 can cause hypervitaminosis. You should immediately stop using aqueous or oily solutions if you experience symptoms such as:

• photophobia;
• complete lack of appetite;
• fast fatiguability;
• the appearance of vomiting and nausea in general;
• dry mucous membranes;
• sensation of a metallic taste in the mouth.

And do not forget that instructions are attached to any drug sold. Only by following it can you avoid complications caused by improper use of the medicine.

In addition, with an overdose of the solution, there is a high risk of problems with blood pressure, heartbeat and the functioning of the digestive system.

For these reasons, before choosing a drug, you need to consult with your doctor. Therapist's recommendations are especially important for children, the elderly and pregnant women.

At the first signs of a deficiency or an excess of vitamins of group D in the body, you should contact a specialist. It is possible to use aqueous solutions and other preparations containing the necessary vitamins only after consultation and strictly according to the instructions that are attached to the medicine.

Aquadetrim

The description is current as of 01/06/2015

• Latin name: Aquadetrim
• ATX Code: A11CC05
• Active ingredient: Colecalciferol (Colecalciferol)
• Producer: MEDANA PHARMA (Poland)

Compound

Additional components: sucrose, macrogol glyceryl ricinoleate, sodium hydrogen phosphate dodecahydrate, anise flavor, citric acid monohydrate, benzyl alcohol, water.

Release form

Colorless, transparent drops for internal use with an anise scent. 10 ml of these drops in a dark glass bottle with a stopper in the form of a dropper, one bottle in a cardboard box.

pharmachologic effect

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Vitamin D3 is a well-known active anti-rachitic agent. Its most important function is to regulate the metabolism of phosphate and calcium - this stimulates the growth of the skeleton and its mineralization.

Vitamin D3 is the physiological form of the simple vitamin D, which is synthesized in the human skin under the influence of the sun. It has 25% more pronounced activity compared to vitamin D2.

Colecalciferol plays a rather important role in the absorption of calcium and phosphates in the organs of the digestive tract, in the transport of salts, in the processes of ossification and excretion of phosphates and calcium in the urine.

The presence of calcium in the blood in the required concentrations is necessary to maintain myocardial function, skeletal muscle tone, blood coagulation processes, nerve impulse conduction, the functioning of the parathyroid glands, and the functioning of the immune system (affects the synthesis of lymphokines).

Vitamin D deficiency in the food taken, impaired absorption, insufficient exposure to ultraviolet rays and calcium deficiency during the growth of the child often leads to rickets in children, in adults to softening of the bone tissue, and in pregnant women, signs of tetany and impaired calcification of bone tissue may occur. newborns.

Pharmacokinetics

After administration, colcalciferol is actively absorbed from the intestine. Undergoes transformation in the liver and kidneys. Penetrates through the placenta and can be excreted during lactation. accumulates in the body. The half-life reaches several days. It is excreted by the kidneys in small quantities, the main part is excreted in the bile.

Indications for use

Warning and treatment:

Contraindications

• hypercalcemia;
• hypervitaminosis D;
• kidney failure;
• hypercalciuria;
• sarcoidosis;
• urolithiasis disease;
• kidney disease;
• less than 4 weeks old;
• pulmonary tuberculosis in active form;
• hypersensitivity to the components of the agent (especially to benzyl alcohol or vitamin D3).

With caution it is necessary to use this drug in patients in a state of immobilization, during pregnancy and lactation, when taking cardiac glycosides, thiazides, in infants (when a small size of the anterior crown is revealed from birth).

Side effects

Symptoms of an excess of vitamin D: nausea, loss of appetite, vomiting, constipation, dry mouth, weakness, polyuria, mental disturbance, weight loss, sleep disturbance, fever, proteinuria, hyaline casts, increased blood calcium, calcification of blood vessels, kidneys or lungs.

When the first symptoms of hypervitaminosis D appear, it is recommended to stop the drug, if possible, prevent the intake of calcium and start taking vitamins C, A and B.

Akvadetrim, instructions for use (Method and dosage)

Instructions for use Aquadetrim advises to set the dose individually, taking into account the values ​​of vitamin D3, which is formed from the vitamin D received by the patient as part of food. The agent is dissolved in 1 spoon of water. One drop of Aquadetrim contains 500 IU of colecalciferol.

For prevention of full-term newborns from the fourth week of life to three years, the drug is prescribed one or two drops a day, and for twins, premature babies and children in adverse conditions - three drops a day. In summer, the dose can be reduced to one drop per day.

Pregnant women are prescribed one drop a day for the entire pregnancy, or two drops a day, starting from the sixth to seventh month of pregnancy. Postmenopausal women are prescribed one to two drops per day.

For the purpose of therapy for rickets, the agent is prescribed daily up to 10 drops per day for a month, depending on the severity of rickets and the clinical variant of the disease. At the same time, the patient's condition and indicators of a biochemical blood test (the level of phosphorus, calcium, alkaline phosphatase in the blood and urine) should be monitored. The initial dose is 4 drops per day for five days, after this period, with good tolerance, the dosage can be increased to an individual treatment (up to 6 drops per day). 10 drops per day is prescribed only for pronounced changes in bone tissue. If necessary, you can repeat the course of treatment with the permission of the doctor after a week break. Therapy should be continued until a clear clinical effect appears, with the transition to a prophylactic dosage subsequently.

In the treatment of rickets-like diseases, drops are prescribed per day, depending on weight, age and severity of the condition, under the control of blood and urine parameters. The course of therapy is 4-6 weeks.

In the treatment of postmenopausal osteoporosis, the drug is taken one to two drops per day.

Overdose

Symptoms of an overdose in a child do not differ from those in adults and are characterized by a decrease in appetite, vomiting, diarrhea, nausea, constipation, thirst, anxiety, polyuria, and intestinal colic.

Quite frequent symptoms are also muscle, headache and joint pain, stupor, mental disorder, depression, ataxia, weight loss. Perhaps the development of kidney damage with erythrocyturia, albuminuria and polyuria, hypostenuria, increased loss of potassium, nocturia and increased pressure.

In especially severe cases, clouding of the cornea, inflammation of the iris or swelling of the optic nerve, the formation of calculi in the kidneys, calcification of tissues and organs, cholestatic jaundice may appear.

Interaction

When combined with thiazide diuretics, the risk of hypercalcemia increases.

Combined use with cardiac glycosides stimulates their toxic effect.

Terms of sale

Storage conditions

Keep away from children. Store at temperatures up to 25 degrees.

Best before date

special instructions

When prescribing a remedy, it is necessary to take into account the intake of vitamin D from all possible sources.

When using the drug for the purpose of treatment, it is necessary to regularly monitor the concentration of calcium in the urine and plasma.

Analogues

children

The drug was created for the treatment and prevention of diseases associated with chronic vitamin D deficiency, including in children. Treatment regimens for diseases associated with vitamin D deficiency in children are described in the "Aquadetrim, instructions for use" section.

Aquadetrim for newborns

For the prevention of diseases associated with vitamin D deficiency, full-term newborns from the fourth week of life and up to three years of age, the drug is prescribed 1-2 drops per day, and premature babies, twins and children in adverse conditions - 3 drops per day.

How to give Aquadetrim to babies?

Among young mothers, the question of how to give Akvadetrim to a newborn is often relevant? For infants, drops are diluted in a spoonful of porridge or milk. Adding drops to a plate or bottle is not recommended, because it cannot be guaranteed that the full dose of the product will be taken.

During pregnancy and lactation

During pregnancy and lactation, the dose of vitamin D3 should be less than 600 IU per day, otherwise a teratogenic effect on the fetus or symptoms of an overdose in an infant may develop.

Reviews about Akvadetrim

Reviews about Akvadetrim testify to the effectiveness of the drug, but there are a large number of reports of side effects and allergic reactions. In such cases, you should immediately contact your doctor.

Aquadetrim price, where to buy

The price of Akvadetrim in standard packaging in Russia is one ruble.

In Ukraine, the average price of this drug, often used for newborns to prevent hypovitaminosis D, is close to 126 hryvnias.

Aquadetrim (aqueous solution or drops) - instructions for use, reviews, analogues, side effects of the drug and indications for the treatment of vitamin D3 deficiency, rickets and osteoporosis in adults and children (including infants and newborns). Compound

This page contains detailed instructions for the use of Akvadetrim. The available dosage forms of the drug (aqueous solution or drops), as well as its analogues, are listed. Information is provided on the side effects that Aquadetrim can cause, on interactions with other drugs. In addition to information about the diseases for the treatment and prevention of which the drug is prescribed (vitamin D3 deficiency, rickets, osteoporosis), the algorithms for admission, possible dosages for adults and children are described in detail, the possibility of using during pregnancy and lactation is specified. Annotation to Akvadetrim is supplemented by reviews of patients and doctors. The composition of the drug.

Prevention and treatment:

• vitamin D deficiency;
• hypocalcemic tetany;
• osteomalacia;

• hypervitaminosis D;
• hypercalcemia;
• hypercalciuria;
• sarcoidosis;
• kidney failure;
• children's age up to 4 weeks;

• loss of appetite;
• nausea, vomiting;
• constipation;
• dry mouth;
• polyuria;
• weakness;
• weight loss;
• sleep disturbance;
• temperature increase;

• Vigantol;
• Videhol;
• Videhol solution in oil;
• Vitamin D3;
• Vitamin D3 Bon;
• Vitamin D3 aqueous solution;
• Cholecalciferol.

Contraindicated in children under 4 weeks of age.

Aquadetrim - instructions for use, reviews, analogs and forms of release (aqueous solution) drugs for the treatment of vitamin D3 deficiency, rickets and osteoporosis in adults, children (including infants and newborns) and during pregnancy. Compound

In this article, you can read the instructions for using the drug Akvadetrim. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Aquadetrim vitamins in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Akvadetrim's analogs in the presence of the available structural analogs. Use for the treatment of vitamin D3 deficiency, rickets and osteoporosis in adults, children (including infants and newborns), as well as during pregnancy and lactation. The composition of the drug.

Akvadetrim - a drug that regulates the exchange of calcium and phosphorus. Vitamin D3 is an active anti-rachitic factor. The most important function of vitamin D is to regulate calcium and phosphate metabolism, which promotes mineralization and skeletal growth.

Vitamin D3 is the natural form of vitamin D, which is formed in the human skin upon exposure to sunlight. Compared to vitamin D2, it is characterized by a 25% higher activity.

Colecalciferol plays a significant role in the absorption of calcium and phosphate in the intestine, in the transport of mineral salts and in the process of bone calcification, and also regulates the excretion of calcium and phosphate by the kidneys.

The presence of calcium ions in the blood in physiological concentrations ensures the maintenance of muscle tone of the skeletal muscles, myocardial function, promotes the conduction of nervous excitation, and regulates the process of blood coagulation.

Vitamin D is necessary for the normal functioning of the parathyroid glands, and is also involved in the functioning of the immune system, affecting the production of lymphokines.

Lack of vitamin D in food, violation of its absorption, calcium deficiency, as well as insufficient sun exposure during the period of rapid growth of the child leads to rickets, in adults - to osteomalacia, in pregnant women, symptoms of tetany, violation of the processes of calcification of the bones of newborns may occur.

An increased need for vitamin D occurs in women during menopause, as they often develop osteoporosis due to hormonal disorders.

Colecalciferol (vitamin D3) + excipients.

Aquadetrim aqueous solution is absorbed better than an oil solution (this is important when used in premature babies, because in this category of patients there is a lack of production and flow of bile into the intestine, which disrupts the absorption of vitamins in the form of oil solutions). After oral administration, cholecalciferol is absorbed from the small intestine. Metabolized in the liver and kidneys. Penetrates through the placental barrier. It is allocated with breast milk. Colecalciferol accumulates in the body. It is excreted by the kidneys in a small amount, most of it is excreted in the bile.

Prevention and treatment:

• vitamin D deficiency;
• rickets and rickets-like diseases;
• hypocalcemic tetany;
• osteomalacia;
• metabolic osteopathies (hypoparathyroidism and pseudohypoparathyroidism);
• osteoporosis, incl. postmenopausal (as part of complex therapy).

Drops for oral administration 10 ml (aqueous solution).

Instructions for use and dosage

The dose is set individually, taking into account the amount of vitamin D that the patient receives as part of the diet and in the form of drugs.

The drug is taken in 1 spoonful of liquid (1 drop contains 500 IU of colecalciferol).

In order to prevent full-term newborns from 4 weeks of life to 2-3 years, with proper care and sufficient exposure to fresh air, the drug is prescribed in a dose of IU (1-2 drops) per day.

Premature babies from 4 weeks of age, twins and children living in adverse conditions are prescribed IU (2-3 drops) per day.

In the summer, the dose can be reduced to 500 IU (1 drop) per day.

Pregnant women are prescribed 500 IU (1 drop) per day throughout pregnancy, or 1000 IU per day, starting from the 28th week of pregnancy.

In the postmenopausal period, IU is prescribed (1-2 drops) per day.

For the purpose of treatment for rickets, the drug is prescribed daily at a dose of IU (4-10 drops) per day for 4-6 weeks, depending on the severity of rickets (1, 2 or 3) and the course of the disease. In this case, the patient's clinical condition and biochemical parameters (calcium, phosphorus, alkaline phosphatase activity in the blood and urine) should be monitored. The initial dose is 2000 IU per day for 3-5 days, then, with good tolerance, the dose is increased to individual treatment (usually up to 3000 IU per day). A dose of 5000 IU per day is prescribed only for severe bone changes. If necessary, after a 1-week break, the course of treatment can be repeated.

Treatment should be continued until a clear therapeutic effect is obtained, followed by a transition to a prophylactic dose of IU per day.

In the treatment of rickets-like diseases, 000 IU (40-60 drops) per day are prescribed, depending on age, body weight and severity of the disease, under the control of blood biochemical parameters and urinalysis. The course of treatment is weeks.

In the treatment of postmenopausal osteoporosis (as part of complex therapy), IU (1-2 drops) are prescribed per day.

• loss of appetite;
• nausea, vomiting;
• headache, muscle and joint pain;
• constipation;
• dry mouth;
• polyuria;
• weakness;
• mental disorder, incl. depression;
• weight loss;
• sleep disturbance;
• temperature increase;
• protein, leukocytes, hyaline cylinders appear in the urine;
• an increase in the level of calcium in the blood and its excretion in the urine;
• possible calcification of the kidneys, blood vessels, lungs;
• hypersensitivity reactions.

• hypervitaminosis D;
• hypercalcemia;
• hypercalciuria;
• urolithiasis (formation of calcium oxalate stones in the kidneys);
• sarcoidosis;
• acute and chronic kidney disease;
• kidney failure;
• active form of pulmonary tuberculosis;
• children's age up to 4 weeks;
• hypersensitivity to vitamin D3 and other components of the drug (especially benzyl alcohol).

Use during pregnancy and lactation

During pregnancy, Aquadetrim should not be used in high doses due to the possibility of a teratogenic effect in case of an overdose.

With caution, Aquadetrim should be prescribed during lactation, because. when using the drug in high doses in a nursing mother, symptoms of an overdose in a child may develop.

During pregnancy and during breastfeeding, the dose of vitamin D3 should not exceed 600 IU per day.

Contraindicated in children under 4 weeks of age.

When prescribing the drug, it is necessary to take into account all possible sources of vitamin D.

The use of the drug for therapeutic purposes in children should be carried out under close medical supervision and adjust the dosage regimen during periodic examinations, especially in the first months of life.

Long-term use of Aquadetrim in high doses or use of the drug in loading doses can lead to chronic hypervitaminosis D3.

Do not use Aquadetrim and calcium in high doses at the same time.

Control of laboratory parameters

When using the drug for medicinal purposes, it is necessary to control the level of calcium in the blood and urine.

With the simultaneous use of Aquadetrim with antiepileptic drugs, rifampicin, cholestyramine, the absorption of cholecalciferol is reduced.

With the simultaneous use of Aquadetrim and thiazide diuretics, the risk of developing hypercalcemia increases.

Simultaneous use of Aquadetrim with cardiac glycosides may increase their toxic effect (increased risk of developing cardiac arrhythmias).

Analogues of the drug Akvadetrim

Structural analogues for the active substance:

• Vigantol;
• Videhol;
• Videhol solution in oil;
• Vitamin D3;
• Vitamin D3 100 SD/S dry;
• Vitamin D3 Bon;
• Vitamin D3 aqueous solution;
• Cholecalciferol.

Like other drugs of similar action, an aqueous solution of vitamin D3 now causes a lot of controversy and questions. Why is it so important and how does it affect the human body, and especially the child? Why is it worth taking it in the form of a solution and how exactly to take this vitamin? And, most importantly, is it worth introducing it into the body artificially? People concerned about these issues are looking for answers in specialized publications. But in order to understand all the features of an aqueous solution of vitamin D3, it is enough to open an anatomy school textbook.

What is Vitamin D3

As the name implies, this vitamin belongs to group D. Vitamin D3 is found in large quantities in fat-soluble compounds and is formed in the body under the influence of ultraviolet rays, in other words, under the light of the sun. Therefore, it can be replenished by taking natural or artificial ultraviolet baths. Or, in case of sunlight deficiency, with foods such as:

• lactose-containing products (cheese, butter, milk, etc.);
• fish fat;
• fish caviar;
• parsley and similar herbs.

In some, especially advanced cases, people are prescribed aqueous solutions containing vitamin D2 or D3, depending on what type of elements are lacking in the body.

Why is the vitamin D group so important, and why does a person need to carefully monitor the amount of this element in the body? The fact is that extremely important systems of the body and its internal organs need these trace elements. Vitamins belonging to the D group have a beneficial effect on:

• bones;
• cell growth process;
• the quality of the immune system;
• work of the nervous system.

First of all, all D vitamins, including D3, affect the absorption of calcium, magnesium and other minerals necessary for the proper formation of human bone and tooth tissues. Vitamin D3 is involved in the exchange of phosphorus and calcium. It regulates their amount in the body, controlling the level of concentration. A large amount of D vitamins in the body leads to the strengthening of the human musculoskeletal system. But do not forget that an excessive amount of these elements can adversely affect health. It is important to control the intake within the daily allowance.

In addition, vitamins of group D are actively involved in the processes of vital activity, development and restoration of the body at the level of the cellular structure. Scientists have shown that vitamins D3, for example, can slow down the rate of development of cancer cells that affect the breasts and intestines.

In addition, vitamin D3 has a general strengthening effect on human immunity. A sufficient concentration of this element helps the development and functioning of the human bone marrow, which plays an important role in the immune system.

Not infrequently, vitamin D3 is used in the treatment of organs of the musculoskeletal system. Calcium in human blood is responsible for the quality of transmission of nerve impulses, and D3, which is involved in the absorption of calcium and magnesium minerals, maintains the quality of this connection and helps the nervous system recover after serious damage or disease.

Back to index

Consequences of vitamin D deficiency in the human body

It is very important to maintain the concentration of vitamin D3 at the proper level. Its deficiency in the human body can lead to extremely serious consequences. Especially detrimental deficiency of this element affects children and pregnant women. To prevent this, it is important to remember the first symptoms of vitamin D deficiency. These include signs such as:

• rapid fatigue of a person;
• decrease in its performance;
• deterioration in general well-being;
• delayed healing of fractures;
• a decrease in the concentration of minerals in the bones.

First of all, the risk of vitamin D deficiency is high in people who rarely get exposed to sunlight, i.e. homebodies, residents of the northern regions and the like.

The lack of these vitamins is especially serious in children, whose body is still being formed and needs a large amount of “building material”.

They have a deficiency of vitamins of group D leads to the development of rickets and diseases of the musculoskeletal system. Parents should start to worry if a child develops symptoms such as:

• slow and long teething;
• flattening of the occipital part of the skull (children's nape becomes flat);
• decrease in tissue density;
• change in the shape of the dome of the skull and facial bones;
• curvature of the legs and deformation of the pelvis;
• changes in the shape of the chest;
• development of hyperhidrosis;
• the appearance of excessive irritation and deterioration of sleep.

All these symptoms are signs of the development of such a serious disease in a child as rickets. It is for this reason that it is extremely important to prevent a deficiency of vitamins of group D in the body.

If it is difficult to replenish these elements naturally, you should take specialized preparations and an aqueous solution of vitamin D3. But remember that their excess in the body can also adversely affect its work. To avoid possible complications, it is worth remembering the daily intake of the solution.

1. Healthy and adult people should take no more than 600 IU of vitamin D per day.
2. The norm for growing children is 400-500 IU per day.
3. For the elderly and patients who are prescribed vitamin therapy as a general tonic, the attending physician calculates the dose depending on the individual characteristics of the patient.

Due to the weakening of the body and the characteristics of the growing fetus, pregnant women should take an increased amount of group D elements. To prevent the development of insufficiency and complications of fetal development, it is enough to take up to 800 IU of an aqueous solution of vitamin D3.

Back to index

Features of an aqueous solution of vitamin

D3 is one of the active forms of vitamin D. It affects the metabolism of calcium and phosphorus minerals in the body, ensuring the proper functioning of the parathyroid glands. D3 is responsible for the absorption of mineral salts, helping to absorb calcium, phosphorus and magnesium in the body.

In addition, it regulates the excretion of these minerals during the work of the urinary system. In case of a lack of vitamin D3 in the body, doctors prescribe its aqueous or oily solutions. It is important to remember that only in this form can vitamin D3 be absorbed in the body.

An aqueous solution of vitamin D3 is prescribed if the patient has the following symptoms:

• avitaminosis;
• hypovitaminosis;
• osteoporosis;
• rickets;
• non-standard nutrition (for example, a vegetarian diet);
• liver failure, cirrhosis and other liver diseases;
• sudden weight loss of various origins;
• pregnancy;
• period of lactation and breastfeeding;
• pathology of the digestive tract;
• recovery period after surgery.

It is important to remember to follow the doses indicated by the doctor. Otherwise, an excess of vitamin D3 can cause hypervitaminosis. You should immediately stop using aqueous or oily solutions if you experience symptoms such as:

• photophobia;
• complete lack of appetite;
• fast fatiguability;
• the appearance of vomiting and nausea in general;
• dry mucous membranes;
• sensation of a metallic taste in the mouth.

And do not forget that instructions are attached to any drug sold. Only by following it can you avoid complications caused by improper use of the medicine.

In addition, with an overdose of the solution, there is a high risk of problems with blood pressure, heartbeat and the functioning of the digestive system.

For these reasons, before choosing a drug, you need to consult with your doctor. Therapist's recommendations are especially important for children, the elderly and pregnant women.

At the first signs of a deficiency or an excess of vitamins of group D in the body, you should contact a specialist. It is possible to use aqueous solutions and other preparations containing the necessary vitamins only after consultation and strictly according to the instructions that are attached to the medicine.

Today, it would seem, we have almost forgotten about such a terrible disease as rickets. Humanity has been overwhelmed by cardiovascular and immune pathologies, and diabetes mellitus is called the “plague of the century”. Nevertheless, on the shelves of almost all pharmacy kiosks, you can find Aquadetrim. Why, with a decline in obvious manifestations of hypovitaminosis of cholecalciferol, this drug does not lose its relevance?

The functions of vitamin D3 are directly related to the regulation of phosphorus-calcium metabolism in the body. That is why all the pathologies caused by a lack of this vitamin lead to diseases of the muscular, cardiovascular, bone and endocrine systems of a person.

Deficiency in the body is directly related to hypovitaminosis vit. D3. Especially often this relationship is manifested in the softening and senile degeneration of bone tissue.

And also in people with low consumption of dairy products, nuts, sea fish and seasonal restriction in greenery. Vitamin-mineral imbalance has also been identified in the following cases:

• Osteoporosis, as well as age-related changes in bone mineral density.
• Violation of the functions of the parathyroid glands.
• Pathologies of the immune system.

The use of therapeutic doses of calcium-containing drugs provokes high mortality from cardiovascular diseases.

It was found that the daily norm of calcium, which is 1000 - 1500 mg, requires a mandatory combination with cholecalciferol in the amount of 800 IU per day.

The lack of vit. D3 also accompanies somatic diseases:

• Chronic hypertension and cardiovascular pathologies.
• Diabetes mellitus type II.
• Chronic gastritis, peptic ulcer of the stomach and intestines, as well as other pathologies of the gastrointestinal tract. A history of cholecystitis increases the risk factor for hypovitaminosis.
• Pulmonary obstruction, tuberculosis.

With a lack of vit. D3 leads to tetanic muscle spasms and premature births. Provokes a violation of the formation of bone tissues of the fetus.

Composition and form of release Akvadetrim

Vit. D3 is unstable to UV radiation and is easily destroyed when exposed to air. Therefore, a dark glass bottle containing 10 ml of an aqueous solution of calciferol is equipped with a dosing pipette and a cap. This not only facilitates the dosage of the drug, but also protects it from oxidation.

From the point of view of compensating for the lack of cholecalciferol, dietary supplements containing at least 400 IU of the active substance have a vitamin value. 1 ml of a solution equivalent to 30 drops contains:

1. Vit. D3 - 15000 IU, 500 IU in 1 drop.
2. Excipients contribute to the stabilization of cholecalciferol and provide the possibility of its long-term storage. They also improve the taste and aroma properties of the drug. In addition, citric acid in bone tissue forms with calcium under the action of vit. D3 insoluble salts that promote bone mineralization.

• Macrogol glyceryl ricinoleate is a substance whose main component is castor oil.
• Citric acid - flavor and preservative E330, benzyl alcohol - flavor and preservative, sucrose - flavor and stabilizer, sodium hydrogen phosphate dodecahydrate - preservative E 339.
• Flavoring - anise essence.
• Purified water.

Indications for taking Akvadetrim

Necessary for activation of macrophage immune responses. Especially with mycosporic lesions of the lungs. Including tuberculosis and chronic obstruction.

To reduce the hyperfunction of the parathyroid glands.

Acquired hypovitaminosis D3 associated with malnutrition, rare exposure to the sun or peculiarities of national dress. Often leads to thyroid adenoma. It is also observed in liver diseases and lipid metabolism disorders such as celiac disease and cholestasis.

Prevention of rickets in children from 2 months to 2 years. The manifestations of this formidable disease are: softening of the bones, deformation of the skull, chest and legs, an increase in the abdomen, muscle flabbiness, slowing down the ossification of the fontanel and an increase in the period of teething. For (and for older children) it is better to use an aqueous solution of vitamin Aquadetrim, as it is absorbed faster and better absorbed by the body than oil drops.

Dosage

With a daily requirement for vit. D3 in children - from 500 to 1000 IU and adults - 800 IU, Aquadetrim is recommended both prophylactically and for the correction of calcium phosphorus metabolism disorders:

Children from 4 weeks to 3 years prophylactically - 1 drop. If there is a risk of developing rickets - from 2 to 3 drops.

1 drop per day. With special instructions from the doctor - 2 drops from 28 weeks.

Postmenopausal period -1 or 2 drops.

Treatment of rickets and rickets-like conditions is carried out only under the supervision of the attending physician and depends on the severity of the disease.

Therapy vit. D3 is individual for each patient and requires biochemical control throughout the treatment.

Contraindications

Hypervitaminosis vit.D.

High levels of calcium in the blood and urine.

Violation of water-salt metabolism, including with a tendency to form calcareous kidney stones.

Chronic renal failure and other disorders of the kidneys or liver.

Sarcoidosis and tuberculosis in the acute phase.

Intolerance to food additives of class "E".

Newborns up to 4 weeks.

Without special instructions from the doctor, you should refrain from taking Aquadetrim when:

Tendency to allergies.

Combination with diuretic thiazides.

Simultaneous reception with glycosides increases the toxicity of digitalis and the risk of cardiac arrhythmias.

Dangers of hypervitaminosis D3 during pregnancy and lactation.

The propensity of newborns to the rapid overgrowth of the fontanel.

Side effects

Overdose. Vitamin D3 is easily absorbed, entering the body as part of fatty milk products (cream, sour cream,), as well as egg yolks, and yeast. In addition to this, it is formed in the skin under the action of sunlight and accumulates. Therefore, uncontrolled intake of Aquadetrim can lead to hyperavitaminosis of cholecalciferol.

Symptoms: nausea, vomiting, loss of appetite and weight, thirst, increased daily diuresis and the appearance of protein in the urine, constipation, hypertension, excessive muscle tone and joint pain. From the side of the National Assembly: headache, mental disorder, depression, insomnia.

Chronic overdose makes the bones brittle and brittle. Vessels, tissues and lungs lose their softness and elasticity during the formation of lime deposits. Ataxia, stupor, inflammatory keratids, cataracts, papilledema, and urolithiasis are possible.

Interaction with other drugs

Suppressed by phosphates and calcium.

Decreased effectiveness when taken simultaneously with cholestyramine, antiepileptic drugs and rifampicin.

Combination with digitalis preparations and thiosides is life threatening.

Aquadetrim is equivalent to dietary supplements. It is believed that such funds do not require the advice of specialists. However, numerous nuances of Aquadetrim's effect on the body urgently require a doctor's consultation.

The average price for vitamin D3 aquadetrim in Moscow pharmacies is about 195 rubles. But, in online pharmacies you can find cheaper (from 125 rubles).

Reviews about Akvadetrim

Pavel S. The summer turned out to be rainy, and my daughter is at the age when children grow up. Heard enough of the doctor's warnings about rickets and decided to insure himself with Aquadetrim. It wouldn't hurt to do it myself either. Before meeting with Akvadetrim, he considered all side effects to be empty talk. To be honest, I didn't even look at the abstract. They said that the vitamin is good, period. Daughter sprinkled immediately, and me - a week later. I sinned on fruits, shampoo and powder, but it turned out that the damned drug was to blame. The auxiliary composition is such that it is easier to drink the solvent. And doctors prescribe this to children! The Poles don't care what they sell us, but children are not a field for experimentation.

Tatiana B. 24 The reason for the appointment of Akvadetrim to my daughter is rickets 2 of the subacute course, the peak period. For a number of reasons, the child was born severely premature. Instructions for the use of vitamin D3 Aquadetrim and reviews on the Internet terrified me. But is allergy so terrible compared to rickets? Moreover, the oil-based vitamin was not suitable for us due to problems with the intestines. I can understand parents canceling Aquadetrim because of the backlash. Their children were prescribed the drug for prophylactic purposes. For us, he was a real lifesaver.

Kuzmin S.E., Dr. med. Sciences. The pathophysiological significance of hypovitaminosis of cholecalciferol in the anamnesis of somatic and cardiovascular diseases is enormous. The use in clinical practice of combination therapy of calcium-containing drugs with Aquadetrim in a daily dose of at least 800 IU recorded a positive trend. I would also like to note the preventive role of Akvadetrim in case of the threat of osteoporotic fractures and other disorders of bone tissue mineralization.

Smirnova E. N., pediatrician. Rickets in children does not pose an immediate threat to life, but increases mortality from concomitant diseases. It is rickets who are difficult to tolerate pneumonia, measles and whooping cough. Often hypovitaminosis D3 leads to the development of anemia, pneumonia, pathologies of the liver and spleen.

Newborns receive the necessary substances with mother's milk. Seasonal solar activity plays a huge role in this. Therefore, the risk group is made up of artificial children and children born in the autumn-winter season.

Rickets is a disease of rapid growth.

The needs of a growing organism for phosphorus, calcium and cholecalciferol are not satisfied by their delivery system.

Aquadetrim showed excellent results in the prevention and treatment of rickets. Its use allows you to normalize the functions of both a number of systems and organs, and the whole organism as a whole. After all, despite the strong opinion about the predominance of musculoskeletal symptoms of rickets, its first manifestations are associated with the nervous system. Anxiety, tearfulness, the appearance of diaper rash due to excessive sweating can be a signal for the appointment of Akvadetrim. At the same time, it is important to prevent the outbreak of the disease.

Features of the metabolism of cholecalciferol and its close relationship with mineral metabolism make Aquadetrim a therapeutic drug rather than a dietary supplement. Too huge connection vit. D3 with the nervous, endocrine, muscular and cardiovascular systems of the body.

In general, Aquadetrim is an excellent prophylactic and therapeutic agent in the presence of factors that reduce the effectiveness of oil solutions of vit. D3.

The allergenic composition of Aquadetrim excipients is associated with the fat-soluble nature of its active ingredient. It is worth noting that chem. class E substances are officially used not only in pharmacology. Most modern products are “rich” in more serious additives, but they do not cause complaints from consumers.

Girls have many times over the past three months faced with questions in posts on the topic of how to use this vitamin! You do not be offended, dear moms, but it surprises you a lot, when you buy a drug, that you do not read the instructions? Or does the doctor not explain to you how to take it correctly? It was especially funny to read when several mothers desperately argued that this was already an aqueous solution and did not need to be dissolved additionally in water !!! Dear moms, this is an instruction for taking this vitamin, whoever is interested can save it, it will come in handy !!! (the main thing is in bold, for those who are too lazy to read). Just don’t need to prove that you are so smart dripping right into your mouth, but you wrote instructions for fools! I wish you all good health and good luck!!!

Pharmachologic effect:

The active substance of the drug is cholecalciferol (vitamin D3) - a regulator of calcium and phosphate metabolism. Synthetic colcalciferol is identical to the endogenous one, which is formed in the body under the influence of sunlight. Colecalciferol has a more pronounced physiological activity in comparison with ergocalciferol (vitamin D2). Under the action of the drug, the metabolism of calcium and phosphates in the human body is normalized. This contributes to the proper formation of the bone skeleton and the preservation of the structure of bone tissue. The drug has a pronounced antirachitic effect. Colecalciferol promotes more intensive adsorption of calcium and phosphates in the distal small intestine, by increasing the permeability of cellular and mitochondrial membranes of the intestinal epithelium. Promotes the passage through the membranes of divalent ions, including calcium. Improves phosphate reabsorption during glomerular filtration. Facilitates the capture of calcium and phosphate by bone tissue, regulates the distribution of these ions in blood plasma, soft tissues and bones.

In addition, without cholecalciferol, the full functioning of the parathyroid glands is impossible. Influencing the production of lymphokines, the drug is involved in the formation of nonspecific immunity. Colecalciferol is involved in the synthesis of adenosine triphosphoric acid.
Normalization of the content of calcium ions in the blood leads to the maintenance of normal skeletal muscle tone, regulates the function of the heart. Vitamin D3 facilitates the conduction of nerve impulses, affects blood clotting.
With hypovitaminosis D and calcium deficiency, diseases such as rickets, osteoporosis can develop. They are especially susceptible to young children during a period of intensive growth and women in the postmenopausal period, due to hormonal changes in the body. In pregnant women with a lack of colecalciferol, symptoms of tetany occur.
Aquadetrim, an aqueous solution of colcalciferol, is better adsorbed and has greater bioavailability than oil solutions. In addition, the aqueous solution does not require the presence of bile for absorption into the blood, which is an important factor for premature babies with an immature digestive system.

Adsorbed in the distal small intestine, metabolized in the liver and kidneys, excreted by the kidneys and partly with bile. After the release of cholecalciferol with bile, it can be re-adsorbed by the intestines, or excreted in the feces. Able to accumulate in the body. The drug penetrates well through the placental barrier, excreted in breast milk.
The half-life is 3-5 days and increases with insufficient kidney function.

Indications for use:
Hypo- and avitaminosis D.
Prevention and treatment of rickets and rickets-like diseases.
Osteopathies caused by metabolic disorders, including hypoparathyroidism and pseudohypoparathyroidism.
Hypocalcemia.
Tetany caused by hypocalcemia.
Osteomalacia of various etiologies.
To accelerate the fusion and recovery of bones after fractures.
Loss of calcium in bones and teeth.
Osteoporosis, including those associated with hormonal changes during menopause and postmenopause.
Spasmophilia.

Mode of application:
The drug is taken orally, dissolved in a small amount of liquid (usually a dose of the drug is dissolved in a tablespoon of water).
1 drop of the drug contains about 500 IU of colecalciferol.
Doses are selected by the attending physician individually for each patient, taking into account many factors, including the amount of cholecalciferol that enters the body with food.

Average doses of Aquadetrim are:
Taking the drug for prophylactic purposes:
Children born after 37 weeks of gestation, starting from 4 weeks of age, are prescribed 500 IU per day.
Children born before 37 weeks of gestation, twins, children living in adverse conditions are prescribed 1000-1500 IU (2-3 drops) per day, starting from 3-4 weeks of life. In the summer, with sufficient exposure to fresh air, the dose can be reduced to 500 IU per day.
Pregnant women, starting from the 28th week of pregnancy, are prescribed 500 IU per day.
During menopause and postmenopause, 500-1000 IU per day is prescribed.

Taking the drug for the purpose of therapy:
In the treatment of rickets, the daily dose is 2000-5000 IU, while at first 2000 IU is prescribed for 5 days, if the drug is well tolerated, the dose is increased to the required therapeutic dose. Colecalciferol at a dose of 5000 IU per day is prescribed only if the patient has severe bone pathologies. The course of treatment is up to 6 weeks, if necessary, the course is repeated after 1-2 weeks until a stable therapeutic effect is achieved, after which a maintenance dose of 500 IU per day is taken.
For rickets-like diseases, 20,000-30,000 IU (40-60 drops) are prescribed per day, depending on age, weight, severity of the disease, with constant laboratory and medical supervision. The course of treatment is 4-6 weeks.
Aquadetrim in the complex therapy of osteoporosis in the postmenstrual period is used in a daily dose of 500-1000 IU.

Side effects:
Side effects when taking the recommended doses of the drug are extremely rare. However, with individual hypersensitivity and / or an increase in the dose, the following side effects may develop:

From the side of the central nervous system: headache, mental disorders, depression, stupor, mood swings, irritability.
From the gastrointestinal tract: nausea, vomiting, stool disorders, weight loss, anorexia, thirst, dry mouth.
From the side of the cardiovascular system: disorders of the heart, in particular arrhythmias, increased heart rate, increased blood pressure.
From the urinary system: polyuria, the formation of kidney stones, nephropathy.
From the musculoskeletal system: myalgia, arthralgia, general muscle weakness.
Others: exacerbation of the course of pulmonary tuberculosis, soft tissue calcification.
The frequency and severity of side effects increase with the course of taking the drug, due to its accumulation in the body.

Contraindications:
Increased individual sensitivity to cholecalciferol, including history. Individual intolerance to benzyl alcohol.
Elevated calcium levels in the blood (hypercalcemia).
Elevated levels of calcium in the urine (hypercalciuria).
Hypervitaminosis D.
Urolithiasis with deposition of calcium oxalate.
Insufficiency of kidney function.
Active form of pulmonary tuberculosis.
Large doses of the drug are contraindicated during prolonged immobilization.
The drug is prescribed with caution during pregnancy and lactation.
In patients with atherosclerosis, sarcoidosis, hyperphosphatemia, acute and chronic diseases of the kidneys and liver. With violations of the gastrointestinal tract, in particular with gastric and duodenal ulcers. With organic heart disease, such as pericarditis, myocarditis, etc.

Pregnancy:
The use of the drug is possible after consultation with your doctor. Pregnant women are not prescribed the drug in high doses, as this can lead to impaired fetal development. The teratogenic effect of Akvadetrim may occur with an overdose of the drug. When a pregnant woman takes high doses, the fetus has an increased sensitivity to vitamin D, depression of the parathyroid gland, a syndrome of a specific elf-like appearance, aortic stenosis, and mental retardation. It is not recommended to take the drug at a dose exceeding 500 IU per day.
During the period of breastfeeding, it is necessary to take the drug with caution, since when the mother takes a large dose of Aquadetrim, symptoms of hypercalcemia in the child are possible.

Interaction with other drugs:
Simultaneous use with antiepileptic drugs, neomycin, rifampicin, liquid paraffin, cholestyramine reduces the reabsorption of Aquadetrim.
Thiazide diuretics increase the risk of hypercalcemia and side effects of cholecalciferol.
The drug is able to enhance the toxic effects of cardiac glycosides, increases the likelihood of complications from the cardiovascular system.
Tocopherol, vitamin A, pantothenic acid, ascorbic acid, riboflavin reduce the risk of side effects of Aquadetrim, reduce its toxicity.
The break between taking Aquadetrim and sodium fluoride should be at least 2 hours. Between taking Aquadetrim and oral tetracyclines - at least 3 hours.
Concomitant use with vitamin D analogues increases the risk of hypercalcemia.
Barbiturates, when taken simultaneously with cholecalciferol, increase the rate of its biotransformation, which can lead to an increase in the need for cholecalciferol.

Overdose:
When taking the recommended doses of the drug, an overdose is unlikely and is possible only in individuals with increased individual sensitivity to cholecalciferol. Overdose is manifested by symptoms characteristic of hypercalcemia - arrhythmias, nausea, vomiting, epigastric pain, headache, mood swings, weight loss, kidney stones, frequent urination, thirst, nephrocalcinosis and soft tissue calcification. Arterial hypertension, renal failure, stool disorders, anorexia.

If the drug is taken for too long or regularly taken in high doses, chronic cholecalciferol poisoning may develop, which is characterized by bone demineralization, instead of calcium deposits in soft tissues, including the kidneys, lungs, heart, blood vessels, and intestines. As a result of such mineral redistribution, organ functions are disrupted, which can lead to severe dysfunction of internal organs and, as a result, to death.
For the treatment of overdose conditions, corticosteroids, magnesium, potassium, retinol, thiamine, ascorbic acid preparations are used. It is also necessary to stop taking the drug Akvadetrim.

Release form:
Solution for oral administration of 10 ml in dark glass bottles, 1 bottle in a carton.